The Minipig in Biomedical Research

695 Pages·2011·53.99 MB·English

by  McAnulty, Peter

Life Sciences McAnulty
The
Dayan
M I N I P I G
Ganderup
Hastings
MINIPIG
The in

in
Biomedical Research
B BIOMEDICAL RESEARCH
The Minipig in Biomedical Research is a comprehensive resource for i
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research scientists on the potential and use of the minipig in basic and applied o
Peter A. McAnulty • Anthony D. Dayan
biomedical research, and the development of drugs and chemicals. Written by
mh Niels-Christian Ganderup • Kenneth L. Hastings
acknowledged experts in the field, and drawing on the authors’ global contacts
and experience with regulatory authorities and the pharmaceutical and other
e
industries, this accessible manual ranges widely over the biological, scientific,
e
and practical uses of the minipig in the laboratory. Its coverage extends from the
minipig’s origins, anatomy, genetics, immunology, and physiology to its welfare, M
d O R I G I N
health, and husbandry; practical dosing and examination procedures; surgical
techniques; and all areas of toxicity testing and the uses of the minipig as a i Trauma & Chemical/ Stem Transgenics
disease model. Regulatory aspects of its use are considered. cI Resuscitation Biological Cells
Warfare
Transplantation
aN Oral &
The reader will find an extensive amount of theoretical and practical information in
Dental
the pharmacology; ADME and toxicology chapters which will help scientists and Neoplasia
l Pharmacology M
managers when deciding which species to use in basic research; drug discovery
I Diabetes & Therapeutics A
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common diseases. It also carefully elucidates ethical and legal considerations in s W E E
their supply, housing, and transport. The result is an all-inclusive and up-to-date G M N
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manual about the experimental uses of the minipig that describes “How to” and
“Why” and “What to expect in the normal”, combining enthusiasm and experi- a Toxicity ECG
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E X P E R I M E N T A L T E C H N I Q U E S
K10559
ISBN: 978-1-4398-1118-4
90000
9 781439 811184

The
M I N I P I G
in
BIOMEDICAL RESEARCH

The
M I N I P I G
in
BIOMEDICAL RESEARCH
Edited by
Peter A. McAnulty • Anthony D. Dayan
Niels-Christian Ganderup • Kenneth L. Hastings
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
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Version Date: 20111003
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Contents
Preface.................................................................................................................................................................xi
Editors...............................................................................................................................................................xiii
Contributors.......................................................................................................................................................xv
Section I
Origin and Management of the Minipig
Chapter.1
History.and.Development.of.Miniature,.Micro-.and.Minipigs................................................................................................3
Friederike Köhn
Chapter.2
Husbandry.and.Management...................................................................................................................................................17
Roberta Scipioni Ball
Chapter..3
Diseases.of.Minipigs...............................................................................................................................................................37
Nanna Grand
Chapter.4
International.Transportation.of.Minipigs...............................................................................................................................69
Finn Raaschou-Nielsen
Section II
Welfare and Experimental Usage of the Minipig
Chapter..5
Ethical.Issues.in.the.Use.of.Minipigs.in.Animal.Research....................................................................................................77
David Morton
Chapter..6
Animal.Welfare.Issues............................................................................................................................................................85
Kathy E. Laber, Alison C. Smith and M. Michael Swindle
Chapter..7
Stress.in.Experiments:.Stress.Issues.in.Porcine.Research......................................................................................................93
Larry Dale Brown and Laust Peter Gade
Chapter.8
Dosing.Methods.....................................................................................................................................................................117
Peter Clausing
v
vi Contents
Chapter.9
In-Life.Clinical.Observations...............................................................................................................................................127
David M. Cameron
Section III
Pharmacology and ADME Studies in the Minipig
Chapter.10
Minipigs.in.Absorption,.Distribution,.Metabolism,.and.Excretion.(ADME).Studies...........................................................143
Cornelia Preuße and Mette Tingleff Skaanild
Chapter..11
The.Minipig.in.Safety.Pharmacology....................................................................................................................................159
Stephane Milano
Section IV
Safety Assessment in the Minipig—Principal Body Systems
Chapter.12
Dermal.Toxicity.Studies:.Skin.Architecture,.Metabolism,.Penetration.and.Toxicological 
and Pharmacological.Methods...............................................................................................................................................185
Andrew Makin, Jens Thing Mortensen and William J. Brock
Chapter.13
Gastrointestinal.Tract.............................................................................................................................................................211
Chris Van Ginneken
Chapter.14
Heart.and.Cardiotoxicity......................................................................................................................................................237
James R. Turk
Chapter.15
Central.and.Peripheral.Nervous.Systems.............................................................................................................................243
Allan Dahl Rasmussen and Karen Malene Wegener
Chapter.16
The.Kidney............................................................................................................................................................................253
Peter A. McAnulty
Chapter.17
Reproductive.System.Including.Studies.in.Juvenile.Minipigs..............................................................................................263
Peter A. McAnulty, Paul Barrow and Edward Marsden
Contents vii
Chapter.18
The.Endocrine.System..........................................................................................................................................................277
Claudia Stark and Jakob Walter
Chapter.19
Skeletal.System.....................................................................................................................................................................283
Hideki Tsutsumi
Chapter.20
Ocular.Examination.and.Background.Observations............................................................................................................293
Helmut Ehall
Chapter.21
Spontaneous/Background.Pathology.of.Göttingen.Minipig.................................................................................................305
Zuhal Dincer and Mikala Skydsgaard
Section V
Genetics and Immunology
Chapter.22
A.Comparative.Assessment.of.the.Pig,.Mouse.and Human Genomes:.Structural.and.Functional.Analysis.
of.Genes.Involved.in Immunity and Inflammation..............................................................................................................323
Harry D. Dawson
Chapter.23
The.Immune.System.of.Pigs:.Structure.and.Function..........................................................................................................343
Patrick Haley
Chapter.24
Transplantation.in.Miniature.Swine......................................................................................................................................357
John S. Hanekamp, Raimon Duran-Struuck and David H. Sachs
Chapter.25
Xenotransplantation...............................................................................................................................................................373
Henk-Jan Schuurman, Melanie L. Graham, Thomas Spizzo, and Clive Patience
Chapter.26
Porcine.Endogenous.Retroviruses.in.Xenotransplantation:.A.Review.of.the.Importance.of.PERVs.in.Porcine.
Studies,.with Particular Emphasis.on.the.Minipig...............................................................................................................387
Linda Scobie and Olga Garkavenko
Chapter.27
Immunotoxicology:.Studies.in.the.Minipig..........................................................................................................................397
André H. Penninks and Geertje J.D. van Mierlo
viii Contents
Section VI
Disease Models
Chapter.28
Creation.and.Conservation.of.Genetically.Modified.Pigs:.Applications.to.Genetic.Disease.Model.
and.Xenotransplantation........................................................................................................................................................415
Hiroshi Nagashima, Hitomi Matsunari, and Kazuhiro Umeyama
Chapter.29
Stem.Cell.Research.and.Minipigs..........................................................................................................................................431
Vanessa J. Hall, Stoyan G. Petkov, and Poul Hyttel
Chapter.30
Minipig.Models.of.Diabetes.Mellitus...................................................................................................................................445
Dwight A. Bellinger, Elizabeth P. Merricks, and Timothy C. Nichols
Chapter.31
Minipig.in.Biomedical.Research:.Diet-Induced.Atherosclerosis.........................................................................................469
James R. Turk and M. Harold Laughlin
Chapter.32
Hemorrhage.and.Resuscitation.Models.Using.the Miniature Swine.....................................................................................479
John W. Burns and Charles E. Wade
Chapter.33
Oral.Biology.and.Dental.Models...........................................................................................................................................491
Susan W. Herring, Yiming Li, Yi Liu, Zi Jun Liu, Tracy E. Popowics,
Katherine L. Rafferty, and Songlin Wang
Chapter.34
Osteoporosis.Model.in.Minipigs............................................................................................................................................517
Hideki Tsutsumi, Satoshi Ikeda, and Toshitaka Nakamura
Chapter.35
Wound.Healing.Models........................................................................................................................................................525
Peter Glerup
Chapter.36
The.Minipig.in.Chemical,.Biological,.and.Radiological Research.......................................................................................533
Stanley W. Hulet, Maria Moroni, Mark H. Whitnall, and Robert J. Mioduszewski
Chapter.37
The.Minipig.and.Pig.in.Medical.Device.Research...............................................................................................................549
Shayne C. Gad