MicroRNAs in Cancer Translational Research

553 Pages·2011·7.335 MB·English

by  Manuela Ferracin, George A. Calin (auth.), William C.S. Cho (eds.)

MicroRNAs in Cancer Translational Research
William C.S. Cho
Editor
MicroRNAs in Cancer
Translational Research
123
Editor
Dr.WilliamC.S.Cho
QueenElizabethHospital
DepartmentofClinicalOncology
30GascoigneRoad
HongKongSAR
PRChina
[email protected]
ISBN978-94-007-0297-4 e-ISBN978-94-007-0298-1
DOI10.1007/978-94-007-0298-1
SpringerDordrechtHeidelbergLondonNewYork
©SpringerScience+BusinessMediaB.V.2011
Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorby
anymeans,electronic,mechanical,photocopying,microfilming,recordingorotherwise,withoutwritten
permissionfromthePublisher,withtheexceptionofanymaterialsuppliedspecificallyforthepurpose
ofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.
Printedonacid-freepaper
SpringerispartofSpringerScience+BusinessMedia(www.springer.com)
Preface
MicroRNAs(miRNAs)havearevolutionaryimpactoncancerresearchoverrecent
years. These small non-coding RNAs emerge as important players in tumorigene-
sis, leading to a paradigm shift in oncology. The rapid discovery of many miRNA
targetsandtheirassociatedpathwayshascontributedtothedevelopmentofmiRNA-
basedtherapeuticsforcancer.TheseexcitingfindingsrevealthepotentialofmiRNA
studiestranslatingfrombenchtobedsideapplications.Thoroughunderstandingof
miRNAs in cancer translational research is apparently a prerequisite for all pro-
fessionals involved and interested in this area. MiRNA is a cutting-edge topic in
the scientific and medical fields, the identification of cancer-related miRNAs and
their state-of-the-art treatment approaches proceed at a fast pace. These stimulat-
ingadvancesdrovemetocompilethisuniquebookentitledMicroRNAsinCancer
TranslationalResearch.
HongKong,China WilliamC.S.Cho
January2011
v
Contents
1 MicroRNAsinCancer(AnOverview) . . . . . . . . . . . . . . . . 1
ManuelaFerracin,GeorgeA.Calin,andMassimoNegrini
2 TheRoleofMicroRNAsinLungCancerDevelopment,
Progression,andMetastasis . . . . . . . . . . . . . . . . . . . . . . 73
DonL.Gibbons,ZainH.Rizvi,andJonathanM.Kurie
3 MicroRNAsinBreastCancer . . . . . . . . . . . . . . . . . . . . . 91
Suvi-KatriLeivonen
4 MicroRNAsinColorectalCancer . . . . . . . . . . . . . . . . . . . 107
OndrejSlaby,MarekSvoboda,JaroslavMichalek,
andRostislavVyzula
5 MicroRNAsinGastricCancer. . . . . . . . . . . . . . . . . . . . . 135
HidekazuSuzuki,YoshimasaSaito,andToshifumiHibi
6 MicroRNAsinProstateCancer:APossibleRoleasNovel
BiomarkersandTherapeuticTargets? . . . . . . . . . . . . . . . . 145
PaoloGandellini,MarcoFolini,andNadiaZaffaroni
7 MicroRNAsinHepatocellularCarcinoma . . . . . . . . . . . . . . 163
JunfangJiandXinWeiWang
8 MicroRNAsinCervicalCarcinoma . . . . . . . . . . . . . . . . . . 189
Jeong-WonLee,Byoung-GieKim,andDuk-SooBae
9 MicroRNAsinEsophagealCancer . . . . . . . . . . . . . . . . . . 201
JianGuandXifengWu
10 MicroRNAsinBladderCancer . . . . . . . . . . . . . . . . . . . . 223
MichaelB.WilliamsandLianaAdam
11 MicroRNAsinLymphoma . . . . . . . . . . . . . . . . . . . . . . . 239
AlbaNavarroLópezandLuisHernándezPous
12 MicroRNAsinLeukemia. . . . . . . . . . . . . . . . . . . . . . . . 269
FlorianKuchenbauer,JohannesBloehdorn,LarsBullinger,
andThorstenZenz
vii
viii Contents
13 MicroRNAs in Pancreatic Cancer: Potential Interests
asBiomarkersandTherapeuticTools . . . . . . . . . . . . . . . . 287
PierreCordelierandJérômeTorrisani
14 MicroRNAsinEpithelialOvarianCancer . . . . . . . . . . . . . . 309
ChunshengLi,YiFeng,GeorgeCoukos,andLinZhang
15 MicroRNAsinBrainTumors . . . . . . . . . . . . . . . . . . . . . 343
TaraSpence,JohnnyNguyen,EricBouffet,andAnnieHuang
16 MicroRNAsandCancerStemCells . . . . . . . . . . . . . . . . . . 373
ZuorenYuandRichardG.Pestell
17 MicroRNAsinCancerInvasionandMetastasis . . . . . . . . . . . 389
AshharS.Ali,ShadanAli,AamirAhmad,
PhilipA.Philip,andFazlulH.Sarkar
18 MicroRNAsinPredictingRadiotherapyandChemotherapy
Response. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415
EmilyJ.Noonan,RobertF.Place,andLong-ChengLi
19 RoleofMicroRNAsinAnti-cancerDrugResistance . . . . . . . . 449
ErikA.C.Wiemer
20 MicroRNAsandCancerMetabolism . . . . . . . . . . . . . . . . . 485
PingGao
21 MicroRNAsasBlood-basedBiomarkersofCancer . . . . . . . . . 499
XiChen,JunfengZhang,KeZen,andChen-YuZhang
22 RNAi-basedApproachestotheTreatmentofBrainTumors . . . . 533
SarojP.Mathupala,SandeepMittal,MuraliGuthikonda,
andAndrewE.Sloan
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 551
Contributors
LianaAdamDepartmentofUrology,MDAndersonCancerCenter,
TheUniversityofTexas,Houston,TX77030,USA,[email protected]
AamirAhmadDepartmentofPathology,KarmanosCancerInstitute,WayneState
University,Detroit,MI48201,USA,[email protected]
AshharS.AliDepartmentofPathology,KarmanosCancerInstitute,WayneState
University,Detroit,MI48201,USA,[email protected]
ShadanAliDivisionofHematologyandOncology,KarmanosCancerInstitute,
WayneStateUniversity,Detroit,MI48201,USA,[email protected]
Duk-SooBaeDepartmentofObstetricsandGynecology,SamsungMedical
Center,SungkyunkwanUniversitySchoolofMedicine,Gangnam-gu,Seoul
135-710,Korea,[email protected]
JohannesBloehdornDepartmentofInternalMedicineIII,UniversityofUlm,
89081Ulm,Germany,[email protected]
EricBouffetPediatricBrainTumourProgram,DivisionofHematologyOncology,
SickKidsHospital,Toronto,ON,Canada;DepartmentofPediatrics,Universityof
Toronto,Toronto,ON,CanadaM5G1X8,[email protected]
LarsBullingerDepartmentofInternalMedicineIII,UniversityofUlm,
89081Ulm,Germany,[email protected]
GeorgeA.CalinDepartmentofExperimentalTherapeuticsandCancerGenetics,
MDAndersonCancerCenter,UniversityofTexas,Houston,TX77030,USA,
[email protected]
XiChenStateKeyLaboratoryofPharmaceuticalBiotechnology,SchoolofLife
Sciences,JiangsuDiabetesCenter,NanjingUniversity,Nanjing,Jiangsu210093,
PRChina,[email protected]
PierreCordelierInsermU858,I2MRInstitutdeMédecineMoléculairede
Rangueil,BP84225,31432ToulouseCedex4,France,pierre.cordelier@inserm
GeorgeCoukosDepartmentofObstetricsandGynecology,AbramsonFamily
CancerResearchInstitute,CenterforResearchonEarlyDetectionandCureof
ix
x Contributors
OvarianCancer,UniversityofPennsylvania,Philadelphia,PA19104,USA,
[email protected]
YiFengAbramsonFamilyCancerResearchInstitute,UniversityofPennsylvania,
Philadelphia,PA19104,USA,[email protected]
ManuelaFerracinDepartmentofExperimentalandDiagnosticMedicine,
UniversityofFerrara,Ferrara44121,Italy,[email protected]
MarcoFoliniDepartmentofExperimentalOncologyandMolecularMedicine,
FondazioneIRCCSIstitutoNazionaledeiTumori,Milan,Italy,
[email protected]
PaoloGandelliniMolecularPharmacologyUnit,DepartmentofExperimental
OncologyandMolecularMedicine,FondazioneIRCCSIstitutoNazionaledei
Tumori,20133Milan,Italy,[email protected]
PingGaoDivisionofHematology,DepartmentofMedicine,JohnsHopkins
UniversitySchoolofMedicine,Baltimore,MD,USA;SchoolofLifeSciences,
UniversityofScienceandTechnologyofChina,Hefei,Anhui230027,PRChina,
[email protected];[email protected]
DonL.GibbonsDepartmentofThoracic,HeadandNeckMedicalOncologyand
Dept.ofMolecular&CellularOncology,MDAndersonCancerCenter,
TheUniversityofTexas,Houston,TX77030,USA,[email protected]
JianGuDepartmentofEpidemiology,MDAndersonCancerCenter,
TheUniversityofTexas,Houston,TX77030,USA,[email protected]
MuraliGuthikondaDepartmentofNeurologicalSurgery,KarmanosCancer
Institute,WayneStateUniversitySchoolofMedicine,Detroit,MI48201,USA,
[email protected]
LuisHernándezPousMolecularPathologyDepartment,Facultaddemedicina,
Institutd’InvestigacionsBiomèdiquesAugustPiiSunyer(IDIBAPS),
08036Barcelona,Spain,[email protected]
ToshifumiHibiDepartmentofInternalMedicine,KeioUniversitySchool
ofMedicine,Tokyo160-8582,Japan,[email protected]
AnnieHuangPediatricBrainTumourProgram,PrograminCellBiology,Division
ofHematologyOncology,DepartmentofPediatrics,SoniaandArthurLabattBrain
TumourResearchCentre,HospitalforSickChildren,Toronto,ON,
Canada,[email protected]
JunfangJiLiverCarcinogenesisSection,LaboratoryofHumanCarcinogenesis,
NationalCancerInstitute,CenterforCancerResearch,Bethesda,MD20892-4258,
USA,[email protected]
Contributors xi
Byoung-GieKimDepartmentofObstetricsandGynecology,SamsungMedical
Center,SungkyunkwanUniversitySchoolofMedicine,Gangnam-gu,
Seoul135-710,Korea,[email protected]
FlorianKuchenbauerDepartmentofInternalMedicineIII,UniversityofUlm,
89081Ulm,Germany,fl[email protected]
JonathanM.KurieDepartmentofThoracic,HeadandNeckMedicalOncology,
MDAndersonCancerCenter,TheUniversityofTexas,Houston,TX77030,USA,
[email protected]
Jeong-WonLeeDepartmentofObstetricsandGynecology,SamsungMedical
Center,SungkyunkwanUniversitySchoolofMedicine,Gangnam-gu,
Seoul135-710Korea,[email protected]
Suvi-KatriLeivonenVTTMedicalBiotechnology,FI-20521Turku,Finland,
suvi-katri.leivonen@vtt.fi
ChunshengLiCenterforResearchonEarlyDetectionandCureofOvarian
Cancer,UniversityofPennsylvania,Philadelphia,PA19104,USA,
[email protected]
Long-ChengLiDepartmentofUrology,HelenDillerComprehensiveCancer
Center,UniversityofCalifornia,SanFrancisco,CA,USA,
[email protected]
SarojP.MathupalaDepartmentofNeurologicalSurgery,KarmanosCancer
Institute,WayneStateUniversitySchoolofMedicine,Detroit,MI48201,USA,
[email protected]
JaroslavMichalekFacultyofMedicine,UniversityCellImmunotherapyCenter,
MasarykUniversity,62500 Brno,CzechRepublic,[email protected]
SandeepMittalDepartmentofNeurologicalSurgery,KarmanosCancerInstitute,
WayneStateUniversitySchoolofMedicine,Detroit,MI48201,USA,
[email protected]
AlbaNavarroLópezMolecularPathologyDepartment,Institutd’Investigacions
BiomèdiquesAugustPiiSunyer(IDIBAPS),Barcelona,Spain,
[email protected]
MassimoNegriniDipartimentodiMedicinaSperimentaleeDiagnostica,
UniversitàdiFerrara,Ferrara44121,Italy,[email protected]
JohnnyNguyenPrograminCellBiology,SoniaandArthurLabattBrainTumour
ResearchCentre,SickKidsHospital,Toronto,ON,CanadaM5G1X8;Department
ofLaboratoryMedicineandPathobiology,UniversityofToronto,Toronto,ON,
Canada,[email protected]