The Inflammatory Myopathies

330 Pages·2009·5.1 MB·English

by  Lawrence J. Kagen (auth.)

The Inflammatory Myopathies
Lawrence J. Kagen
Editor
The Inflammatory Myopathies
Editor
Lawrence J. Kagen
Department of Rheumatology
Weill Medical College of Cornell University
Hospital for Special Surgery
New York Presbyterian Hospital
New York, NY
USA
[email protected]
ISBN 978-1-60327-828-7 e-ISBN 978-1-60327-827-0
DOI 10.1007/978-1-60327-827-0
Springer Dordrecht Heidelberg London New York
Library of Congress Control Number: 2009926029
© Humana Press, a part of Springer Science+Business Media, LLC 2009
All rights reserved. This work may not be translated or copied in whole or in part without the written pemrission
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Preface
This book is dedicated to our readers with the intention of providing an informative
exposition of the myositis syndromes. It is also presented in the hope that perhaps
it may serve to inspire and stimulate discussion and research into these disabling
disorders. Included are descriptions of clinical features, dif ferential diagnosis,
pathogenetic mechanisms, and approaches to therapy. Current concepts of classifi-
cation and diagnostic techniques are also presented.
The production staf f at Humana Springer , especially Ms. F . Louie and
Ms. C. Walsh, have been instrumental and invaluable in allowing this work to see
the light of day.
Above all, the scholarly essays of the contributing authors are acknowledged
with gratitude. They have given this volume its character and existence.
New York, NY Lawrence J. Kagen
v
Contents
Preface . ............................................................................................................ v
Contributors ................................................................................................... ix
1 Evaluation of the Patient ......................................................................... 1
Lawrence J. Kagen
2 Classification of Idiopathic Inflammatory Myopathies ........................ 15
Frederick W. Miller
3 The Inflammatory Milieu: Cells and Cytokines.................................... 29
Ann M. Reed and Thomas A. Griffin
4 Juvenile Dermatomyositis: An Update on
Clinical and Laboratory Findings .......................................................... 55
Lauren M. Pachman
5 Inclusion Body Myositis .......................................................................... 87
Lawrence J. Kagen
6 The Role of Muscle Biopsy in the Diagnosis
of Inflammatory Myopathy ..................................................................... 95
Sakir Humayun Gultekin
7 Electr omyography .................................................................................... 111
Hans L. Carlson
8 Magnetic Resonance Imaging of Myopathies and Myositis ................. 127
Carolyn M. Sofka
9 Ultrasound in the Evaluation of the Inflammatory Myopathies ......... 147
Ronald S. Adler and Giovanna Garofalo
vii
viii Contents
10 Ser ological Findings ............................................................................... 165
Ira N. Targoff
11 Antisynthetase Syndrome ..(MISSING)...................................... 191
Galina S. Marder and Robert Greenwald
12 Pulmonary Manifestations of Inflammatory Myopathy .................... 207
Eun Ha Kang and Yeong Wook Song
13 Dermatological Manifestations of Dermatomyositis ........................... 223
Mark Kagen
14 The Differential Diagnosis of Inflammatory Myopathy ..................... 231
Michael Rubin and Asaf Klein
15 Outcomes and Assessment for Inflammatory Muscle Disease ........... 253
Lisa G. Rider
16 Muscle Strength and Exercise in Patients
with Inflammatory Myopathies ............................................................ 277
Helene Alexanderson and Ingrid E. Lundberg
17 The Risk of Malignancy in Patients with
Dermatomyositis and Polymyositis. ...................................................... 307
Alan N. Baer and Robert L. Wortmann
18 T reatment ................................................................................................ 319
Stephen J. DiMartino
Index ................................................................................................................ 333
Contributors
Ronald S. Adler, MD, PhD
Division of Ultrasound and Body Imaging,
Hospital for Special Surgery, Weill Medical College of Cornell University,
New York, NY, USA
Helene Alexanderson, PhD, RPT
Department of Physical Therapy,
Orthopedic and Rheumatology Unit, Karolinska University Hospital,
Rheumatology Unit, Department of Medicine, Karolinska Institutet Solna,
Stockholm, Sweden
Alan N. Baer, MD
Division of Rheumatology, Johns Hopkins University
School of Medicine, Baltimore, MD, USA
Hans L. Carlson, MD
Department of Orthopaedics and Rehabilitation,
Oregon Health and Science University, Portland, OR, USA
Stephen J. DiMartino, MD, PhD
Division of Rheumatology, Hospital for Special Surgery,
Weill Medical College of Cornell University, New York,
NY, USA
Giovanna Garofalo, MD
Unità Operativa di Immunologia e Allergologia, Ospedale A. Murri,
Fermo, Italy
Robert A. Greenwald, MD
Medicine Department, Long Island Jewish
Medical Center, Lake Success, NY, USA
Thomas A. Griffin, MD, PhD
William S. Rowe Division of Pediatric Rheumatology, Cincinnati Children’s
Hospital Medical Center and University of Cincinnati College of Medicine,
Cincinnati, OH, USA
ix
x Contributors
Sakir Humayun Gultekin, MD
Department of Pathology, Division of Neuropathology,
Oregon Health and Science University, Portland, OR, USA
Lawrence J. Kagen, MD
Department of Rheumatology, Weill Medical College of Cornell University,
Hospital for Special Surgery, New York Presbyterian Hospital,
New York, NY, USA
Mark Kagen, MD
Riverchase Dermatology, Naples, FL, USA
Eun Ha Kang, MD, PhD
Division of Rheumatology, Department of Internal Medicine,
Seoul National University Hospital, Seoul, Korea
Asaf Klein, BSc
State University of New York, Downstate College of Medicine,
Brooklyn, NY, USA
Ingrid E. Lundberg, MD, PhD
Rheumatology Unit, Department of Medicine,
Karolinska University Hospital, Karolinska Institutet Solna,
Stockholm, Sweden
Galina S. Marder, MD
The Myositis and Vasculitis Center, North Shore Long Island Jewish Health
System, Albert Einstein College of Medicine, Lake Success, NY, USA
Frederick W. Miller, MD, PhD
Environmental Autoimmunity Group,
National Institute of Environmental Health Sciences, National Institutes
of Health, Bethesda, MD, USA
Lauren M. Pachman, MD
Division of Rheumatology, Children’s Memorial Hospital,
Northwestern University’s Feinberg School of Medicine,
FOCIS/CMRC Center of Excellence in Clinical Immunology,
Cure JM Program of Excellence in Juvenile Myositis, Chicago, IL, USA
Ann M. Reed, MD
Departments of Pediatrics and Medicine, Division of Rheumatology,
Mayo Clinic College of Medicine, Rochester, MN, USA
Lisa G. Rider, MD
Environmental Autoimmunity Group, National Institute
of Environmental Health Sciences, National Institutes of Health,
Bethesda, MD, USA
Contributors xi
Michael Rubin, MD, FRCP(C)
Department of Neurology, Division of Neuromuscular Disease,
Weill Medical College of Cornell University,
New York, NY, USA
Carolyn M. Sofka, MD
Department of Radiology and Imaging, Hospital for Special Surgery,
Weill Medical College of Cornell University, New York, NY, USA
Yeong Wook Song, MD, PhD
Division of Rheumatology, Department of Internal Medicine,
Seoul National University Hospital, Seoul, Korea
Ira N. Targoff, MD
Department of Medicine, University of Oklahoma Health Sciences Center,
Department of Veterans Affairs Medical Center Oklahoma City, Oklahoma
Medical Research Foundation, Oklahoma City, OK, USA
Robert L. Wortmann, MD
Department of Rheumatology, Dartmouth Hitchcock Medical Center,
Lebanon, NH, USA