Neurology and Psychiatry of Women: A Guide to Gender-based Issues in Evaluation, Diagnosis, and Treatment

234 Pages·2019·5.83 MB·English

by  Mary Angela O’Neal

Mary Angela O’Neal
Editor
Neurology and
Psychiatry of Women
A Guide to Gender-based Issues in
Evaluation, Diagnosis, and Treatment
123
Neurology and Psychiatry of Women
Mary Angela O’Neal
Editor
Leena Mittal
Guest Editor
Neurology and Psychiatry
of Women
A Guide to Gender-based Issues in
Evaluation, Diagnosis, and Treatment
Editor
Mary Angela O’Neal
Department of Neurology
Brigham and Women’s Hospital
Boston, MA
USA
Guest Editor
Leena Mittal
Department of Psychiatry
Brigham and Women’s Hospital
Boston, MA
USA
ISBN 978-3-030-04244-8 ISBN 978-3-030-04245-5 (eBook)
https://doi.org/10.1007/978-3-030-04245-5
Library of Congress Control Number: 2019930963
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Preface
The need to understand how neurologic and psychiatric disorders are different in women is
important to appropriately care for female patients. There is a vast amount of knowledge about
how sex affects disease incidence, course, and treatment, as well as how drugs and disease
interact with reproductive health, pregnancy, and menopause. Yet many practitioners only have
a limited understanding of these important concerns. Further, there is no single text which
provides this critical information. This book was written for all providers who take care of
women with these conditions to provide sex-appropriate care guidelines.
Many providers think that women’s issues in medicine only relate to pregnancy. In fact,
gender concerns are important throughout a woman’s life. Of course, the factors important to
consider vary as to where patients are in their life cycle. For example, to understand stroke risk
in women, a history regarding pregnancy-related disorders such as preeclampsia/eclampsia
and gestational diabetes is essential.
I wanted to assemble a comprehensive textbook that reflects the significant issues as regards
both neurologic and psychiatric disorders spanning a woman’s life including reproductive
health, pregnancy, and healthy aging. Each chapter is written by experts in their field to give
practical up-to-date advice about some of the considerations to best address our female
patients’ health. I hope you enjoy reading the book.
Boston, MA, USA Mary Angela O’Neal, MD
v
Contents
Part I I ssues in Women During Their Reproductive Years
Women and Migraine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Regina Krel and Paul G. Mathew
Connective Tissue Disorders in Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7
Sophia L. Ryan, Shamik Bhattacharyya, and Mary Angela O’Neal
Functional Neurological Disorder and Dissociative Disorders in Women . . . . . . . . . . . 15
Geoffrey Raynor and Gaston Baslet
Contraception in Neurologic and Psychiatric Disorders . . . . . . . . . . . . . . . . . . . . . . . . . 27
Caryn Dutton, Andrea Hsu Roe, and Deborah Bartz
Neuroendocrine Disorders in Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37
Alexandra J. Lovett and Whitney W. Woodmansee
Somatoform Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47
Timothy M. Scarella
Anxiety Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Madeleine A. Becker, Nazanin E. Silver, Ann Chandy, and Subani Maheshwari
Neuro-inflammatory Disorders in Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77
Ivana Vodopivec
Catamenial Epilepsy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
P. Emanuela Voinescu
Neuro-oncological Disorders in Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 95
Na Tosha N. Gatson and Erika N. Leese
Substance Use Disorders in Women . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .103
Whitney Peters, Connie Guille, and Leena Mittal
Part II Pregnancy
Neurologic Imaging in Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .117
Jesse M. Thon, Robert Regenhardt, and Joshua P. Klein
The Normal Physiology of Pregnancy: Neurological Implications. . . . . . . . . . . . . . . . .121
Cesar R. Padilla and Nicole A. Smith
Epilepsy and Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .125
Mariel Velez and Kimford J. Meador
Headaches in Pregnancy and Postpartum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .131
Mary Angela O’Neal
vii
viii Contents
Stroke in Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .139
Steven K. Feske
Demyelinating Disease and Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .145
Tamara B. Kaplan and Riley Bove
Mood Disorders in Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .157
Kara Brown and Dylan Kathol
Postpartum Neuropathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .173
Janet F. R. Waters
Myasthenia Gravis and Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .177
Christyn Edmundson and Mohammad Kian Salajegheh
Ethical Decisions in Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .183
Thomas I. Cochrane
Part III Women’s Health and Aging
Menopausal Hot Flashes, Sleep and Mood Disturbances . . . . . . . . . . . . . . . . . . . . . . . .191
Geena Athappilly and Margo Nathan
Stroke Risk Factors in Women. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .205
Emer R. McGrath and Kathryn M. Rexrode
Gender Differences in Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .213
Michael T. Hayes
Sex-Related Differences in Alzheimer’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .219
Diler Acar and Carolyn Jane King
Successful Aging . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .227
Marie Pasinski
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .233
Contributors
Diler Acar, MD Brigham and Women’s Hospital, Boston, MA, USA
Geena Athappilly, MD Harvard Medical School, Boston, MA, USA
Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA, USA
Site Director for Boston University Family Medicine Residency at Edith Nourse Rogers
Memorial Veteran Affairs Hospital, Boston, MA, USA
Deborah  Bartz, MD, MPH Department of Obstetrics and Gynecology, Brigham and
Women’s Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Gaston Baslet, MD Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA,
USA
Harvard Medical School, Boston, MA, USA
Madeleine A. Becker, MD, FACLP Department of Psychiatry and Human Behavior, Thomas
Jefferson University Hospital, Philadelphia, PA, USA
Shamik  Bhattacharyya, MD, MS Department of Neurology, Brigham and Women’s
Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Riley Bove, MD, MMSc Department of Neurology, Weill Institute for the Neurosciences,
University of California, San Francisco, CA, USA
Kara Brown, MD Southeast Louisiana Verterans Health Care System, New Orleans, LA,
USA
Ann  Chandy, MD Department of Psychiatry and Human Behavior, Thomas Jefferson
University Hospital, Philadelphia, PA, USA
Thomas I. Cochrane, MD, MBA Brigham and Women’s Hospital, Center for Bioethics,
Harvard Medical School, Boston, MA, USA
Caryn Dutton, MD, MS Department of Obstetrics and Gynecology, Brigham and Women’s
Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Christyn Edmundson, MD Division of Neuromuscular Medicine, Department of Neurology,
Hospital of the University of Pennsylvania, Philadelphia, PA, USA
Steven K. Feske, MD Harvard Medical School, Division of Stroke and Cerebrovascular
Disease, Neurology Department, Brigham and Women’s Hospital, Boston, MA, USA
Na Tosha N. Gatson, MD, PhD Geisinger Neuroscience Institute, Danville, PA, USA
Geisinger Cancer Institute, Danville, PA, USA
ix
x Contributors
Connie Guille, MD Medical University of South Carolina, Institute of Psychiatry, Charleston,
SC, USA
Michael T. Hayes, MD Department of Neurology, Brigham and Women’s Hospital, Boston,
MA, USA
South Shore Hospital, Weymouth, MA, USA
Harvard Medical School, Boston, MA, USA
Tamara B. Kaplan, MD Department of Neurology, Harvard Medical School, Brigham and
Women’s Hospital, Boston, MA, USA
Dylan  Kathol, MD Department of Psychiatry, NorthShore University Health System,
Evanston, IL, USA
Carolyn Jane King, BA Brigham and Women’s Hospital, Boston, MA, USA
Joshua P. Klein, MD, PhD Department of Neurology, Brigham and Women’s Hospital,
Boston, MA, USA
Regina Krel, MD Hackensack Meridian School of Medicine at Seton Hall University, Nutley,
NJ, USA
Neuroscience Institute, Hackensack University Medical Center, Hackensack, NJ, USA
Brigham & Women’s Hospital, Department of Neurology, John R. Graham Headache Center,
Boston, MA, USA
Harvard Vanguard Medical Associates, Department of Neurology, Braintree, MA, USA
Cambridge Health Alliance, Division of Neurology, Cambridge, MA, USA
Harvard Medical School, Boston, MA, USA
Erika N. Leese, PA-C Geisinger Neuroscience Institute, Danville, PA, USA
Alexandra J. Lovett, MD Massachusetts General Hospital, Boston, MA, USA
Subani Maheshwari, MD Department of Psychiatry, Wilmington Hospital, Christiana Care
Health System, Wilmington, DE, USA
Paul G. Mathew, MD, DNBPAS, FAAN, FAHS Hackensack University Medical Center,
Hackensack, NJ, USA
Seton Hall University, Nutley, NJ, USA
Brigham & Women’s Hospital, Department of Neurology, John R. Graham Headache Center,
Boston, MA, USA
Harvard Vanguard Medical Associates, Department of Neurology, Braintree, MA, USA
Emer R. McGrath, MB, PhD Department of Neurology, Brigham and Women’s Hospital
and Harvard Medical School, Boston, MA, USA
Kimford J. Meador, MD Department of Neurology and Neurological Sciences, Stanford
University, Palo Alto, CA, USA
Leena Mittal, MD Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA,
USA
Margo Nathan, MD Division of Women’s Mental Health and Department of Psychiatry,
Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, USA
Mary Angela O’Neal, MD Department of Neurology, Brigham and Women’s Hospital,
Boston, MA, USA
Cesar R. Padilla, MD Brigham and Women’s Hospital, Boston, MA, USA
Contributors xi
Marie Pasinski, MD Harvard Medical School, Nahant, MA, USA
Whitney Peters, MD Department of Psychiatry, Beth Israel Deaconess Medical Center,
Boston, MA, USA
Geoffrey Raynor, MD Department of Psychiatry, Brigham and Women’s Hospital, Boston,
MA, USA
Robert  Regenhardt, MD, PhD Partners Neurology Residency Program, Brigham and
Women’s Hospital, Massachusetts General Hospital, Boston, MA, USA
Kathryn M. Rexrode, MD, MPH Division of Women’s Health, Department of Medicine,
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
Andrea Hsu Roe, MD, MPH Department of Obstetrics and Gynecology, Hospital of the
University of Pennsylvania, Philadelphia, PA, USA
Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Sophia L. Ryan, MD Department of Neurology, Brigham and Women’s Hospital, Boston,
MA, USA
Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
Harvard Medical School, Boston, MA, USA
Mohammad Kian Salajegheh, MD Neuromuscular Center & EMG Laboratory, Department
of Neurology, VA Boston Healthcare System, Harvard Medical School, Boston, MA, USA
Timothy M. Scarella, MD Department of Psychiatry, Beth Israel Deaconess Medical Center/
Harvard Medical School, Boston, MA, USA
Nazanin E. Silver, MD, MPH, FACOG Division of Women’s Behavioral Health, Department
of Obstetrics and Gynecology, University of Pittsburg Medical Center Pinnacle, Camp Hill,
PA, USA
Nicole A. Smith, MD, MPH Maternal Fetal Medicine, Brigham and Women’s Hospital,
Boston, MA, USA
Department of ob/gyn, Brigham and Women’s Hospital, Boston, MA, USA
Jesse M. Thon, MD Department of Neurology, Massachusetts General Hospital, Boston,
MA, USA
Mariel Velez, MD, PhD California Pacific Medical Center, California Pacific Neurosciences
Institute, San Francisco, CA, USA
Ivana Vodopivec, MD, PhD Department of Neurology, Brigham and Women’s Hospital,
Harvard Medical School, Boston, MA, USA
P. Emanuela Voinescu, MD, PhD Brigham and Women’s Hospital, Harvard Medical School,
Boston, MA, USA
Janet F.R. Waters, MD, MBA University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Whitney W. Woodmansee, MD Division of Endocrinology, Diabetes and Metabolism,
University of Florida, Gainesville, FL, USA