Table Of ContentLIST OF CONTRIBUTORS
L. BOLUND J. L. MANDEL
HARRIS BUSCH ROSEMONDE MANDEVILLE
P. CHAMBON ANTHONY R. MEANS
YONG C. CHOI M. MEILHAC
R. K. CRAIG ROSS N. NAZAR
G. P. GEORGIEV MARK O. J. OLSON
F. GISSINGER BERT W. O'MALLEY
URSULA I. HEINE N. R. RINGERTZ
C. KEDINGER TAE SUK RO-CHOI
H. M. KEIR ANDRΙ ROYAL
LEROY KUEHL RENΙ SIMARD
YVES LANGELIER BERNARD S. STRAUSS
NICOLE MAESTRACCI ANDRZEJ VORBRODT
EDITORIAL ADVISORY BOARD
VINCENT ALLFREY
The Rockefeller University
New York, New York 10021
DANIEL MAZIA
Department of Zoology
University of California, Berkeley
Berkeley, California 94720
W. BERNHARD
Institut de Recherches Scientifiques sur le Cancer
94, Villejuif
France
LIST OF CONTRIBUTORS
L. BOLUND J. L. MANDEL
HARRIS BUSCH ROSEMONDE MANDEVILLE
P. CHAMBON ANTHONY R. MEANS
YONG C. CHOI M. MEILHAC
R. K. CRAIG ROSS N. NAZAR
G. P. GEORGIEV MARK O. J. OLSON
F. GISSINGER BERT W. O'MALLEY
URSULA I. HEINE N. R. RINGERTZ
C. KEDINGER TAE SUK RO-CHOI
H. M. KEIR ANDRΙ ROYAL
LEROY KUEHL RENΙ SIMARD
YVES LANGELIER BERNARD S. STRAUSS
NICOLE MAESTRACCI ANDRZEJ VORBRODT
EDITORIAL ADVISORY BOARD
VINCENT ALLFREY
The Rockefeller University
New York, New York 10021
DANIEL MAZIA
Department of Zoology
University of California, Berkeley
Berkeley, California 94720
W. BERNHARD
Institut de Recherches Scientifiques sur le Cancer
94, Villejuif
France
THE CELL NUCLEUS
Volume III
EDITED BY
HARRIS BUSCH
Department of Pharmacology
Baylor College of Medicine
Texas Medical Center
Houston, Texas
ACADEMIC PRESS New York and London 1974
A Subsidiary of Harcourt Brace Jovanovich, Publishers
COPYRIGHT © 1974, BY ACADEMIC PRESS, INC.
ALL RIGHTS RESERVED.
NO PART OF THIS PUBLICATION MAY BE REPRODUCED OR
TRANSMITTED IN ANY FORM OR BY ANY MEANS, ELECTRONIC
OR MECHANICAL, INCLUDING PHOTOCOPY, RECORDING, OR ANY
INFORMATION STORAGE AND RETRIEVAL SYSTEM, WITHOUT
PERMISSION IN WRITING FROM THE PUBLISHER.
ACADEMIC PRESS, INC.
Ill Fifth Avenue, New York, New York 10003
United Kingdom Edition published by
ACADEMIC PRESS, INC. (LONDON) LTD.
24/28 Oval Road. London NW1
Library of Congress Cataloging in Publication Data
Main entry under title:
The Cell nucleus.
Includes bibliographies.
1. Cell nuclei. I. Busch, Harris, ed.
[DNLM: 1. Cell nucleus. QH595 B977c]
QH595.C44 574.8'732 73-18944
ISBN 0-12-147603-0 (v. 3)
PRINTED IN THE UNITED STATES OF AMERICA
List of Contributors
Numbers in parentheses indicate the pages on which the authors' contributions begin.
L. BOLUND (417), Institute for Medical Cell Research and Genetics, Medi-
cal Nobel Institute, Karolinska Institutet, Stockholm, Sweden
HARRIS BUSCH (109, 151, 211), Department of Pharmacology, Baylor Col-
lege of Medicine, Texas Medical Center, Houston, Texas
P. CHAMBON (269), Institut de Chimie Biologique, Faculté de Médecine
de Strasbourg, Strasbourg, France
YONG, C. CHOI (109), Department of Pharmacology, Baylor College of
Medicine, Texas Medical Center, Houston, Texas
R. K. CRAIG (35), Department of Biochemistry, Marischal College, University
of Aberdeen, Aberdeen, Scotland
G. P. GEORGIEV (67), Institute of Molecular Biology, Academy of Sciences
of USSR, Moscow, USSR
F. GISSINGER (269), Institut de Chimie Biologique, Faculté de Médecine de
Strasbourg, Strasbourg, France
URSULA I. HEINE (489), Virus Studies Section, Viral Oncology Area, Divi-
sion of Cancer Cause and Prevention, National Cancer Institute, National
Institutes of Health, Bethesda, Maryland
C. KEDINGER (269), Institut de Chimie Biologique, Faculté de Médecine de
Strasbourg, Strasbourg, France
H. M. KEIR (35), Department of Biochemistry, Marischal College, University
of Aberdeen, Aberdeen, Scotland
LEROY KUEHL (345), Department of Biological Chemistry, College of
Medicine, University of Utah, Salt Lake City, Utah
xi
xîi LIST OF CONTRIBUTORS
YVES LANGELIER (447), Department de Biologie Cellulaire, Centre Hos-
pitalier Universitaire, Université de Sherbrooke, Sherbrooke, Quebec, Canada
NICOLE MAESTRACCI (447), Department de Biologie Cellulaire, Centre
Hospitalier Universitaire, Université de Sherbrooke, Sherbrooke, Quebec.
Canada
J. L. MANDEL (269), Institut de Chimie Biologique, Faculté de Médecine de
Strasbourg, Strasbourg, France
ROSEMONDE MANDE VILLE (447), Department de Biologie Cellulaire,
Centre Hospitalier Universitaire, Université de Sherbrooke, Sherbrooke,
Quebec, Canada
ANTHONY R. MEANS (379), Department of Cell Biology, Baylor College
of Medicine, Texas Medical Center, Houston, Texas
M. MEILHAC (269), Institut de Chimie Biologique, Faculté de Médecine,
de Strasbourg, Strasbourg, France
ROSS N. NAZAR (109), Department of Pharmacology, Baylor College of
Medicine, Texas Medical Center, Houston, Texas
MARK O. J. OLSON (211), Department of Pharmacology, Baylor College of
Medicine, Texas Medical Center, Houston, Texas
BERT W. O'MALLEY (379), Department of Cell Biology, Baylor College of
Medicine, Texas Medical Center, Houston, Texas
N. R. RINGERTZ (417), Institute for Medical Cell Research and Genetics,
Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden
TAE SUK RO-CHOI (151), Department of Pharmacology, Baylor College of
Medicine, Texas Medical Center, Houston, Texas
ANDRÉ ROYAL (417), Department de Biologie Cellulaire, Centre Hospitalier
Universitaire, Université de Sherbrooke, Sherbrooke, Quebec, Canada
RENÉ SIMARD (447), Department de Biologie Cellulaire, Centre Hospitalier
Universitaire, Université de Sherbrooke, Sherbrooke, Quebec, Canada
BERNARD S. STRAUSS (3), Department of Microbiology, The University
of Chicago, Chicago, Illinois
ANDRZEJ VORBRODT (309), Department of Tumor Biology, Institute of
Oncology, Gliwice, Poland
Preface
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J.
oonn ""TThhee CCeelll lNNuucclleeuuss"" cchhaairierde dbyb yJ. S.S .MMiticthcehlel ll(A(Acacdaedmemic icPrPersess, s1,916906)0 )
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AAccaaddeemmiicc PPrreessss,, 11996633)). .WWhheen nththe emmoonnoogrgarpahp hono n"T"hTeh eNuNculceloeloulsu" s"(H(.H .
BBuusscchh aanndd KK.. SSmmeettaannaa, ,AAccaaddeemmici cPPreresss,s ,1199770)0 )wwasa sunudnedretratkaekne nit ibtebceacmame e
aappppaarreenntt tthhaat t tthheerree wweerer esoso mmaanyn ycocnotnrtirbiubtuotroyr yfifeiledlsd stot onunculcelaer aranadn d
nnuucclleeoollaarr ffuunnccttiioonn tthhaat taa tthhoorroouugghh rreevvieieww oof fththe esusbujbejcetc twwouoludl dbeb ewworothrt-h
wwhhiillee.. TThhiiss tthhrreeee--vvoolluummee ttrreeaattiissee isis ddeessigignnede dtot opprorovivdied esuscuhc ha awworokr.k .
IItt sshhoouulldd bbee cclleeaar rtoto rereseseaarcrchheresr sanadn dstsutduednetns tsofo fthteh ececlle llnunculceluesu s
tthhaatt tthheerree iiss ssuucchh aann eennoorrmmoouus sggapa pbebtewtweeene nouoru rprperseesnet ntinifnofromrmataiotino n
aanndd tthhee ccoommpplleetete uunnddeerrssttaannddiningg oof fnnuuccleleara rccoommpopsoistiitoino nanadn dfufunnctcitoino n
tthhaatt tthhiiss wwoorrkk rreepprreesseenntsts oonnlyly aa ssmmaalll lppoortritoion nofo fthteh eknkonwowleldegdeg estsiltli ll
ttoo bbee ddeevveellooppeedd inin ththisi sffieieldld/ .-ItI twwasa ssismimplpyl ynonto tpopsossibsilbe leto tococvoevr ertheth e
ccoommpplleettee lliitteerraattuurree.. IInntteerreesstteedd rreeaaddeerrss aarere uurrggede dtot ococnosnuslut ltpprirmimarayr y
ssoouurrcceess oorr ssppeecciiaall rreevviieewwss..
II aamm iinnddeebbtteedd ttoo mmyy mmaannyy ccoollleleaagguuese saarorouundn dthteh ewworoldrl dwwhoh ohahvaev e
ccoonnttrriibbuutteedd ttoo tthhee aaccttuuaal l wwrriittiinngg oof fththisi swwoorkr kaandn dpapratritciuclualralyrl ytot othteh e
eeddiittoorriiaall aaddvviissoorrss ffoorr tthheeiirr mmaannyy ssuuggggeesstitoionns sththata thhaavev ebrboruoguhgth tthtihs iswworokr k
ttoo ffrruuiittiioonn.. IInn aaddddiittiioonn, ,wwee aarer eggraratetfeuflu lfofro rthteh eaiadi dprporvoivdiedde dfofr ormmucuhc h
ooff tthhee bbaassiicc rreesseeaarrcchh ffrroomm tthhee NNaatitoionnaal lInInsstittiututetse sofo fHHeaelatlht,h ,thteh eNNataitoinoanla l
CCaanncceerr IInnssttiittuuttee,, tthhee AAmmeerriiccaann CCaanncceer r SSooccieietyty, ,ththe eNNataitoinoanla lSSciceinencec e
FFoouunnddaattiioonn,, aanndd tthhee WWeellcchh FFoouunnddaattiioonn. .
TThhee cceellll nnuucclleeuuss iiss ssoo iimmppoorrttaannt ttoto ththe ebbasaisci cuundnedresrtsatnadnidnign gofo fbiboiloolgoig-i
ccaall aanndd mmeeddiiccaall pprroobblleemmss tthhaat titi thhooldlds sa afafascscininataitoino nfofro ronoen eanadn dalal.l l.
IItt iiss hhooppeedd tthhaatt tthhiiss ttrreeaattiissee wwilill lpprorovvidide ea auusesfeuflu lgguuidied efofro rrerseesaeracrhc h
aanndd ssttuuddyy ooff tthhiiss vveerryy eexxcciittiinngg aarreeaa oof fhhuummana neennddeeaavvoor.r .
HHaarrrriiss BBuusscchh
xxiiiiii
Contents of Other Volumes
Volume I
Nuclear Structure
Localization of Nuclear Functions as Revealed by
Ultrastructural Autoradiography and Cytochemistry
M. Bouteille, M. Laval, and A. M. Dupuy-Coin
The Nucleolus and Nucleolar DNA
Karel Smetana and Harris Busch
Ultrastructural Organization of Plant Cell Nuclei
Jean-G. Lafontaine
The Nucleus of the Plasmodial Slime Molds
Joyce Mohberg
Structures and Functions of the Nuclear Envelope
Werner W. Franke and Ulrich Scheer
Structures and Functions of the Nuclear Envelope
Charles B. Kasper
Nuclear-Cytoplasmic Interactions
Movement of Molecules between Nucleus and Cytoplasm
Lester Goldstein
Heterokaryons and Their Uses in Studies of Nuclear Function
E. Sidebottom
The Genome in Specialized Cells, as Revealed by
Nuclear Transplantation in Amphibia
/. B. Gurdon
xv
xvi CONTENTS OF OTHER VOLUMES
Chromatin
The Molecular Organization of the Chromatin Fiber
Alberto J. Solari
The Structure of Human Chromosomes
David E. Comings
Ultrastructure and Function of Heterochromatin and Euchromatin
John H. Frenster
Author Index—Subject Index
Volume II
Chromosomes—General
Mammalian Chromosomes
Frances E. Arrighi
The Human Cell Nucleus: Quinacrine and Other Differential Stains
in the Study of Chromatin and Chromosomes
Frederick Hecht, Herman E. Wyandt, and R. Ellen Heath Magenis
Studies of Isolated Mammalian Metaphase Chromosomes
John Mendelsohn
The Kinetics of DNA Replication in Chromosomes
Elton Stubblefield
The Organization of Meiotic Chromosomes
Peter Luykx
Progress in Human Gene Mapping by Somatic Cell Hybridization
Raju S. Kucherlapati, Richard P. Creagen, and Frank H. Ruddle
Chromosomes—Specific
Chromosomes of Birds
Robert N. Shoffner
Plant Cytogenetics
A. K. Sharma
Polytene Chromosomes in Studies of Gene Expression
J.-E. Edstrφm
Contents of Other Volumes xvii
Giant Chromosomes
Wolfgang Hennig
Chromosomes—Pathology
Clinical Cytogenetics
Jean de Grouchy
Viruses and Chromosomes
Warren W. "Nichols
Mitosis and Meiosis
The Mitotic Apparatus
John F. Hartmann and Arthur M. Zimmerman
Genome Separation Mechanisms in Prokaryotes, Algae, and Fungi
I. Brent Heath
Author Index—Subject Index
