Urinary tract

591 Pages·2011·5.58 MB·English

by  Christopher Chapple (auth.)

Handbook of Experimental Pharmacology
Volume 202
Editor-in-Chief
FranzB.Hofmann
EditorialBoard
JosephA.Beavo
DetlevGanten
Jan-AndersKarlsson
MartinC.Michel
CliveP.Page
WalterRosenthal
Forfurthervolumes:
http://www.springer.com/series/164
.
Karl-Erik Andersson Martin C. Michel
l
Editors
Urinary Tract
Editors
Dr.Karl-ErikAndersson Prof.Dr.MartinC.Michel
WakeForestUniversity UniversityofAmsterdam
MedicalCenterBlvd. AcademicMedicalCenter
27157-1088Winston-Salem Dept.Pharmacology&
NorthCarolina Pharmacotherapy
USA Meibergdreef15
[email protected] 1105AZAmsterdam
Netherlands
[email protected]
ISSN0171-2004 e-ISSN1865-0325
ISBN978-3-642-16498-9 e-ISBN978-3-642-16499-6
DOI10.1007/978-3-642-16499-6
SpringerHeidelbergDordrechtLondonNewYork
LibraryofCongressControlNumber:2011921350
#Springer-VerlagBerlinHeidelberg2011
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ThisbookisdedicatedtothememoryofthelateProf.AlisonBradingwho
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.
Preface
Functionaldisordersoftheurinarytractarecommonandinmanycaseshavemajor
adverse effects on the quality of life of the afflicted patients. These include
disorders of the ureters, the bladder, the urethra, the prostate and the pelvic floor.
For a long time, only surgical approaches and conservative treatment could be
offeredforsuchdisorders.Thelasttwodecadeshaveseenanamazingproliferation
ofknowledgeinthefieldofanatomy,physiologyandpharmacologyoftheurinary
tract. Several major new treatments have emerged from such research and are
benefitting millions of patients. However, therapeutic needs remain and only a
profoundknowledgeontheunderlyingtissue,cellandmolecularprocessesislikely
to provide novel treatments addressing such needs. Therefore, we are very happy
that internationally leading experts have contributed to the writing of this book
and we thank all of them for their efforts. Their combined insight provides a
comprehensive overview of the state of knowledge regarding the pharmacology
oftheurinarytract.Therefore,wetrustthatthisbookwillbecomeavaluablesource
of information for basic and clinical researchers alike in a dynamically growing
field.
Winston-Salem,NC,USA Karl-ErikAndersson
Amsterdam,TheNetherlands MartinC.Michel
September2010
vii
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Contents
OverviewontheLowerUrinaryTract ....................................... 1
ChristopherChapple
AnimalModelsinOveractiveBladderResearch ........................... 15
BrianA.ParsonsandMarcusJ.Drake
AnimalModelsofStressUrinaryIncontinence ............................. 45
Hai-HongJiangandMargotS.Damaser
AnimalModelsforBenignProstaticHyperplasia .......................... 69
J.PaulHieble
UseofFunctionalImagingtoMonitorCentralControlofVoiding
inHumans ..................................................................... 81
DerekJ.Griffiths
NeuroanatomyoftheLowerUrinaryTract ................................ 99
JonathanM.BeckelandGertHolstege
AnatomyandHistologyoftheLowerUrinaryTract ..................... 117
WisuitPradidarcheep,ChristianWallner,NoshirF.Dabhoiwala,
andWouterH.Lamers
NeurophysiologyoftheLowerUrinaryTract ............................. 149
JonathanM.BeckelandGertHolstege
AfferentMechanismintheUrinaryTract ................................. 171
AnthonyJ.Kanai
UrothelialSignaling .......................................................... 207
LoriA.Birder
ix