Phytochemical Society of North America 50th Anniversary Meeting

248 Pages·2011·5.74 MB·English

2011
Phytochemical Society of North America
50th Anniversary Meeting
December10-15, 2011
Fairmont Orchid, Hawai’i
Table of Contents
Meeting Program 7
Invited Speakers 45
Session Abstracts 77
Session 1: PSNA Plenary Session – A Celebration 79
Session 2: The Legacy of Meinhart H. Zenk 81
Session 3: Natural Products in Agriculture 91
Session 4: Chemoprevention 97
Session 5: Biochemistry/Enzymology 109
Session 6: Dietary Supplements 119
Session 7: Botanicals/Medicinals 123
Session 8: New Characterization Methods 131
Session 9: Natural Products Drug Discovery 135
Session 10: Metabolism/Metabolomics 143
Session 11: Phytochemistry/Phytomedicine 153
Session 12: Transcriptomics 157
Session 13: Biofuels and Bioproducts 165
Poster Abstracts 171
Natural Products in Agriculture 173
Chemoprevention 177
Biochemistry/Enzymology 181
Botanicals/Medicinals 189
New Characterization Methods 205
Natural Product Drug Discovery 207
Metabolism/Metabolomics 221
Phytomedicine/Phytochemistry 227
Transcriptome Profiling 243
Biofuels and Bioproducts 245
Author Index 249
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50 A M
TH NNIVERSARY EETING
Phytochemical Society of North America
December 10th – 15th, 2011 The Fairmont Orchid, Hawai’i

Welcome and ALOHA PSNA50 Conference Delegates, Accompanying Persons, Sponsors and
Exhibitors!
We are very pleased to have the 50th anniversary meeting of the Phytochemical Society of North
America hosted on the Kohala Coast of the island of Hawaii, the bridge between the west and
the east. In true Hawaiian tradition, we welcome each of you (ALOHA and E KOMO MAI). This
is a very special time in the society’s history, and we hope that you will enjoy the quite
remarkable science, the opportunity to meet with scientific colleagues, as well as the wonderful
richness and splendor of Hawaii itself.
PSNA 50 represents the culmination of two years intense planning, and brings together a
remarkable group and diversity of scientific experts and young scientists alike in each of the
main areas of phytochemical research. The program of oral contributions is outstanding, as are
the poster sessions. We are very grateful to all of the conference contributors, to our scientific
committee and to the local hosts in enabling this wonderful gathering.
We also wish to gratefully acknowledge the wonderfully generous support by our various
sponsors to whom we give a big MAHALO! (THANK YOU!). Without their support, this meeting
would not be possible.
The meeting begins with reflections about the Society from Professor Eric Conn, one of the
pioneers in PSNA, this being followed by key plenary contributions from HRH Princess
Chulabhorn Mahidol (on Thailand’s phytochemical diversity and promise), Mansukh C. Wani
(co-discoverer of taxol and camptothecin), Koji Nakanishi (seminal work on ginkgolides), and
Daneel Ferreira (on proanthocyanidin/polyphenols). Together, they provide wonderful examples
of the importance of our remarkable phytochemical treasures, much of which has only been
discovered in the last 50 years.
We are saddened with the passing of Professor Meinhart H. Zenk, but honored by the wonderful
slate of speakers in sessions dedicated to his quite remarkable scientific legacy. He lives on in
very many different ways.
The scientific program, thanks to all of you, has wonderful contributions in areas spanning:
chemoprevention, natural products drug discovery, medicinal plants, biosynthesis,
metabolism/metabolomics, natural products in agriculture, new characterization methods,
dietary supplements, phytochemistry/phytomedicine, transcriptomics/metabolomics, as well as
the emerging areas of biofuels/bioproducts. There is something for everyone!
PSNA 50 also has special sessions dedicated to our young scientists, at the undergraduate,
graduate and postdoctoral levels. We would ask each of you to participate in these activities as
well, and to provide your support for their endeavors.
Welcome to Hawaii. Welcome to PSNA 50. (MAHALO! ALOLHA AND MALAMA PONO!)
(THANK YOU, WELCOME AND ‘TAKE CARE’ (BE SAFE) DURING THE CONFERENCE)

Norman G. Lewis Cecilia Mcintosh John Pezzuto
Conference Chair President Local Host
PSNA 50 PSNA 50 PSNA 50

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Scientific Committee
Norman G. Lewis, Chair, Washington State University
Ikuro Abe, University of Tokyo
Gynheung An, Kyung Hee University
Yoshinori Asakawa, Tokushima Bunri University
K. Hüsnü Can Baser, Anadolu University
Rudolf Bauer, University of Graz
Jörg Bohlmann, University of British Columbia
G. Paul Bolwell, Royal Holloway, University of London
Vanderlan Da Silva Bolzani, Universidade Estadual Paulista, Instituto de Química
Wanchai De-Eknamkul, Chulalongkorn University
Daneel Ferreira, University of Mississippi
Mary Garson, University of Queensland
Jonathan Gershenzon, Max Planck Institute for Chemical Ecology
De-an Guo, Shanghai Institute of Materia Medica
Mahabir P. Gupta,
Massuo Jorge Kato, University of São Paulo
Ikhlas A. Khan, University of Mississippi
Toni M. Kutchan, Donald Danforth Plant Science Center
Rachel Mata, Universidad Nacional Autónoma de Mexico
Susan McCormick, United States Dept. of Agriculture
Cecilia A. McIntosh, East Tennessee State University
Birger Lindberg Møller, University of Copenhagen
W. David Nes, Texas Tech University
Hermann M. Niemeyer, Universidad de Chile
M. Soledade C. Pedras, University of Saskatchewan
John M. Pezzuto, University of Hawaii at Hilo
Richard Robins, Université de Nantes
Michel Rohmer, Université de Strasbourg
Rosario Rojas,
Kazuki Saito, RIKEN and Chiba University,
Joachim Stöckigt, Zhejiang University
Dieter Strack, Leibniz-Institute of Plant Biochemistry
Hermann Stuppner, University of Innsbruck
Toshiaki Umezawa, Kyoto University
Robert Verpoorte, Leiden University
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Organizing Committee
Norman G. Lewis, Ph.D. John M. Pezzuto, Ph.D.
Committee Chair Local Host
Director, Institute of Biological Chemistry Professor and Dean College of Pharmacy
Washington State University University of Hawai’i at Hilo
Charles L. Cantrell, Ph.D. Cecilia A. Mcintosh, Ph.D.
PSNA President PSNA President-Elect
National Center for Natural Products Research Professor, Biological Sciences
USDA-ARS Dean, School of Graduate Studies
East Tennessee State University
David R. Gang, Ph.D. Mark A. Bernards, Ph.D.
PSNA Past-President PSNA Past-President
Associate Professor and Fellow Professor & Chair
Institute of Biological Chemistry Department of Biology
Washington State University The University of Western Ontario
John Thor Amason, Ph.D. Laurence B. Davin, Ph.D.
Professor of Biology Institute of Biological Chemistry
Department of Biology Washington State University
University of Ottawa
Judith Fox-Goldstein, CFEE
Administrative Director
University of Hawai’i at Hilo
Conference Center

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Meeting Program
SATURDAY 10 DECEMBER
03:00–05:00 pm Executive Committee Meeting
Plaza III
02:30–08:30 pm Registration and Information Table
Paniolo Hospitality
02:30–06:00 pm Poster Setup
Salon III & Ballroom Courtyard
06:00–08:30 pm Welcome Reception
Turtle Point

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SUNDAY 11 DECEMBER
07:30–03:30 Registration and Information Table
Grande Ballroom Foyer
Opening Remarks: Salon I, II
08:00–08:10 Hawaiian Protocol
John M. Pezzuto and Norman G. Lewis
08:10–08:15 Welcome Address: William "Billy" Kenoi, Mayor of Hawaii
08:15–08:35 Eric E. Conn (University of California at Davis) OR1
PSNA: Some reflections
Session 1: PSNA Plenary Session – A Celebration Salon I, II
Chair: Norman G. Lewis
08:40–09:20 Chulabhorn Mahidol (Chulabhorn Graduate Institute) S1.1
Natural products with biological activities from Thai bioresources
09:20–10:00 Koji Nakanishi (Columbia University) S1.2
Ginkgolides - Structures, reactions and bioactivities
10:00–10:30 Break Ballroom Courtyard & Grande Ballroom Foyer
10:30–11:10 Mansukh C. Wani (RTI International) S1.3
From yew to me to you: A personal history of the discovery and
development of plant-derived anticancer agent, taxol
11:10–11:50 Daneel Ferreira (University of Mississippi) S1.4
Half a century of proanthocyanidin/polyphenol research
11:50–12:00 pm Photos
12:00–01:00 Lunch Ballroom Courtyard & Grande Ballroom Foyer
12:00–01:00 Finding a Graduate Program Workshop Plaza Ballroom
Chair: Daniel Owens
Panelists: Aruna Kilaru, Norman G. Lewis, Cecilia A. McIntosh, and
John Romeo
01:00–06:00 Concurrent Session 2: The Legacy of Meinhart H. Zenk S2
Salon I, II
Concurrent Session 3: Natural Products in Agriculture S3
Promenade Ballroom
Concurrent Session 4: Chemoprevention S4
Plaza Ballroom
07:00–10:00 Poster Session I and Student/Postdoctoral Fellow Competition – Reception
Salon III & Ballroom Courtyard

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SUNDAY 11 DECEMBER
Concurrent Session 2: The Legacy of Meinhart H. Zenk Salon, I, II
Chair: Nick Amrhein
01:00–01:30 Norman G. Lewis (Washington State University) S2.1
The road from Munich: Meinhart H. Zenk’s legacy
01:30–02:00 Birger Lindberg Møller (University of Copenhagen) S2.2
Functioning dependent metabolons: The "oxime bomb" in cyanogenic
glucoside metabolism
02:00–02:30 Fumihiko Sato (Kyoto University) S2.3
The great footprints of the late Prof. Meinhart Zenk in isoquinoline alkaloid
biosynthesis studies
02:30–03:00 Kazuki Saito (Chiba University and RIKEN) S2.4
Biosynthetic study of quinolizidine alkaloid – History and recent
advancement
03:00–03:30 Joachim Stöckigt (Zhejiang University) S2.5
Alkaloid synthesis beyond the Rauvolfia alkaloidal network
03:30–04:00 Break Ballroom Courtyard & Grande Ballroom Foyer
04:00–04:30 Wanchai De-Eknambul (Chulalongkorn University) S2.6
My research experience with Prof. Meinhart Zenk, the pioneer of
benzylisoquinoline alkaloid biosynthesis
04:30–05:00 Vincenzo De Luca (Brock University) S2.7
Catharanthus roseus expresses a leaf epidermis specific amyrin synthase
involved in triterpene biosynthesis
05:00–05:30 Kazufumi Yazaki (Kyoto University) S2.8
Membrane transport of alkaloid in plants
05:30–06:00 Jan Frederik Stevens (Oregon State University) S2.9
Xanthohumol from hops (Humulus lupulus): Pharmacokinetics and effects
on biomarkers of metabolic syndrome in rats
07:00–10:00 Poster Session I – Student/Postdoctoral Fellow Competition – Reception
Salon III & Ballroom Courtyard

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SUNDAY 11 DECEMBER
Concurrent Session 3: Natural Products in Agriculture Promenade Ballroom
Chair: Murray B. Isman
01:00–01:30 Stephen O. Duke (United States Department of Agriculture) S3.1
Phytochemicals and genes for their synthesis in pest management
01:30–02:00 Suzanne R. Abrams (Plant Biotechnology Institute, NRC) S3.2
Improved crop productivity through manipulation of phytohormone signaling
02:00–02:30 Robert Stipanovic (United States Department of Agriculture) S3.3
Biosynthesis of gossypol in cotton: From farnesyl diphosphate to (+)- and
(–)-gossypol
02:30–03:00 M. Soledade C. Pedras (University of Saskatchewan) S3.4
Natural products in agriculture: The arms race between crucifers and their
fungal pathogens
03:00–03:30 Murray B. Isman (University of British Columbia) S3.5
Insecticides based on plant natural products: Long on promise, short on
products
03:30–04:00 Break Ballroom Courtyard & Grande Ballroom Foyer
04:00–04:15 Russell L. Rouseff (University of Florida) O3.1
Sulfur volatiles in Allium canadense and A. tuberosum
04:15–04:30 Efraim Lewinsohn (Newe Ya’ar Research Center) O3.2
L-Methionine catabolism into sulfur aroma volatiles in melon fruits
04:30–04:45 Mitchell L. Wise (United States Department of Agriculture) O3.3
Plant defense activators as elicitors of oat avenanthramide biosynthesis
04:45–05:00 Charles L. Cantrell (United States Department of Agriculture) O3.4
Identification of the mosquito biting deterrent constituents from the Indian
folk remedy plant, Jatrophas curcas
05:00–05:15 Anthony D. Wright (University of Hawaii at Hilo) O3.5
Correlation between tea leaf age and chemical content and shade levels
05:15–05:30 Roslyn Gleadow (Monash University) O3.6
Impact of climate on allocation of N to cyanogenic glucosides
07:00–10:00 Poster Session I – Student/Postdoctoral Fellow Competition – Reception
Salon III & Ballroom Courtyard

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