The Epididymis: From Molecules to Clinical Practice: A Comprehensive Survey of the Efferent Ducts, the Epididymis and the Vas Deferens

571 Pages·2002·19.184 MB·English

by  David W. Hamilton (auth.), Bernard Robaire, Barry T. Hinton (eds.)

The Epididymis:
From Molecules to Clinical Practice
A Comprehensive Survey of the Efferent Ducts,
the Epididymis and the Vas Deferens
The Epididymis
From Molecules to Clinical Practice
A Comprehensive Survey of the Efferent Ducts,
the Epididymis and the Vas Deferens
Edited by
Bernard Robaire
McGill University
Montreal, Quebec, Canada
and
Barry T. Hinton
University of Virginia
Charlottesville, Virginia
Advisory Editorial Board
Marie-Claire Orgebin-Crist
Terry T Turner
Russell C Jones
Louis Hermo
Trevor Cooper
Rex Hess
Springer Science+Business Media, LLC
Library of Congress Cataloging-in-Publication Data
The epididymis: from molecules to clinical practice: a comprehensive survey of the
efferent ducts, the epididymis, and the vas deferens/edited by Bernard Robaire, Barry T.
Hinton; advisory editorial board, Marie-Claire Orgebin-Crist ... [et al.].
p. ; cm.
Includes bibliographical references and index.
ISBN 978-1-4613-5191-7 ISBN 978-1-4615-0679-9 (eBook)
DOI 10.1007/978-1-4615-0679-9
1. Epididymis. 2. Vas deferens. 3. Epididymis—Pathophysiology. I. Robaire, Bernard.
II. Hinton, Barry T. III. Orgebin-Crist, M.-C.
[DNLM]: 1. Epididymis. 2. Efferent Pathways. 3. Vas Deferens. WH 800 E636 2001]
QP255 .E654 2001
612.6'1—dc21
2001038959
ISBN 978-1-4613-5191-7
©2002 Springer Science+Business Media New York
Originally published by Kluwer Academic/Plenum Publishers, New York in 2002
Softcover reprint of the hardcover 1ts edition 2002
http://www.wkap.nl/
10 9 8 7 6 5 4 3 21
A CLP. record for this book is available from the Library of Congress
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any
means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written
permission from the Publisher
List of Contributors
R. J. Aitken G.A. Cornwall,
School of Biological and Chemical Sciences Department of Cell Biology & Biochemistry,
Centre for Li fe Sciences Texas Tech University
University of Newcastle Health Sciences Center
Callaghan, NSW 2308, Australia Lubbock, Texas, 79430, USA
A-H. Amin P.S. Cuasnicu
Male Infertility Program Instituto de Biologfa y Medicina Experimental
Hospital University of Pennsylvania Buenos Aires (1428), Argentina
Philadelphia, PA 19104, USA
D,G. Cyr
S. Andonian Human Health Research Centre
Department of Anatomy and Cell Biology INRS-Institut Armand Frappier
McGill University Universite du Quebec
3640 University Street 234 Hymus Boulevard
Montreal, Quebec, Canada Pointe Claire, QC, H9R I G6, Canada
Y. Araki, F. Dacheux
Center for Reproductive Biology Research Institut National de la Recherche Agronomique
Vanderbilt School of Medicine Physiologie de la Reproduction et des
Room D-2303 MCN Comportements
Nashville, TN, USA, 37232 37380 Monnaie, France
H. Badran J.-L. Dacheux
Department of Anatomy and Cell Biology Institut National de la Recherche Agronomique
McGill University Physiologie de la Reproduction et des
3640 University Street Comportements.
Montreal, Quebec, Canada 37380 Monnaie, France.
D. Busso V.G. Da Ros
Instituto de Biologfa y Medicina Experimental Instituto de Biologfa y Medicina Experimental
Buenos Aires (1428), Argentina Buenos Aires (1428), Argentina
P.T.K. Chan J. Dufresne
James Buchanan Brady Foundation Human Health Research Centre
Department of Urology INRS-Institut Armand Frappier
New York Presbyterian Hospital Universite du Quebec
Weill Medical College of Cornell University 234 Hymus Boulevard
New York, NY, 1002l, USA Pointe Claire, QC, H9R I G6, Canada
B.L.Y. Cheuk D.A. Ellerman
Department of Physiology Instituto de Biologfa y Medicina Experimental
Faculty of Medicine Buenos Aires (1428), Argentina
The Chinese University of Hong Kong
Shatin, N.T., Hong Kong N. Ezer
Department of Pharmacology and Therapeutics
D.J. Cohen, McGill University
Instituto de Biologfa y Medicina Experimental 3655 Promenade Sir-William Osler
Buenos Aires (1428), Argentina Montreal, Quebec, H3G I Y6, Canada
T.G. Cooper K. Finnson
Institut fur Reproduktionsmedizin Human Health Research Centre
University,of Munster INRS-Institut Armand Frappier
Domagkstrasse II Universite du Quebec
48 149 Munster, Germany 234 Hymus Boulevard
Pointe Claire, QC, H9R IG6, Canada
v
C.J. Flickinger
Department of Cell Biology J.L. Kirby
University of Virginia School of Medicine Department of Cell Biology
Charlottesville, V A 22908, USA University of Virginia Health System
Charlottesville, VA 22908, USA
S. Fouchecourt
Center for Reproductive Biology Research C. Kirchhoff
Vanderbilt School of Medicine IHF Institute for Hormone and Fertility Research
Room D-2303 MCN University of Hamburg
Nashville, TN, 37232, USA Grandweg 63, D-22529 Hamburg, Germany
X.D. Gong G.R. Klinefelter
Department of Physiology The United States Environmental Protection Agency
Faculty of Medicine National Health and Environmental Effects Research
The Chinese University of Hong Kong Laboratory
Shatin, N.T., Hong Kong Reproductive Toxicology Division, MD #72
Research Triangle Park, NC 27711, USA
M. Gregory
Human Health Research Centre J.-J. Lareyre
INRS-Institut Armand Frappier INRA-SCRIBE
U ni versite du Quebec Campus de Beaulieu
234 Hymus Boulevard Rennes Cedex, France
Pointe Claire, QC, H9R IG6, Canada
G.P.H. Leung
D.W. Hamilton Department of Physiology
Department of Genetics, Cell Biology & Faculty of Medicine
Development The Chinese University of Hong Kong
University of Minnesota Medical School Shatin, N.T., Hong Kong
Minneapolis, MN, 55455, USA
Robert J. Matusik
L. Hermo Department of Urologic Surgery
Department of Anatomy and Cell Biology Vanderbilt University Medical Center
McGill University Nashville, TN, 37232, USA
3640 University Street
Montreal, Quebec, H3A 2B2, Canada H.D.M. Moore
Department of Molecular Biology and
R.A. Hess Biotechnology
Department of Veterinary Biosciences University of Sheffield
University of Illinois Sheffield, S 10 2TN, United Kingdom
Urbana, IL 61802, USA
M.M. Morgenfeld.
B.T. Hinton Instituto de Biologfa y Medicina Experimental
Department of Cell Biology Buenos Aires (1428), Argentina
University of Virginia Health System
Charlottesville, V A 22908, USA S.K. NagDas
Department of Cell Biology
S.S. Howards Vanderbilt University
Department of Urology Nashville, TN 37232, USA
University of Virginia School of Medicine
Charlottesville, VA 22908, USA R. Nie
Department of Veterinary Biosciences
R. Jones University of Illinois
Gamete Signalling Laboratory Urbana, IL 61802, USA
The Babraham Institute
Cambridge CB2 4AT, UK I.J. Okazaki
Department of Medicine
R.C. Jones University of Minnesota School of Medicine
Department of Biological Sciences Mayo Mail Code 394,
University of Newcastle 420 Delaware Street S.E.
Newcastle, NSW 2308, Australia Minneapolis, Minnesota 55455, USA
vi
G.E.Olson R. Schoysman
Department of Cell Biology Schoysman Infertility Management Foundation
Vanderbilt University Van Helmont Hospital
Nashville. TN. 37232. USA Vaart Straat 42
B-1800
D.E.Ong Vilvoorde, Belgium
Center for Reproductive Biology Research
Vanderbilt School of Medicine V. Serre
Room D-2303 MCN Division of Reproductive Biology
Nashville. TN. 37232. USA Department of Biochemistry and Molecular Biology
Johns Hopkins University
M.-C. Orgebin-Crist 615 North Wolfe Street. Room 3606
Center for Reproductive Biology Research Baltimore, MD, USA, 21205
Vanderbilt School of Medicine
Room D-2303 MCN. B.P. Setchell
Nashville. TN. 37232. USA Pediatric Endocrinology Unit
Karolinska Hospital.
P. Patrizio SI71 76 Stockholm, Sweden
Male Inferti Ii ty Program
Hospital University of Pennsylvania K. Suzuki
Philadelphia. PA 19104. USA Center for Reproductive Biology Research
Vanderbilt School of Medicine
S.D. Perreault Room D-2303 MCN
Reproductive Toxicology Division Nashville. TN. 37232, USA
U.S. Environmental Protection Agency
National Health and Environmental Effects Research T. Turner
Laboratory Departmentt of Urology
Research Triangle Park. NC 27711. USA University of Virginia School of Medicine
Charlottesville, Virginia. 22908 • USA
J.L. Pryor
Department of Urologic Surgery, M.F. Wilkinson
University of Minnesota School of Medicine Department of Immunology
Mayo Mail Code 394. The University of Texas
420 Delaware Street S.E .. M. D. Anderson Cancer Center
Minneapolis. Minnesota 55455. USA 1515 Holcombe Blvd.
Houston. TX. 77030, USA
M.Rao
Department of Immunology V.P. Winfrey
The University of Texas Department of Cell Biology
M. D. Anderson Cancer Center Vanderbilt University
1515 Holcombe Blvd. Nashville. TN, 37232. USA
Houston. TX, 71030. USA
P.Y.D. Wong
B. Robaire Department of Physiology
Department of Pharmacology and Therapeutics Faculty of Medicine
and of Obstetrics and Gynecology The Chinese University of Hong Kong
McGill University Shatin, N.T. . Hong Kong
3655 Promenade Sir-William Osler
Montreal. Quebec. H3G I Y6, Canada c.-H. Yeung
Institut fur Reproduktionsmedizin
C.M. Rodriguez University of Munster
Department of Cell Biology Domagkstrasse II
University of Virginia Health System 48 149 Munster, Germany
Charlottesville. VA 22908. USA
Q.Zhou
P. N. Schlegel Department of Veterinary Biosciences
James Buchanan Brady Foundation University of Illinois
Department of Urology Urbana. IL, 61802, USA
New York Presbyterian Hospital
Weill Medical College of Cornell University.
New York. NY. 10021. USA
vii
PREFACE
Since the late 1960s, there has been an acceleration of research focused on
understanding how the efferent ducts, the epididymis, and the vas deferens function with
respect to the maturation and storage of spermatozoa and as hormone dependent tissues.
Another major interest in the epididymis is that it is an attractive target for the development
of male contraceptives. There are well over 16,000 peer reviewed articles in the literature
on these tissues, their structure, gene expression, protein synthesis and function. Regular
international meetings have been initiated that are dedicated to this field. Thus, there is an
urgent need for a comprehensive reference volume that spans every facet of epididymal
biology, from historical background to the most current results, from basic cell and
molecular biology to clinical issues.
Well-established experts from every part of the world have contributed to this
volume. By necessity, each author was given page limitations so that many topics are not
dealt with exhaustively. Whenever possible, references to more comprehensive discussion
of specific topics are included.
We sincerely hope that this volume will serve not only as a resource for graduate
students, postdoctoral fellows, and fellow scientists already working in this field, but also
as a catalyst to entice young investigators and attract established colleagues to take up the
challenges of understanding this important, complex and exciting group of tissues. It is
apparent that we are merely beginning to get a glimpse into the functioning of this amazing
duct. There is a pressing need for more fundamental research as well as clinical studies to
elucidate the role played by these tissues in the processes of sperm transport, maturation,
storage and protection.
We should express our appreciation to Sid Parkinson for the excellent contributions
as Editorial Assistant and to the staff of Kluwer-Plenum for their support and
encouragement.
Bernard Robaire
Barry T. Hinton
June 2001
ix
CONTENTS
1. The Testicular Excurrent Duct System: A Historical Outlook
D. W. Hamilton ................................................................................. 1
2. Evolution of the Vertebrate Epididymis
R. C. lones ....................................................................................... 11
3. Innervation and Vasculature of the Excurrent Duct System
B. P. Setchell ...................................................................................3 5
THE EPITHELIUM OF THE EXCURRENT DUCT SYSTEM
4. The Efferent Ductules: Structure and Functions
R. A. Hess ...................................................................................... .49
5. Epididymal Cell Types and Their Functions
L. Hermo andB. Robaire .................................................................... 81
6. Cellular Interactions and the Blood-Epididymal Barrier
D. G. Cyr, K. Finnson, 1. Dufresne and M. Gregory ................................... 103
7. Formation of the Epididymal Fluid Microenvironment
P. Y.D. Wong, X.D. Gong, G.P.H. Leung and B.L. Y. Cheuk ........................... 119
8. Necessity's Potion: Inorganic Ions and Small Organic Molecules in the Epididymal
Lumen.
T.T. Turner ................................................................................... 131
9. Protein Secretion in the Epididymis
1.-L. Dacheux and F. Dacheux ............................................................................... 151
10. Gene Expression and Epididymal Function
G. A. Cornwall, 1.-1. Lareyre, R.I. Matusik, B. T. Hinton,
and M.-C. Orgebin-Crist .......................................................... 169
11. Specific Gene Expression in the Human and Non-Human Primate Epididymis
C. Kirchhoff. ................................................................................ 201
xi
12. Interactions of the Immune System and the Epididymis
V Serre and B. Robaire .................................................................... 219
13. The Structural Organization and Functions of the Epithelium of the Vas Deferens
L. Hermo, H. Badran, and S. Andonian ...................................................2 33
DEVELOPMENT AND AGING
14. The Development of the Epididymis
C. M. Rodriguez, J. L. Kirby, and B. T. Hinton .......................................... 251
15. Homeobox Genes and the Male Reproductive System
M. Rao and M. F. Wilkinson .................................................................... 269
16. Aging of the Epididymis
B. Robaire .........................................................................................2 85
HORMONAL REGULATION AND EFFECfS OF TOXICANTS
17. Androgenic Regulation of the Structure and Functions of the Epididymis
N Ezer and B. Robaire ......................................................................... .297
18. The Role of Estrogens in the Endocrine and Paracrine Regulation of
the Efferent Ductules, Epididymis and Vas Deferens
R. A. Hess, Q. Zhou, and R. Nie ............................................................3 17
19. Retinoids and Epididymal Function
M. -CO Orgebin-Crist, J. -J. Lareyre, K. Suzuki, Y Araki, S. F oucMcourt,
R. J. Matusik, and D. E. Ong ..................................................... .339
20. Actions of Toxicants on the Structure and Function of the Epididymis
G. R. Klinefelter ............................................................................ .353
CHANGES IN SPERMATOZOA DURING EPIDIDYMAL TRANSIT
21. Structural Differentiation of Spermatozoa During Post-Testicular Maturation
G. E. Olson, S. K. NagDas, and V P. Winfrey .......................................... 371
22. Changes in Sperm Proteins During Epididymal Maturation.
P. S. Cuasnicu, D. J. Cohen, D. A. Ellerman, D. Busso, V G. Da Ros,
and M. M. Morgenfeld ............................................................ 389
23. Plasma Membrane Composition and Organisation During Maturation
of Spermatozoa in the Epididymis
R. Jones ....................................................................................... 405
xii
24. Acquisition and Development of Sperm Motility upon Maturation
in the Epididymis
C.-H. Yeung and T. G. Cooper .......................................................... .417
25. Active Oxygen in Spermatozoa During Epididymal Transit
R. J. Aitken .................................................................................. .435
NOVEL TECHNOLOGICAL APPROACHES
26. Cell and Organ Epididymal Cultures
H. D. M. Moore ............................................................................. .449
27. Smart Use of Computer-Aided Sperm Analysis (CASA) to Characterize
Sperm Motion
S. D. Perreault .............................................................................. 459
CLINICAL CONSIDERATIONS
28. Management of EpIdidymal Dysfunction: Correlation with Basic Physiology
R. Schoysman .................................................................................... .473
29. The Epididymis as a Target for Male Contraception
T. G. Cooper ................................................................................. .483
30. Consequences of Obstruction on the Epididymis
C. J. Flickinger and S. S. Howards .......................................................... .503
31. Infertility, ICSI, and the Epididymis
P. Patrizio and A.-H. Amin ................................................................5 23
32. Epididymitis and Other Inflammatory Conditions of the Male
Excurrent Ductal System
P. T. K. Chan and P. N. SchlegeL ......................................................... 533
33. Cancer of the Epididymis
I. J. Okazaki andJ. L. Pryor ...............................................................5 55
Author Index .......................................................................................... 563
Subject Index .........................................................................................5 65
xiii