Table Of ContentPolysaccharide-based
Nano-Biocarrier
in Drug Delivery
Polysaccharide-based
Nano-Biocarrier
in Drug Delivery
Edited by
Tapan Kumar Giri and Bijaya Ghosh
CRC Press
Taylor & Francis Group
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Contents
Preface..............................................................................................................................................vii
About the Editors ..............................................................................................................................ix
Contributors ......................................................................................................................................xi
Chapter 1 Oral Delivery of Proteins and Polypeptides through Polysaccharide Nanocarriers .......1
Hemant Ramchandra Badwaik, Kartik Nakhate, Leena Kumari,
and Kalyani Sakure
Chapter 2 Oral Absorption of Polysaccharide Nanoparticles Loaded with
Drug Molecule across the GIT ...................................................................................25
Tapan Kumar Giri
Chapter 3 Cellulose-Based Nanocomposites for Pharmaceutical and Biomedical
Applications .............................................................................................................39
Manuel Palencia, María E. Berrio, Angelica García-Quintero,
and Tulio A. Lerma
Chapter 4 Recent Advances of Chitosan Nanoparticles as a Carrier for Delivery
of Antimicrobial Drugs ..............................................................................................63
Bijaya Ghosh and Tapan Kumar Giri
Chapter 5 Heparin and Its Derivatives-Based Nanoparticles for Cancer Therapy .....................81
Amit Kundu, Prasanta Dey, Subham Banerjee, Pradipta Sarkar, Arnab De,
Amit Maity, and Hyung Sik Kim
Chapter 6 Delivery of Biomolecules to the Central Nervous System Using
a Polysaccharide Nanocomposite .............................................................................105
Anroop B. Nair, Shah Jigar, Chavda Vishal, Shah Hiral, and Patel Snehal
Chapter 7 Polysaccharide-Based Nanoparticles for the Enhanced Delivery of Poorly
Soluble Drugs ...........................................................................................................129
Prithviraj Chakraborty, Urmi Chaurasia, Debarupa Dutta Chakraborty,
and Indranil Chanda
Chapter 8 Development of Nanoparticles from Grafted Natural Polysaccharides
for Drug Delivery .....................................................................................................153
Anupam Roy, Sreyajit Saha, and Animesh Ghosh
v
vi Contents
Chapter 9 Environmental Responsive Polysaccharide Nanocarriers for
Controlled Drug Delivery ........................................................................................169
Yamini S. Bobde and Balaram Ghosh
Chapter 10 Advancement of Biodegradable Polysaccharide Nanocarriers
for Delivery of Herbal Extracts and Bio-Actives .....................................................191
Pallavi Krishna Shetty and Chethan Gejjalagere Honnappa
Chapter 11 Use of Polysaccharide Nanocarrier Systems for the Delivery
of Curcumin and Its Derivative ................................................................................207
Narayanan Kasinathan and Kiran S. Avadhani
Chapter 12 Polysaccharide-Based Nanocarriers for Drug Delivery
into and through the Skin .........................................................................................227
Hemant Ramchandra Badwaik
Chapter 13 Polysaccharide Nanoparticle-Based Drug Delivery Approaches for Efficient
Therapy of Diabetes .................................................................................................251
Vaswati Rita Das, Dibyendu Dutta, and Srijita Halder
Chapter 14 Chitosan-Based Nanoparticulate System for Pulmonary Drug Delivery ................273
Tapan Kumar Giri, Bijaya Ghosh, and Falguni Patra
Chapter 15 Polysaccharide-Based Nanoparticles for Colon-Specific Drug Delivery ................291
Moumita Das, Arindam Maity, Debanjana Chakraborty,
and Lakshmi Kanta Ghosh
Chapter 16 Passive and Active Tumor Targeting of Polysaccharide Nanocarriers
for Cancer Therapy ...................................................................................................323
Miltu Kumar Ghosh and Falguni Patra
Chapter 17 Polysaccharide-Based Nanocarriers Loaded with Drugs for
the Management of Obesity .....................................................................................339
Sandipan Dasgupta, Souvik Roy, Tania Chakraborty, and Nilanjan Sarkar
Index ..............................................................................................................................................361
Preface
With the growing awareness of drug-induced diseases in the last few decades, the trend of phar-
maceutical research had shifted to drug targeting. The research community seems to be fascinated
with idea of delivering drugs at an optimal rate to their exact site of action. Once considered wishful
thinking, nanotechnology has made this a reality. Many drug-loaded nanostructures have already
demonstrated their superiority over their conventional counterparts. Inspired by this success, work
is ongoing to develop nanosized dosage forms for almost all the important drugs that have signifi-
cant delivery problems.
However, materials employed in the fabrication of nanostructures determine their properties.
Being pharmaceutical ingredients, these materials have to meet stringent regulatory standards
of safety. Cost is also an important factor that determines the feasibility of mass production and
marketing. So stress is given to usage of easily available natural substances such as nanomaterials.
Bio-based natural polysaccharides are excellent candidate materials for these purposes. As nano-
carriers, polysaccharides have greater stability in the blood as they can bypass the reticuloendo-
thelial system. Further, the existence of several functional groups in their structure make them
modifiable chemically and biochemically. The presence of hydrophilic moieties in their structure,
such as carboxyl, hydroxyl, and amino groups, improves the bioavailability of the drugs by increas-
ing their bioadhesion with the cells and tissues. Due to their natural origin and ease of availability,
they have been widely employed in the design of nanocarriers loaded with antimicrobial drugs.
Finally, as the most abundant material found in nature, they are much cheaper than other nanoma-
terials. Hence a nanodosage form developed in the laboratory has high potential for being upgraded
to a marketed product.
All these factors have influenced us in our review of the recent advances in polysaccharide-based
nano-biocarriers in drug delivery application and we have compiled them in this book.
This book is organized to provide the most relevant and realistic information on polysaccharide-
based nanocarriers for different types of drug delivery. The current state-of-the-art research has
been accumulated in 17 chapters.
To make this book reader friendly and useful, we have provided some in-depth literature. The
chapters discuss the fundamental ideas as well as the development and application of these systems
for the delivery of small molecules, proteins, peptides, oligonucleotides, and genes. We hope that
this book will meet the demands of a reference book for concerned professionals and researchers
who intend to conceptualize and develop nano delivery systems for drugs using polysaccharides as
nanomaterials.
Preparation of this book would not have been possible without the valuable contributions from
various experts in the field. We would like to thank the authors who took time from their busy
schedules and responded to our request. We deeply appreciate their timely contributions. We are
thankful to the management of the NSHM Knowledge Campus, Kolkata-Group of Institutions and
our colleagues for their continued support. We are grateful to our family members for their con-
tinuous moral support and inspiration during the preparation of this book. We are thankful to CRC
Press for extending this opportunity to us and their expert assistance. Constructive comments and
suggestions from readers in improving the quality of this book are welcome.
Tapan Kumar Giri
Bijaya Ghosh
vii
About the Editors
Tapan Kumar Giri was educated at Jadavpur University, Kolkata, India, where he received phar-
macy degrees in B.Pharm, M.Pharm and a Ph.D. He has held academic posts in various phar-
macy institutes of North India and is currently working as an Assistant Professor in Pharmaceutics
at NSHM Knowledge Campus, Kolkata-Group of Institutions, Kolkata, India. His main research
interests are formulation development and drug delivery. He has mentored over 20 Master’s stu-
dents. He has published around 60 research papers, 7 book chapters and 2 pharmacy books. He
has served as a guest editor for the Current Chemical Biology Journal, Bentham Science. He has
received the prestigious highly cited article award from Elsevier as well as the teacher of the year
2017 award from Maulana Abul Kalam Azad University of Technology, West Bengal, India.
Bijaya Ghosh has been teaching for the last 30 years and has taught pharmacy to undergradu-
ates and graduate students in some of the premier institutions of North and South India. Currently
she is working as a Professor in Pharmaceutics at NSHM Knowledge Campus, Kolkata-Group of
Institutions, Kolkata, India. She received her B.Pharm, M.Pharm and Ph.D. degrees from Jadavpur
University in the years 1983, 1986 and 1994, respectively. She has authored 2 pharmacy text books
and has published some 40 research papers in national and international journals. Her research
interests involve various streams of novel drug delivery like sustaining drug release, passive and
iontophoretic drug delivery and nanobiotechnology. Ever interested in experimenting with new con-
cepts, currently she is working on the reverse iontophoretic extraction of small molecules for thera-
peutic drug monitoring.
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