Table Of ContentSensitive Skin Syndrome
Second Edition
Sensitive Skin Syndrome
Second Edition
Edited by
Golara Honari
Rosa M. Andersen
Howard Maibach
CRC Press
Taylor & Francis Group
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Library of Congress Cataloging‑in‑Publication Data
Names: Honari, Golara, editor. | Andersen, Rosa M. editor. | Maibach, Howard I., editor.
Title: Sensitive skin syndrome / [edited by] Golara Honari, Rosa M. Andersen, Howard I. Maibach.
Description: Second edition. | Boca Raton, FL : CRC Press/Taylor & Francis
Group, [2017] | Includes bibliographical references and index.
Identifiers: LCCN 2016043692| ISBN 9781498737340 (hardback : alk. paper) |
ISBN 9781498737357 (ebook)
Subjects: | MESH: Dermatitis, Contact--diagnosis | Dermatitis,
Contact--therapy | Skin Care--methods
Classification: LCC RL244 | NLM WR 175 | DDC 616.5/1--dc23
LC record available at https://lccn.loc.gov/2016043692
Visit the Taylor & Francis Web site at
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Contents
Preface .....................................................................................................................................................vii
Contributors ............................................................................................................................................viii
Section I Introduction and Background
1. What Is Sensitive Skin? ...................................................................................................................2
Renée J. H. Richters, Natallia E. Uzunbajakava, Piet E. J. van Erp,
and Peter C. M. van de Kerkhof
2. Sensitive Skin: A Review of Prevalence Worldwide ....................................................................12
Charles Taïeb and Laurent Misery
3. Skin Structure and Function .........................................................................................................16
Golara Honari
4. The Somatosensory System ...........................................................................................................23
Francis McGlone and David Reilly
Section II Pathophysiology of Sensitive Skin
5. Stratum Corneum and Sensitive Skin ..........................................................................................38
Enzo Berardesca
6. Altered Somatosensory Pathways ..................................................................................................41
Eun Ju Kim, Dong Hun Lee, and Jin Ho Chung
7. Itch and Sensitive Skin ...................................................................................................................54
Martin Schmelz
Section III Investigative Methods
8. Challenges of Investigation............................................................................................................65
Lidia Maroñas-Jiménez, Elena González-Guerra, and Aurora Guerra-Tapia
9. Self-Assessment of Sensitive Skin .................................................................................................71
Charles Taïeb and Laurent Misery
10. Confocal Raman Microspectroscopy: A New Paradigm in the Diagnosis of Sensitive Skin? ...73
Denise Falcone, Natallia E. Uzunbajakava, Piet E. J. van Erp, and Peter C. M. van de Kerkhof
11. Dynamic Quantification of the Human Skin Barrier in Sensitive Skin Syndrome .................83
Luís M. Rodrigues, Henrique Silva, and Catarina Rosado
v
vi Contents
12. Irritant Reactivity Tests ................................................................................................................90
David A. Basketter
13. Neurosensory Assessment .............................................................................................................95
Roland Jourdain
Section IV Clinical Considerations
14. Sensitive Skin: Is There a Link with Ethnicity? .......................................................................105
Laurent Misery and Charles Taïeb
15. Gender and Age Influence on Sensitive Skin .............................................................................108
Rosa M. Andersen
16. Sensitive Skin: Do We Observe an Impact on Quality of Life? ................................................114
Laurent Misery and Charles Taïeb
17. Perceived Sensitive Skin at Different Anatomical Sites ............................................................117
Miranda A. Farage
18. Sensitive Skin and Noneczematous Dermatoses .......................................................................136
Ian McDonald, Helen Rea, and Martin Steinhoff
19. Sensitive Skin and Eczematous Dermatoses ...............................................................................145
Arun C. Inamadar and Aparna Palit
Section V Environmental Factors and Everyday Products
20. Influence of Air Pollution on Skin ..............................................................................................150
Sparsha Saxena and Golara Honari
21. Sensitive Skin, Skin Care Products, and Cosmetics .................................................................157
Enzo Berardesca
22. Fabrics and Sensitive Skin ...........................................................................................................160
Gérald E. Piérard and Howard Maibach
Section VI Management
23. Dermatotoxicology and Sensitive Skin Syndrome .....................................................................168
Golara Honari and Howard Maibach
24. Formulations for Sensitive Skin ..................................................................................................196
Golara Honari and Howard Maibach
25. Treatments for Sensitive Skin .....................................................................................................202
Martina Kerscher and Heike Buntrock
Index .......................................................................................................................................................212
Preface
Sensitive skin is a prevalent clinical condition that dermatologists should be prepared to recognize,
understand, and manage. Affected individuals mostly report unpleasant sensations of itching, burning,
and stinging with exposure to various skin care products and/or environmental factors. In some western
counties, as high as 50% of women and a 33% of men report various degrees of skin sensitivity affecting
their quality of life.
New developments and research over the past few years have shed light on some aspects of underlying
pathomechanisms, yet there is much to be learned. Correct clinical categorization of patients is key for
clinical management and focused research. Currently, the diagnosis is clinical and based on constella-
tion of symptoms, suggesting the diagnosis of sensitive skin syndrome; however, patients may, in fact,
be affected with more than one syndrome/condition. Work of astute clinicians and directed research can
further elucidate involved mechanisms and provide management solutions.
We hope that this book provides a comprehensive overview on the main physiological basis of skin
reactivity, as well as underlying pathomechanisms associated with sensitive skin and management
options.
We sincerely thank all the authors, editors, and publisher, in particular, Mr. Robert Peden, Ms. Adel
Rosario, and Ms. Judith Simon for their generous contributions. We also thank our readers in advance
and appreciate any comments, corrections, and suggestions for future editions of this book.
Golara Honari
Rosa M. Andersen
Howard Maibach
vii
Contributors
Rosa M. Andersen Denise Falcone
Department of Dermatology Department of Dermatology
University of California at San Francisco Radboud University Medical Center
San Francisco, California Nijmegen, the Netherlands
and
National Allergy Research Centre Miranda A. Farage
Department of Dermato-Allergology The Procter & Gamble Company
Gentofte University Hospital Cincinnati, Ohio
University of Copenhagen
Elena González-Guerra
Copenhagen, Denmark
Department of Dermatology
Hospital Clínico San Carlos
David A. Basketter
Madrid, Spain
DABMEB Consultancy Ltd
Sharnbrook, United Kingdom
Aurora Guerra-Tapia
Department of Dermatology
Enzo Berardesca
Hospital 12 de Octubre
San Gallicano Dermatological Institute
and
IRCCS
Department of Medicine
Rome, Italy
Universidad Complutense
Madrid, Spain
Heike Buntrock
Department of Cosmetic Science
Golara Honari
Division of Biochemistry and Molecular Biology
Department of Dermatology
and
Stanford School of Medicine
Division of Chemistry
Stanford, California
Department of Cosmetic Science
University of Hamburg
Arun C. Inamadar
Hamburg, Germany
Department of Dermatology
Sri BM Patil Medical College Hospital &
Jin Ho Chung
Research Center
Department of Dermatology
BLDE University
Seoul National University College of Medicine
Karnataka, India
and
Laboratory of Cutaneous Aging Research Roland Jourdain
Biomedical Research Institute L’Oréal Research and Innovation
Seoul National University Hospital Aulnay-sous-Bois, France
and
Institute of Human–Environment Interface Martina Kerscher
Biology Department of Cosmetic Science
Seoul National University Division of Biochemistry and Molecular Biology
Seoul, Republic of Korea and
Division of Chemistry
Department of Cosmetic Science
University of Hamburg
Hamburg, Germany
viii
Contributors ix
Eun Ju Kim Laurent Misery
Department of Dermatology Laboratory of NeuroSciences of Brest
Seoul National University College of Medicine Faculty of Medicine
and University of Brest
Laboratory of Cutaneous Aging Research and
Biomedical Research Institute Department of Dermatology
Seoul National University Hospital University Hospital of Brest
and Brest, France
Institute of Human–Environment Interface
Biology Aparna Palit
Seoul National University Department of Dermatology
Seoul, Republic of Korea Sri BM Patil Medical College Hospital &
Research Center
Dong Hun Lee BLDE University
Department of Dermatology Karnataka, India
Seoul National University College of Medicine
and Gérald E. Piérard
Laboratory of Cutaneous Aging Research Laboratory of Skin Bioengineering and Imaging
Biomedical Research Institute Department of Dermatopathology
Seoul National University Hospital University Hospital of Liège
and Liège, Belgium
Institute of Human–Environment Interface
Biology Helen Rea
Seoul National University Department of Dermatology and UCD Charles
Seoul, Republic of Korea Institute of Translational Dermatology
University College Dublin
Howard Maibach
Dublin, Ireland
Department of Dermatology
University of California
David Reilly
School of Medicine
Life Sciences Group
San Francisco, California
Unilever Research & Development
Colworth, United Kingdom
Lidia Maroñas-Jiménez
Department of Dermatology
Renée J. H. Richters
Hospital 12 de Octubre
Department of Dermatology
Madrid, Spain
Radboud University Medical Center
Ian McDonald Nijmegen, the Netherlands
Department of Dermatology and UCD Charles
Institute of Translational Dermatology Luís M. Rodrigues
University College Dublin Universidade Lusófona (CBIOS—Research
Dublin, Ireland Center for Biosciences and Health
Technologies)
Francis McGlone and
School of Natural Sciences & Psychology Department of Pharmacological Sciences
Liverpool John Moores University Universidade de Lisboa—School of Pharmacy
and Lisboa, Portugal
Institute of Psychology
Health & Society University of Liverpool
Liverpool, United Kingdom
