training workshop on quality control of medicinal and aromatic plants and their products

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UNIDO PROJECT NO.: TF/GL0/96/105
CONTRACT NO. 98/168
T.RAINING WORKSHOP ON
QUALITY CONTROL
OF MEDICINAL & AROMATIC PLANTS AND THEIR PRODUCTS
,
15-20 JUNE 1998
Regional Research Laboratory,
Council of Scientific & Industrial Research, Canal Road, Jammu,
India
r-
S.S.Handa
Director
The training workshop on "Quality Control of medicinal and
aromatic plants and their products 11 was conducted in accordance
with the terms and conditions of the contract No.98/168(Project
No.TF/GL0/96/105). A bound volume (237 pages) of the Manual (copy
enclosed Annexure I) containing the entire course material prepared
by the resource persons (Faculty) was provided to all the
participants a day before the start of the workshop. The workshop
bags given to the participants contained in addition to the manual
other material such as information leaflet on field visit to
Patnitop for medicinal aromatic plant collection, details of the
daily programme including lectures, demonstrations and practicals,
newsletter and annual report of the Institute.
"
On 15th June after the invocation at 09.10 a.m. Professor s.
S. Banda, Director of the Institute gave formal welcome address
followed by introduction to the training workshop by Prof. T. de
Silva. The Training Workshop was inaugurated (card Annex II) by
Prof. N. K. Ganguly, Director general, Indian Council of Medical
Research. The key-note address {Annex III) was delivered by Prof.
B .. Dhawan, National Resource Person. This was followed by the
country presentations (copies of the country status papers
enclosed, Annex IV) . The post lunch session started with an hour's
lecture on standardization and quality control of medicinal and
s.
aromatic plants and their products by Professor S. Banda (copy
of the lecture Annex I p 1-14) . This was followed by demonstration
on authentication of MAPs and practical on plant drug
identification (Manual p. 15-48 Annex I).
On 16th June visit to Chatha Farm i.e. Medicinal Plant garden
and Medicinal and Aromatic Plant Farm station of the Institute (10
Km. from the Institute) was organised in the morning from 08.00 to
11.00 hrs followed by two lectures on Good Cultivation Practices
and Post harvest Management (Annex I p.49-69) and on Organoleptic
macroscopic, microscopic examination for authentication of
Medicinal Aromatic Plants (Annex I p.70-77) followed by practical
on crude drug identification, microscopic examination, staining of
slides and microbial count in herbal drugs (Annex I p. 78-93).
In the morning session on 17th June, lectures on Processing
technology and extraction procedures (Annex I p .101-110). Isolation
of markers from medicinal plants (Annex I p.112-127) were delivered
and thereafter demonstration on physicochemical parameters was
given. This followed a visit to pilot plant for 'on the spot'
demonstration on various extraction processes.
During the post lunch session lecture on Chromatographic
finger print profile of medicinal plants and their products (Annex
I p.128-138) was delivered and this followed by demonstration and
practical Training on HPLC, HPTLC and densitometric techniques.
,-
In the prelunch session of June 18, lectures on
'Qualitative/quantitative GLC techniques for MAPs (Annex I p.139-
150) and 'Stability testing of plant drugs' (Annex I, p 151-161)
as well as demonstration and practical training on GLC/GCMS and
stability study of plant preparations (Annex I p. 162-170) were
organised.
During the post lunch session lectures on 'Bioevaluation by
invitro techniques (Annex I, p.171-198) in manunalian cell cultures
and 'Bioevaluation by in vivo techniques (Annex I p.218-227) were
delivered and practical demonstrations were arranged on in vitro
Antihepatotoxic and anticancer screening techniques as well as on
various pharmacological models of bioactivity testing.
A field trip to Patnitop for medicinal aromatic plant
collection in nature and on the spot taxonomical identification
•·
(Annex V) were undertaken on 19th June.
On the last day (June 20) of the training workshop, lecture on
'Safety evaluation (Annex I p.228-237) was followed by
practical/demonstration on various pharmacological techniques on
Bioevaluation of plant drugs in the prelunch session. During the
post lunch session visit to the division of Natural Product
Chemistry, Essential Oils, Biotechnology, Food Technology,
Biopharmaceutics and Instrumentation of the Institute was arranged.
~-
An open session on discussion relating to the technical
assistance needs and cooperation among the countries resulted in
certain reconunendations which were placed in the concluding session
of the progranune. These reconunendations are enclosed as Annex VI.
All the lectures were delivered by the Institutional faculty
"·
and the resource persons (List attached Annx VII) in the Conference
hall and the practical demonstrations were conducted in various
laboratories (Annex· VIII). of the Institute by the faculty and
scientific/technical staff. The participants (list attached, Annx
XI) interacted freely amongst thernselv es as well as with the
faculty and the resource persons. The press media exhibited good
coverage of the training workshop (Newspaper clippings, Annex X).
The participation certificate to each participant was given
(Annexure XI) .
ANNEXURES
Annexure No.
I Manual
II Inaugural card
III Key note address
IV Country status papers
v Field trip to Patnitop brochure
VI Recommendations
VII List of faculty
VIII Arrangement schedule of practicals and
demonstration
IX List of participants
x
Press clippings about the training workshop
XI Participation certificate
XII Lecture of International Resource Person
~-
Director, Regional Research Laboratory (CSIR), Jammu
invites you on the inauguration of
ICS-UNIDO Training Workshop
on
Quality Control of Medicinal and Aromatic Plant•
and Their Produc:ts
by
Professor N. K. Ganguly
M. D., F. A. M. S., F, N. A., F. N. A. Sc., F. A, Sc., t=, f'!, C:, i:;aH1
Director General
Indian Council of Medical Research,
New Delhi
on 15th June, 1998 (Monday) at 9.00 A. M in the
RRL Conference Hall
Programme
9.00 a. m. Invocation
Welcome Address Prof. S. S. Handa
~~
Director, RfH.
~
:.1:
Introduction to the Dr. T. da Silva
Workshop ICS/UNIDO 1ntarnistlm1a I
Aasourca l"erstm
Inaugural Address Prof. N. K. Ganguly
·-::
DG, ICMR
Keynote Address Prof. 8. N. Ohawan
Fotmar Pi rector, CDRI
Vote of thanks Dr. G. N. Qazi
10.30 a. m. Tea
ANNEXURE III
KEY-NOTE ADDRESS
B.N.DHAWAN
EX-DIRECTOR, CENTRAL DRUG RESEARCH INST1TUTE,
LUCKNOW, INDIA
I am happy to be associated with this important workshop. It is appropriate that it is being
held in Laboratory which has been so intimately involved in multidisciplinary research on
medicinal and aromatic plants, including Quality Control, for almost half a century. My
familiarity with aromatic plants is limited to being an end user hence my remarks will be
centred around the medicinal plants even though some of them may be equally applicable
to aromatic plants.
Our planet is said to be inhabited by over 3 million species of plants and animals out of
which only 1.75 million have been described and 900/o have not been studied in any detail.
About 21,000 plants have been ascribed medicinal properties in various countries, a large
percentage coming from the countries represented in this workshop. Only about 10,000
of these have been so far investigated. In depth studies have been done on much fewer
plants. The problem of standardizing such a large number of plants and their resulting
products is not only enormous but also difficult. I will, therefore , limit myself to what
WHO has defined as herbal medicine. It is a plant derived material or preparation with
therapeutic or other human health benefits and it contains either raw or processed
ingredients from one or more plants. In some traditional medicinal preparations materials
of inorganic or animal origin may also be present. WHO has assigned the highest priority
to botanical authentication;-Characterisation of active principles and standardisation of
dosage form. In India , a similar strategy was proposed by the pioneer investigator of
medicinal plants in India and also the founder of RRL, 'Jammu, Sir Ram Nath Chopra , in
mid thirties. The concept is however, evident and stressed even in the earliest treatises of
Ayurveda by Charak and others.
Historically, the earliest method of standardising plant products was the use of
observational procedures. Simple laboratory procedures like amount of extractives etc.
got added as science progressed . During the last century and the earlier part of the