Table Of Content®
USMLE STEP 1: PHARMACOLOGY
Lecture Notes
2018
Table of Contents
USMLE Step 1 Lecture Notes 2017: Pharmacology
Cover
Title Page
Copyright
Editors
Feedback Page
Part I: General Principles
Chapter 1: Pharmacokinetics
Pharmacokinetics
Absorption
Distribution
Biotransformation
Elimination
Steady State
Pharmacokinetics Calculations
Chapter 2: Pharmacodynamics
Definitions
Graded (Quantitative) Dose-Response (D-R) Curves
Quantal (Cumulative) D-R Curves
Signaling Mechanisms: Types of Drug-Responsive Signaling
Mechanisms
Chapter 3: Practice Questions
Practice Questions
Practice Questions: Answer Key
Practice Questions: Answers and Explanations
Part II: Autonomic Pharmacology
Chapter 1: The Autonomic Nervous System
Anatomy of the ANS
Blood Pressure Control Mechanisms
Pupillary Size and Accommodation Mechanisms
Chapter 2: Cholinergic Pharmacology
Cholinergic Neuroeffector Junctions
Muscarinic Receptor Activators
Muscarinic Receptor Antagonists
Nicotinic Receptor Antagonists
Chapter 3: Adrenergic Pharmacology
Adrenergic Neuroeffector Junctions
Direct-Acting Adrenoceptor Agonists
Indirect-Acting Adrenergic Receptor Agonists
Adrenergic Antagonists
Chapter 4: Autonomic Drugs: Glaucoma Treatment and ANS
Practice Problems
Glaucoma Treatment
ANS Practice Problems
ANS Practice Problems: Answers and Explanations
Chapter 5: Autonomic Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part III: Cardiac and Renal Pharmacology
Chapter 1: Diuretics
Types of Diuretics
Chapter 2: Antihypertensives
Drug Strategy
Thiazide Diuretics
Drugs Altering Sympathetic Activity
Direct-Acting Vasodilators
Indications for Use of Antihypertensive Drugs in Comorbid
Conditions
Treatment of Pulmonary Hypertension
Chapter 3: Drugs for Heart Failure
Primary Treatments for CHF
Inotropes
Chapter 4: Antiarrhythmic Drugs
Cardiac Action Potential
Na+ Channels
ANS Regulation of Heart Rate
Class I: Na+ Channel Blockers
Class II: Beta Blockers
Class III: K+ Channel Blockers
Class IV: Ca2<sup>+</sup> Channel Blockers
Unclassified
Chapter 5: Antianginal Drugs
Rationale for Use
Key Antianginal Drugs
Chapter 6: Antihyperlipidemics
Cardiovascular Risks of Hyperlipidemia
Lipid-Lowering Drugs
Chapter 7: Cardiac and Renal Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part IV: CNS Pharmacology
Chapter 1: Sedative-Hypnotic-Anxiolytic Drugs
Drugs Used for Sedation, Sleep, Anxiety
Chapter 2: Alcohols
Chapter 3: Drugs Used for Depression, Bipolar Disorders, and
Attention Deficit Hyperactivity Disorder (ADHD)
Drugs Used in Depression
Drugs Used in Bipolar Disorders
Drugs Used in ADHD
Chapter 4: Drugs Used in Parkinson Disease and Psychosis
Dopaminergic Neural Pathways
Dopamine Receptors
Drugs Used in Parkinson Disease
Antipsychotic Drugs
Chapter 5: Anticonvulsants
Drugs Used in Seizures
Chapter 6: Drugs Used in Anesthesia
General Anesthetics
Local Anesthetics
Skeletal Muscle Relaxants
Chapter 7: Opioid Analgesics
Properties of Opioids
Chapter 8: Drugs of Abuse
Chapter 9: CNS Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part V: Antimicrobial Agents
Chapter 1: Antibacterial Agents
Principles of Antimicrobial Chemotherapy
Inhibitors of Cell-Wall Synthesis
Inhibitors of Bacterial Protein Synthesis
Inhibitors of Nucleic Acid Synthesis
Unclassified Antibiotic
Antitubercular Drugs
Chapter 2: Antifungal Agents
Polyenes (Amphotericin B [Amp B], Nystatin)
Chapter 3: Antiviral Agents
Antiviral Drug Properties
Treatment of HIV
Other Antivirals
Chapter 4: Antiprotozoal Agents
Overview
Chapter 5: Antimicrobial Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part VI: Drugs for Inflammatory and Related Disorders
Chapter 1: Histamine and Antihistamines
Histamine
Chapter 2: Drugs Used in Gastrointestinal Dysfunction
Drugs Used in Peptic Ulcer Disease (PUD)
Antiemetics
Chapter 3: Drugs Acting on Serotonergic Systems
Drug Actions on 5HT Receptors
Drugs Used in Migraine Headaches
Chapter 4: Eicosanoid Pharmacology
Eicosanoids
Nonsteroidal Antiinflammatory Drug (NSAIDs)
Other Drugs
Chapter 5: Drugs Used for Treatment of Rheumatoid Arthritis
Rheumatoid Arthritis
Chapter 6: Drugs Used for Treatment of Gout
Gout
Chapter 7: Glucocorticoids
Glucocorticoid Properties
Chapter 8: Drugs Used for Treatment of Asthma
Asthma Treatments
Chapter 9: Inflammatory Disorder Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part VII: Drugs Used in Blood Disorders
Chapter 1: Anticoagulants
Anticoagulant Overview
Chapter 2: Thrombolytics
Thrombolytic Overview
Chapter 3: Antiplatelet Drugs
Antiplatelet Overview
Chapter 4: Blood Disorder Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part VIII: Endocrine Pharmacology
Chapter 1: Drugs Used in Diabetes
Diabetes Mellitus
Insulins Forms
Drugs for Type II Diabetes
Chapter 2: Steroid Hormones
Adrenal Steroids
Estrogens
Progestins
Oral Contraceptives
Androgens
Chapter 3: Antithyroid Agents
Thyroid Hormones
Chapter 4: Drugs Related to Hypothalamic and Pituitary Hormones
Chapter 5: Drugs Used for Bone and Mineral Disorders
Osteoporosis Treatment
Chapter 6: Endocrine Drug List and Practice Questions
Practice Questions
Practice Questions: Answers and Explanations
Part IX: Anticancer Drugs
Chapter 1: Anticancer Drugs
Principles
Drugs and Drug Properties
Chapter 2: Anticancer Drug Practice Questions
Anticancer Drug Practice Questions
Anticancer Drug Practice Questions: Answers and Explanations
Part X: Immunopharmacology
Chapter 1: Immunopharmacology
Immunosuppressants
Chapter 2: Immunopharmacology Practice Questions
Immunopharmacology Practice Questions
Immunopharmacology Practice Questions: Answers and
Explanations
Part XI: Toxicology
Chapter 1: Toxicology
Toxicology
Chapter 2: Toxicology Practice Questions
Toxicology Practice Questions
Toxicology Practice Questions: Answers and Explanations
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