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Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology (Ernst Schering Foundation Symposium Proceedings 07.4) PDF

275 Pages·2008·3.887 MB·English
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About Oncogenes Meet Metabolism: From Deregulated Genes to a Broader Understanding of Tumour Physiology (Ernst Schering Foundation Symposium Proceedings 07.4)

In 1920s, Otto Warburg described the phenomenon of ‘aerobic glycolysis’, the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg’s hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).

Detailed Information

Author:Guido Kroemer, Dominik Mumberg, Hector Keun, Björn Riefke, Thomas Steger-Hartmann, Kirstin Petersen
Publication Year:2008
ISBN:3540794778
Pages:275
Language:English
File Size:3.887
Format:PDF
Price:FREE
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