Program and Abstracts

140 Pages·2017·6.14 MB·English

May 21-25, 2017
HILTON ATLANTA
Atlanta, GA
hosted by the
INTERNATIONAL
SOCIETY FOR ANTIVIRAL
RESEARCH
(ISAR)
Program AND Abstracts
Table of
Contents
Daily Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
Keynotes & Networking . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
Schedule at a Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
ISAR Awardees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10
Women in Science Career Development
Award Winners . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14
Speaker Biographies . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Program Schedule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
Abstracts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49
Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 132
2
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Daily
Schedule
Sunday, May 21, 2017
› Women in Science Roundtable
› Drug Discovery and Development 101
› Welcome and Keynote Address
› Opening Reception
Monday, May 22, 2017
› Keynote Address
› Antiviral Immunity Symposium
› Gertrude Elion Memorial Award Lecture
› Hepatitis Viruses and Retroviruses
› Poster Session 1
Tuesday, May 23, 2017
› Antonin Holy ’ Memorial Award Lecture
› Emerging Viruses
› New Member and First Time Attendee Networking
› Career Development Panel
Wednesday, May 24, 2017
› Shotgun Oral Presentations
› Keynote Address
› Emerging Infections Symposium
› William Prusoff Young Investigator Award Lecture
› Respiratory Viruses
› Poster Session 2
› Closing Reception and Banquet
Thursday, May 25, 2017
› Medicinal Chemistry
› DNA Viruses and Respiratory Viruses
3
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Organization
International Society for Antiviral Research and
30th International Conference on Antiviral Research
Officers
President
José Esté
Barcelona, Spain
President-Elect Past President
Johan Neyts Robert Buckheit, Jr.
Leuven, Belgium Frederick, MD, USA
Treasurer Secretary
Brian Gowen Graciela Andrei
Logan, UT, USA Leuven, Belgium
Board of Directors
Andrea Brancale Jennifer Moffat Mike Bray
Cardiff, UK Syracuse, NY, USA Chevy Chase, MD, USA
Roger Ptak Rhonda Cardin Kathie Seley-Radtke
Frederick, MD, USA Cincinnati, OH, USA Baltimore, MD, USA
Program Committee
Co-Chairs
Mark Prichard and Justin Julander
Graciela Andrei Andrea Brancale Chris Meier
Tim Block José Esté Johan Neyts
Mike Bray Maaike Everts Don Smee
Randall Lanier
Conference Committee
Co-Chairs
José Esté and Robert Buckheit, Jr.
Graciela Andrei Rhonda Cardin Amy Patick
Masanori Baba Phil Furman Roger Ptak
Mike Bray Brian Gowen Johan Neyts
4
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Contributors
Confirmed Sponsors as of April 27, 2017
Platinum
Gilead Sciences, Inc.
Foster City, CA, USA
Gold
Alios BioPharma Inc.,
part of the Janssen Pharmaceutical Companies
South San Francisco, CA, USA
Silver
AbbVie Inc. JCR Pharmaceutical Co., Ltd.
North Chicago, IL, USA Chimerix Inc. Ashiya, Japan
Burroughs Wellcome Fund Durham, NC, USA Southern Research Institute
Research Triangle Park, NC, USA Birmingham, AL, USA
Bronze
ACS Infectious Diseases Elsevier B.V. Oxeltis
Washington, DC, USA Amsterdam, The Netherlands Montpellier, France
Antiva Biosciences Inc. ImQuest BioSciences Inc. Riboscience LLC
South San Francisco, CA, USA Frederick, MD, USA Sunnyvale, CA, USA
Center for Drug Design, Institute for Antiviral Research, Toyama Chemical Co., Ltd.
University of Minnesota Utah State University Tokyo, Japan
Minneapolis, MN, USA Logan, UT, USA
XpressBio
Frederick, MD, USA
The ISAR Presidents’ Fund
Jan Balzarini Phillip A. Furman
José A. Esté
Joseph M. Colacino Douglas D. Richman
5
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Keynotes &
Networking
Keynote Addresses
Sunday, May 21, 2017 Monday, May 22, 2017
Historical Context and Biological Enigma Impact of Transmitted HIV Phenotype
of Rhinovirus C on Host-Virus Interactions
and Disease Progression
Ann C. Palmenberg, PhD
University of Wisconsin-Madison Eric Hunter, PhD
Emory University
Antivirals at the Interface
with Public Health:
Wednesday, May 24, 2017
A Case Study of Polio
Zika Antiviral and Vaccine Development
Mark A. Pallansch, PhD
Pei-Yong Shi, PhD
Centers for Disease Control
and Prevention University of Texas Medical Branch
Networking Events
Women in Science Roundtable New Member and First Time
Sunday, May 21, 2017 Attendee Networking
12:00 PM – 1:45 PM Tuesday, May 22, 2017
CRYSTAL BALLROOM 12:30 PM – 2:00 PM
ROOM 204-205
Opening Reception
Sunday, May 21, 2017 Career Development Panel
6:30 PM – 8:30 PM Tuesday, May 22, 2017
CRYSTAL BALLROOM 2:00 PM – 3:00 PM
ROOM 203
Conference Reception and Banquet
Wednesday, May 23, 2017
7:00 PM – 10:00 PM
WEST BALLROOM
6
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Schedule
at a Glance
Sunday, May 21, 2017
TIME EVENT LOCATION
11:00 AM – 5:00 PM Registration GRAND BALLROOM
PRE-FUNCTION
12:00 PM – 1:45 PM Women in Science Roundtable CRYSTAL BALLROOM
2:00 PM – 4:00 PM Drug Discovery and Development 101 WEST BALLROOM
4:00 PM – 4:30 PM Coffee Break GRAND BALLROOM
PRE-FUNCTION
4:30 PM – 6:30 PM Welcome/Keynote Address: WEST BALLROOM
Ann C. Palmenberg, PhD and Mark A. Pallansch, PhD
6:30 PM – 8:30 PM Opening Reception CRYSTAL BALLROOM
Light hors d’oeuvres served
Monday, May 22, 2017
TIME EVENT LOCATION
8:00 AM – 5:30 PM Registration GRAND BALLROOM
PRE-FUNCTION
8:00 AM – 9:00 AM Continental Breakfast GRAND BALLROOM
PRE-FUNCTION
9:00 AM – 9:55 AM Keynote Address: Eric Hunter, PhD WEST BALLROOM
9:55 AM – 12:30 PM Antiviral Immunity Symposium WEST BALLROOM
11:00 AM – 11:30 AM Coffee Break GRAND BALLROOM
PRE-FUNCTION
12:30 PM – 2:00 PM Lunch ON YOUR OWN
2:00 PM – 2:45 PM Gertrude Elion Memorial Award Lecture WEST BALLROOM
2:50 PM – 5:00 PM Hepatitis Viruses and Retroviruses WEST BALLROOM
3:30 PM – 4:00 PM Coffee Break GRAND BALLROOM
PRE-FUNCTION
5:00 PM – 7:00 PM Poster Session 1 EAST BALLROOM
Light hors d’oeuvres served
7
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Schedule at a Glance
Tuesday, May 23, 2017
TIME EVENT LOCATION
8:00 AM – 3:00 PM Registration GRAND BALLROOM
PRE-FUNCTION
8:00 AM – 9:00 AM Continental Breakfast GRAND BALLROOM
PRE-FUNCTION
9:00 AM – 9:30 AM Antonin Holý Memorial Award Lecture WEST BALLROOM
9:30 AM – 12:30 PM Emerging Viruses WEST BALLROOM
10:30 AM – 11:00 AM Coffee Break GRAND BALLROOM
PRE-FUNCTION
12:30 PM – 2:00 PM New Member and First Time Attendee ROOM 204-205
Networking
Light snacks served
2:00 PM – 3:00 PM Career Development Panel ROOM 203
Snacks and beverages served
Wednesday, May 24, 2017
TIME EVENT LOCATION
7:30 AM – 5:00 PM Registration GRAND BALLROOM
PRE-FUNCTION
7:30 AM – 8:30 AM Continental Breakfast GRAND BALLROOM
PRE-FUNCTION
8:30 AM – 9:00 AM Shotgun Oral Presentations WEST BALLROOM
9:00 AM – 9:50 AM Keynote Address: Pei-Yong Shi, PhD WEST BALLROOM
9:50 AM – 12:30 PM Emerging Infections Symposium WEST BALLROOM
10:30 AM – 11:00 AM Coffee Break GRAND BALLROOM
PRE-FUNCTION
12:30 PM – 1:45 PM Lunch ON YOUR OWN
1:45 PM – 2:00 PM ISAR Business Meeting WEST BALLROOM
2:00 PM – 2:30 PM William Prusoff Young Investigator Award Lecture WEST BALLROOM
2:30 PM – 3:30 PM Respiratory Viruses WEST BALLROOM
3:30 PM – 5:30 PM Poster Session 2 EAST BALLROOM
Light hors d’oeuvres served
7:00 PM – 7:30 PM Closing Reception GRAND BALLROOM
Light hors d’oeuvres served PRE-FUNCTION
7:30 PM – 10:00 PM Closing Banquet WEST BALLROOM
Dinner served
8
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
Schedule at a Glance
Thursday, May 25, 2017
TIME EVENT LOCATION
8:00 AM – 12:00 PM Registration GRAND BALLROOM
PRE-FUNCTION
8:00 AM – 9:00 AM Continental Breakfast GRAND BALLROOM
PRE-FUNCTION
9:00 AM – 10:30 AM Medicinal Chemistry WEST BALLROOM
10:30 AM – 11:00 AM Coffee Break GRAND BALLROOM
PRE-FUNCTION
11:00 AM – 12:30 PM DNA Viruses and Respiratory Viruses WEST BALLROOM
12:30 PM Conference Concludes
9
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)
2017 ISAR
Award Winners
Gertrude Elion
Memorial Lecture Award
Michael J. Sofia, PhD
Mike Sofia is the principle inventor of sofosbuvir (Sovaldi and Harvoni), the
first curative treatment for chronic hepatitis C . He is Chief Scientific Officer of
Arbutus Biopharma, a company focused on the discovery and development of
curative therapies for hepatitis B . He is listed on more than 50 US patents and on
numerous patent applications, and has authored over 100 research papers and
12 book chapters . He holds a professorship at the Baruch S . Blumberg Institute
in Doylestown, PA and is an adjunct professor at Drexel University School of
Medicine in Philadelphia .
Mike earned a BA degree in chemistry from Cornell University in 1980 and received his PhD in organic
chemistry from the University of Illinois, Urbana-Champaign in 1984 . He did his postdoctoral training
in synthetic organic chemistry as an NIH fellow at Columbia University . During his early career in the
pharmaceutical industry, he held the position of Group Director for New Leads Chemistry at Bristol-
Myers Squibb, Vice President of Research at Intercardia Research Labs and research positions of
increasing responsibility at Eli Lilly and at the Squibb Institute for Medical Research . He then moved to
Pharmasset and was senior vice president for chemistry until its acquisition by Gilead in 2012 . He then
co-founded OnCore Biopharma, which merged with Tekmira in 2015 to form Arbutus .
In addition to his “day job,” Mike is a member of the editorial advisory boards of several scientific
journals, the Board of the Blumberg Institute and the Board of Trustees of the University of the Sciences
in Philadelphia . He was the recipient of Pennsylvania Bio’s 2014 Scientific Achievement Award, the
2015 Heroes of Chemistry Award of the American Chemical Society and the 2016 IUPAC-Richter Prize .
Together with Charlie Rice and Ralf Bartenschlager, he received the 2016 Lasker-Debakey Award in
Clinical Medical Research for his contributions to the discovery of a cure for hepatitis C .
Antonín Holý Memorial
Lecture Award
C. K. (David) Chu, PhD
David Chu is a Distinguished Research Professor, Emeritus at the College of
Pharmacy of the University of Georgia . He obtained a BS degree in pharmacy
from Seoul National University, and after serving as an officer in the Korean
Navy, he came to the United States, receiving a MS degree from Idaho State
University in 1968 and a PhD in chemistry from the State University of New York
at Buffalo in 1975 . After working as a postdoctoral fellow in drug discovery at
the Memorial Sloan-Kettering Institute of Cancer Research, New York, he stayed
on as a research associate for six years before joining the faculty of the University
of Georgia in 1982 .
10
Program and Abstracts of the 30th International Conference on Antiviral Research (ICAR)