Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis

5227 Pages·2014·19.87 MB·English

by  Mary A. Williamson

Wallach’s
Interpretation of Diagnostic Tests
Pathways to Arriving at a Clinical
Diagnosis
TENTH EDITION
Wallach’s
Interpretation of Diagnostic Tests
Pathways to Arriving at a
Clinical Diagnosis
TENTH EDITION
Edited by
Mary A. Williamson, MT (ASCP), PhD
Vice President, Scientific Affairs & Laboratory Operations ACM
Medical Laboratory
Rochester, New York
Former Assistant Professor Department of Pathology University of
Massachusetts Medical School Worcester, Massachusetts L.
Michael Snyder, MD
Professor
Department of Medicine and Pathology University of Massachusetts
Medical School UMass Memorial Medical Center Worcester,
Massachusetts Chief Medical Officer
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Executive Editor: Rebecca Gaertner
Senior Product Development Editor: Kristina Oberle
Production Project Manager: Alicia Jackson
Design Coordinator: Joan Wendt
Senior Manufacturing Coordinator: Beth Welsh
Marketing Manager: Stephanie Manzo
Prepress Vendor: SPi Global
Printed in China
Copyright © 2015 Wolters Kluwer
© 2011, 2007 by LIPPINCOTT WILLIAMS & WILKINS, a Wolters Kluwer Business, © 2000 by
Lippincott Williams & Wilkins, © 1996, 1992 and 1986 by Jacques Wallach, MD, © 1978, 1974 and 1970
by Little, Brown and Company
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2001 Market Street
Philadelphia, PA 19103 USA
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Library of Congress Cataloging-in-Publication Data Wallach's interpretation of diagnostic tests. —
Tenth edition / edited by Mary A. Williamson, L. Michael Snyder.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-4511-9176-9 (paperback : alk. paper)
I. Williamson, Mary A., editor. II. Snyder, L. Michael, editor.
[DNLM: 1. Clinical Laboratory Techniques. 2. Diagnostic Techniques and Procedures. QY 25]
RB38.2
616.07'56—dc23
2014012353
Care has been taken to confirm the accuracy of the information presented and to describe generally
accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions
or for any consequences from application of the information in this book and make no warranty, expressed
or implied, with respect to the currency, completeness, or accuracy of the contents of the publication.
Application of this information in a particular situation remains the professional responsibility of the
practitioner; the clinical treatments described and recommended may not be considered absolute and
universal recommendations.
The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set
forth in this text are in accordance with the current recommendations and practice at the time of publication.
However, in view of ongoing research, changes in government regulations, and the constant flow of
information relating to drug therapy and drug reactions, the reader is urged to check the package insert for
each drug for any change in indications and dosage and for added warnings and precautions. This is
particularly important when the recommended agent is a new or infrequently employed drug.
Some drugs and medical devices presented in this publication have Food and Drug Administration (FDA)
clearance for limited use in restricted research settings. It is the responsibility of the health care provider to
ascertain the FDA status of each drug or device planned for use in his or her clinical practice.
9 8 7 6 5 4 3 2 1
I am deeply grateful to my parents Priscilla and Thomas Williamson
for their unconditional love. Sincere thanks to Joanne Saksa for her
gracious hospitality and warmest gratitude to Brenda DeMay, for her
unconditional love and continually encouraging me to challenge
myself.
I am most indebted to Dr. L. Michael Snyder, a true mentor
throughout the years who has taught me that anything is possible—
even the Boston Red Sox can win the World Series! Special thanks to
all of the authors for their hard work and commitment, especially
Liberto Pechet, a true gentleman.
Mary A. Williamson, MT(ASCP), PhD
To my wife Barbara, and children Cathe, Lizzy, and John for their
tireless understanding and support throughout the years.
To my assistant Suzanne O’Brien for her dedication and help with the
textbook.
I would also like to acknowledge Dr. Mary Williamson, for without
her commitment, dedication and hard work, we would not have met
the target date for completion of the tenth edition.
L. Michael Snyder, MD
Contributors
M. Rabie Al-Turkmani, BPharm, PhD
Assistant Professor
Department of Pathology
University of Massachusetts Medical School Associate Director, Immunology,
Immunoassay & Hematology Laboratories UMass Memorial Medical Center
Worcester, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Vishesh Chhibber
Medical Director, Transfusion Medicine North Shore University Hospital
Hofstra North Shore-LIJ School of Medicine North Shore-LIJ Health System
Manhasset, New York
Marzena M. Galdzicka, PhD, MP(ASCP)CM, DABCC
Clinical Assistant Professor
Department of Pathology
University of Massachusetts Medical School Shrewsbury, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Edward I. Ginns, MD, PhD, DABCC
Professor of Neurology, Pathology, Pediatrics and Psychiatry Director,
Lysosomal Disorders Treatment and Research Program University of
Massachusetts Medical School Shrewsbury, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Amanda J. Jenkins, PhD
Associate Professor
Department of Pathology
University of Massachusetts Medical School Director, Toxicology
UMass Memorial Medical Center
Worcester, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Charles R. Kiefer, PhD
Associate Professor
Department of Pathology
University of Massachusetts Medical School Director, Andrology Laboratory
Director, Clinical Assay Research UMass Memorial Medical Center
Worcester, Massachusetts
Patricia Minehart Miron, PhD
Clinical Associate Professor of Pathology and Pediatrics University of
Massachusetts Medical School Director, Cytogenetics
UMass Memorial Medical Center
Worcester, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Michael J. Mitchell, MD
Clinical Associate Professor
Department of Pathology
University of Massachusetts Medical School Director, Microbiology
UMass Memorial Medical Center
Worcester, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Liberto Pechet, MD
Professor Emeritus
Departments of Pathology and Medicine University of Massachusetts Medical
School Worcester, Massachusetts
Lokinendi V. Rao, PhD
Clinical Associate Professor
Department of Pathology
University of Massachusetts Medical School Laboratory Director, UMass
Memorial Clinical Laboratories UMass Memorial Medical Center
Worcester, Massachusetts
Scientific Director,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Craig S. Smith, MD
Assistant Professor
Department of Medicine
University of Massachusetts Medical School Director, Cardiac Intensive Care
Division of Cardiology
UMass Memorial Medical Center
Worcester, Massachusetts
L. Michael Snyder, MD
Professor
Department of Medicine and Pathology University of Massachusetts Medical
School UMass Memorial Medical Center
Worcester, Massachusetts
Chief Medical Officer,
Quest Diagnostics MA, LLC
Marlborough, Massachusetts
Juliana G. Szakacs, MD, MSW
Director of Pathology and Laboratory Medicine Harvard Vanguard Medical
Associates Boston, Massachusetts
Mary A. Williamson, MT (ASCP), PhD
Vice President, Scientific Affairs & Laboratory Operations ACM Medical
Laboratory
Rochester, New York
Former Assistant Professor
Department of Pathology
University of Massachusetts Medical School Worcester, Massachusetts