Pharmacokinetics and Dosing of Antibiotics in Neonates

119 Pages·2007·0.8 MB·English

Pharmacokinetics and dosing of antibiotics in
neonates
Citation for published version (APA):
Pullen, J. (2007). Pharmacokinetics and dosing of antibiotics in neonates. [Doctoral Thesis, Maastricht
University]. Datawyse / Universitaire Pers Maastricht. https://doi.org/10.26481/dis.20070426jp
Document status and date:
Published: 01/01/2007
DOI:
10.26481/dis.20070426jp
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Download date: 18 Feb. 2023
Pharmacokinetics and Dosing of Antibiotics in Neonates
The studies in this thesis and publication of this thesis were financially supported by a grant
from the ‘Profileringsfonds’ of the University Hospital of Maastricht.

Publication of this thesis was financially supported by:

VB-GROEP BVBA

GlaxoSmithKline BV

Novartis Pharma BV

Pharmachemie BV

Copyright © 2007 J. Pullen, Maastricht
ISBN 978-90-5278-617-9

Cover design: Robbert Oidtmann
Printing and layout: Datawyse Boekproducties Maastricht
Pharmacokinetics and Dosing of Antibiotics in Neonates

PROEFSCHRIFT

ter verkrijging van de graad van doctor aan de Universiteit Maastricht, op gezag van de
Rector Magnificus, prof. mr. G.P.M.F. Mols, volgens het besluit van het College van
Decanen, in het openbaar te verdedigen op donderdag 26 april 2007 om 14.00 uur

door

Joyce Pullen

geboren op 31 maart 1982 te Eindhoven
U
P
M
UNIVERSITAIRE
PERSMAASTRICHT
Promotores
Prof. dr. L.J.I. Zimmermann
Prof. dr. C. Neef

Copromotores
Dr. L.M.L. Stolk
Dr. P.L.J. Degraeuwe

Beoordelingscommissie
Prof. dr. J.F.M. Smits (voorzitter)
Prof. dr. J.N. van den Anker (George Washington University School of Medicine and Health
Sciences, Washington, DC)
Prof. dr. C.A. Bruggeman
Dr. D.J. Touw (Apotheek Haagse Ziekenhuizen)
De gezonde mens heeft
duizend wensen,
de zieke slechts één.
Ton Luiting, dichter

Contents

Chapter 1 General Introduction 9

Chapter 2 Microanalysis of Amoxicillin, Flucloxacillin, and Rifampicin in Neonatal 17
Plasma

Chapter 3 Population Pharmacokinetics and Dosing of Amoxicillin in (Pre)term 31
Neonates

Chapter 4 Amoxicillin Pharmacokinetics in (Preterm) Infants Aged 10 to 52 Days: 47
Effect of Postnatal Age

Chapter 5 Population Pharmacokinetics and Dosing of Flucloxacillin in Preterm 55
and Term Neonates

Chapter 6 Protein Binding of Flucloxacillin in Neonates 69

Chapter 7 Pharmacokinetics of Intravenous Rifampicin (Rifampin) in Neonates 81

Chapter 8 Application of Artificial Neural Network Modeling to Predict Gentamicin 95
Clearance in Neonates: Preliminary Study

Chapter 9 General Discussion and Future Perspectives 103

Summary 107

Samenvatting 111

Dankwoord 115

Curriculum Vitae 117

List of Publications 119

1

Chapter 1
General Introduction
9