Table Of ContentTHE JOURNAL
OF
IMMUNOLOGY
VOLUME 163
NUMBERS I To 12
CopyriGut © 1999 py THE AMERICAN ASSOCIATION OF IMMUNOLOGISTS
VOLUME 163/ N° 1 / JULY 1, 1999
(UTTIDG ue
Cutting Edge: Combined Treatment of TNF-a and IFN-y Causes Redistribution of
Junctional Adhesion Molecule in Human Endothelial Cells
Harunobu Ozaki, Kenji Ishii, Hisanori Horiuchi, Hidenori Arai, Takahiro Kawamoto,
Katsuya Okawa, Akihiro Iwamatsu, and Toru Kita
Cutting Edge: Trimolecular Interaction of TCR with MHC Class II and Bacterial
Superantigen Shows a Similar Affinity to MHC:Peptide Ligands
Stella Redpath, S. Munir Alam, Christina M. Lin, Anne M. O’Rourke, and Nicholas R. J. Gascoigne
Cutting Edge: Proteasome Involvement in the Degradation of Unassembled Ig Light Chains
Thomas O’Hare, Gregory D. Wiens, Elizabeth A. Whitcomb, Caroline A. Enns,
and Marvin B. Rittenberg
Cutting Edge: A Short Polypeptide Domain of HIV-1-Tat Protein Mediates Pathogenesis
Robert A. Boykins, Renaud Mahieux, Uma T. Shankavaram, Yong Song Gho, Sherwin F. Lee,
Indira K. Hewlett, Larry M. Wahl, Hynda K. Kleinman, John N. Brady, Kenneth M. Yamada,
and Subhash Dhawan
Cutting Edge: Expression of the NF of Activated T Cells in Eosinophils: Regulation by IL-4
and IL-5
Tan Jinquan, Sha Quan, Henrik H. Jacobi, Claus M. Reimert, Anders Miliner, Jens B. Hansen,
Charlotte Thygesen, Lars P. Ryder, Hans O. Madsen, Hans-Jorgen Malling, and Lars K. Poulsen
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
25 The CD3e Subunit of the TCR Contains Endocytosis Signals
Aldo Borroto, Juan Lama, Florence Niedergang, Alice Dautry-Varsat, Balbino Alarcon,
and Andrés Alcover
Presentation of the Self Antigen Myelin Basic Protein by Dendritic Cells Leads to
Experimental Autoimmune Encephalomyelitis
Bonnie N. Dittel, Irene Visintin, Raina M. Merchant, and Charles A. Janeway, Jr.
Myelin Oligodendrocyte Glycoprotein Induces Experimental Autoimmune
Encephalomyelitis in the “Resistant” Brown Norway Rat: Disease Susceptibility Is
Determined by MHC and MHC-Linked Effects on the B Cell Response
Andreas Stefferl, Uschi Brehm, Maria Storch, Doris Lambracht-Washington, Carole Bourquin,
Kurt Wonigeit, Hans Lassmann, and Christopher Linington
Degradation of ZAP-70 Following Antigenic Stimulation in Human T Lymphocytes: Role of
Calpain Proteolytic Pathway
Doris Penna, Sabina Miiller, Fabio Martinon, Stephane Demotz, Makio Iwashima,
and Salvatore Valitutti
Polyriboinosinic Polyribocytidylic Acid (Poly(I:C)) Induces Stable Maturation of
Functionally Active Human Dendritic Cells
Rob M. Verdijk, Tuna Mutis, Ben Esendam, Janine Kamp, Cees J. M. Melief, Anneke Brand,
and Els Goulmy
Expression of a Variant of CD28 on a Subpopulation of Human NK Cells: Implications for
B7-Mediated Stimulation of NK Cells
Joanna Galea-Lauri, David Darling, Shu-Uin Gan, Leonid Krivochtchapov, Marcel Kuiper,
Joop Gdken, Bernard Souberbielle, and Farzin Farzaneh
CONTENTS [VoL. 163
The Regulatory Role of CD45 on Rat NK Cells in Target Cell Lysis
Katinka M. Giezeman-Smits, Arko Gorter, Ronald L. P. van Vlierberghe, Jaap D. H. v. Eendenburg,
AlexanderM . M. Eggermont, Gert Jan Fleuren, and PeterJ .K . Kuppen
Impaired Ability of MHC Class II-’~ Dendritic Cells to Provide Tumor Protection Is
Rescued by CD40 Ligation
Ian F. Hermans, David S. Ritchie, Angela Daish, Jianping Yang, Marilyn R. Kehry,
and Franca Ronchese
Calcium Mobilization in Human Myeloid Cells Results in Acquisition of Individual Dendritic
Cell-Like Characteristics Through Discrete Signaling Pathways
Gary K. Koski, Gretchen N. Schwartz, David E. Weng, Brian J. Czerniecki, Charles Carter,
Ronald E. Gress, and PeterA . Cohen
A Novel Function of Val4*CD4* NKT Cells: Stimulation of IL-12 Production by APC in the
Innate Immune System
Michio Tomura, Wen-Gong Yu, Hyun-Jong Ahn, Motozo Yamashita, Yi-Fu Yang, Shiro Ono,
Toshiyuki Hamaoka, Tetsu Kawano, Masaru Taniguchi, Yasuhiko Koezuka, and Hiromi Fujiwara
CD8" T Cells Become Nonresponsive (Anergic) Following Activation in the Presence of
Costimulation
Matthew J. Deeths, Ross M. Kedl, and Matthew F. Mescher
Induction of Cyclooxygenase-2 on Activated T Lymphocytes: Regulation of T Cell
Activation by Cyclooxygenase-2 Inhibitors
Miguel A. Iniguez, Carmen Punzon, and Manuel Fresno
CD28-Mediated Regulation of mRNA Stability Requires Sequences Within the Coding
Region of the IL-2 mRNA
Jack A. Ragheb, Mary Deen, and Ronald H. Schwartz
Immunogenicity of Apoptotic Cells In Vivo: Role of Antigen Load, APC and Cytokines
Anna Ronchetti, Patrizia Rovere, Giandomenica Iezzi, Giacomo Galati, Silvia Heltai,
Maria Pia Protti, Maria Paola Garancini, Angelo A. Manfredi, Claudio Rugarli, and Matteo Bellone
The Guanine-Nucleotide Exchange Factor Vav Is a Crucial Regulator of B Cell Receptor
Activation and B Cell Responses to Nonrepetitive Antigens
Martin F. Bachmann, Lars Nitschke, Connie Krawczyk, Kerry Tedford, Pamela S. Ohashi,
Klaus D. Fischer, and JosefM .P enninger
Bioactive IL-18 Expression Is Up-Regulated in Crohn’s Disease
Giovanni Monteleone, Francesco Trapasso, Tiziana Parrello, Livia Biancone, Antonella Stella,
Rodolfo Iuliano, Francesco Luzza, Alfredo Fusco, and Francesco Pallone
IFN-y- and Cell-to-Cell Contact-Dependent Cytotoxicity of Allograft-Induced Macrophages
Against Syngeneic Tumor Cells and Cell Lines: An Application of Allografting to Cancer
Treatment
Ryotaro Yoshida, Yukio Yoneda, Manabu Kuriyama, and Takahiro Kubota
Anergic CD8* T Cells Can Persist and Function In Vivo
Catherine A. Blish, Stacey R. Dillon, Andrew G. Farr, and Pamela J. Fink
Differential Expression and Cross-Regulatory Function of RANTES During Mycobacterial
(Type 1) and Schistosomal (Type 2) Antigen-Elicited Granulomatous Inflammation
Stephen W. Chensue, Kelly S. Warmington, Eric J. Allenspach, Bao Lu, Craig Gerard,
Steven L. Kunkel, and Nicholas W. Lukacs
CONTENTS
Transfection of Immature Murine Bone Marrow-Derived Dendritic Cells with the
Granulocyte-Macrophage Colony-Stimulating Factor Gene Potently Enhances Their In Vivo
Antigen-Presenting Capacity
Clara Curiel-Lewandrowski, Karsten Mahnke, Marta Labeur, Berthold Roters, Walter Schmidt,
Richard D. Granstein, Thomas A. Luger, Thomas Schwarz, and Stephan Grabbe
A Model for CD8* CTL Tumor Immunosurveillance and Regulation of Tumor Escape by
CD4 T Cells Through an Effect on Quality of CTL
So Matsui, Jeffrey D. Ahlers, Alex O. Vortmeyer, Masaki Terabe, Taku Tsukui, David P. Carbone,
Lance A. Liotta, and Jay A. Berzofsky
CD30 Overexpression Enhances Negative Selection in the Thymus and Mediates
Programmed Cell Death Via a Bcl-2-Sensitive Pathway
Roberto Chiarle, Antonello Podda, Gabriel Prolla, Eckhard R. Podack, G. Jeanette Thorbecke,
and Giorgio Inghirami
Development of T Lymphocytes at Extrathymic Sites
Mariastefania Antica and Roland Scollay
Diversity of NK Cell Receptor Repertoire in Adult and Neonatal Mice
Akira Kubota, Satoko Kubota, Stefan Lohwasser, Dixie L. Mager, and Fumio Takei
Humoral Response Suppression Observed with CD23 Transgenics
Margaret E. Payet, Elaine C. Woodward, and Daniel H. Conrad
Bacterial DNA or Oligonucleotides Containing Unmethylated CpG Motifs Can Minimize
Lipopolysaccharide-Induced Inflammation in the Lower Respiratory Tract Through an IL-
12-Dependent Pathway
David A. Schwartz, Christine L. Wohlford-Lenane, TimothyJ . Quinn, and Arthur M. Krieg
BALB/c Invariant Chain Mutant Mice Display Relatively Efficient Maturation of CD4° T
Cells in the Periphery and Secondary Proliferative Responses Elicited upon Peptide
Challenge
George Kenty and Elizabeth K. Bikoff
Depletion of IL-10- and TGF-B-Producing Regulatory yé T Cells by Administering a
Daunomycin-Conjugated Specific Monoclonal Antibody in Early Tumor Lesions Augments
the Activity of CTLs and NK Cells
Naohiro Seo, Yoshiki Tokura, Masahiro Takigawa, and Kohji Egawa
MOLECULAR AND STRUCTURAL IMMUNOLOGY
250 A Single-Chain IL-12 IgG3 Antibody Fusion Protein Retains Antibody Specificity and IL-12
Bioactivity and Demonstrates Antitumor Activity
Lisan S. Peng, Manuel L. Penichet, and Sherie L. Morrison
Predicting Regional Mutability in Antibody V Genes Based Solely on Di- and Trinucleotide
Sequence Composition
Gary S. Shapiro, Katja Aviszus, David Ikle, and Lawrence J. Wysocki
Constitutive Nuclear Translocation of NF-«B in B Cells in the Absence of IkB Degradation
Stefan Doerre and Ronald B. Corley
Genes Encoding Three New Members of the Leukocyte Antigen 6 Superfamily and a Novel
Member of Ig Superfamily, Together with Genes Encoding the Regulatory Nuclear Chloride
Ion Channel Protein (hHRNCC) and a N°-N°-Dimethylarginine Dimethylaminohydrolase
Homologue, Are Found in a 30-kb Segment of the MHC Class III Region
Gloria Ribas, Matt Neville, Joanne L. Wixon, Jianhua Cheng, and R. Duncan Campbell
CONTENTS [VoL. 163
The Specificity of a Weak yé TCR Interaction Can Be Modulated by the Glycosylation of
the Ligand
Johannes Hampl, Hansjérg Schild, Christa Litzenberger, Miriam Baron, Michael P. Crowley,
and Yueh-hsiu Chien
Enhancer-Blocking Activity Within the DNase I Hypersensitive Site 2 to 6 Region Between
the TCR a and Dad1 Genes
Xiao-Ping Zhong and Michael S. Krangel
Invariant or Highly Conserved TCR a Are Expressed on Double-Negative
(CD3*CD4 CD8~) and CD8* T Cells
Mei Han, Lisa Harrison, Patricia Kehn, Kimberly Stevenson, Jeffrey Currier,
and Mary Ann Robinson
HOST DEFENSE
312 Surfactant Protein D Binds to Mycobacterium tuberculosis Bacilli and Lipoarabinomannan
Via Carbohydrate-Lectin Interactions Resulting in Reduced Phagocytosis of the Bacteria by
Macrophages
J. Scott Ferguson, Dennis R. Voelker, Francis X. McCormack, and Larry S. Schlesinger
Genetic Immunization of Mice Against Listeria monocytogenes Using Plasmid DNA
Encoding Listeriolysin O
Kenneth A. Cornell, H. G. Archie Bouwer, David J. Hinrichs, and Ronald A. Barry
Protective Immunity from Naive CD8* T Cells Activated In Vitro with MHC Class I Binding
Immunogenic Peptides and IL-2 in the Absence of Specialized APCs
Conrad Hauser, Frank Zipprich, Isabelle Leblond, Susanne Wirth, and Ambros W. Hiigin
Schistosome-Infected IL-4 Receptor Knockout (KO) Mice, in Contrast to IL-4 KO Mice, Fail
to Develop Granulomatous Pathology While Maintaining the Same Lymphokine Expression
Profile
Dragana Jankovic, Marika C. Kullberg, Nancy Noben-Trauth, Patricia Caspar, Jerrold M. Ward,
Allen W. Cheever, William E. Paul, and Alan Sher
INFLAMMATION
343 Characterization of Eosinophil Adhesion to TNF-a-Activated Endothelium Under Flow
Conditions: a, Integrins Mediate Initial Attachment, and E-Selectin Mediates Rolling
Laurien H. Ulfman, Philip H. M. Kuijper, Jan A. M. van der Linden, Jan-Willem J. Lammers,
Jaap Jan Zwaginga, and Leo Koenderman
Involvement of Thioredoxin in Rheumatoid Arthritis: Its Costimulatory Roles in the TNF-a-
Induced Production of IL-6 and IL-8 from Cultured Synovial Fibroblasts
Shinichi Yoshida, Tetsuji Katoh, Toshifumi Tetsuka, Kazuko Uno, Nobuo Matsui,
and Takashi Okamoto
Deficiency of 5-Lipoxygenase Abolishes Sex-Related Survival Differences in MRL-lpr/pr
Mice
Jennifer L. Goulet, Robert C. Griffiths, Phillip Ruiz, Robert F. Spurney, David S. Pisetsky,
Beverly H. Koller, and Thomas M. Coffman
P-Selectin Binding Promotes the Adhesion of Monocytes to VCAM-1 Under Flow
Conditions
Tadayuki Yago, Mamoru Tsukuda, and Mutsuhiko Minami
Estrogen Protects Against Cellular Infiltration by Reducing the Expressions of E-Selectin
and IL-6 in Endotoxin-Induced Uveitis
Noriko Miyamoto, Michiko Mandai, Izumi Suzuma, Kiyoshi Suzuma, Kaori Kobayashi,
and Yoshihito Honda
CONTENTS
Differential Cytokine Modulation and T Cell Activation by Two Distinct Classes of
Thalidomide Analogues That Are Potent Inhibitors of TNF-a
Laura G. Corral, Patrick A. J. Haslett, George W. Muller, Roger Chen, Lu-Min Wong,
ChristopherJ .O campo, Rebecca T. Patterson, David I. Stirling, and Gilla Kaplan
Pulmonary Surfactant Protein A Modulates the Cellular Response to Smooth and Rough
Lipopolysaccharides by Interaction with CD14
Hitomi Sano, Hitoshi Sohma, Tatsushi Muta, Shin-ichi Nomura, Dennis R. Voelker,
and Yoshio Kuroki
Decreased Expression of Th2 Type Cytokine mRNA Contributes to the Lack of Allergic
Bronchial Inflammation in Aged Rats
Kyotaro Ide, Hiroshi Hayakawa, Takeshi Yagi, Atsuhiko Sato, Yukio Koide, Atsushi Yoshida,
Masato Uchijima, Takafumi Suda, Kingo Chida, and Hirotoshi Nakamura
Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung
Inflammation
Jose-Angel Gonzalo, Yang Pan, Clare M. Lloyd, Gui-Quan Jia, Gary Yu, Barry Dussault,
Christine A. Powers, Amanda E. I. Proudfoot, Anthony J. Coyle, David Gearing,
and Jose-Carlos Gutierrez-Ramos
The Murine Antiapoptotic Protein Al Is Induced in Inflammatory Macrophages and
Constitutively Expressed in Neutrophils
Amos Orlofsky, Robert D. Somogyi, Louis M. Weiss, and Michael B. Prystowsky
Induction of Phosphorylation and Intracellular Association of CC Chemokine Receptor 5
and Focal Adhesion Kinase in Primary Human CD4° T Cells by Macrophage-Tropic HIV
Envelope
Claudia Cicala, James Arthos, Margaret Ruiz, Mauro Vaccarezza, Andrea Rubbert, Agostino Riva,
Kathryn Wildt, Oren Cohen, and Anthony S. Fauci
NF-«B Regulation by IxB Kinase in Primary Fibroblast-Like Synoviocytes
Karlfried R. Aupperle, Brydon L. Bennett, David L. Boyle, Paul-Peter Tak, Anthony M. Manning,
and Gary S. Firestein
Osteoclast Differentiation Factor Acts as a Multifunctional Regulator in Murine Osteoclast
Differentiation and Function
Eijiro Jimi, Shuichi Akiyama, Taro Tsurukai, Nobuo Okahashi, Kanichiro Kobayashi,
Nobuyuki Udagawa, Tatsuji Nishihara, Naoyuki Takahashi, and Tatsuo Suda
CLINICAL IMMUNOLOGY
443 In Situ T Cell Responses Against Melanoma Comprise High Numbers of Locally Expanded
T Cell Clonotypes
Per thor Straten, Per Guldberg, Kirsten Gronbeek, Mia Riise Hansen, Alexei F. Kirkin, Tina Seremet,
Jesper Zeuthen, and Jiirgen C. Becker
Repeated Administration of Adenoviral Vectors in Lungs of Human CD4 Transgenic Mice
Treated with a Nondepleting CD4 Antibody
Narendra Chirmule, Alemseged Truneh, Sarah Ehlen Haecker, John Tazelaar, Guang-ping Gao,
Steven E. Raper, Joseph V. Hughes, and James M. Wilson
IL-5 Increases Expression of 5-Lipoxygenase-Activating Protein and Translocates 5-
Lipoxygenase to the Nucleus in Human Blood Eosinophils
Andrew S. Cowburn, Stephen T. Holgate, and Anthony P. Sampson
Skin Homing (Cutaneous Lymphocyte-Associated Antigen-Positive) CD8* T Cells Respond
to Superantigen and Contribute to Eosinophilia and IgE Production in Atopic Dermatitis
Miibeccel Akdis, Hans-Uwe Simon, Lorenz Weigl, Oliver Kreyden, Kurt Blaser, and Cezmi A. Akdis
CONTENTS [VoL. 163
A Complementary Peptide Vaccine That Induces T Cell Anergy and Prevents Experimental
Allergic Neuritis in Lewis Rats
Shigeru Araga, Masahiro Kishimoto, Satoko Doi, and Kenji Nakashima
A Non-AUG-Defined Alternative Open Reading Frame of the Intestinal Carboxyl Esterase
mRNA Generates an Epitope Recognized by Renal Cell Carcinoma-Reactive Tumor-
Infiltrating Lymphocytes In Situ
Christophe Ronsin, Véronique Chung-Scott, Isabelle Poullion, Nicolas Aknouche, Catherine Gaudin,
and Frédéric Triebel
Altered Memory T Cell Differentiation in Patients with Early Rheumatoid Arthritis
Alla Skapenko, Jorg Wendler, PeterE . Lipsky, Joachim R. Kalden, and Hendrik Schulze-Koops
Endogenous CD8* T Cell Expansion During Regression of Monoclonal EBV-Associated
Posttransplant Lymphoproliferative Disorder
Vijay P. Khatri, Robert A. Baiocchi, Ruoqi Peng, Adam R. Oberkircher, Jean M. Dolce, Pamela M.
Ward, Geoffrey P. Herzig, and Michael A. Caligiuri
Efficient Transfer of a Tumor Antigen-Reactive TCR to Human Peripheral Blood
Lymphocytes Confers Anti-Tumor Reactivity
Timothy M. Clay, Mary C. Custer, Jessica Sachs, Patrick Hwu, Steven A. Rosenberg,
and Michael I. Nishimura
Induced Expression of B7-1 on Myeloma Cells Following Retroviral Gene Transfer Results
in Tumor-Specific Recognition by Cytotoxic T Cells
Karin Tarte, Xue-Guang Zhang, Eric Legouffe, Catherine Hertog, Majid Mehtali,
Jean-Francois Rossi, and Bernard Klein
Early Autoantibody Responses in Prediabetes Are IgG1 Dominated and Suggest Antigen-
Specific Regulation
Ezio Bonifacio, Miriam Scirpoli, Katharina Kredel, Martin Fiichtenbusch, and Anette-G. Ziegler
Increased Apoptosis in Patients with Major Depression: A Preliminary Study
Eran Eilat, Shlomo Mendlovic, Adiel Doron, Vera Zakuth, and Zvi Spirer
Author Index
Information for Authors
Editorial Policies and Practices
Submission Form: Full Length Articles
AAI Membership Application
Submission Form: Cutting Edge
AAI Trainee Membership Application
VOLUME 163 / N° 2/ JULY 15, 1999
CUTTING Crue
553 Cutting Edge: Combined Treatment of TNF-a and IFN-y Causes Redistribution of
Junctional Adhesion Molecule in Human Endothelial Cells
Harunobu Ozaki, Kenji Ishii, Hisanori Horiuchi, Hidenori Arai, Takahiro Kawamoto,
Katsuya Okawa, Akihiro Iwamatsu, and Toru Kita
1999] CONTENTS
558 Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing
Mechanisms in Macrophages Through a P2X--Independent Mechanism
Andrew Sikora, Judy Liu, Celia Brosnan, Gary Buell, Iain Chessel, and Barry R. Bloom
CELLULAR IMMUNOLOGY AND IMMUNE REGULATION
563 Cas-L Is Required for B, Integrin-Mediated Costimulation in Human T Cells
Kenjiro Kamiguchi, Kouichi Tachibana, Satoshi Iwata, Yoshiyuki Ohashi, and Chikao Morimoto
How Specific Should Immunological Memory Be?
José A. M. Borghans, André J. Noest, and Rob J. De Boer
Immune System Development and Function in Prolactin Receptor-Deficient Mice
Brigitte Bouchard, Christopher J.O rmandy, James P. Di Santo, and PaulA . Kelly
Differential Antitumor Effects of Administration of Recombinant IL-18 or Recombinant
IL-12 Are Mediated Primarily by Fas-Fas Ligand- and Perforin-Induced Tumor Apoptosis,
Respectively
Wataru Hashimoto, Tadashi Osaki, Haruki Okamura, Paul D. Robbins, Masashi Kurimoto,
Shigekazu Nagata, Michael T. Lotze, and Hideaki Tahara
Inhibition of NF-«B Activity in Human T Lymphocytes Induces Caspase-Dependent
Apoptosis Without Detectable Activation of Caspase-1 and -3
Vladimir Kolenko, Tracy Bloom, Patricia Rayman, Ronald Bukowski, Eric Hsi, and James Finke
Differential CD3¢ Phosphorylation Is Not Required for the Induction of T Cell Antagonism
by Altered Peptide Ligands
Haiyan Liu and Dario A. A. Vignali
Slow Accumulation of Active Mitogen-Activated Protein Kinase During Thymocyte
Differentiation Regulates the Temporal Pattern of Transcription Factor Gene Expression
Hui Shao, Beverley Wilkinson, Brian Lee, Pei-Chen Han, and Jonathan Kaye
Differential Involvement of the Transcription Factor Blimp-1 in T Cell-Independent and
-Dependent B Cell Differentiation to Plasma Cells
Pilar G. Soro, Patricia Morales-A., Jose A. Martinez-M., Susana Morales-A., Sergio G. Copin,
Miguel A.R. Marcos, and Marta-Luisa Gaspar
IgG-Mediated Enhancement of Antibody Responses Is Low in Fc Receptor y Chain-
Deficient Mice and Increased in FcyRII-Deficient Mice
Sara Wernersson, Mikael C. I. Karlsson, Jérgen Dahlstrém, Ragnar Mattsson, J. Sjef Verbeek,
and Birgitta Heyman
The Transcription Factors Elf-1 and GATA-1 Bind to Cell-Specific Enhancer Elements of
Human High-Affinity IgE Receptor a-Chain Gene
Chiharu Nishiyama, Toyokazu Yokota, Ko Okumura, and Chisei Ra
Differential Induction of Cytokine Genes and Activation of Mitogen-Activated Protein
Kinase Family by Soluble CD40 Ligand and TNF in a Human Follicular Dendritic Cell Line
Sun-Mi Park, Han-Soo Kim, Jongseon Choe, and Tae H. Lee
Signaling Events Induced by Lipopolysaccharide-Activated Toll-Like Receptor 2
Ruey-Bing Yang, Melanie R. Mark, Austin L. Gurney, and Paul J. Godowski
CD4-Mediated Signals Induce T Cell Dysfunction In Vivo
Narendra Chirmule, Andris Avots, S. M. LakshmiTamma, Savita Pahwa, and Edgar Serfling
CONTENTS [VoL. 163
Hypervariable Region 1 Variants Act as TCR Antagonists for Hepatitis C Virus-Specific
CD4* T Cells
Loredana Frasca, Paola Del Porto, Loretta Tuosto, Barbara Marinari, Cristiano Scotta,
Maurizio Carbonari, Alfredo Nicosia, and Enza Piccolella
In Vivo Polysaccharide-Specific IgG Isotype Responses to Intact Streptococcus pneumoniae
Are T Cell Dependent and Require CD40- and B7-Ligand Interactions
Zheng-Qi Wu, Quirijn Vos, Yi Shen, Andrew Lees, Samuel R. Wilson, David E. Briles,
William C. Gause, James J. Mond, and Clifford M. Snapper
ICAM-1-Coupled Signaling Pathways in Astrocytes Converge to Cyclic AMP Response
Element-Binding Protein Phosphorylation and TNF-a Secretion
Sandrine Etienne-Manneville, Nathalie Chaverot, A. Donny Strosberg, and Pierre-Olivier Couraud
Phenotypic Identification of Antigen-Dependent and Antigen-Independent CD8 CTL
Precursors in the Draining Lymph Node During Acute Cutaneous Herpes Simplex Virus
Type 1 Infection
James M. McNally, Deborah Dempsey, R. Michael Wolcott, Robert Chervenak,
and Stephen R. Jennings
A New Role for Platelet-Endothelial Cell Adhesion Molecule-1 (CD31): Inhibition of TCR-
Mediated Signal Transduction
Debra K. Newton-Nash and Peter J. Newman
Negative Selection of T Cells Occurs Throughout Thymic Development
Kristin K. Baldwin, Brian P. Trenchak, John D. Altman, and Mark M. Davis
Induction of Antitumor Immunity with Dendritic Cells Transduced with Adenovirus Vector-
Encoding Endogenous Tumor-Associated Antigens
Johanne M. Kaplan, Queendy Yu, Susan T. Piraino, Sarah E. Pennington, Srinivas Shankara,
Lisa A. Woodworth, and Bruce L. Roberts
Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G, to S Transition Through a
Phosphatidylinositol-3 Kinase-Independent Mechanism
Ignacio Flores, David R. Jones, Angel Ciprés, Ernesto Diaz-Flores, Miguel Angel Sanjuan,
and Isabel Mérida
Activation of the Extracellular Signal-Related Kinase/Mitogen-Activated Protein Kinase
Pathway Discriminates CD4 Versus CD8 Lineage Commitment in the Thymus
Ursula Bommhardt, M. Albert Basson, Ulrike Krummrei, and Rose Zamoyska
Antigen Concentration and Precursor Frequency Determine the Rate of CD8* T Cell
Tolerance to Peripherally Expressed Antigens
David J. Morgan, Huub T. C. Kreuwel, and Linda A. Sherman
TCR and IL-12 Receptor Signals Cooperate to Activate an Individual Response Element in
the IFN-y Promoter in Effector Th Cells
Feng Zhang, Tetsuo Nakamura, and Thomas M. Aune
Functional Gene Transfer of HIV DNA by an HIV Receptor-Independent Mechanism
Anna-Lena Spetz, Bruce K. Patterson, Karin Lore, Jan Andersson, and Lars Holmgren
I-A®’-Mediated Antigen Presentation by B Lymphocytes Is Critical in Overcoming a
Checkpoint in T Cell Tolerance to Islet 8 Cells of Nonobese Diabetic Mice
Hooman Noorchashm, Yen K. Lieu, Negin Noorchashm, Susan Y. Rostami, Siri Atma S. Greeley,
Alexander Schlachterman, Howard K. Song, Lauren E. Noto, Anthony M. Jevnikar, ClydeF . Barker,
and Ali Naji
