Orlando, G: Transplantation, Bioengineering, and Regeneratio

816 Pages·2019·18.948 MB·English

by  Giuseppe Orlando (editor), Lorenzo Piemonti (editor), Camillo Ricordi (editor), Robert J. Stratta (editor), Rainer W.G. Gruessner (editor)

TRANSPLANTATION, BIOENGINEERING,
AND REGENERATION OF THE
ENDOCRINE PANCREAS
TRANSPLANTATION,
BIOENGINEERING,
AND
REGENERATION
OF THE ENDOCRINE
PANCREAS
VOLUME 1
Edited by
Giuseppe Orlando
Lorenzo Piemonti
Camillo Ricordi
Robert J. Stratta
Rainer W.G. Gruessner
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Dedications
To our patients who entrust us with their lives for the prevention and cure of diabetes mellitus.
The secret of the care of the patient is in caring for the patient. Francis Peabody, American Physician, 1927
To the pioneers of transplant and regenerative medicine who laid the foundations of our work.
If I have seen further, it is by standing on the shoulders of giants. Sir Isaac Newton, 1676
Contributors
Peter Abrams MedStar Georgetown Transplant Institute, Alain Gerald Bertoni Wake Forest School of Medicine,
Georgetown University School of Medicine, Washington, Department of Epidemiology & Prevention,
DC, United States Winston-Salem, NC, United States
Joel T. Adler Department of Surgery, Division of Federico Bertuzzi Diabetology Unit, Niguarda Hospital,
Transplantation, University of Wisconsin-Madison School of Milano, Italy
Medicine and Public Health, Madison, WI, United States Ugo Boggi Division of General and Transplant Surgery,
Rodolfo Alejandro Diabetes Research Institute; Department University of Pisa, Pisa, Italy
of Medicine, Division of Endocrinology, Diabetes and Caroline Bonner Université de Lille, INSERM U1190,
Metabolism, University of Miami Miller School of Translational Research for Diabetes, EGID (European
Medicine, Miami, FL, United States Genomic Institute for Diabetes), Faculté de Médecine;
Mohamed Alibashe-Ahmed Division of Transplantation, Institut Pasteur de Lille, Lille, France
Department of Surgery, Cell Isolation and Transplantation Adel Bozorgzadeh Department of Surgery, Division of
Center, University of Geneva Hospitals and School of Transplant, University of Massachusetts, Worcester, MA,
Medicine, Geneva, Switzerland United States
Ana Alvarez Diabetes Research Institute, University of Julien Branchereau Centre de Recherche en Transplantation
Miami Miller School of Medicine, Miami, FL, United States et Immunologie (CRTI), Inserm, Université de Nantes;
Takayuki Anazawa Division of Hepato-Biliary-Pancreatic Institut de Transplantation Urologie Néphrologie (ITUN),
Surgery and Transplantation, Department of Surgery, CHU Nantes, Nantes, France
Graduate School of Medicine, University of Kyoto, Kyoto, Jonathan Bromberg Department of Surgery, University of
Japan Maryland School of Medicine, Baltimore, MD, United
Axel Andres Division of Transplantation, Department of States
Surgery, Cell Isolation and Transplantation Center, George W. Burke, III Miami Transplant Institute, Jackson
University of Geneva Hospitals and School of Medicine, Memorial Hospital; Department of Surgery, Division of
Geneva, Switzerland Transplantation; Diabetes Research Institute, University of
Barbara Antonioli Tissue Therapy Unit, Niguarda Hospital, Miami Miller School of Medicine, Miami, FL, United States
Milano, Italy Fanny Buron Hospices Civils de Lyon, Edouard Herriot
Alan Apete Université de Lille, INSERM U1190, Hospital, Department of Transplantation, Nephrology and
Translational Research for Diabetes, EGID (European Clinical Immunology, Lyon, France
Genomic Institute for Diabetes), Faculté de Médecine, Robert Caiazzo Université de Lille, INSERM U1190,
Lille, France Translational Research for Diabetes, EGID (European
David A. Axelrod University of Iowa, Iowa City, IA, United Genomic Institute for Diabetes), Faculté de Médecine;
States Department of General and Endocrine Surgery, CHU Lille,
Lionel Badet Service d’urologie et de chirurgie de la Lille, France
transplantation, Hospices Civils de Lyon, Lyon, France Rossana Caldara Department of Internal Medicine,
David Baidal Diabetes Research Institute; Department of Transplant Medicine Unit, IRCCS San Raffaele Scientific
Medicine, Division of Endocrinology, Diabetes and Institute, Milano, Italy
Metabolism, University of Miami Miller School of Stephanie S. Camhi University of Miami Miller School of
Medicine, Miami, FL, United States Medicine, MD/MPH Program, Miami, FL, United States
Kaylene Barrera Department of Surgery, State University of Diego Cantarovich Centre de Recherche en Transplantation
New York (SUNY) Downstate Medical Center, Brooklyn, et Immunologie (CRTI), Inserm, Université de Nantes;
NY, United States Institut de Transplantation Urologie Néphrologie (ITUN),
Pierre-Yves Benhamou Department of Endocrinology, CHU Nantes, Nantes, France
Grenoble University Hospital, Grenoble, France Massimo Cardillo UOC Coordinamento Trapianti, Milano,
Thierry Berney Division of Transplantation, Department of Italy
Surgery, Cell Isolation and Transplantation Center, D. Castanares-Zapatero Critical Care Department,
University of Geneva Hospitals and School of Medicine, Cliniques universitaires St Luc, Université Catholique de
Geneva, Switzerland Louvain, Brussels, Belgium
xvii
xviii Contributors
Pierre Cattan Department of Digestive Surgery, University Hector De Leon University of Arizona, Department of
Hospital Saint-Louis, Paris, France Surgery, Institute of Cellular Transplantation, Tucson, AZ,
United States
Suresh Rama Chandran Department of Diabetes Research
(Denmark Hill), King’s College London, London, United Nathalie Delalleau Université de Lille, INSERM U1190,
Kingdom; Department of Endocrinology, Level III, Translational Research for Diabetes, EGID (European
Academia, Singapore General Hospital, Singapore, Genomic Institute for Diabetes), Faculté de Médecine,
Singapore Lille, France
Erin Chang Department of Surgery, State University of Laura DiChiacchio Department of Surgery, University of
New York (SUNY) Downstate Medical Center, Brooklyn, Maryland School of Medicine, Baltimore, MD, United States
NY, United States
Jason B. Doppenberg Department of Internal Medicine,
Linda Chen Miami Transplant Institute Jackson Memorial Leiden University Medical Center, Leiden, The
Hospital; Department of Surgery, Division of Netherlands
Transplantation, University of Miami Miller School of
Cinthia B. Drachenberg Department of Pathology;
Medicine, Miami, FL, United States
Department of Surgery, University of Maryland School of
Mikael Chetboun Université de Lille, INSERM U1190, Medicine, Baltimore, MD, United States
Translational Research for Diabetes, EGID (European
Erica Dugnani IRCCS Ospedale San Raffaele, San Raffaele
Genomic Institute for Diabetes), Faculté de Médecine;
Diabetes Research Institute, Milan, Italy
Department of General and Endocrine Surgery, CHU Lille;
Service de Chirurgie de l’Obésité, Centre Hospitalier Ty B. Dunn University of Pennsylvania, Philadephia, PA,
Universitaire de Lille, Lille, France USA
Pratik Choudhary Department of Diabetes Research Marten A. Engelse Department of Internal Medicine,
(Denmark Hill), King’s College London, London, United Leiden University Medical Center, Leiden, The
Kingdom Netherlands
Gaetano Ciancio Miami Transplant Institute, Jackson Ahmed Farag Miami Transplant Institute, Jackson
Memorial Hospital; Department of Surgery, Division of Memorial Hospital, University of Miami Miller School of
Transplantation, University of Miami Miller School of Medicine, Miami, FL, United States
Medicine, Miami, FL, United States Alan Farney Department of Surgery, Wake Forest Baptist
Maria Pia Cicalese San Raffaele Telethon Institute for Gene Medical Center, Winston-Salem, NC, United States
Therapy (HSR-TIGET); Pediatric Immunohematology and Anne Elizabeth Farrow Annette C. and Harold C.
Bone Marrow Transplantation Unit, IRCCS San Raffaele Simmons Transplant Institute, Baylor University Medical
Scientific Institute, Milan, Italy Center, Dallas, TX, United States
Antonio Citro IRCCS Ospedale San Raffaele, San Raffaele Ibrahim Fathi Division of Transplantation and
Diabetes Research Institute, Milan, Italy Regenerative Medicine, Tohoku University, Sendai, Japan
C. Collienne Critical Care Department, Cliniques Jose Figueiro Miami Transplant Institute, Jackson Memorial
universitaires St Luc, Université Catholique de Louvain, Hospital; Department of Surgery, Division of
Brussels, Belgium Transplantation, University of Miami Miller School of
Caterina Conte Vita-Salute San Raffaele University; Clinical Medicine, Miami, FL, United States
Transplant Unit, Division of Immunology, Transplantation Anneliese Flatt Institute of Cellular Medicine, Newcastle
and Infectious Diseases, IRCCS San Raffaele Scientific University, Newcastle upon Tyne, United Kingdom
Institute, Milano, Italy
Georgia Fousteri Division of Immunology Transplantation
Claire Counter Statistics and Clinical Studies, NHS Blood and Infectious Diseases (DITID), Diabetes Research
and Transplant, Bristol, United Kingdom Institute (DRI) IRCCS San Raffaele Scientific Institute,
Khaled Z. Dajani Department of Surgery and Clinical islet Milan, Italy
Transplant Program, University of Alberta, Edmonton, AB, Jonathan A. Fridell Department of Surgery, Indiana
Canada University School of Medicine, Indianapolis, IN, United
Carly M. Darden Institute of Biomedical Studies, Baylor States
University, Waco; Islet Cell Laboratory, Baylor University Peter J. Friend Nuffield Department of Surgical Sciences,
Medical Center, Baylor Scott and White Research Institute, University of Oxford, Oxford, United Kingdom
Dallas, TX, United States
Giacomo Gastaldi Division of Diabetes/Endocrinology,
Francesco De Cobelli Department of Radiology and Center Department of Internal Medicine, University of Geneva
for Experimental Imaging, IRCCS San Raffaele Scientific Hospitals, Geneva, Switzerland
Institute, Milano, Italy
Valery Gmyr Université de Lille, INSERM U1190,
Eelco J.P. de Koning Department of Internal Medicine, Translational Research for Diabetes, EGID (European
Leiden University Medical Center, Leiden, The Genomic Institute for Diabetes), Faculté de Médecine,
Netherlands Lille, France
Contributors xix
Javier Gonzalez Servicio de Urología, Hospital General Raja Kandaswamy Division of Transplantation,
Universitario Gregorio Marañón, Madrid, Spain Department of Surgery, University of Minnesota,
Jeevan Prakash Gopal West London Renal and Minneapolis, MN, United States
Transplant Centre, Hammersmith Hospital, Imperial Georges Karam Centre de Recherche en Transplantation et
College Healthcare NHS Trust, London, United Immunologie (CRTI), Inserm, Université de Nantes;
Kingdom Institut de Transplantation Urologie Néphrologie (ITUN),
CHU Nantes, Nantes, France
Frans K. Gorus Diabetes Research Center, Vrije Universiteit
Brussel; Department of Clinical Chemistry, Universitair Dixon B. Kaufman Department of Surgery, UW School of
Ziekenhuis Brussel, Brussels, Belgium Medicine and Public Health, UW-Madison SMPH,
Madison, WI, United States
Masafumi Goto Division of Transplantation and
Regenerative Medicine, Tohoku University, Sendai, Japan WF Kendall Jr University of Florida-Halifax Health Center
for Transplant Services, Daytona Beach, FL, United States
Mitsukazu Gotoh Osaka General Medical Center, Osaka,
Japan Clark D. Kensinger Department of Surgery, Division of
Transplantation, University of Wisconsin-Madison School
Michel Greget Department of Radiology, University
of Medicine and Public Health, Madison, WI, United
Hospital, Strasbourg, France
States
Dominique Grenet Department of Pneumology, Foch
Norma S. Kenyon Diabetes Research Institute; Department
Hospital, Suresnes, France
of Surgery, Division of Cellular Transplantation, University
Paolo Antonio Grossi Infectious Diseases Section,
of Miami Miller School of Medicine, Miami, FL, United
Department of Medicine and Surgery, University of
States
Insubria, Varese; ID Consultant National Center for
Julie Kerr-Conte Université de Lille, INSERM U1190,
Transplantation, Rome, Italy
Translational Research for Diabetes, EGID (European
Rainer W.G. Gruessner Department of Surgery, State
Genomic Institute for Diabetes), Faculté de Médecine,
University of New York (SUNY) Downstate Medical
Lille, France
Center, Brooklyn, NY, United States
Delphine Kervella Centre de Recherche en Transplantation
Angelika C. Gruessner Department of Nephrology, SUNY et Immunologie (CRTI), Inserm, Université de Nantes;
Downstate Medical Center, New York, NY; School of Institut de Transplantation Urologie Néphrologie (ITUN),
Public Health, University of Arizona, Tucson, AZ, United CHU Nantes, Nantes, France
States
Laurence Kessler Department of Diabetology, University
David I. Harriman Department of Surgery, Wake Forest Hospital; INSERM–UMR 1260, Regenerative
Baptist Medical Center, Winston-Salem, NC, United States Nanomedicine, Federation of Translational Medicine,
Wayne J. Hawthorne National Pancreas and Islet University of Strasbourg; Service d’Endocrinologie Diabète
Transplant Laboratories, The Westmead Institute for et Maladies Métaboliques, Hôpitaux Universitaires de
Medical Research; Department of Surgery, Westmead Strasbourg, Strasbourg, France
Clinical School, University of Sydney, Westmead Hospital, Romain Kessler INSERM–UMR 1260, Regenerative
Westmead, NSW, Australia Nanomedicine, Federation of Translational Medicine,
Jarl Hellman Department of Medical Sciences, Uppsala University of Strasbourg; Department of Pneumology,
University, Uppsala, Sweden University Hospital, Strasbourg, France
Brenda Lee Holbert Wake Forest School of Medicine, Bart Keymeulen Diabetes Research Center, Vrije
Department of Radiology, Wake Forest Baptist Medical Universiteit Brussel; Department of Diabetology,
Center, Winston-Salem, North Carolina, United States Universitair Ziekenhuis Brussel, Brussels, Belgium
Thomas Hubert Université de Lille, INSERM U1190, Olle Korsgren Department of Immunology, Genetics and
Translational Research for Diabetes, EGID (European Pathology, Uppsala University, Uppsala; Department of
Genomic Institute for Diabetes), Faculté de Médecine, Biomedicine, University of Gothenburg, Gothenburg,
Lille, France Sweden
Sara Iacopi Division of General and Transplant Surgery, Sandrine Lablanche Department of Endocrinology,
University of Pisa, Pisa, Italy Grenoble University Hospital, Grenoble, France
Marco Infante Diabetes Research Institute, University of Muhaib Lakhani Islet Cell Laboratory, Baylor University
Miami Miller School of Medicine, Miami, FL, United Medical Center, Baylor Scott and White Research Institute,
States; Department of Systems Medicine, University of Dallas, TX, United States
Rome “Tor Vergata”, Rome, Italy
Neeraj Lalwani Wake Forest School of Medicine,
Peter Jacob Department of Diabetes Research (Denmark Department of Radiology, Wake Forest Baptist Medical
Hill), King’s College London, London, United Kingdom Center, Winston-Salem, North Carolina, United States
Paul Johnson Oxford Centre for Diabetes, Endocrinology P.F. Laterre Critical Care Department, Cliniques
and Metabolism, Oxford University, Oxford, United universitaires St Luc, Université Catholique de Louvain,
Kingdom Brussels, Belgium
xx Contributors
Michael C. Lawrence Islet Cell Laboratory, Baylor Irene Mosca Nuffield Department of Surgical Sciences,
University Medical Center, Baylor Scott and White University of Oxford, Oxford, United Kingdom
Research Institute, Dallas, TX, United States M. Mourad Surgery and Abdominal Transplantation
Frances Tangherlini Lee Department of Surgery, Department, Cliniques universitaires St Luc, Université
Northwestern University; McGaw Medical Center, Catholique de Louvain, Brussels, Belgium
Evanston, IL, United States Anand S. Rathnasamy Muthusamy West London Renal
Roger Lehmann Department of Endocrinology, Diabetes, and Transplant Centre, Hammersmith Hospital, Imperial
and Clinical Nutrition, University Hospital Zurich, Zürich, College Healthcare NHS Trust; Academic Department of
Switzerland Surgery, Imperial College, London, United Kingdom
Elina Linetsky Diabetes Research Institute; Department of Rita Nano Diabetes Research Institute, IRCCS San Raffaele
Surgery, Division of Cellular Transplantation, University of Scientific Institute, Milano, Italy
Miami Miller School of Medicine, Miami, FL, United States
Bashoo Naziruddin Annette C. and Harold C. Simmons
Barbara Ludwig Department of Medicine III, University Transplant Institute, Baylor University Medical Center,
Hospital Carl Gustav Carus, Dresden, Germany Dallas, TX, United States
Torbjörn Lundgren Department of Transplantation Surgery, Christian Noel Department of Nephrology, CHU Lille,
Karolinska University Hospital; Department of Clinical Lille, France
Science, Intervention and Technology, Karolinska Institute,
John O’Callaghan Oxford Transplant Centre, Oxford
Solna, Sweden
University Hospitals, Oxford, United Kingdom
Xunrong Luo Department of Nephrology and
Jon S. Odorico Department of Surgery, Division of
Hypertension, Northwestern University; McGaw Medical
Transplantation, University of Wisconsin-Madison, School
Center, Evanston, IL, United States
of Medicine and Public Health, Madison, WI, United States
SriGita Madiraju Florida Atlantic University, Charles E.
Anne Olland INSERM–UMR 1260, Regenerative
Schmidt School of Medicine, Boca Raton, FL, United States
Nanomedicine, Federation of Translational Medicine,
Paola Maffi Diabetes Research Institute, IRCCS San University of Strasbourg; Department of Thoracic Surgery,
Raffaele Scientific Institute, Milano, Italy University Hospital, Strasbourg, France
Paola Magistretti Diabetes Research Institute, IRCCS San EC Opara Institute for Regenerative Medicine, Biomedical
Raffaele Scientific Institute, Milano, Italy Engineering, Wake Forest Medical School, Winston Salem,
Kristell Le Mapihan Department of Endocrinology NC, United States
Diabetology and Metabolism, CHU Lille, Lille, France
Giuseppe Orlando Department of Surgery, Division of
James F. Markmann Division of Transplantation, Transplant, Wake Forest University School of Medicine,
Department of Surgery, Massachusetts General Hospital; Wiston Salem, NC, United States
Center for Transplantation Sciences, Department of
Nathalia Padilla Diabetes Research Institute, University of
Surgery, Massachusetts General Hospital, Harvard Medical
Miami Miller School of Medicine, Miami, FL, United States
School, Boston, MA, United States
John C. Papadimitriou Department of Pathology;
Geert Martens Diabetes Research Center, Vrije Universiteit
Department of Surgery, University of Maryland School of
Brussel, Brussels; Department of Laboratory Medicine,
Medicine, Baltimore, MD, United States
Algemeen Ziekenhuis Delta, Roeselare, Belgium
Vassilios E. Papalois West London Renal and Transplant
Paulo N. Martins Department of Surgery, Division of
Centre, Hammersmith Hospital, Imperial College
Transplant, University of Massachusetts, Worcester, MA,
Healthcare NHS Trust; Academic Department of Surgery,
United States
Imperial College, London, United Kingdom
Francesco Antonio Mazzotta Department of Systems
Klearchos K. Papas University of Arizona, Department of
Medicine, University of Rome Tor Vergata, Rome, Italy
Surgery, Institute of Cellular Transplantation, Tucson, AZ,
Kavya Chitra Mekala Wake Forest School of Medicine, United States
Section on Endocrinology & Metabolism, Winston-Salem,
Gianni Pasquetti Université de Lille, INSERM U1190,
NC, United States
Translational Research for Diabetes, EGID (European
Raffaella Melzi Diabetes Research Institute, IRCCS San Genomic Institute for Diabetes), Faculté de Médecine,
Raffaele Scientific Institute, Milano, Italy Lille, France
Alessia Mercalli Diabetes Research Institute, IRCCS San François Pattou Université de Lille, INSERM U1190,
Raffaele Scientific Institute, Milano, Italy Translational Research for Diabetes, EGID (European
Paolo Monti Diabetes Research Institute, IRCCS San Genomic Institute for Diabetes), Faculté de Médecine;
Raffaele Scientific Institute, Milan, Italy Department of General and Endocrine Surgery, CHU Lille;
Service de Chirurgie de l’Obésité, Centre Hospitalier
Mahmoud Morsi Miami Transplant Institute, Jackson
Universitaire de Lille, Lille, France
Memorial Hospital; Department of Surgery, Division of
Transplantation, University of Miami Miller School of Silvia Pellegrini Diabetes Research Institute, IRCCS San
Medicine, Miami, FL, United States Raffaele Scientific Institute, Milan, Italy
Contributors xxi
Nadine Pernin Division of Transplantation, Department of Hanne Scholz HTH Centre of Excellence, Institute of Basic
Surgery, Cell Isolation and Transplantation Center, Medical Sciences, University of Oslo; Department of
University of Geneva Hospitals and School of Medicine, Transplant Medicine and Institute for Surgical Research,
Geneva, Switzerland Oslo University Hospital, Oslo, Norway
Vittorio Grazio Perrone Division of General and Transplant Antonio Secchi Vita-Salute San Raffaele University; Clinical
Surgery, University of Pisa, Pisa, Italy Transplant Unit, Division of Immunology, Transplantation
and Infectious Diseases; Department of Internal Medicine,
Lorenzo Piemonti Diabetes Research Institute, IRCCS San
Transplant Medicine Unit, IRCCS San Raffaele Scientific
Raffaele Scientific Institute; Vita-Salute San Raffaele
Institute, Milano, Italy
University, Milano, Italy
Oscar K. Serrano Division of Transplantation, Department
Rutger Ploeg Nuffield Department of Surgical Sciences,
of Surgery, University of Minnesota, Minneapolis, MN,
University of Oxford, Oxford, United Kingdom
United States
John A. Powelson Department of Surgery, Indiana University
A.M. James Shapiro Department of Surgery and Clinical
School of Medicine, Indianapolis, IN, United States
islet Transplant Program, University of Alberta, Edmonton,
Alberto Pugliese Diabetes Research Institute; Department
AB, Canada
of Medicine, Division of Endocrinology, Diabetes and
Sidharth Sharma Department of Surgery, State University
Metabolism; Department of Microbiology and
of New York (SUNY) Downstate Medical Center, Brooklyn,
Immunology, University of Miami Miller School of
NY, United States
Medicine, Miami, FL, United States
Edward Sharples Oxford University Hospitals NHS Trust,
Shanthini K. Rajan Islet Cell Laboratory, Baylor University
University of Oxford, Oxford, United Kingdom
Medical Center, Baylor Scott and White Research Institute,
Dallas, TX, United States James A.M. Shaw Institute of Cellular Medicine, Newcastle
University, Newcastle upon Tyne, United Kingdom
Karthik V. Ramanathan Department of Surgery, University
of Minnesota, Minneapolis, MN, United States Sanjay Sinha Oxford University Hospitals NHS Trust,
University of Oxford, Oxford, United Kingdom
Violeta Raverdy Université de Lille, INSERM U1190,
Translational Research for Diabetes, EGID (European Carlo Socci Department of Surgery, IRCCS San Raffaele
Genomic Institute for Diabetes), Faculté de Médecine; Scientific Institute, Milano, Italy
Department of General and Endocrine Surgery, CHU Lille, Jean-Paul G. Squifflet Department of Abdominal Surgery
Lille, France and Transplantation, University of Liege, Liege, Belgium
Robert R. Redfield Department of Surgery, Division of Peter G. Stock Department of Transplant Surgery, UC San
Transplantation, University of Wisconsin-Madison School Francisco, San Francisco, CA, United States
of Medicine and Public Health, Madison, WI, United
Robert J. Stratta Department of Surgery, Section of
States
Transplantation, Wake Forest School of Medicine, Winston-
John Renz Department of Surgery, State University of New Salem, NC, United States
York (SUNY) Downstate Medical Center, Brooklyn, NY,
David E.R. Sutherland Department of Surgery, University
United States
of Minnesota, MN, United States
Michael R. Rickels Institute for Diabetes, Obesity &
Manfredi Tesauro Department of Systems Medicine,
Metabolism, University of Pennsylvania Perelman School
University of Rome Tor Vergata, Rome, Italy
of Medicine, Philadelphia, PA, United States
Olivier Thaunat Hospices Civils de Lyon, Edouard Herriot
Charles G. Rickert Center for Transplantation Sciences,
Hospital, Department of Transplantation, Nephrology and
Department of Surgery, Massachusetts General
Clinical Immunology; Claude Bernard University (Lyon 1);
Hospital, Harvard Medical School, Boston, MA,
French National Institute of Health and Medical Research
United States
(Inserm) Unit 1111, Lyon, France
Camillo Ricordi Diabetes Research Institute; Department
Julien Thévenet Université de Lille, INSERM U1190,
of Surgery, Division of Cellular Transplantation,
Translational Research for Diabetes, EGID (European
University of Miami Miller School of Medicine, Miami,
Genomic Institute for Diabetes), Faculté de Médecine,
FL, United States
Lille, France
Jeffrey Rogers Department of Surgery, Wake Forest Baptist
Christoph Troppmann Department of Surgery, School of
Medical Center, Winston-Salem, NC, United States
Medicine, University of California, Davis, CA, United States
Joseph R. Scalea Department of Pathology; Department of
Marie-Christine Vantyghem Université de Lille,
Surgery, University of Maryland School of Medicine,
INSERM U1190, Translational Research for Diabetes,
Baltimore, MD, United States
EGID (European Genomic Institute for Diabetes),
Jesse D. Schold Department of Quantitative Health Faculté de Médecine; Department of Endocrinology
Sciences; Center for Populations Health Research, Lerner Diabetology and Metabolism, CHU Lille; Service
Research Institute, Cleveland Clinic, Cleveland, OH, d’Endocrinologie, Centre Hospitalier Universitaire de
United States Lille, Lille, France