Table Of ContentThe NPY Family of Peptides in Immune Disorders,
Inflammation, Angiogenesis and Cancer
Zofia Zukowska
Giora Z. Feuerstein
Editors
Birkhäuser Verlag
Basel · Boston · Berlin
Editors
Zofia Zukowska Giora Z. Feuerstein
Department of Physiology and Biophysics Wyeth Research
Georgetown University Medical Center Building A3153
3900 Reservoir Rd., NW, 500 Arcola Rd
Washington, DC 20057 Collegeville, PA 19426
USA USA
Library of Congress Cataloging-in-Publication Data
The NPY family of peptides in immune disorders, inflammation, angiogenesis and cancer /
Zofia Zukowska, Giora Z. Feuerstein, editors.
p. ; cm. -- (Progress in inflammation research)
Includes bibliographical references and index.
ISBN-13: 978-3-7643-7159-3 (alk. paper)
ISBN-10: 3-7643-7159-5 (alk. paper)
1. Neuropeptide Y--Pathophysiology. I. Zukowska, Zofia. II. Feuerstein, Giora Z., 1946-.
III. PIR (Series)
QP552.N38N4767 2005
612’.015756--dc22
20050053007
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ISBN-10: 3-7643-7159-5 Birkhäuser Verlag, Basel – Boston – Berlin
ISBN-13: 978-3-7643-7159-3 Birkhäuser Verlag, Basel – Boston – Berlin
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Contents
List of contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii
Introduction
Zofia Zukowska and Giora Z. Feuerstein
NPY family of peptides: from neurotransmitters and hormones to
immune modulators, cytokines and growth factors. . . . . . . . . . . . . . . . . . . . . . xiii
Biology of the NPY family of peptides, their receptors and processing enzymes
Dan Larhammar and Erik Salaneck
Evolutionary perspective on the NPY-PYY-PP peptides and their receptors. . . . . . 3
Magnus M. Berglund, Philip A. Hipskind and Donald R. Gehlert
Function, distribution and molecular pharmacology of NPY-family receptors . . . 29
Eric Grouzmann and Noureddine Brakch
NPY processing in neuronal and non-neuronal tissues by proconvertases. . . . . . . 63
Rolf Mentlein
Dipeptidyl-peptidase IV and aminopeptidase P: molecular switches
of NPY/PYY receptor affinities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
The NPY family of peptides in immune disorders and inflammation
Sammy Bedoui and Stephan von Hörsten
NPY, NPY receptors and DPPIV in innate immunity and
autoimmune disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87
Mónica De la Fuente and Sonia Medina
NPY and phagocytic cell functions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Basile N. Landis, Isabelle Plouin-Gaudon and Jean-Silvain Lacroix
NPY in allergic and respiratory disorders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123
Bradley K. Taylor
NPY analgesia: moving from acute to chronic pain. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 135
The NPY family of peptides and angiogenesis
Edward W. Lee, Jason U. Tilan, Lydia Kuo, and Zofia Zukowska
NPY as a mediator of neurogenic angiogenesis and revascularization
of ischemic tissues. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 151
Meit Björndahl, Renhai Cao, Luxun Xue and Yihai Cao
NPY-induced angiogenesis in retinopathy and wound healing. . . . . . . . . . . . . . . . . . . 167
Lijun Li, Ken Abe, Edward W. Lee and Zofia Zukowska
NPY in vascular inflammation, remodeling and atherosclerosis. . . . . . . . . . . . . . . . . . . 175
The NPY family of peptides as growth factors in neurodegenerative
diseases and tumor biology
Joanna B. Kitlinska, Lydia E. Kuo and Jennifer Pons
NPY as a pleiotropic growth factor. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189
William P. Gray and Helen E. Scharfman
NPY and hippocampal neurogenesis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201
Joanna B. Kitlinska
NPY family of peptides in neural crest-derived tumors . . . . . . . . . . . . . . . . . . . . . . . . . . . 223
Massimiliano Ruscica, Elena Dozio, Marcella Motta and Paolo Magni
NPY family of peptides in endocrine, breast and prostate tumors. . . . . . . . . . . . . . . . 237
Summary
Zofia Zukowska and Giora Z. Feuerstein
Future directions and therapeutic perspectives for NPY/PYY-based
anti-inflammatory and tumor suppressor drugs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 251
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 255
List of contributors
Ken Abe, Department of Physiology & Biophysics, Georgetown University Medical
Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA
Sammy Bedoui, Hannover Medical School, Department of Functional and Applied
Anatomy, OE4120, Carl-Neuberg Str. 1, 30625 Hannover, Germany;
e-mail: [email protected]
Magnus M. Berglund, Biovitrum AB, Department of Lead Discovery, Stockholm,
Sweden
Meit Björndahl, Karolinska Institutet, Microbiology and Tumor Biology Center,
17177 Stockholm, Sweden; e-mail: [email protected]
Noureddine Brakch, Lausanne University Hospital School, Division of Angiology,
Lausanne, Switzerland
Renhai Cao, Karolinska Institutet, Microbiology and Tumor Biology Center, 17177
Stockholm, Sweden; e-mail: [email protected]
Yihai Cao, Karolinska Institutet, Microbiology and Tumor Biology Center, 17177
Stockholm, Sweden; e-mail: [email protected]
Mónica De la Fuente, Department of Physiology (Animal Physiology II), Faculty of
Biological Sciences, Complutense University, 28040 Madrid, Spain;
e-mail: [email protected]
Elena Dozio, Università degli Studi di Milano, Istituto di Endocrinologia, via G.
Balzaretti, 9, 20133 Milano, Italy
Giora Z. Feuerstein, Wyeth Research, Building A3153, 500 Arcola Rd, Collegeville,
PA 19426, USA; e-mail: [email protected]
vii
List of contributors
Donald R. Gehlert, Eli Lilly and Company, Lilly Research Laboratories, Lilly Cor-
porate Center, Indianapolis, IN 46285, USA; e-mail: [email protected]
William P. Gray, Division of Clinical Neurosciences, University of Southampton,
Room 6207, Biomedical Sciences Building, Bassett Crescent East, Southampton
SO16 7PX, UK; e-mail: [email protected]
Eric Grouzmann, CHUV, Division of Clinical Pharmacology and Toxicology, 1011
Lausanne, Switzerland; e-mail: [email protected]
Philip A. Hipskind, Eli Lilly and Company, Lilly Research Laboratories, Lilly Cor-
porate Center, Indianapolis, IN 46285, USA
Joanna B. Kitlinska, Department of Physiology & Biophysics, Georgetown Univer-
sity Medical Center, 3900 Reservoir Rd NW, Basic Science Building, Washington,
DC 20057, USA; e-mail: [email protected]
Lydia E. Kuo, Department of Physiology & Biophysics, Georgetown University
Medical Center, 3900 Reservoir Rd NW, Basic Science Building, Washington, DC
20057, USA
Jean-Silvain Lacroix, Unité de Rhinologie-Olfactologie, Service d’Oto-Rhino-Laryn-
gologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest 24, 1211 Gene-
va, Switzerland; e-mail: [email protected]
Basile N. Landis, Unité de Rhinologie-Olfactologie, Service d’Oto-Rhino-Laryn-
gologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest 24, 1211 Gene-
va, Switzerland
Dan Larhammar, Department of Neuroscience, Unit of Pharmacology, Uppsala Uni-
versity, Box 593, 75124 Uppsala, Sweden; e-mail: [email protected]
Edward W. Lee, Department of Physiology & Biophysics, Georgetown University
Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA;
e-mail: [email protected]
Lijun Li, Department of Physiology & Biophysics, Georgetown University Medical
Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA
Paolo Magni, Università degli Studi di Milano, Istituto di Endocrinologia, via G.
Balzaretti, 9, 20133 Milano, Italy; e-mail: [email protected]
viii
List of contributors
Sonia Medina, Department of Physiology (Animal Physiology II), Faculty of Bio-
logical Sciences, Complutense University, 28040 Madrid, Spain;
e-mail: [email protected]
Rolf Mentlein, Department of Anatomy, University of Kiel, Olshausenstrasse 40,
24098 Kiel, Germany; e-mail: [email protected]
Marcella Motta, Università degli Studi di Milano, Istituto di Endocrinologia, via G.
Balzaretti, 9, 20133 Milano, Italy
Isabelle Plouin-Gaudon, Unité de Rhinologie-Olfactologie, Service d’Oto-Rhino-
Laryngologie, Hôpitaux Universitaires de Genève, Rue Micheli-du-Crest 24, 1211
Geneva, Switzerland
Jennifer Pons, Department of Physiology & Biophysics, Georgetown University
Medical Center, 3900 Reservoir Rd NW, Basic Science Building, Washington, DC
20057, USA
Massimiliano Ruscica, Università degli Studi di Milano, Instituto di Endocrinologia,
via G. Balzaretti, 9, 20133 Milano, Italy
Erik Salanek, Department of Neuroscience, Unit of Pharmacology, Uppsala Univer-
sity, Box 593, 75124 Uppsala, Sweden
Helen E. Scharfman, Helen Hayes Hospital, New York State Department of Health,
Columbia University, New York, NY, USA
Bradley K. Taylor, Department of Pharmacology, SL83, Tulane University Universi-
ty Health Sciences Center, New Orleans, LA 70112, USA;
e-mail: [email protected]
Jason U. Tilan, Department of Physiology & Biophysics, Georgetown University
Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA
Stephan von Hörsten, Hannover Medical School, Department of Functional and
Applied Anatomy, OE4120, Carl-Neuberg Str. 1, 30625 Hannover, Germany;
e-mail: [email protected]
Luxun Xue, Zhenzhou University Cancer Center, Zhenzhou, Henan, China
Zofia Zukowska, Department of Physiology & Biophysics, Georgetown University
Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA;
e-mail: [email protected]
ix
Introduction
