Non-Steroidal Anti-Inflammatory Drugs in Water: Emerging Contaminants and Ecological Impact

342 Pages·2020·7.18 MB·English

by  Leobardo Manuel Gómez-Oliván

The Handbook of Environmental Chemistry 96
Series Editors: Damià Barceló · Andrey G. Kostianoy
Leobardo Manuel Gómez-Oliván  Editor
Non-Steroidal
Anti-Inflammatory
Drugs in Water
Emerging Contaminants and Ecological
Impact
The Handbook of Environmental Chemistry
Volume 96
Founding Editor: Otto Hutzinger
(cid:1)
Series Editors: Damia Barcelo´ (cid:129) Andrey G. Kostianoy
Editorial Board Members:
Jacob de Boer, Philippe Garrigues, Ji-Dong Gu,
KevinC.Jones,ThomasP.Knepper,AbdelazimM.Negm,
Alice Newton, Duc Long Nghiem, Sergi Garcia-Segura
Inoverthreedecades,TheHandbookofEnvironmentalChemistryhasestablished
itselfasthepremierreferencesource,providingsoundandsolidknowledgeabout
environmentaltopicsfromachemicalperspective.Writtenbyleadingexpertswith
practical experience in the field, the series continues to be essential reading for
environmental scientists as well as for environmental managers and decision-
makersinindustry,government,agenciesandpublic-interestgroups.
Two distinguished Series Editors, internationally renowned volume editors as
wellasaprestigiousEditorialBoardsafeguardpublicationofvolumesaccordingto
highscientificstandards.
Presenting a wide spectrum of viewpoints and approaches in topical volumes,
thescopeoftheseriescoverstopicssuchas
• localandglobalchangesofnaturalenvironmentandclimate
• anthropogenicimpactontheenvironment
• water,airandsoilpollution
• remediationandwastecharacterization
• environmentalcontaminants
• biogeochemistryandgeoecology
• chemicalreactionsandprocesses
• chemical and biological transformations as well as physical transport of
chemicalsintheenvironment
• environmentalmodeling
Aparticularfocusoftheseriesliesonmethodologicaladvancesinenvironmen-
talanalyticalchemistry.
TheHandbookofEnvironmentalChemistryisavailablebothinprintandonline
via http://link.springer.com/bookseries/698. Articles are published online as soon
astheyhavebeenreviewedandapprovedforpublication.
Meeting the needs of the scientific community, publication of volumes in
subserieshasbeendiscontinuedtoachieveabroaderscopefortheseriesasawhole.
Non-Steroidal
Anti-Inflammatory Drugs
in Water
Emerging Contaminants and Ecological
Impact
Volume Editor: Leobardo Manuel Gómez-Oliván
With contributions by
L. Aranda-Lara (cid:1) D. Arizmendi-Cotero (cid:1) J. Blasco (cid:1) S. E. Brewer (cid:1)
L. C. Can-Ubando (cid:1) J. D. Cardoso-Vera (cid:1) L. I. Castro-Pastrana (cid:1)
M. Cerro-Lo´pez (cid:1) J. J. Cisneros (cid:1) A. S. Commault (cid:1)
G. A. Elizalde-Vela´zquez (cid:1) M. Galar-Mart´ınez (cid:1) O. D. Garc´ıa (cid:1)
S. Garc´ıa-Medina (cid:1) R. M. Go´mez-Espinosa (cid:1) L. M. Go´mez-Oliva´n (cid:1)
M. Hampel (cid:1) M. D. Herna´ndez-Navarro (cid:1) K. Isaac-Olive´ (cid:1)
H. Islas-Flores (cid:1) G. L. Manzanares-Leal (cid:1) S. L. Mart´ınez-Vargas (cid:1)
A. Mej´ıa-Garc´ıa (cid:1) M. A. Me´ndez-Rojas (cid:1) A. Mendoza (cid:1)
E. Morales-Avila (cid:1) P. Moreno-Pe´rez (cid:1) M. P. A. Moreno-Pe´rez (cid:1)
R.Natividad(cid:1)A.E.Navarro-Fro´meta(cid:1)L.D.Nghiem(cid:1)L.N.Nguyen(cid:1)
K. A. Novoa (cid:1) B. Nunes (cid:1) S. Oh (cid:1) E. Olive´-Alvarez (cid:1)
J.M.Ortega-Olvera(cid:1)E.Palacios-Rosas(cid:1) M.Parolini(cid:1) I.Pe´rez-Alvarez(cid:1)
J. L. Pe´rez-Mazariego (cid:1) R. Pe´rez-Paste´n Borja (cid:1) M. Ramesh (cid:1)
N. Ram´ırez-Dura´n (cid:1) R. Romero (cid:1) A. H. Sandoval-Trujillo (cid:1)
H. Sandoval-Trujillo (cid:1) N. SanJuan-Reyes (cid:1) G. U. Semblante (cid:1)
S. Siddeswaran (cid:1) D. Sutherland (cid:1) M. L. Toledo-Wall (cid:1) C. Trombini (cid:1)
S. Umamaheswari
Editor
LeobardoManuelGo´mez-Oliva´n
EnvironmentalToxicologyLab,FacultyofChemistry
AutonomousUniversityoftheStateofMexico
Toluca,EstadodeMe´xico,Mexico
ISSN1867-979X ISSN1616-864X (electronic)
TheHandbookofEnvironmentalChemistry
ISBN978-3-030-56293-9 ISBN978-3-030-56294-6 (eBook)
https://doi.org/10.1007/978-3-030-56294-6
©SpringerNatureSwitzerlandAG2020
Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof
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Thepublisher,theauthors,andtheeditorsaresafetoassumethattheadviceandinformationinthisbook
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Series Editors
Prof. Dr. Dami(cid:1)a Barcelo´ Prof. Dr. Andrey G. Kostianoy
Department of EnvironmentalChemistry ShirshovInstituteofOceanology
IDAEA-CSIC RussianAcademyofSciences
C/Jordi Girona18–26 36,NakhimovskyPr.
08034Barcelona, Spain 117997Moscow,Russia
and and
Catalan InstituteforWaterResearch (ICRA) S.Yu.WitteMoscowUniversity
H20Building Moscow,Russia
Scientific and Technological Parkof the [email protected]
University ofGirona
Emili Grahit,101
17003Girona, Spain
[email protected]
Editorial Board Members
Prof. Dr. Jacob de Boer
VUUniversityAmsterdam, Amsterdam, The Netherlands
Prof. Dr. Philippe Garrigues
Universite´ de Bordeaux,Talence Cedex,France
Prof. Dr. Ji-Dong Gu
Guangdong Technion-Israel Instituteof Technology, Shantou,Guangdong,China
Prof. Dr. Kevin C. Jones
Lancaster University, Lancaster, UK
Prof. Dr. Thomas P. Knepper
Hochschule Fresenius,Idstein, Hessen,Germany
Prof. Dr. Abdelazim M. Negm
Zagazig University, Zagazig,Egypt
Prof. Dr. Alice Newton
Universityof Algarve, Faro,Portugal
Prof. Dr. Duc Long Nghiem
Universityof TechnologySydney, Broadway, NSW,Australia
Prof. Dr. Sergi Garcia-Segura
ArizonaState University, Tempe, AZ,USA
Series Preface
Withremarkablevision,Prof. OttoHutzingerinitiatedTheHandbook ofEnviron-
mentalChemistry in1980andbecamethe foundingEditor-in-Chief.Atthattime,
environmental chemistry was an emerging field, aiming at a complete description
of the Earth’s environment, encompassing the physical, chemical, biological, and
geologicaltransformationsofchemicalsubstancesoccurringonalocalaswellasa
global scale. Environmental chemistry was intended to provide an account of the
impact of man’s activities on the natural environment by describing observed
changes.
Whileaconsiderableamountofknowledgehasbeenaccumulatedoverthelast
four decades, as reflected in the more than 150 volumes of The Handbook of
Environmental Chemistry, there are still many scientific and policy challenges
ahead due to the complexity and interdisciplinary nature of the field. The series
will therefore continue to provide compilations of current knowledge. Contribu-
tions are written by leading experts with practical experience in their fields. The
Handbook of Environmental Chemistry grows with the increases in our scientific
understanding, and provides a valuable source not only for scientists but also for
environmental managers and decision-makers. Today, the series covers a broad
rangeofenvironmentaltopicsfromachemicalperspective,includingmethodolog-
icaladvancesinenvironmentalanalyticalchemistry.
Inrecentyears,therehasbeenagrowingtendencytoincludesubjectmatterof
societal relevance in the broad view of environmental chemistry. Topics include
life cycle analysis, environmental management, sustainable development, and
socio-economic, legal and even political problems, among others. While these
topics are of great importance for the development and acceptance of The Hand-
bookofEnvironmentalChemistry,thepublisherandEditors-in-Chiefhavedecided
tokeepthehandbookessentiallyasourceofinformationon“hardsciences”witha
particular emphasis on chemistry, but also covering biology, geology, hydrology
andengineeringasappliedtoenvironmentalsciences.
Thevolumesoftheseriesarewrittenatanadvancedlevel,addressingtheneeds
ofbothresearchersandgraduatestudents,aswellasofpeopleoutsidethefieldof
vii
viii SeriesPreface
“pure” chemistry, including those in industry, business, government, research
establishments, and public interest groups. It would be very satisfying to see
these volumes used as a basis for graduate courses in environmental chemistry.
Withitshighstandardsofscientificqualityandclarity,TheHandbookofEnviron-
mental Chemistry provides a solid basis from which scientists can share their
knowledge on the different aspects of environmental problems, presenting a wide
spectrumofviewpointsandapproaches.
TheHandbookofEnvironmentalChemistryisavailablebothinprintandonline
via www.springerlink.com/content/110354/. Articles are published online as soon
as they have been approved for publication. Authors, Volume Editors and
Editors-in-Chief are rewarded by the broad acceptance of The Handbook of Envi-
ronmentalChemistrybythescientificcommunity,fromwhomsuggestionsfornew
topicstotheEditors-in-Chiefarealwaysverywelcome.
Dami(cid:1)aBarcelo´
AndreyG.Kostianoy
SeriesEditors
Preface
Pharmaceuticals are designed to persist and perform their therapeutic action and,
consequently,oncetheyentertheaquaticenvironment,theypersistinit,damaging
thehealthoforganismslivingintheseecosystemsandevenhumanhealth.There-
fore, these products are currently of worldwide environmental concern and have
been called“emergingcontaminants”. Thelatterterm includesnon-steroidalanti-
inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals with
anti-inflammatory, analgesic and antipyretic properties, which act as selective
inhibitors of the enzyme cyclooxygenase (COX), inhibiting cyclooxygenase-1
(COX-1)andcyclooxygenase-2(COX-2)whichareresponsiblefortheproduction
ofprostaglandins,prostacyclinsandthromboxanes.
SomeNSAIDsdonotdegradeintheenvironment,othersaredegradablebutata
veryslowpaceandalthoughsomeothersarenotpersistentintheenvironment,they
canbetransformedthroughnaturalprocesses.Thecontinuousintroductionofthis
typeofproductsfromvarioussources(municipal,hospitalandindustrialeffluents)
prolongsandmaintainsitspresenceinthewatersincreasinganypossibleimpacton
aquaticlife.
TheappearanceofNSAIDsinwaterrepresentsahighrisktotheenvironmentfor
many reasons. The main one is that they contain active ingredients that were
designed to induce specific pharmacological effects in humans but, when they
dissolve in water, can reach non-target populations such as fish, amphipods,
amphibians, among others, which produces toxicological effects. Diverse studies
havereportedNSAID-inducedtoxicityinaquaticorganismssincetheseorganisms
aremoresusceptibletotoxiceffectsduetotheircontinuedexposuretowastewater
dischargesthroughoutthelifecycle.
In the chapters included in this book are indicated data about fate, occurrence,
toxicological findings identified by the presence of NSAIDs in various aquatic
organisms of economic and ecological interest. Also are included avant-garde
technologies for the removal of NSAIDs and the regulatory framework for the
presenceofthesedrugsintheworld.
ix
x Preface
The authors are well-known researchers from Mexico, Spain, Portugal, Italy,
AustraliaandIndiaandmakeexhaustivereviewsandshowthefindingsidentifiedin
their investigations related to NSAIDs occurrence, toxicity characterization using
different biomarkers, as well as showing some technologies for the removal of
NSAIDsandlegalframeworkoftheNSAIDsaroundtheworld.Thiscompilationof
researchinworldcountriesallowsustohaveaveryspecificvisionofthespecific
waterproblembyNSAIDsandconsidersolutionproposals.
TheauthorsandIhopethatourbookcomplieswiththediverseandgeneralized
expectations and needs for information about the contamination problem in the
worldbyNSAIDs.
Ithankalltheauthorsofthisbookfortheirprofessionalexpertiseandthorough-
nessinwritinguptheirchapters;theUniversidadAuto´nomadelEstadodeMe´xico
fortheunendingsupportithasshownasmyemployingentity;myresearchgroup;
and my family, most especially my mother, Aida Oliva´n, and friends for the
enthusiasmandsupporttheyhavealwaysshown.
Toluca,Mexico LeobardoManuelGo´mez-Oliva´n