Table Of ContentNEUROSCIENCE De Luca Jr.
Menani
Johnson
A timely symposium entitled Body-Fluid Homeostasis: Transduction and Integration NEUROBIOLOGY of
was held at Araraquara, São Paulo, Brazil in 2011. This meeting was convened as
an official satellite of a joint gathering of the International Society for Autonomic
Neuroscience (ISAN) and the American Autonomic Society (AAS) held in Buzios, N
E BODY FLUID HOMEOSTASIS
Rio de Janeiro. Broad international participation at this event generated stimulating
U
discussion among the invited speakers, leading to the publication of Neurobiology
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of Body Fluid Homeostasis: Transduction and Integration. O
B
TRANSDUCTION AND INTEGRATION
Drawn from the proceedings and filled with rich examples of integrative neurobiology I
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and regulatory physiology, this volume:
L
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• Provides updated research using human and animal models for the control G
of bodily fluids, thirst, and salt appetite Y
o
• Explores neural and endocrine control of body fluid balance, arterial pressure,
f
thermoregulation, and ingestive behavior B
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• Discusses recent developments in molecular genetics, cell biology,
D
and behavioral plasticity
Y
• Reviews key aspects of brain serotonin and steroid and peptide control F
of fluid consumption and arterial pressure L
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Arterial pressure
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The book highlights research conducted by leading scientists on signal transduction D Behavior
and sensory afferent mechanisms, molecular genetics, perinatal and adult long- H Kidney
term influences on regulation, central neural integrative circuitry, and autonomic/ O
Neuroplasticity
neuroendocrine effector systems. The findings discussed by the learned contributors M
Serotonin & Peptides
are relevant for a basic understanding of disorders such as heat injury, hypertension, E
O Temperature
and excess salt intake. A unique reference on the neurobiology of body fluid
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homeostasis, this volume is certain to fuel additional research and stimulate further
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debate on the topic. A Edited by
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I Laurival Antonio De Luca Jr.
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José Vanderlei Menani
Alan Kim Johnson
K14645
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NEUROBIOLOGY of
BODY FLUID HOMEOSTASIS
TRANSDUCTION AND INTEGRATION
NEUROBIOLOGY of
BODY FLUID HOMEOSTASIS
TRANSDUCTION AND INTEGRATION
Edited by
Laurival Antonio De Luca Jr.
São Paulo State University
UNESP
Araraquara, Brazil
José Vanderlei Menani
São Paulo State University
UNESP
Araraquara, Brazil
Alan Kim Johnson
University of Iowa
Iowa City, USA
Boca Raton London New York
CRC Press is an imprint of the
Taylor & Francis Group, an informa business
CRC Press
Taylor & Francis Group
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Boca Raton, FL 33487-2742
© 2014 by Taylor & Francis Group, LLC
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Version Date: 20130719
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Dedication
This book is dedicated to Alan Neil Epstein and Miguel
Rolando Covian, whose high scientific endeavors and
mentoring inspired generations of students in the field of the
neurobiology of body fluid homeostasis throughout the world.
© 2010 Taylor & Francis Group, LLC
Contents
Preface.......................................................................................................................ix
Editors .......................................................................................................................xi
Contributors ...........................................................................................................xiii
Chapter 1 The Human Penchant for Deranged Salt Balance ................................1
Micah Leshem
Chapter 2 Circumventricular Organs: Integrators of Circulating Signals
Controlling Hydration, Energy Balance, and Immune Function .......23
Alastair V. Ferguson
Chapter 3 Neuroendocrinology of Hydromineral Homeostasis .........................37
José Antunes-Rodrigues, Silvia G. Ruginsk, André S.
Mecawi, Lisandra O. Margatho, Wagner L. Reis, Renato
R. Ventura, Andréia L. da Silva, Tatiane Vilhena-Franco,
and Lucila L. K. Elias
Chapter 4 Preoptic–Periventricular Integrative Mechanisms Involved in
Behavior, Fluid–Electrolyte Balance, and Pressor Responses ...........67
José Vanderlei Menani, Alexandre A. Vieira,
Débora S. A. Colombari, Patrícia M. De Paula,
Eduardo Colombari, and Laurival A. De Luca Jr.
Chapter 5 Diverse Roles of Angiotensin Receptor Intracellular Signaling
Pathways in the Control of Water and Salt Intake ..............................89
Derek Daniels
Chapter 6 Separating Thirst from Hunger ........................................................103
Gina L. C. Yosten and Willis K. Samson
Chapter 7 Interdependent Preoptic Osmoregulatory and Thermoregulatory
Mechanisms Influencing Body Fluid Balance and Heat Defense.........111
Michael J. McKinley and Michael L. Mathai
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© 2010 Taylor & Francis Group, LLC
viii Contents
Chapter 8 Catecholaminergic Medullary Pathways and Cardiovascular
Responses to Expanded Circulating Volume and Increased
Osmolarity ........................................................................................123
Gustavo R. Pedrino, Daniel A. Rosa, Oswaldo U. Lopes, and
Sergio L. Cravo
Chapter 9 Neurochemical Circuits Subserving Fluid Balance and
Baroreflex: A Role for Serotonin, Oxytocin, and Gonadal
Steroids .........................................................................................141
Laura Vivas, Andrea Godino, Carolina Dalmasso,
Ximena E. Caeiro, Ana F. Macchione, and Maria J. Cambiasso
Chapter 10 Brain Serotonergic Receptors and Control of Fluid Intake and
Cardiovascular Function in Rats ......................................................167
Josmara B. Fregoneze, Hilda S. Ferreira, and Carla Patricia N. Luz
Chapter 11 Serotonergic Autoinhibition within Dorsal Raphe Nucleus
Modulates Sodium Appetite .............................................................197
André S. Mecawi, Fabricia V. Fonseca, Iracema G. de Araujo,
and Luis C. Reis
Chapter 12 A Classic Innate Behavior, Sodium Appetite, Is Driven by
Hypothalamic Gene-Regulatory Programs Previously Linked to
Addiction and Reward ......................................................................215
Wolfgang Liedtke
Chapter 13 Development of Local RAS in Cardiovascular/Body Fluid
Regulatory Systems and Hypertension in Fetal Origins ..................223
Caiping Mao, Lijun Shi, Na Li, Feichao Xu, and Zhice Xu
Chapter 14 Sodium Appetite Sensitization .........................................................279
Seth W. Hurley, Robert L. Thunhorst, and Alan Kim Johnson
Chapter 15 Homeostasis and Body Fluid Regulation: An End Note ..................303
Laurival A. De Luca Jr., Richard B. David, and José V. Menani
© 2010 Taylor & Francis Group, LLC
Preface
Life of terrestrial vertebrates depends on the maintenance of water and salt in the
extracellular compartment (“internal milieu”) within strictly regulated boundaries.
Recognition of this fact was the basis upon which Walter Cannon* formulated his
definition of the term homeostasis almost a century ago. This book, Neurobiology of
Body Fluid Homeostasis: Transduction and Integration, was inspired by Cannon’s
definition, and it is the result of an invitation made by the Frontiers in Neuroscience
Series editors, Sidney Simon and Miguel Nicolelis, to produce a volume based on an
international symposium with a similar title.
The symposium was held in Araraquara, São Paulo, Brazil, in September 2011
and was convened as an official satellite of a joint meeting held in Buzios, Rio de
Janeiro, of the International Society for Autonomic Neuroscience (ISAN) and the
American Autonomic Society (AAS).†,‡ The initial proposal for a satellite sympo-
sium on body fluid homeostasis was made by the chair of the Local Organizing
Committee, Professor Sérgio Cravo, and it was selected by the International
Programming Committee of ISAN–AAS. The symposium attracted speakers from
countries across the globe (Argentina, Australia, Brazil, Canada, China, Israel, and
United States) and from states representing several different regions of Brazil (Bahia,
Goiás, Rio de Janeiro, and São Paulo) and it was sponsored by CAPES, Brazilian
Society of Physiology (SBFis), Joint Graduate Program in Physiological Sciences
(PIPGCF UFSCar-UNESP), FAPESP, and UNESP,§ which allowed for their sup-
port. Such broad international participation generated stimulating discussion among
the invited speakers, faculty and young investigators (post-doctoral fellows, graduate
and undergraduate students) presenting their work at the symposium and ultimately
played a very positive role in the production of this book.
The study of the neural control of body fluid homeostasis provides rich examples
of integrative neurobiology and regulatory physiology. The reader will find many
examples in this book of research conducted by leading scientists on signal trans-
duction and sensory afferent mechanisms, molecular genetics, perinatal and adult
long-term influences on regulation, central neural integrative circuitry, and autonomic/
neuroendocrine effector systems. In the spirit of integration, many examples are
provided demonstrating the interface between body fluid homeostasis with systems
controlling cardiovascular function, temperature, energy balance, and behavior.
Hormones and neurotransmitters are at the core of the mechanisms that control body
fluid balance, and in this volume they are found to be involved with the control of the
hypothalamic–neurohypophysial axis, neuroplasticity, thirst, and sodium appetite.
We thank the contributors for their time and effort to produce excellent chapters.
It is important to emphasize their patience when asked to revise their chapters. Each
* Cannon, W. B. 1929. Organization for physiological homeostasis. Physiol Rev 9:399–31.
† http://200.145.81.21/body_fluid2011/interna_program.php.
‡ http://www.eventus.com.br/isan2011/.
§ Several offices from UNESP sponsored the symposium: FOAr, FUNDUNESP, PROPe, and PROPG.
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© 2010 Taylor & Francis Group, LLC
