Table Of ContentThe GnRH Neuron and its Control
The GnRH Neuron
and its Control
EDITED BY
Allan E. Herbison
University of Otago, Dunedin, New Zealand
Tony M. Plant
University of Pittsburgh, Pittsburgh, USA
This edition first published 2018
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Library of Congress Cataloging-in-Publication Data has been applied for
Names: Herbison, Allan E., editor. | Plant, Tony M., editor.
Title: The GnRH neuron and its control / edited by Allan E. Herbison, Tony M. Plant.
Description: First edition. | Hoboken, NJ : Wiley, 2018. | Includes
bibliographical references and index. |
Identifiers: LCCN 2017048924 (print) | LCCN 2017051618 (ebook) | ISBN
9781119233251 (pdf) | ISBN 9781119233268 (epub) | ISBN 9781119233244
(cloth)
Subjects: | MESH: Neurons–physiology | Gonadotropin-Releasing
Hormone–secretion
Classification: LCC QP363 (ebook) | LCC QP363 (print) | NLM WL 102.5 | DDC
573.8/536–dc23
LC record available at https://lccn.loc.gov/2017048924
Cover Design: Wiley
Cover Image: Courtesy of Rebecca Campbell and Allan E. Herbison
Set in 9.5/13pt Meridien LT by SPi Global, Chennai, India
10 9 8 7 6 5 4 3 2 1
Contents
List of Contributors, vii
Series Preface, xi
Preface, xiii
About the Companion Website, xv
PART I Historical Introduction to the GnRH Neuron
1 The Framework Upon Which Current Research on the GnRH Neuron
and its Control is Built, 3
Tony M. Plant and Allan E. Herbison
PART II GnRH Neuron Development
2 Prenatal Development of GnRH Neurons, 15
Yufei Shan and Susan Wray
3 Fetal/perinatal Programming Causing Sexual Dimorphism
of the Kisspeptin–GnRH Neuronal Network, 43
Hiroko Tsukamura, Kei‐ichiro Maeda and Yoshihisa Uenoyama
4 Postnatal Development of GnRH Neuronal Function, 61
Ei Terasawa
PART III GnRH Neuron Biology
5 Regulation of GnRH Gene Expression, 95
Hanne M. Hoffmann and Pamela L. Mellon
6 Morphology of the Adult GnRH Neuron, 121
Rebecca E. Campbell
7 The Anatomy of the GnRH Neuron Network in the Human, 149
Katalin Skrapits and Erik Hrabovszky
8 Electrophysiology of Rodent GnRH Neurons, 177
Richard Piet and Allan E. Herbison
9 Anatomy and Physiology of GnRH Neurons and Their Control
of Pituitary Function in Fish, 203
Yoshitaka Oka
v
vi Contents
PART IV Regulation of GnRH Neuron Function
10 Unveiling the Importance of Glia and Vascular Endothelial Cells
in the Control of GnRH Neuronal Function, 227
Vincent Prevot and Ariane Sharif
11 Genetic Strategies Examining Kisspeptin Regulation of GnRH
Neurons, 259
Michael Candlish, Philipp Wartenberg and Ulrich Boehm
12 KNDy Hypothesis for Generation of GnRH Pulses: Evidence
from Sheep and Goats, 289
Robert L. Goodman, Satoshi Okhura, Hiroaki Okamura, Lique M. Coolen,
and Michael N. Lehman
13 Generation of the GnRH Surge and LH Surge by the Positive
Feedback Effect of Estrogen, 325
Iain Clarke
14 Influence of Stress on the GnRH Neuronal Network, 357
Pasha Grachev and Kevin T. O’Byrne
15 Metabolic Regulation of GnRH Neurons, 383
Maggie C. Evans and Greg M. Anderson
16 Seasonal Control of the GnRH Neuronal Network as a Means
of Uncovering Novel Central Mechanisms Governing Mammalian
Reproduction, 411
Sébastien Milesi, Paul Klosen and Valerie Simonneaux
PART V GnRH in the Clinic
17 Human Genetics of GnRH Neuron Function, 445
A. Kemal Topaloglu and L. Damla Kotan
18 Modulators of GnRH Secretion and Therapeutic Applications, 469
Claire L. Newton, Ross C. Anderson and Robert P. Millar
Index, 499
List of Contributors
Greg M. Anderson Maggie C. Evans
Centre for Neuroendocrinology and Centre for Neuroendocrinology and
Department of Anatomy Department of Anatomy
University of Otago School of Biomedical University of Otago School of Biomedical
Sciences Sciences
Dunedin, New Zealand Dunedin, New Zealand
Ross C. Anderson Robert L. Goodman
Centre for Neuroendocrinology Department of Physiology and Pharmacology
Departments of Physiology and Immunology West Virginia University
University of Pretoria Morgantown, WV, USA
Pretoria, South Africa
Pasha Grachev
Ulrich Boehm Department of Physiology & Pharmacology
Experimental Pharmacology, Center for Oregon Health & Science University
Molecular Signaling (PZMS) Portland, OR, USA
Saarland University School of Medicine
Homburg, Germany Allan E. Herbison
Centre for Neuroendocrinology and
Rebecca E. Campbell Department of Physiology
Centre for Neuroendocrinology and University of Otago School of Biomedical
Department of Physiology Sciences
University of Otago School of Biomedical Dunedin, New Zealand
Sciences
Dunedin, New Zealand Hanne M. Hoffmann
Department of Reproductive Medicine
Michael Candlish Center for Reproductive Science and Medicine
Experimental Pharmacology, Center for University of California, San Diego
Molecular Signaling (PZMS) La Jolla, CA, USA
Saarland University School of Medicine
Homburg, Germany Erik Hrabovszky
Laboratory of Endocrine Neurobiology
Iain Clarke Institute of Experimental Medicine
Neuroscience Program Hungarian Academy of Sciences
Monash Biomedicine Discovery Institute Budapest, Hungary
Department of Physiology
Monash University Paul Klosen
Clayton, Victoria, Australia Institute of Cellular and Integrative
Neurosciences
Lique M. Coolen CNRS & University of Strasbourg
Department of Physiology and Biophysics Strasbourg, France
University of Mississippi Medical Center
Jackson, MS, USA L. Damla Kotan
Cukurova University
Faculty of Medicine
Division of Pediatric Endocrinology
Adana, Turkey
vii
viii List of Contributors
Michael N. Lehman Hiroaki Okamura
Department of Neurobiology and Anatomical Laboratory of Neurobiology
Sciences National Institute of Agrobiological Sciences
University of Mississippi Medical Center Ibaraki, Japan
Jackson, MS, USA
Satoshi Okhura
Kei‐ichiro Maeda Graduate School of Bioagricultural Sciences
Department of Veterinary Medical Sciences Nagoya University
University of Tokyo Nagoya, Japan
Tokyo, Japan
Richard Piet
Pamela L. Mellon Centre for Neuroendocrinology and
Department of Reproductive Medicine Department of Physiology
Center for Reproductive Science and Medicine University of Otago School of Biomedical
University of California, San Diego Sciences
La Jolla, CA, USA Dunedin, New Zealand
Sébastien Milesi Tony M. Plant
Institute of Cellular and Integrative Department of Obstetrics, Gynecology and
Neurosciences Reproductive Sciences
CNRS & University of Strasbourg University of Pittsburgh School of Medicine
Strasbourg, France and Magee Womens Research Institute
Pittsburgh, PA, USA
Robert P. Millar
Centre for Neuroendocrinology Vincent Prevot
Departments of Physiology and Immunology Inserm, Laboratory of Development and
University of Pretoria Plasticity of the Neuroendocrine Brain
Pretoria, South Africa Jean‐Pierre Aubert Research Centre
University of Lille, School of Medicine
Lille, France
and
Yufei Shan
Department of Integrative Biomedical S ciences Cellular and Developmental Neurobiology
and Institute of Infectious Diseases and Laboratory
Molecular Medicine NINDS, NIH
University of Cape Town Bethesda, MD, USA
Cape Town, South Africa
Ariane Sharif
Claire L. Newton Inserm, Laboratory of Development and
Centre for Neuroendocrinology Plasticity of the Neuroendocrine Brain
Departments of Physiology and Immunology Jean‐Pierre Aubert Research Centre
University of Pretoria University of Lille, School of Medicine
Pretoria, South Africa Lille, France
Kevin T. O’Byrne Valerie Simonneaux
Department of Women and Children’s Health Institute of Cellular and Integrative
King’s College London Neurosciences
London, UK CNRS & University of Strasbourg
Strasbourg, France
Yoshitaka Oka
Department of Biological Sciences Katalin Skrapits
Graduate School of Science Laboratory of Endocrine Neurobiology
The University of Tokyo Institute of Experimental Medicine
Tokyo, Japan Hungarian Academy of Sciences
Budapest, Hungary
