Table Of ContentPATHOLOGY OF LABORATORY RODENTS AND RABBITS
F O U R T H E D I T I O N
PATHOLOGY OF
LABORATORY
RODENTS AND
RABBITS
Stephen W. Barthold, DVM, MS, PhD, Dipl. ACVP
Distinguished Professor Emeritus
Veterinary and Medical Pathology
University of California
Davis, CA
Stephen M. Griffey, DVM, PhD
Clinical Professor of Laboratory Animal Pathology
Director of the Comparative Pathology Laboratory
School of Veterinary Medicine
University of California
Davis, CA
Dean H. Percy, DVM, MSc, PhD, Dipl. ACVP
Professor Emeritus
Pathobiology Department
Ontario Veterinary College
Guelph, Ontario
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Contents
Preface vii 2 Rat 119
Introduction, 119
About the companion website ix
Anatomic Features, 119
Bibliography for Behavioral and Anatomic
1 Mouse 1
Features, 121
Introduction, 1
General References on Diseases of Rats, 121
Mouse Genetics and Genomics, 2
DNA Viral Infections, 121
Nomenclature, 2
RNA Viral Infections, 125
Common Inbred Strains, 3
Bibliography for Viral Infections, 130
Genomic Considerations for the Pathologist, 4
Bacterial Infections, 132
Anatomic Features, 5
Fungal Infections, 145
Immunologic Idiosyncracies, 10
Bibliography for Bacterial and Fungal Infections, 148
Bibliography for Introduction Through Anatomic
Parasitic Diseases, 151
Features, 11
Bibliography for Parasitic Diseases, 154
General References on Diseases of Mice, 12
Age-Related Disorders, 154
Infections of Laboratory Mice: Effects on
Miscellaneous Disorders, 159
Research, 12
Environmental Disorders, 161
Bibliography for Infections of Laboratory Mice:
Drug-Related Disorders, 162
Effects on Research, 13
Bibliography for Age-, Miscellaneous-, Environmental-
DNA Viral Infections, 14
and Drug-Related Disorders, 162
RNA Viral Infections, 23
Neoplasms, 164
Retroelements and Retrovirus Infections, 38
Bibliography for Neoplasms, 170
Bibliography for Viral Infections, 44
Bacterial Infections, 50
3 Hamster 173
Bibliography for Bacterial Infections, 72
Introduction, 173
Fungal Infections, 78
Anatomic Features, 173
Bibliography for Fungal Infections, 81
Bibliography for Introduction and Anatomic
Parasitic Diseases, 82
Features, 174
Bibliography for Parasitic Diseases, 88
DNA Viral Infections, 175
Behavioral Disorders, 89
RNA Viral Infections, 178
Bibliography for Behavioral Disorders, 91
Bibliography for Viral Infections, 179
Aging, Degenerative, and Miscellaneous Disorders, 91
Bacterial and Fungal Infections, 180
Bibliography for Aging, Degenerative, and
Bibliography for Bacterial and Fungal Infections, 186
Miscellaneous Disorders, 106
Parasitic Diseases, 188
Neoplasms, 108
Bibliography for Parasitic Diseases, 192
Bibliography for Neoplasms, 117
Nutritional and Metabolic Disorders, 193
v
vi Contents
Diseases Associated With Aging, 194
Bibliography for Nutritional, Metabolic, and Toxic
Environomental, Genetic, and Other Disorders, 196
Disorders, 244
Bibliography for Noninfectious Diseases, 197
Miscellaneous Other Disorders, 245
Neoplasms, 197
Bibliography for Miscellaneous Disorders, 249
Bibliography for Neoplasms, 198
Neoplasms, 250
Bibliography for Neoplasms, 252
4 Gerbil 199
Introduction, 199
6 Rabbit 253
Anatomic Features, 199
Introduction, 253
Bibliography for Anatomic Features, 200
Behavioral, Physiologic, and Anatomic Features, 253
Viral Infections, 200
Bibliography for Behavioral, Physiologic, and
Bibliography for Viral Infections, 201
Anatomic Features, 257
Bacterial Infections, 201
DNA Viral Infections, 257
Bibliography for Bacterial Infections, 204
RNA Viral Infections, 264
Parasitic Diseases, 204
Bibliography for Viral Infections, 269
Bibliography for Parasitic Diseases, 205
Bacterial Infections, 271
Genetic, Metabolic, and Other Disorders, 206
Bibliography for Bacterial Infections, 288
Bibliography for Genetic, Metabolic, and Other
Fungal Infections, 292
Disorders, 209
Bibliography for Fungal Infections, 296
Neoplasms, 209
Parasitic Diseases, 297
Bibliography for Neoplasms, 211
Bibliography for Parasitic Diseases, 304
Noninfectious Gastrointestinal Disorders, 306
Bibiliography for Noninfectious Gastrointestinal
5 Guinea Pig 213
Disorders, 308
Behavioral, Physiologic, and Anatomic Features, 213
Aging and Miscellaneous Disorders, 308
Bibliography for Behavioral, Physiologic, and
Bibliography for Aging and Miscellaneous
Anatomic Features, 217
Disorders, 312
Viral Infections, 218
Nutritional, Metabolic and Toxic Disorders, 313
Bibliography for Viral Infections, 221
Bibliography for Nutritional, Metabolic, and Toxic
Bacterial Infections, 222
Disorders, 316
Bibliography for Bacterial Infections, 231
Genetic Disorders, 318
Fungal Infections, 234
Bibliography for Genetic Disorders, 319
Bibliography for Fungal Infections, 235
Neoplasms, 320
Parasitic Diseases, 235
Bibliography for Neoplasms, 323
Bibliography for Parasitic Diseases, 239
Nutritional, Metabolic, and Toxic Disorders, 239
Index 325
Preface
The Fourth Edition of Pathology of Laboratory Rodents and assistance of his friend and colleague, Stephen Griffey.
Rabbits has been extensively revised in response to Reviewers suggested a third, younger author (Dr. Griffey)
reviewers’ and colleagues’ comments, as well as addition to carry on the tradition of this text in future editions.
of new material that has arisen since the Third edition Dr. Griffey, like Drs. Percy and Barthold, is a veterinary
was published in 2007. In particular, the chapter on pathologist with extensive experience and expertise in
rabbits has been significantly revised and expanded. A laboratory animal pathology.
resounding message from reviewers and colleagues was Delving into the literature has been a thought-
to publish this edition in color. Technology has provoking journey down memory lane. Many of the
advanced such that color images are not only possible contributors to the laboratory animal pathology field
but also cost-effective. The images in this text are non are deceased. Unfortunately, younger members of our
pareil, and have been generously contributed by col profession must forego the privilege of personally know
leagues, gleaned from the recent literature, and derived ing these giants upon whose shoulders our field has been
from personal collections of the authors. built. Discovery of new diseases continues, but not at the
Also notable in this edition is the change in author pace that took place in the 1970s and 1980s.
ship. Dean Percy has fully retired as an active author of This book is dedicated to our families, our mentors,
this text, but his significant input remains throughout our colleagues, and our students . . . past, present, and
the text from previous editions. This book was his dream, future. It is especially dedicated to the subjects of this
and its long-term success since publication of the First text: laboratory rodents and rabbits. They contribute
Edition in 1993 can be largely attributed to his vision, enormously to biomedical and veterinary science, and
energy, and perseverance. Stephen Barthold stepped up deserve our respect and full support.
to the leadership for this edition, with the considerable
vii
