Neurovascular Events After Subarachnoid Hemorrhage: Towards Experimental and Clinical Standardisation

348 Pages·2015·19.61 MB·English

by  Javier Fandino

Acta Neurochirurgica Supplement 120
Javier Fandino
Serge Marbacher
Ali-Reza Fathi
Carl Muroi
Emanuela Keller Editors
Neurovascular
Events After
Subarachnoid
Hemorrhage
Towards Experimental
and Clinical Standardisation
Vasospasm2013 12th International Conference on
Neurovascular Events after Subarachnoid Hemorrhage
July 10-12, 2013, Lucerne, Switzerland
Acta Neurochirurgica Supplement 120
Series Editor
H.-J. Steiger
For further volumes:
http://www.springer.com/series/4

Javier Fandino (cid:129) Serge Marbacher
Ali-Reza Fathi (cid:129) C arl Muroi (cid:129) Emanuela Keller
Editors
Neurovascular Events After
Subarachnoid Hemorrhage
Towards Experimental and Clinical
Standardisation
Editors
Javier Fandino Carl Muroi
Department of Neurosurgery Department of Neurosurgery
Kantonsspital Aarau Kantonsspital Aarau
Aarau Aarau
Switzerland Switzerland
Serge Marbacher Emanuela Keller
Department of Neurosurgery Department of Neurosurgery
Kantonsspital Aarau Neurointensive Care Unit
Aarau University Hospital Zurich
Switzerland Zurich
Switzerland
Ali-Reza F athi
Department of Neurosurgery
Kantonsspital Aarau
Aarau
Switzerland
ISBN 978-3-319-04980-9 ISBN 978-3-319-04981-6 (eBook)
DOI 10.1007/978-3-319-04981-6
Springer Cham Heidelberg New York Dordrecht London
Library of Congress Control Number: 2014951213
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Preface
F orty-two years after the fi rst International Conference on Cerebral Vasospasm (ICCV) was
held in Jackson, Mississippi, USA, a new horizon of translational research and interdisciplin-
ary interests motivated our community to change the name of this traditional meeting. It was
in fact during the last ICCV in Cincinnati, OH, USA, in 2011, that a new name arose to
embrace all disciplines and events related to subarachnoid hemorrhage. After celebrating ven-
ues on all fi ve continents, we had the privilege to hold the newly baptized 12th Conference on
Neurovascular Events After Subarachnoid Hemorrhage (former ICCV) in Lucerne,
Switzerland. During a magical week, from July 10 to 12, 2013, surrounded by the beautiful
Lake of Lucerne and the Swiss Alps, more than 300 participants had the opportunity to meet
and exchange experiences and visions, which will led us T oward Experimental and Clinical
Standardization in this fi eld. This book contains the proceedings of the Conference. We were
motivated by the superb quality of 102 submitted abstracts, most of them included in this book.
The collection of papers were divided into topical chapters: Aneurysm Formation, Early Brain
Injury and Neuroprotection, Macro- and Microcirculatory Disturbances, Pathophysiology of
DIND, Imaging and Endovascular Management, Techniques and Surgical Innovations,
Neurocritical Care, and Clinical Trials. For the fi rst time the Conference included a session on
Animals Models which allowed the participants to have an overview of all experimental tech-
niques routinely used worldwide. This summary will contribute to the standardization of labo-
ratory techniques and will enable the application of data into clinical trials in a more reliable
fashion. We want to acknowledge the authors of the chapters of this book and would like to
express our deepest gratitude to all of those who made the meeting in Lucerne possible, espe-
cially Mrs. Anna Scrowther and Mrs. Antonella Ricci. Finally, we are indebted to our institu-
tion, the Kantonsspital Aarau, and its CEO, Mr. Hans Leuenberger, for the support and
encouragement throughout the organization of the conference. This book will contribute to a
better understanding of cerebrovascular events related to subarachnoid hemorrhage.
Aarau, Switzerland Javier Fandino
v

Acknowledgment
T his volume has been made possible thanks to a generous educational grant from the
Kantonsspital Aarau Education and Research Fund.
vii

Contents
Vasospasm: My First 25 Years—What Worked?
What Didn’t? What Next? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
R. Loch Macdonald
Aneurysm Formation
Molecular Basis for Intracranial Aneurysm Formation . . . . . . . . . . . . . . . . . . . . . . 13
Miyuki Fukuda and Tomohiro Aoki
Aneurysm Wall Thickness Measurements of Experimental Aneurysms:
In Vivo High-Field MR Imaging Versus Direct Microscopy . . . . . . . . . . . . . . . . . . . 17
Camillo Sherif , Günther Kleinpeter , Michel Loyoddin , Georg Mach ,
Roberto Plasenzotti , Thomas Haider , Erwin Herbich , and Martin Krssak
Early Brain Injury and Neuroprotection
Early Events After Aneurysmal Subarachnoid Hemorrhage . . . . . . . . . . . . . . . . . . 23
Fatima A. Sehba and Victor Friedrich
Mouse Genetic Background Is Associated with Variation in Secondary
Complications After Subarachnoid Hemorrhage. . . . . . . . . . . . . . . . . . . . . . . . . . . . 29
Josephine A. D’Abbondanza , Elliot Lass , Jinglu Ai , and R. Loch Macdonald
The Value of Perfusion Computed Tomography (PCT) Imaging After
Aneurysmal Subarachnoid Hemorrhage: A Review of the Current Data. . . . . . . . 35
Kerim Beseoglu , Nima Etminan , and Daniel Hänggi
Neurovascular Events After Subarachnoid Hemorrhage: Focusing
on Subcellular Organelles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39
Sheng Chen , Haijian Wu , Jiping Tang , Jianmin Zhang , and John H. Zhang
Effects of Diltiazem on Sympathetic Activity in Patients
with Aneurysmal Subarachnoid Hemorrhage . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Takeshi Ogura , Ririko Takeda , Hidetoshi Ooigawa , Hiroyuki Nakajima ,
and Hiroki Kurita
Haemoglobin Scavenging After Subarachnoid Haemorrhage. . . . . . . . . . . . . . . . . . 51
A. Durnford , J. Dunbar , J. Galea , D. Bulters , J. A. R. Nicoll , D. Boche ,
and I. Galea
Mild Exercise Reduces Cerebral Vasospasm After Aneurysm
Subarachnoid Hemorrhage: A Retrospective Clinical Study
and Correlation with Laboratory Investigation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
Margaret A. Riordan , Michele Kyle , Christina Dedeo , Mark R. Villwock ,
Matthew Bauer , Mary Lou Vallano , and Eric M. Deshaies
ix