Synaptic Plasticity and the Mechanism of Alzheimer's Disease

186 Pages·2008·2.91 MB·English

by  Marianne Renner

researchandperspectivesinalzheimer’sdisease
Dennis J. Selkoe Antoine Triller Yves Christen (Eds.)
Synaptic Plasticity
and the Mechanism
of Alzheimer’s
Disease
With34Figures,28incolor
123
Dr.DennisJ.Selkoe
CenterforNeurologicDiseases
BrighamandWomen’sHospital
HarvardMedicalSchool
Boston,MA02115,USA
email:[email protected]
Dr.AntoineTriller Dr.YvesChristen
LaboratoiredeBiologieCellulairedelaSynapse FondationIPSEN
Institut National de la Santé et de la Recherche PourlaRechercheThérapeutique
MédicaleUnite789 24,rueErlanger
EcoleNormaleSupérieure,46rued’Ulm 75781ParisCedex16
75005Paris France
France email:[email protected]
email:[email protected]
ISBN 978-3-540-76329-1 e-ISBN 978-3-540-76330-7
DOI10.1007/978-3-540-76330-7
LibraryofCongressControlNumber:2007938204
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Preface
Remarkable progress has been made in Alzheimer’s research over the last decade.
Our understanding of which molecular mechanisms are involved in the cascade of
events characteristic of the disease is growing. However, the mechanisms by which
theyinducedeleteriouseffectarestillnotclear.Manyrecentstudieshaveconfirmed
thatthesynapseisakeytargetinthepathogenesisofAlzheimer’sdisease.Notonly
β
doessynapticlossoccuratanearlystageofthedisease,butitseemsthat -amyloid
peptidedepositsormicrotubulardisordersaffectsynapticfunction.Thismayexplain
thememorydeficitsthataresocharacteristicofthedisease.Itisthereforelogicalto
investigate therapeutic approaches targeting the deleterious mechanisms that affect
the synapse. This area of research promises to be all the more productive because
synapticdysfunctionisinvolvedinvariousotherneurodegenerativediseasesor,more
generallyspeaking,centralnervoussystemdisorders.
Thisnewawarenesshasemergedatatimewhenneuroscientificresearchisuncov-
eringmoreaboutsynapticfunctionandthemultipleproteinsitinvolves;henceour
decision to invite both fundamental researchers in synaptic biology and specialists
inneurogenerativediseasetotheColloqueMédecineetRechercheorganizedbythe
FondationIpseninParisonApril16,2007.
D.J.Selkoe,A.TrillerandY.Christen
Acknowledgements. TheeditorswanttothankJacquelineMervaillie,AstriddeGérardand
SoniaLeCornecfortheorganizationofthismeetingandMaryLynnGagefortheeditingofthe
book.
TableofContents
PermanenceoftheSynapseandMolecularInstability
M.Renner,A.Triller...................................................... 1
CellularBiologyofAMPAReceptorTraffickingandSynapticPlasticity
J.A.Esteban ............................................................. 19
ImagingofExperience-DependentStructuralPlasticity
intheMouseNeocortexinvivo
A.Holtmaat,V.DePaola,L.Wilbrecht,G.Knott.............................. 37
SynapseLoss,SynapticPlasticityandthePostsynapticDensity
M.Sheng ............................................................... 51
ImpactofBetaAmyloidonExcitatorySynapticTransmissionandPlasticity
R.Malinow,H.Hsieh,W.Wei.............................................. 63
QuantitativeNeuropathologyinAlzheimer’sMouseModels
F.E.Bloom .............................................................. 69
MultipleLevelsofSynapticRegulationbyNMDA-typeGlutamateReceptor
inNormalandDiseaseStates
V.A.Alvarez,G.M.Shankar,B.L.Bloodgood,D.J.Selkoe,B.L.Sabatini ........... 75
β
SolubleOligomersoftheAmyloid -Protein:
ImpairSynapticPlasticityandBehavior
D.J.Selkoe .............................................................. 89
WhyAlzheimer’sisaDiseaseofMemory:
β
SynapticTargetingbyPathogenicA Oligomers(ADDLs)
W.L.Klein,F.d.Felice,P.N.Lacor,M.P.Lambert,W.-Q.Zhao ................... 103
SynapticTransmissionDynamicallyModulates
β
InterstitialFluidAmyloid- Levels
J.R.Cirrito,F.R.Stewart,S.Mennerick,D.M.Holtzman........................ 133
β
A -InducedToxicityMediatedbyCaspaseCleavage
oftheAmyloidPrecursorProtein(APP)
E.H.Koo,D.E.Bredesen................................................... 145
VIII TableofContents
β β
Long-TermPotentiationandA :TargetingA Species,CellularMechanisms
andPutativeReceptors
M.J.Rowan,I.Klyubin,W.K.Cullen,N.W.Hu,R.Anwyl ....................... 157
Genes,SynapsesandAutismSpectrumDisorders
T.Bourgeron ............................................................ 169
SubjectIndex ........................................................... 181
ListofContributors
Alvarez,VeronicaA.
DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA
Anwyl,Roger
DepartmentofPhysiology,andTrinityCollegeInstituteofNeuroscience,TrinityCol-
legeDublin2,Ireland
Bloodgood,BrendaL.
DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA
Bloom,FloydE.
MolecularandIntegrativeNeuroscienceDepartment,TheScrippsResearchInstitute,
LaJollaCA92037,USA
Bourgeron,Thomas
InstitutPasteur,UniversitéDenisDiderotParis7,25rueduDocteurRoux,75724Paris
Cedex15,France
Bredesen,DaleE.
Buck Institute for Age Research, Novato, CA 94945 and Department of Neurology,
UniversityofCalifornia,SanFranciscoCA94143,USA
Cirrito,JohnR.
Department of Psychiatry, Neurology, Molecular Biology and Pharmacology, Hope
Center for Neurological Disorders, Washington University School of Medicine, St.
Louis,MO63110,USA
Cullen,WilliamK.
DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege
Dublin2,Ireland
DeFelice,Fernanda
Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s
DiseaseCenter,NorthwesternUniversity,Evanston,IL60208
X ListofContributors
Esteban,JoséA.
DepartmentofPharmacology,UniversityofMichiganMedicalSchool,AnnArbor,MI
48109-0632,USA
DePaola,V.
ColdSpringHarborlaboratory,ColdSpringHarbor,NewYork11724,USA
MRC-Clinical Sciences Centre, Imperial College London, London W12 0NN, United
Kingdom
Holtmaat,Antony
ColdSpringHarborlaboratory,ColdSpringHarbor,NewYork11724,USA
Départment des Neurosciences fondamentales, University of Geneva, 1211 Geneve,
Switzerland
Holtzman,DavidM.
Department of Neurology, Molecular Biology and Pharmacology, Hope Center for
Neurological Disorders, Washington University School of Medicine, St. Louis, MO
63110,USA
Hsieh,Helen
WatsonSchoolofBiologicalSciences,ColdSpringHarborLaboratory,NewYork,NY
11724-2213,USA
Hu,NengWei
DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege
Dublin2,Ireland
Klein,WilliamL.
Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s
DiseaseCenter,NorthwesternUniversity,Evanston,IL60208
Klyubin,Igor
DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege
Dublin2,Ireland
Knott,Graham
Départment de Biologie Cellulaire et de Morphologie, University of Lausanne, 1005
Lausanne,Switzerland
Koo,EdwardH.
DepartmentofNeurosciences,UniversityofCalifornia,SanDiego,LaJollaCA92037,
USA
Lacor,PascaleN.
Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s
DiseaseCenter,NorthwesternUniversity,EvanstonIL60208,USA
ListofContributors XI
Lambert,MaryP.
Department of Neurobiology and Physiology, Cognitive Neurology and Alzheimer’s
DiseaseCenter,NorthwesternUniversity,EvanstonIL60208,USA
Malinow,Roberto
ColdSpringHarborLaboratory,ColdSpringHarbor,NewYorkNY11724,USA
StateUniversityofNewYorkandStonybrook,Dept.Neurobiology,USA
WatsonSchoolofBiologicalSciences,ColdSpringHarborLaboratory,USA
Mennerick,Steven
DepartmentofPsychiatry,Anatomy,andNeurolobiology,HopeCenterforNeurological
Disorders,WashingtonUniversitySchoolofMedicine,St.Louis,Missouri,63110,USA
Renner,Marianne
LaboratoiredeBiologieCellulairedelaSynapse,InstitutNationaldelaSantéetdela
RechercheMédicaleUnite789,EcoleNormaleSupérieure,46rued’Ulm,75005Paris,
France
Rowan,MichaelJ.
DepartmentofPharmacology&Therapeutics,BiotechnologyBuilding,TrinityCollege
Dublin2,Ireland
Sabatini,BernardoL.
DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA
Selkoe,DennisJ.
CenterforNeurologicDiseases,BrighamandWomen’sHospitalandHarvardMedical
School,BostonMA02115,USA
Shankar,GaneshM.
DepartmentofNeurobiology,HarvardMedicalSchool,BostonMA02115,USA
CenterforNeurologicDiseases,BrighamandWomen’sHospitalandHarvardMedical
School,BostonMA02115,USA
Sheng,Morgan
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute,
DeptsofBrainandCognitiveSciences,andBiology,MassachusettsInstituteofTech-
nology,77MassachusettsAvenue(46-4303)CambridgeMA02139,USA
Stewart,FloyR.
DepartmentofNeurology,HopeCenterforNeurologicalDisorders,WashingtonUni-
versitySchoolofMedicine,St.Louis,MO63110,USA
Triller,Antoine
LaboratoiredeBiologieCellulairedelaSynapse,InstitutNationaldelaSantéetdela
RechercheMédicaleUnite789,EcoleNormaleSupérieure,46rued’Ulm,75005Paris,
France