Research Note - Treatment of Bertiellosis in Macaca fascicularis with Praziquantel

1 Pages·1991·0.16 MB·English

by  Conder, G A

J. Helminthol. Soc. Wash.
58(1), 1991, p. 128
Research Note
Treatment of Bertiellosis in Macaca fascicularis with Praziquantel
G. A. CONDER, P. A. ROEHM, D. A. DUPREY,
S. S. JOHNSON, AND P. J. PAGANO
Parasitology Research, Drug Safety Research, and Research Animal Support and Laboratory Services,
The Upjohn Company, Kalamazoo, Michigan 49001
ABSTRACT: A single Macaca fascicularis recently re- Duwel et al., 1981; Graber and Gevrey, 1981;
ceived from the Philippines was found to harbor Ber- Jueco, 1982; Imamkuliev et al., 1983; Bandyo-
tiella studeri. To eliminate the infection, the monkey
padhyay and Manna, 1987). It appears that pra-
was treated with praziquantel in a single oral dose at
ziquantel can be added to the list of drugs which
5 mg/kg of body weight. Two strobilae but no scolices
were found in the feces following treatment. Bertiella can be used to control bertiellosis.
studeri were not present at necropsy 1 mo after treat-
ment. It appears that praziquantel can be added to the Literature Cited
list of drugs which can be used to control bertiellosis.
Andrews, P., H. Thomas, R. Pohlke, and J. Seubert.
KEY WORDS: Macaca fascicularis, Bertiella studeri,
1983. Praziquantel. Medicinal Research Reviews
praziquantel, monkey, tapeworm.
3:147-200.
Bandyopadhyay, A. K., and B. Manna. 1987. The
During routine fecal examination of a newly pathogenic and zoonotic potentiality of Bertiella
received group of monkeys (Macaca fascicularis) studeri. Annals of Tropical Medicine and Parasi-
tology 81:465-466.
from the Philippines, 1 animal was found to har-
Dissanaike, A. S., V. Thomas, and N. Nagappan. 1977.
bor Bertiella studeri (Blanchard, 1891) Stiles and
Bertiella studeri (Blanchard, 1891) Stiles and Has-
Hassall, 1902. The monkey was treated with pra- sall, 1902 infection in a child—first case from Ma-
ziquantel to eliminate the infection. Praziquantel laysia. Southeast Asian Journal of Tropical Med-
was used because it has become the drug of choice icine and Public Health 3:421-422.
Duwel, D., E. Weinman, and R. Kirsch. 1981. Zur
in treating cestode infections over the last several
Panacur®—Behandlung des Prosthenorchis- und
years (Harriett, 1988;KingandMahmoud, 1989). Bertiella-befalls bei Affen. Pages 247-251 in R.
It is highly efficacious against both adult and Ippen and H. D. Schroder, eds. Erkrankungen der
larval tapeworms and is extremely well tolerated Zootiere. Verhandlungsbericht des XXIII Inter-
nationalen Symposiums iiber die Erkrankungen
(Andrews et al., 1983). To our knowledge, how-
der Zootiere, Mulhouse, 24-28 June 1981. Aka-
ever, the drug has never been tried against B.
demie Verlag, Berlin, GDR.
studeri. Graber, M., and J. P. Gevrey. 1981. Parasites in-
Praziquantel (Droncit canine tablets) was ad- ternes des primates de la Republique Democra-
ministered to the infected monkey in a single oral tique du Congo (d'apres la collection Cassard-
Chambron 1956-1960). Role pathogene-diagnos-
dose at 5 mg/kg of body weight. Feces were mon-
tic-prophylaxie. Revue d'Elevage et de Medecine
itored for the next 48 hr following treatment, Veterinaire des Pays Tropicaux 34:27—41.
during which time 2 strobilae were observed to Harnett, W. 1988. The anthelmintic action of pra-
have been passed. Scolices were not found in the ziquantel. Parasitology Today 4:144-146.
Imamkuliev, K. D., M. I. Alekseeva, Yu. P. Gorbunova,
feces. No additional proglottids were observed
and G. G. Belikova. 1983. Bertielliasis: descrip-
in the feces at any later time after treatment.
tion of an imported case in USSR. Meditsinskaya
About 1 mo following treatment, the monkey Parazitologiya i Parazitarnye Bolezni 4:77-78.
was found to have tuberculosis and was sacrificed Jueco, N. L. 1982. Bertiella infection. Pages 215-216
by an overdose of sodium pentobarbital to pro- in L. Jacobs and P. Arambulo, eds. CRC Hand-
book Series in Zoonoses. Section C: Parasitic Zoo-
tect the colony and caretakers. At necropsy, no
noses. Vol. 1. CRC Press, Inc., Boca Raton, Flor-
B. studeri were found. Thus, it appears that pra- ida.
ziquantel was effective in eliminating B. studeri King, C. H., and A. A. F. Mahmoud. 1989. Drugs
from the monkey. No adverse effects of treat- five years later: praziquantel. Annals of Internal
Medicine 110:290-296.
ment with praziquantel were observed.
Schutze, H. R. 1977. Diagnose und Therapie parasi-
A number of drugs have been reported to be
tarer Infektionen bei Affen. Praktische Tierarzt 58:
effective in treating bertiellosis in animals and 53-56.
humans (Dissanaike et al., 1977; Schutze, 1977;
128
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