Unravelling the role of the cerebellum in drug addiction. Cerebellum-prefrontal networks in drug

132 Pages·2017·8.28 MB·English

by  Isis Gil Miravet

Unravelling the role of the cerebellum in drug
addiction. Cerebellum-prefrontal networks in
drug-induced preference memory
Author:
Isis Gil Miravet
Directed by:
Dra. Marta Miquel Salgado-Araujo
May 2019

Programa de Doctorat en Psicologia

Escola de Doctorat de la Universitat Jaume I

Unravelling the role of the cerebellum in drug addiction. Cerebellum-prefrontal
networks in drug-induced preference memory

Memòria presentada per Isis Gil Miravet per a optar al grau de doctora per la
Universitat Jaume I

Isis Gil Miravet Marta Miquel Salgado-Araujo

Castelló de la Plana, maig de 2019

Finançament rebut
Aquesta recerca ha comptat amb el suport de les següents beques i subvencions
publiques:
• Universitat Jaume I (PREDOC2014/11)
• Universitat Jaume I (E-2016-44)
• Universitat Jaume I (14I307.01/1)
• Ministerio de Educación Cultura y Deporte (FPU12/04059)
• Ministerio de Economía y Competitividad (MINECO) (PSI2015-68600-P)
• Plan Nacional de Drogas 2017 (PND-132400)

A la meua família

TABLE OF CONTENTS

PREFACE ___________________________________________________________________________ 1
GENERAL INTRODUCTION __________________________________________________________ 5
Addiction and drug reward _________________________________________________________ 5
The addiction circuitry _____________________________________________________________ 6
Cerebellum: “the little brain” _______________________________________________________ 9
Cerebellum anatomy ______________________________________________________________ 9
Cerebellum-cerebro reciprocal loops _________________________________________________ 11
The cerebellum in addiction ________________________________________________________ 12
Drug-induced plasticity changes in the cerebellum ______________________________________ 14
AIMS AND HYPOTHESIS____________________________________________________________ 17
EXPERIMENTAL STUDIES ___________________________________________________________ 19
Chapter 1: The role of the cerebellum in drug-cue associative memory: functional
interactions with the medial prefrontal cortex ______________________________________ 19
Chapter 2: Changes in neural activity and perineuronal net expression in the cerebellum
after deactivation of the medial prefrontal cortex ___________________________________ 29
Chapter 3: From back to front: A functional model for the cerebellar modulation in the
establishment of conditioned preferences for cocaine-related cues ___________________ 57
GENERAL DISCUSSION _____________________________________________________________ 83
STRENGTHS AND PITFALLS _________________________________________________________ 87
Strengths ________________________________________________________________________ 87
Pitfalls, weaknesses, and future directions __________________________________________ 87
REFERENCES _______________________________________________________________________ 89
ACKNOWLEDGEMENTS ____________________________________________________________ 99