Table Of ContentMicrobial Products
Microbial Products: Applications and Translational Trends offers complete coverage of the produc-
tion of microbial products, including biopolymers, biofuels, bioactive compounds, and their appli-
cations in fields such as bioremediation, agriculture, medicine, and other industrial settings. This
book focuses on multiple processes including upstream procedures and downstream processing,
and the tools required for their production. Lab-scale development processes may not be as efficient
when aiming for large-scale industrial production, so it is necessary to utilize in-silico modeling
tools such as graph theory and Petri net modeling for bioprocess design to ensure success at trans-
lational levels. Therefore, this book presents in-silico and mathematical simulations and approaches
used for such applications. Further, it examines microbial products produced from bacteria, fungi,
and algae. These major microbial categories have the capacity to produce various diverse second-
ary metabolites, bioactive compounds, enzymes, biopolymers, biofuels, probiotics, and more. The
bioproducts examined in this book are of great social, medical, and agricultural benefit, and include
examples of biodegradable polymers, biofuels, biofertilizers, and drug delivery agents.
• Presents approaches and tools that aid in the design of eco-friendly, efficient, and economic
bioprocesses.
• Utilizes in-silico and mathematical simulations for optimal bioprocess design.
• Examines approaches to be used for bioproducts from the lab scale to widely applied
microbial biotechnologies.
• Presents the latest trends and technologies in production approaches for microbial bioprod-
uct manufacture and application.
This book is ideal for both researchers and academics, as it provides up-to-date knowledge of applied
microbial biotechnology approaches for bioproducts.
Microbial Biotechnology for Food, Health, and the Environment Series
Series Editor: Ashok Kumar Nadda
Plant-Microbial Interactions and Smart Agricultural Biotechnology
Edited by Swati Tyagi, Robin Kumar, Baljeet Saharan, Ashok Kumar Nadda
Microbial Products
Applications and Translational Trends
Edited by Mamtesh Singh, Gajendra Pratap Singh, Shivani Tyagi
For more information about this series, please visit: www.routledge.com
https://www.routledge.com/Microbial-Biotechnology-for-Food-Health-and-the-Environment/
book-series/CRCMBFHE
Microbial Products
Applications and Translational Trends
Edited by
Mamtesh Singh
Gajendra Pratap Singh
Shivani Tyagi
Cover image: Dr. Gajendra Pratap Singh
First edition published 2023
by CRC Press
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and by CRC Press
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CRC Press is an imprint of Taylor & Francis Group, LLC
© 2023 selection and editorial matter, Mamtesh Singh, Gajendra Pratap Singh, Shivani Tyagi; individual chapters, the
contributors
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Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used only for identification
and explanation without intent to infringe.
ISBN: 978-1-032-30820-3 (hbk)
ISBN: 978-1-032-30839-5 (pbk)
ISBN: 978-1-003-30693-1 (ebk)
DOI: 10.1201/9781003306931
Typeset in Times
by SPi Technologies India Pvt Ltd (Straive)
To my late loving father Mr Sher Singh,
to whom (along with my mother Mrs Jagroshni)
I owe everything I am today and will be.
M.S.
To my late grandparents and to my parents
(Mr Suraj Singh & Mrs Krishna Devi)
G.P.S.
Contents
Preface ...............................................................................................................................................xi
Contributors ....................................................................................................................................xiii
About the Editors ............................................................................................................................xix
PART I Environment
Chapter 1 Microbial Products: Applications in the Field of Biotechnology and
Bioremediation ...........................................................................................................3
Shalini Porwal, Sonal Chaudhary, Ayushi Singh and Ajit Varma
Chapter 2 Microbial Proteases: A Significant Tool for Industrial Applications ........................11
Tanvi Singh, Sushma Sharma and Yamini Tiwari
Chapter 3 Microbial Melanin: Role, Biosynthesis, and Applications .......................................25
Sanjay Kumar, Sawraj Singh and Rajeev Kumar Kapoor
Chapter 4 Cyanobacteria as Natural Biofactories .....................................................................35
Garvita Singh, Paushali Ghosh, Divya Singh and Jay Kumar
Chapter 5 Microbial Production of Polyhydroxyalkanoate from Biological Waste ..................57
Tarika Kumar and Vijay Rayasam
Chapter 6 Exopolysaccharides for Heavy Metal Remediation: A Review of
Current Trends and Future Prospects ........................................................................73
Anina James, Deepika Yadav and Mohit Kumar
Chapter 7 Biosurfactants: A Greener Alternative for a Sustainable Future ...............................85
Neha Dhingra
Chapter 8 Biosurfactants: Versatile Molecules with Potential Applications .............................97
Manju Bhaskar and Vinod Kumar Verma
Chapter 9 Production of Microbial Enzymes Using Spent Mushroom
Compost (SMC) and Its Application ......................................................................109
Anjali Kosre, Deepali, Ashish Kumar and Nagendra Kumar Chandrawanshi
vii
viii Contents
Chapter 10 Indigenous Fermented Food and Beverages of Manipur ........................................119
Vera Yurngamla Kapai, Leisan Judith and Gladys Muivah
Chapter 11 Microorganisms in Cosmetology ............................................................................137
Rita Rath, Neeraja Sood and Sadhna Gupta
PART II Agriculture
Chapter 12 Microbes and Their Products in Sustainable Agriculture .......................................157
Smriti Sharma and Jyotsna Singh
Chapter 13 Microbial Biopesticides: An Eco-Friendly Approach for a Sustainable
Agro-ecosystem ......................................................................................................189
Nidhi Srivastava, Usha Kumari and Jai Kumar
Chapter 14 Application and Impact of Biofertilizers in Sustainable Agriculture .....................205
Sourabh, Nirmal Singh and Preeti
Chapter 15 Microbial Endophytes of Medicinal Plants as an Emerging Bioresource for
Novel Therapeutic Compounds ..............................................................................235
Ashish Kumar, Rameshwari A. Banjara, Roman Kumar Aneshwari and
Nagendra Kumar Chandrawanshi
Chapter 16 Utility of Probiotics in Aquaculture ........................................................................249
Reema Mishra, Renu Soni, Preeti Agarwal and Aparajita Mohanty
Chapter 17 The Potential Role of Microbes in the Sustainable Growth of
Ornamental Fish Culture .........................................................................................273
Archana Aggarwal and Rakhi Gupta
Chapter 18 Microbial Metabolites as Fish Immunostimulants: Implications for
Aquaculture and Fish Vaccines ...............................................................................293
M. Divya Gnaneswari, Parasuraman Aiya Subramani and
Chandrasekaran Binuramesh
PART III Medicine
Chapter 19 Probiotics for Improving COVID-19 Infection-Linked Microbiome
Disparities in Gut ....................................................................................................337
Shivani Tyagi, Divyanshi Chauhan, Aarti Venkatesan and Mamtesh Singh
Contents ix
Chapter 20 Algal Products in Medicine ....................................................................................345
Neelam Gandhi
Chapter 21 Microbial Production and Emerging Applications of Lantibiotics .........................361
Indra Mani, Vijai Singh and Sunil Kumar
Chapter 22 Bacterial Drug Delivery Vehicles for Targeted Treatment of Tumors ....................373
Pooja Gulati, Anubhuti Kawatra, Sonika Dhillon and Rakhi Dhankhar
Chapter 23 Fungal Products in Medicine ..................................................................................387
Neelam Gandhi
Chapter 24 Virosomes: A Drug Delivery System ......................................................................401
Kuntal, Aashita Singh, Twinkle Kathuria, Seema Kalra and Madhu Yashpal
Chapter 25 Bioactive Compounds As Potential Remedy Against Coronaviruses .....................417
Kuntal, Prabhleen Kaur, Sakshi Dawer, Madhu Yashpal,
Seema Kalra and Archna Chaudhary
PART IV In-Silico and Mathematical Tools
Chapter 26 Bioinformatics and Vaccine Development: Overview and Prospects .....................435
Swati Bajaj, Pallee Shree and Dileep K. Singh
Chapter 27 Petri Net Modeling as an Aid in Bioprocess Designing .........................................455
Gajendra Pratap Singh, Riddhi Jangid and Mamtesh Singh
Chapter 28 Applications of Machine Learning in Bioprocess Development and
Optimization ...........................................................................................................463
Dharmesh Harwani and Jyoti Lakhani
Index ����������������������������������������������������������������������������������������������������������������������������������������������473
