Towards Personalized Medicine in Treatment and Care of Patients with Peritoneal Metastases of

246 Pages·2016·25.15 MB·English

INVITATION
voor het bijwonen van
de openbare verdediging
van het proefschrift
Towards Personalized Medicine Towards Personalized
Medicine in Treatment
and Care of Patients with
in Treatment and Care of Patients
Peritoneal Metastases
of Colorectal Cancer
with Peritoneal Metastases
door
of Colorectal Cancer Erienne Marie-Luise
Véronique de Cuba
Erienne Marie-Luise Véronique de Cuba
Donderdag, 9 juni 2016
was born on the 25th of October 1983 on
the sunny island of Aruba as the eldest Om 13.45
child in a family of four. After completing
high school (VWO) in 2002 on the one In de aula van de
happy island at the Colegio Arubano, she Vrije Universiteit
proceeded to study medicine in Groningen De Boelelaan 1105
at the Rijksuniversiteit Groningen. te Amsterdam
In December 2009 she completed her met aansluitend receptie
medical studies, during which she
concluded several internships focussed
on gastro-intestinal malignancies and
a research project at the department of Paranimfen
Gastroenterology and Hepatology of Pien Delis-van Diemen
the Academic Medical Center Amsterdam on the treatment of pancreatic pseudocysts after
13653_DeCuba_OM_v1.indd 2 19-04-16 12:33
Towards personalized medicine in treatment
and care of patients with peritoneal
metastases of colorectal cancer
Erienne Marie-Luise Véronique de Cuba
The work described in this thesis was performed at the Tumor Profling Unit of the
Department of Pathology and the division of Surgical Oncology of the Department of
Surgery of the VU University Medical Center in Amsterdam, the Netherlands.
Printing of this thesis was fnancially supported by
ISBN: 978-94-6299-346-4
Cover and illustrations: Erienne de Cuba
Lay-out: Nikki Vermeulen - www.ridderprint.nl
Printing: Ridderprint BV - www.ridderprint.nl
Copyright © 2016, Erienne de Cuba
All rights reserved. No parts of this publication may be reproduced, stored in a retrieval
system or transmitted in any form or means without the prior permission in writing from
the author.
VRIJE UNIVERSITEIT
Towards personalized medicine in treatment
and care of patients with peritoneal
metastases of colorectal cancer
ACADEMISCH PROEFSCHRIFT
ter verkrijging van de graad Doctor aan
de Vrije Universiteit Amsterdam,
op gezag van de rector magnifcus
prof.dr. V. Subramaniam,
in het openbaar te verdedigen
ten overstaan van de promotiecommissie
van de Faculteit der Geneeskunde
op donderdag 9 juni 2016 om 13.45 uur
in de aula van de universiteit,
De Boelelaan 1105
door
Erienne Marie-Luise Véronique de Cuba
geboren te Oranjestad, Aruba
promotoren: prof.dr. G.A. Meijer
prof.dr. H.J. Bonjer
copromotor: dr. E.A. te Velde
“Impossible is a word to be found only in the dictionary of fools”
- Napoleon Bonaparte

Voor mijn moeder
Table of contents
Chapter 1 General introduction and outline of the thesis
Part I Clinical Decision Making / Treatment Allocation
Chapter 2 Cytoreductive surgery and HIPEC for peritoneal metastases
combined with curative treatment of colorectal liver metastases
- Systematic review of all literature and meta-analysis of
observational studies -
Cancer Treat Rev. 2013 Jun;39(4):321-7
Chapter 3 Morbidity associated with colostomy reversal after cytoreductive
surgery and HIPEC
Ann Surg Oncol. 2014 Mar;21(3):883-90
Part II Molecular Approach
– Possible Aids in Future Clinical Decision Making –
Chapter 4 Understanding molecular mechanisms in peritoneal dissemination of
colorectal cancer;
- Future possibilities for personalised treatment by use of biomarkers -
Virchows Arch. 2012 Sep;461(3):231-43
Chapter 5 Adhesion molecules in peritoneal metastases of colorectal cancer:
- Function, prognostic relevance and therapeutic options -
Accepted Clin Exp Metastasis April 2016
Chapter 6 Versican and vascular endothelial growth factor expression levels in
peritoneal metastases from colorectal cancer are associated with
survival after cytoreductive surgery and hyperthermic
intraperitoneal chemotherapy
Clin Exp Metastasis. 2016 Apr;33(4):297-307
Chapter 7 Angiogenesis related markers and prognosis after Cytoreductive
Surgery and Hyperthermic Intra-peritoneal Chemotherapy for
Metastatic Colorectal Cancer
Ann Surg Oncol. 2016 May;23(5):1601-8
Chapter 8 Glucose transporter 1 (SLC2A1) and vascular endothelial growth
factor A (VEGFA) predict survival after resection of colorectal
cancer liver metastasis
Ann Surg. 2016 Jan;263(1):138-45
Chapter 9 Tailoring heated intraperitoneal Mitomycin C for peritoneal
metastases originating from colorectal carcinoma
- A translational approach to improve survival -
Br J Cancer. 2015 Mar 3;112(5):851-6
Chapter 10 Prognostic value of BRAF and KRAS mutation status in
stage II and III microsatellite instable colon cancers
Int J Cancer. 2016 Mar 1;138(5):1139-45