Theoretical and Experimental Insights into Immunology

484 Pages·1992·13.839 MB·English

by  Franco Celada (auth.), Alan S. Perelson, Gérard Weisbuch (eds.)

Theoretical and Experimental Insights
into Immunology
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Series H: Cell Biology, Vol. 66
Theoretical and Experimental
Insights into Immunology
Edited by
Alan S. Perelson
Theoretical Division
Los Alamos National Laboratory
Los Alamos, NM 87545, USA
Gerard Weisbuch
Laboratoire de Physique Statistique
de l'Ecole Normale Superieure
24 rue Lhomond
75231 Paris Cedex 5, France
Springer-Verlag
Berlin Heidelberg New York London Paris Tokyo
Hong Kong Barcelona Budapest
Published in cooperation with NATO Scientific Affairs Division
Proceedings of the NATO Advanced Research Workshop on Theoretical Immunology
held in Paris, September 27-October 1, 1991
ISBN-13:978-3-642-76979-5 e-ISBN-13:978-3-642-76977-1
001: 10.1007/978-3-642-76977-1
Library of Congress Cataloging-in-Publication Data
Theoretical and experimental insights into immunology / edited by Alan S. Perelson. Gerard Weisbuch.
(NATO ASI series. Series H, Cell biology; vol. 66)
Includes bibliographical references and index.
ISBN-13:978-3-642-76979-5
1. Experimental immunology-Congresses. 3. Immunology-Computer simulation-Congresses. I. Perelson.
Alan S., 1947-11. Weisbuch. G. III. Series. QR180.3.T48 1992 616.07'9--dc20
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© Springer-Verlag Berlin Heidelberg 1992
Softcover reprint of the hardcover 1s t edition 1992
Typesetting: Camera ready by author
31/3145 -5 43210 -Printed on acid-free paper
Contents
Contrib ut ors
Preface
Introduction
I. General Perspectives 1
1. Computer modeling of the immune system: Who are the "fruitori"? 3
Franco Celada
2. Is the function of the immune system only to protect? 15
Edward S. Golub
3. The immune system in an evolutionary perspective 27
John Stewart
4. A simulation of the humoral immune system 49
Philip E. Seiden and Franco Celada
5. Probability of self-nonself discrimination 63
Jerome K. Percus, Ora E. Percus and Alan S. Perelson
6. Contextual discrimination of antigens by the immune system:
Towards a unifying hypothesis 71
Zvi Grossman
II. T-Cell Models 91
7. Theoretical insight into antigen-induced T-cell unresponsiveness 93
Marcelline Kaufman, F. Andris, and o. Leo
8. Interaction of interleukin-2 with its cell surface receptors:
Interpretation of equilibrium binding experiments via Scatchard plots 117
Alan S. Perelson and Byron Goldstein
9. T memory cells in a model of T-cell memory 149
Angela R. McLean
10. A "minimal" basic T-cell model 163
Karl E. Kurten
11. Mathematical modeling of Th1-Th2 dynamics 171
Benoit F. Morel, Jayant Kalagnanam and Penelope A. Morel
12. Complex outcomes in mouse Leishmaniasis: A model for the
dynamics of the Th1 response 191
A. Nicola Schweitzer, Jonathan Swinton and Roy M. Anderson
VI
III. Networks and Attractors 203
13. Generic modeling of the immune network 205
Gerard Weisbuch and Avidan U. Neumann
14. Growth and recruitment in the immune network 223
Rob J. De Boer, Pauline Hogeweg and Alan S. Perelson
15. Memory B-cells stabilize cycles in a repressive network 249
Ulrich Behn, J. Leo van Hemmen and Bernhard Sulzer
IV. From Molecular to Cellular Immunology 261
16. Implications of cooperativity and dimensional complexity for
immunological recognition 263
Neil S. Greenspan and Laurence J. N. Cooper
17. Shannon information as a measure of amino acid diversity 279
Samuel Litwin and Rita Jores
18. Experimental strategies, antigenicity and interpretation of
intermolecular interactions 289
Frederique Lisacek
19. Receptor-ligand interactions and diffusion effects 297
Stig I. Andersson
V. Theories and Applications to Clinical Immunology 307
20. Mathematical modeling of the immune response during acute
viral infections 309
Gena Bocharov and A. Rornanyukha
21. 11imicking the strategy of the immune system: Insight gained
from mathematics 323
Z'IIia Agttr, Gadi Mazor and Isaac 1Vfeilijson
22. Rash theory 333
Lee A. Segel, Alan S. Perelson, James M. Hyman and Sidney N. Klaus
2:3. On second symmetry and AIDS 353
Geoffrey W. Hoffmann and Tracy A. Kion
24. Superantigens, allorr;activity, immunological tolerance and AIDS:
A unified hypothesis 365
Haynes W. Sheppard and Michael S. Ascher
VII
25. Paradoxical effects of suppressor T-cells in adjuvant arthritis:
Neural network analysis 379
Henri Atlan and Irun R. Cohen
26. Idiotypic regulation in experimental autoimmune thyroiditis (EAT) 397
H. Tang, C. Bedin, B. Texier, and J. Charreire
VI. Repertoire Selection 409
27. The secrets of crypticity and its relationship to medical problems:
Autoimmune disease, transplantation and cancer 411
Gilles Benichou, Vatsala Bhardwaj, Stephen P. Schoenberger, and Eli E. Sercarz
28. Role of cryptic self germline encoded Ig epitopes in the selection
of the T-cell repertoire 425
Jian-Jun Chen, Srinivas-Venkatesh Kaveri and Heinz Kohler
29. T-cell repertoire in autoreactive immunoglobulin-transgenic mice 437
Margot Zoller
30. Experimental and theoretical investigations on idiotypic mimicry 45g
Al! Grandien, Antonio Coutinho and John Stewart
Index 477
Contributors
Zvia Agur, Department of Applied Mathematics, Weizmann Institute of Science, Re
hovot, Israel
Roy M. Anderson, Wellcome Centre for Research on Parasite Infections, Department of
Pure and Applied Biology, Imperial College, London SW7 2BB, England
Stig I. Andersson, Research Group of Global Analysis and Applications, Chalmers Uni
versity of Technology, University of Goteborg, S-412 88 Goteborg, Sweden
F. Andris, Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, 67, rue
des Chevaux, 1640-Rhode St. Genese, Belgium
Michael Ascher, Viral and Rickettsial Laboratory, California Department of Health Ser
vices, 2151 Berkeley Way, Berkeley, CA 94704
Henri Atlan, Department of Medical Biophysics, Hadassah University Hospital, Jeru
salem, Israel
C. Bedin, INSERM U 283, Hopital Cochin, 27, rue du Fg St-Jacques, 75674 Paris Cedex
14, France
Ulrich Behn, Sektion Physik, Universitiit Leipzig, Augustusplatz, 10, 0-7010 Leipzig,
Germany
Gilles Benichou, Department of Microbiology and Molecular Genetics, 5304 Life Sciences
Building, University of California, Los Angeles, CA 90024
Vatsala Bhardwaj, Department of Microbiology and Molecular Genetics, 5304 Life Sci
ences Building, University of California, Los Angeles, CA 90024
G. Bocharov, Institute of Numerical Mathematics, Academy of Sciences, Leninskij
Prospect 32-A, Moscow, 117334, Russia
Franco Celada, NYU Department of Pathology, Hospital for Joint Diseases, 301 E 17th
Street, New York, NY 10003
Jeannine Charreire, INSERM U 283, Hopital Cochin, 27, rue du Fg St-Jacques, 75674
Paris Cedex 14, France
Jian-Jun Chen, San Diego Regional Cancer Center, 3099 Science Park Road, San Diego,
CA 92121
IX
!run R. Cohen, Department of Cell Biology, \\Teizmann Institute of Science, Rehovot,
Israel
Laurence J. N. Cooper, Institute of Pathology, Case Western Reserve University, 2085
Aldebert Road, Cleveland, OH 44106
Antonio Coutinho, Unite d'Immunobiologie, Institut Pasteur, 25 rue du Dr. Roux,
F-75724 Paris Cedex 15, France
Rob J. De Boer, Bioinformatica, University of Utrecht, Padualaan 8,3584 CH, Utrecht,
The Netherlands
Byron Goldstein, Theoretical Biology and Biophysics, Group T-10, Mail Stop K-710,
Los Alamos National Laboratory, Los Alamos, NM 87545
Edward S. Golub, R.W. Johnson Pharmaceutical Research Institute, The Research In
stitute of Scripps Clinic, 10666 N. Torrey Pines Road, La Jolla, Ca 92037
Alf Grandien, Department of Immunology, University of Upsala, 75123 Uppsala, Sweden
Neil S. Greenspan, Institute of Pathology, Case Western Reserve University, 2085 Alde
bert Road, Cleveland, OH 44106
Zvi Grossman Department of Physiology and Pharmacology, Sackler School of Medicine,
Tel Aviv University, Tel Aviv 69978, Israel
Leo van Hemmen, Physik-Department, TU Miinchen, James-Frank-Strafle, W-8046
Garching bei Miinchen, Germany
Geoffrey Hoffmann, Departments of Microbiology and Physics, The University of British
Columbia, Vancouver, B.C., Canada, V6T 1Z3
Pauline Hogeweg, Bioinformatica, University of Utrecht, Padualaan 8,3584 CH, Utrecht,
The Netherlands
James M. Hyman Theoretical Division, Los Alamos National Laboratory, Los Alamos,
NM 87545
Rita Jores, Institut Pasteur, 25 rue du Docteur Roux, 75634 Paris Cedex 15, France
J ayant Kalagnanam, Department of Engineering and Public Policy, Carnegie Mellon
University, Schenley Park, Pittsburgh, PA 15213
Marcelline Kaufman, Universite Libre de Bruxelles, Service de Chimie-Physique II, Cam
pus Plaine C.P. 231, Boulevard du Triomphe, 1050 Bruxelles, Belgium
x
Srinivas-Venkatesh Kaveri, San Diego Regional Cancer Center, 3099 Science Park Road,
San Diego, CA 92121
Tracy A. Kion, Department of Microbiology, The University of British Columbia, Van
couver, B.C., Canada, V6T 1Z3
Sidney N. Klaus, M.D., Department of Dermatology and Venereology, Hadassah Hospi
tal, Jerusalem IL-91120, Israel
Heinz Kohler, San Diego Regional Cancer Center, 3099 Science Park Road, San Diego,
CA 92121
Karl E. Kurten, Institute fur Theoretische Physik, Johannes-Kepler-Universitat Linz,
Austria
O. Leo, Laboratoire de Physiologie Animale, Universite Libre de Bruxelles, 67, rue des
Chevaux, 1640-Rhode St. Genese, Belgium
Frederique Lisacek, Centre de Genetique Moleculaire, CNRS, 91190 Gif sur Yvette,
France
Samuel Litwin, Institute for Cancer Research, Fox Chase Cancer Center, 7701 Burholme
Avenue, Philadelphia, PA 19111
Gadi Mazor, School of Mathematical Sciences, Raymond and Beverly Sackler Faculty of
Exact Sciences, Tel Aviv University, Israel
Angela R. McLean, Zoology Department, S. Parks Road, Oxford University, Oxford OX1
3PS, England
Isaac Meilijson, School of Mathematical Sciences, Raymond and Beverly Sackler Faculty
of Exact Sciences, Tel Aviv University, Israel
Benoit F. Morel, Department of Engineering and Public Policy, Carnegie Mellon Uni
versity, Schenley Park, Pittsburgh, PA 15213
Penelope Morel, Pittsburgh Cancer Institute, Division of Basic Research, Basic Science
Tower, Lathrop and Terrace, Pittsburgh, PA 15213
Avidan U. Neumann, Department of Applied Mathematics, Weizmann Institute of Sci
ence, Rehovot, Israel
Jerome K. Percus, Courant Institute of Mathematical Sciences and Department of
Physics, New York University, 251 Mercer Street, New York, NY 10012