Oncology and Basic Science

576 Pages·2007·24.15 MB·English

by  Timothy A. Damron MD

ORTHOPAEDIC SURGERY ESSENTIALS
ONCOLOGY AND
BASIC SCIENCE
ORTHOPAEDIC SURGERY ESSENTIALS
ONCOLOGY AND BASIC SCIENCE
ORTHOPAEDICSURGERYESSENTIALS
AdultReconstruction
DanielJ.Berry,MD
ScottP.Steinmann,MD
FootandAnkle
DavidB.Thordarson,MD
HandandWrist
JamesR.Doyle,MD
OncologyandBasicScience
TimothyA.Damron,MD
Pediatrics
SusanA.Scherl,MD
KathrynE.Cramer,MD
Spine
ChristopherM.Bono,MD
StevenR.Garfin,MD
SportsMedicine
AnthonyA.Schepsis,MD
BrianD.Busconi,MD
Trauma
CharlesCourt-Brown,MD
MargaretM.McQueen,MD
PaulTornettaIII,MD
ORTHOPAEDIC SURGERY ESSENTIALS
ONCOLOGY AND
BASIC SCIENCE
Series Editors Book Editor
PAUL TORNETTA III, MD TIMOTHY A. DAMRON, MD
Professor DavidG.MurrayEndowedProfessorofOrthopedicSurgery
DepartmentofOrthopaedicSurgery ViceChairman,DepartmentofOrthopedicSurgery
BostonUniversitySchoolofMedicine StateUniversityofNewYorkUpstateMedicalUniversity
DirectorofOrthopaedicTrauma AdjunctProfessor,DepartmentofBiomedicaland
BostonUniversityMedicalCenter ChemicalEngineering
Boston,Massachusetts SyracuseUniversity
Syracuse,NewYork
THOMAS A. EINHORN, MD
ProfessorandChairman
DepartmentofOrthopaedicSurgery
BostonUniversitySchoolofMedicine
Boston,Massachusetts
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LibraryofCongressCataloging-in-PublicationData
Oncologyandbasicscience/[editedby]TimothyA.Damron.
p.;cm. — (Orthopaedicsurgeryessentials)
Includesbibliographicalreferencesandindex.
ISBN-13:978-0-7817-8045-2
ISBN-10:0-7817-8045-4
1.Musculoskeletalsystem—Tumors.2.Orthopedics.3.Orthopedicsurgery.I.Damron,
TimothyA.II.Series.
[DNLM:1.BoneNeoplasms.2.OrthopedicProcedures—methods.3.SoftTissueNeoplasms.
WE258O582008]
RC280.M83O532008
616.99’4—dc22
2006100177
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Dedicated to the many students, residents, attendings, and researchers—past, present, and future—
whom I have worked with, learned from, and taught. Thank you.

CONTENTS
ContributingAuthors xi Preface xvii
SeriesPreface xv Acknowledgment xix
SECTION I: EVALUATION AND MANAGEMENT OF
MUSCULOSKELETAL ONCOLOGY PROBLEMS
1 Evaluation of Bone Tumors 3 4.2 BenignTumorsofBone 54
TimothyA.Damron CynthiaM.Kelly
2 Evaluation of Soft Tissue Tumors 28 4.3 MalignantBoneLesions 60
CarolD.Morris FrancisR.Patterson,TimothyA.Damron,and
CarolD.Morris
3 Biopsy of Musculoskeletal Tumors 37
4.4 SoftTissueTumors 87
EdwardA.Athanasian
JohnHeinerandJeremyWhite
4 Treatment Principles 50
4.5 PathologicFractures 92
4.1 SurgicalMargins 50 TimothyA.Damron
RobertQuinn
SECTION II: SPECIFIC BONE NEOPLASMS
AND SIMULATORS
5 Benign Bone Tumors 117 5.6 GiantCellTumorofBone 159
SeanV.McGarryandC.ParkerGibbs
5.1 BoneLesions 117
FelasfaM.Wodajo 5.7 VascularLesions 164
5.2 CartilageLesions 126 SeanV.McGarryandC.ParkerGibbs
FelasfaM.Wodajo
5.8 OtherTumorsofUndefinedNeoplasticNature 170
5.3 CysticLesions 140 SeanV.McGarryandC.ParkerGibbs
SungWookSeo,YoungLaeMoon,and
6 Bone Sarcomas 177
FrancisYoung-InLee
5.4 Myogenic,Lipogenic,andNeuralTumors 147 6.1 Osteosarcoma 177
SeanV.McGarryandC.ParkerGibbs FrancisR.Patterson
5.5 FibrousLesionsofBone 149 6.2 EwingSarcomaandPrimitiveNeuroectodermalTumor
SungWookSeo,YoungLaeMoon,and ofBone 187
FrancisYoung-InLee BruceRougraff
vii
viii Contents
6.3 Chondrosarcoma 192 7.3 SkeletalDysplasias 215
R.LorRandallandKennethJ.Hunt DanielleA.Katz
6.4 Fibrous,Fibrohistiocytic,andGiantCellTumor 7.4 RetinoblastomaSyndrome 224
Malignancies 201
TimothyA.Damron
HannahD.Morgan
7.5 Rothmund-ThomsonSyndrome 226
6.5 NotochordalTumors 204
KathrynPalomino
HannahD.Morgan
7.6 WernerSyndrome 227
6.6 VascularSarcomasofBone 206
KathrynPalomino
HannahD.Morgan
6.7 Myogenic,Lipogenic,andEpithelialBoneSarcomas 8 Metastatic Disease 229
209 TimothyA.Damron
HannahD.Morgan
9 Hematologic Malignancies 244
7 Congenital and Inherited Bone Conditions 212 ValeraeO.Lewis
7.1 FamilialAdenomatousPolyposis 212
10 Metabolic Bone Diseases 251
KathrynPalomino
SusanV.Bukata
7.2 Beckwith-WiedemannSyndrome 214
DanielleA.Katz
SECTION III: SPECIFIC SOFT TISSUE NEOPLASMS
AND SIMULATORS
11 Benign Soft Tissue Tumors 263 12 Soft Tissue Sarcomas 294
TimothyA.DamronandGustavodelaRoza CarolD.Morris
SECTION IV: BASIC SCIENCE
18 Principles of Orthopaedic Pharmacology 387
13 Cellular and Molecular Biology 309
CarolD.Morris
MatthewJ.Allen
19 Bone Form, Function, Injury, Regeneration, and
14 Growth and Development of the Musculoskeletal
Repair 393
System 321
AlexiaHernandez-SoriaandMathiasBostrom
DonaldE.SweetandThomasV.Smallman
20 Articular Cartilage Structure, Composition, and
15 Genetic Basis of Musculoskeletal Disorders 347 Repair 405
SathappanS.Sathappan,KirillIlalov,and PeterJ.RoughleyandThomasV.Smallman
PaulE.DiCesare
21 Diarthrodial Joints 418
16 Biomechanics 367 ThomasV.Smallman,KrisShekitka,and
FrederickW.WernerandJosephA.Spadaro DonaldFlemming
17 Biomaterials 373 22 Meniscal Structure, Function, Repair, and
JosephA.Spadaro,MichaelT.Clarke,and Replacement 443
JulieM.Hasenwinkel MarkC.DrakosandAnsworthA.Allen
Contents ix
23 Intervertebral Disk Structure, Composition, and 27.1 BacterialInfection 496
Mechanical Function 452
SamuelA.Joseph,Jr.,andPatrickBoland
27.2 GranulomatousInfection 508
24 Tendon and Ligament Anatomy, Biology, and
Biomechanics 463
BrianJ.HarleyandJosephW.Bergman 27.3 InfectionAssociatedwithNeuropathy 521
25 Peripheral Nerve Physiology, Anatomy, and
Pathology 474
27.4 ViralDisorders 524
ShikhaSethi,BrianJ.Harley,ChristianCustodio,and
MichaelStubblefield
26 Skeletal Muscle Anatomy, Physiology, and 28 Neoplasia 525
Mechanics 484
MatthewJ.Allen
BryanT.KellyandWilliamJ.Robertson
27 Infectious Disorders of Bone and Joint 495
ThomasV.Smallman,KrisShekitka,DonaldFlemming,
andBrianJ.Harley
Index 533