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Radiation Oncology: Rationale, Technique, Results ISBN: 978-0-323-04971-9
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Library of Congress Cataloging-in-Publication data
Radiation oncology: rationale, technique, results. — 9th ed. / [edited by] James D. Cox, K. Kian Ang.
P. ; cm.
Includes bibliographical references and index.
ISBN 978-0-323-04971-9
1 . Cancer—Radiotherapy. I. Cox, James D. (James Daniel), 1938- II. Ang, K. K. (K. Kian)
[DNLM: 1. Neoplasms—radiotherapy. QZ 269 R12803 2010]
RC271.R3R3315 2010
616.99’40642-dc22 2009018138
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Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
ConTRibuToRs
Anesa Ahamad, M.D. James D. Cox, M.D., F.A.C.R., F.A.S.T.R.O.
Associate Lecturer, Faculty of Medical Sciences Professor and Head, Division of Radiation Oncology
University of the West Indies at St. Augustine The University of Texas M. D. Anderson Cancer Center
Trinidad and Tobago Houston, Texas
K. Kian Ang, M.D., Ph.D. Christopher H. Crane, M.D.
Professor and Deputy Chair, Department of Radiation Professor, Department of Radiation Oncology
Oncology The University of Texas M. D. Anderson Cancer Center
Gilbert H. Fletcher Distinguished Memorial Chair Houston, Texas
The University of Texas M. D. Anderson Cancer Center
Houston, Texas Bouthaina Dabaja, M.D.
Assistant Professor, Department of Radiation Oncology
Matthew T. Ballo, M.D. The University of Texas M. D. Anderson Cancer Center
Associate Professor, Department of Radiation Oncology Houston, Texas
The University of Texas M. D. Anderson Cancer Center
Houston, Texas Prajnan Das, M.D., M.S., M.P.H.
Assistant Professor, Department of Radiation Oncology
Peter A. Balter, Ph.D., D.A.B.R. The University of Texas M. D. Anderson Cancer Center
Assistant Professor, Department of Radiation Physics Houston, Texas
The University of Texas M. D. Anderson Cancer Center
Houston, Texas Marc E. Delclos, M.D.
Associate Professor, Department of Radiation Oncology
James D. Brierley, M.B.B.S., F.R.C.P.(UK), F.R.C.R., The University of Texas M. D. Anderson Cancer Center
F.R.C.P.(C) Houston, Texas
Professor, Department of Radiation Oncology
University of Toronto Lei Dong, Ph.D.
Princess Margaret Hospital Associate Professor, Department of Radiation Physics
Toronto, Ontario The University of Texas M. D. Anderson Cancer Center
Canada Houston, Texas
Thomas A. Buchholz, M.D. Patricia J. Eifel, M.D., F.A.C.R., F.A.S.T.R.O
Professor and Chair, Department of Radiation Oncology Professor, Department of Radiation Oncology
The University of Texas M. D. Anderson Cancer Center The University of Texas M. D. Anderson Cancer Center
Houston, Texas Houston, Texas
Roger W. Byhardt, M.D. Douglas B. Evans, M.D.
Professor, Department of Radiation Oncology Professor and Chairman, Department of Surgery
Medical College of Wisconsin Medical College of Wisconsin
Milwaukee, Wisconsin Milwaukee, Wisconsin
Min Rex Cheung, M.D., Ph.D. Selim Y. Firat, M.D.
Assistant Professor, Department of Radiation Assistant Professor, Department of Radiation Oncology
Oncology Medical College of Wisconsin
The University of Texas M. D. Anderson Cancer Center Milwaukee, Wisconsin
Houston, Texas
Adam S. Garden, M.D.
Jay S. Cooper, M.D., F.A.C.R., F.A.C.R.O., F.A.S.T.R.O. Professor, Department of Radiation Oncology
Director, Maimonides Cancer Center The University of Texas M. D. Anderson Cancer Center
Chair, Department of Radiation Oncology Houston, Texas
Maimonides Medical Center
Brooklyn, New York
v
vi Contributors
Michael Gillin, Ph.D. Sunil Krishnan, M.D.
Professor, Department of Radiation Physics Associate Professor, Department of Radiation Oncology
The University of Texas M. D. Anderson Cancer Center The University of Texas M. D. Anderson Cancer Center
Houston, Texas Houston, Texas
Mary K. Gospodarowicz, M.D., F.R.C.P.C., F.R.C.R.(Hon) Deborah A. Kuban, M.D.
Professor and Chair, Department of Radiation Oncology Professor, Department of Radiation Oncology
University of Toronto The University of Texas M. D. Anderson Cancer Center
Princess Margaret Hospital Houston, Texas
Toronto, Ontario
Canada Colleen A. Lawton, M.D., F.A.C.R.
Professor, Department of Radiation Oncology
B. Ashleigh Guadagnolo, M.D. Medical College of Wisconsin
Assistant Professor, Department of Radiation Oncology Milwaukee, Wisconsin
The University of Texas M. D. Anderson Cancer Center
Houston, Texas Andrew K. Lee, M.D., M.P.H.
Associate Professor, Department of Radiation Oncology
Chul S. Ha, M.D. The University of Texas M. D. Anderson Cancer Center
Distinguished Chair in Radiation Oncology Houston, Texas
Professor and Chair, Department of Radiation Oncology
The University of Texas Health Science Center Valerae O. Lewis, M.D.
at San Antonio Associate Professor, Department of Orthopedic Oncology
Associate Director & Associate Physician in Chief The University of Texas M. D. Anderson Cancer Center
Cancer Therapy and Research Center Houston, Texas
San Antonio, Texas
Zhongxing Liao, M.D.
Eric J. Hall D.Sc., F.A.C.R., F.R.C.R. Associate Professor, Department of Radiation Oncology
Higgins Professor Emeritus The University of Texas M. D. Anderson Cancer Center
Columbia University Houston, Texas
New York, New York
Michelle S. Ludwig, M.D., M.P.H.
David H. Hussey, M.D., F.A.C.R. Resident, Department of Radiation Oncology
Professor Emeritus, Department of Radiation Oncology The University of Texas M. D. Anderson Cancer Center
The University of Texas Health Science Center at Houston, Texas
San Antonio
San Antonio, Texas Marvin L. Meistrich, Ph.D.
Ashbel Smith Professor, Department of Experimental
Nora A. Janjan, M.D. Radiation Oncology
Professor, Department of Radiation Oncology The University of Texas M. D. Anderson Cancer Center
The University of Texas M. D. Anderson Cancer Center Houston, Texas
Houston, Texas
Raymond E. Meyn, Jr., Ph.D.
Anuja Jhingran, M.D. Professor, Department of Experimental
Associate Professor, Department of Radiation Oncology Radiation Oncology
The University of Texas M. D. Anderson Cancer Center The University of Texas M. D. Anderson Cancer Center
Houston, Texas Houston, Texas
Stella K. Kim, M.D. Luka Milas, M.D., Ph.D.
Associate Professor, Section of Ophthalmology Professor, Department of Experimental Radiation
Department of Head and Neck Surgery Oncology
The University of Texas M. D. Anderson Cancer Center The University of Texas M. D. Anderson Cancer Center
Houston, Texas Houston, Texas
Ritsuko Komaki, M.D., F.A.C.R., F.A.S.T.R.O. Michael F. Milosevic, M.D., F.R.C.P.C.
Professor, Department of Radiation Oncology Professor, Department of Radiation Oncology
Gloria Lupton Tennison Endowed Professor in University of Toronto
Lung Cancer Research Princess Margaret Hospital
The University of Texas M.D. Anderson Cancer Center Toronto, Ontario
Houston, Texas Canada
Contributors vii
Radhe Mohan, Ph.D. Elizabeth L. Travis, Ph.D.
Professor and Chair, Department of Radiation Physics Professor, Department of Experimental Radiation
The University of Texas M. D. Anderson Cancer Center Oncology
Houston, Texas The University of Texas M. D. Anderson Cancer Center
Houston, Texas
William H. Morrison, M.D.
Professor, Department of Radiation Oncology Richard W. Tsang, M.D., F.R.C.P.(C)
The University of Texas M. D. Anderson Cancer Center Professor, Department of Radiation Oncology
Houston, Texas University of Toronto
Princess Margaret Hospital
Firas Mourtada, Ph.D. Toronto, Ontario
Associate Professor, Department of Radiation Physics Canada
The University of Texas M. D. Anderson Cancer Center
Houston, Texas Gauri R. Varadhachary, M.D., M.B.B.S.
Associate Professor, Department of Gastrointestinal
Michael S. O’Reilly, M.D. Medical Oncology
Associate Professor, Department of Radiation Oncology The University of Texas M. D. Anderson Cancer Center
The University of Texas M. D. Anderson Cancer Center Houston, Texas
Houston, Texas
B-Chen Wen, M.D.
Alan Pollack, M.D., Ph.D. Professor, Department of Radiation Oncology
Chair and Sylvester Professor of Radiation Oncology Miller School of Medicine
The University of Miami Miller School of Medicine The University of Miami
Miami, Florida Miami, Florida
David L. Schwartz, M.D. Robert A. Wolff, M.D.
Assistant Professor, Department of Radiation Oncology Professor of Medicine
The University of Texas M. D. Anderson Cancer Center Department of Gastrointestinal Medical Oncology
Houston, Texas Division of Cancer Medicine
The University of Texas M. D. Anderson Cancer Center
Almon S. Shiu, Ph.D. Houston Texas
Professor, Department of Radiation Physics
The University of Texas M. D. Anderson Cancer Center Shiao Y. Woo, M.D.
Houston, Texas Professor, Department of Radiation Oncology
The University of Texas M. D. Anderson Cancer Center
George Starkschall, Ph.D. Houston, Texas
Professor, Department of Radiation Physics
The University of Texas M. D. Anderson Cancer Center Gunar K. Zagars, M.D.
Houston, Texas Professor, Department of Radiation Oncology
The University of Texas M. D. Anderson Cancer Center
Eric A. Strom, M.D. Houston, Texas
Professor, Department of Radiation Oncology
The University of Texas M. D. Anderson Cancer Center
Houston, Texas
Gillian M. Thomas, B.Sc., M.D., F.R.C.P.C., F.R.C.R.(Hon)
Department of Radiation Oncology
Edmond Odette Cancer Centre at Sunnybrook
University of Toronto
Toronoto, Ontario
Canada
pRefaCe
Radiation oncology has undergone a major transformation As in previous editions, we have sought consistency in the
in the past few years. Results of three-dimensional presentation of each chapter. Each begins with discussions
conformal radiation therapy and intensity-modulated of effects of treatments on normal tissues. Emphasis has
radiation therapy have confirmed the promise that was been placed on synthesis of the available literature for clarity
evident from treatment-planning studies and early results and brevity. The thrust of this approach is accessibility of
of phase II and phase III trials. Advances in functional and radiation oncology to students and colleagues from other
metabolic imaging have augmented the tools for evaluating disciplines as well as physicians, physicist, and biologists
disease and planning treatments. Refinements of cytotoxic from various countries. We are thankful to our colleagues
chemotherapy in conjunction with radiation therapy have who have worked arduously to meet the guidelines we
reduced side effects and improved efficacy. The rapidly have set for presenting their material in this manner.
developing arena of molecular therapeutic agents and the This edition has been prepared in the context of ongoing
emerging ability to select some agents based on molecular care of patients, research, and administration. We are
abnormalities in tumors promise to revolutionize combined grateful to those who have worked with us to permit its
modality therapy. Surgical procedures have emphasized completion. We are indebted beyond words to Christine
preservation of structures, video assistance, and robotic Wogan, who has edited this edition and the previous one.
tools such that the indications for adjuvant radiation Her knowledge and advice has served to gather the thoughts
therapy have been expanded and modified. and words of the many contributors into a more unified
This ninth edition has updated, replaced, and eliminated whole. Her patience and goodwill are without compare.
chapters from previous editions to seek the most
contemporary discussions of principles and specific disease James d. Cox, M.d.
sites. New contributors have been enlisted and new subjects
K. Kian Ang, M.d., Ph.d.
have been added. In recognition of the importance of color
displays, most figures in the ninth edition are now in color.
This greatly enhances the value of the figures, especially
those that show dose distributions for specific diseases.
ix
Description:Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the
