Table Of ContentS E C O N D E D I T I O N
Metabolic
and
Therapeutic
Aspects
of
Amino Acids
in
ClinIcal Nutrition
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S E C O N D E D I T I O N
Metabolic
and
Therapeutic
Aspects
of
Amino Acids
in
ClinIcal Nutrition
Edited by
Luc a. Cynober
CRC PR ESS
Boca Raton London New York Washington, D.C.
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Library of Congress Cataloging-in-Publication Data
Metabolic & therapeutic aspects of amino acids in clinical nutrition / edited by Luc A.
Cynober. --2nd ed.
p. ; cm.
Rev. ed of: Amino acid metabolism and therapy in health and nutritional disease. 1995.
Includes bibliographical references and index.
ISBN 0-8493-1382-1 (alk. paper)
1. Amino acids--Metabolism. 2. Amino acids--Pathophysiology. 3. Amino acids in
human nutrition. I. Title: Metabolic and therapeutic aspects of amino acids in clinical
nutrition. I. Cynober, Luc A. II. Amino acid metabolism and therapy in health and
nutritional disease.
[DNLM: 1. Amino acids--metabolism. 2. Amino Acids--therapeutic use. 3. Amino
Acids--administration & dosage. QU 60 M5867 2003]
QP561.A4615 2003
612.3'98—dc22 2003047263
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Printed in the United States of America 1 2 3 4 5 6 7 8 9 0
Printed on acid-free paper
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Dedication
Prof. Bernard Beaufrère Prof. Peter Reeds
The second edition of this book is dedicated to the memories of
Prof. Bernard Beaufrère and Prof. Peter Reeds.
Both were first-rate scientists, and their contributions to the field
of amino acid and protein metabolism were considerable.
They were life-loving people and are sorely missed
by their many friends across the world.
Luc A. Cynober
Editor
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Preface
When CRC Press urged me a year ago to supervise a second edition of this book, I accepted
for several reasons. First, this book remained the only one devoted exclusively to the
metabolic and therapeutic aspects of amino acids in clinical nutrition. Second, in the 9
years since the first edition, a number of very important advances had been made in the
field. Third, some new topics had emerged with recent work, for example, on amino acids
and aging, and on arginine as a nutraceutical in cardiovascular disease. There were also
interesting new findings concerning taurine and other sulfur amino acids. Additionally, I
had reached the conclusion that the aftereffects of sports were a catabolic disorder and so
deserved a chapter. Finally, technical considerations concerning amino acid measurements,
which were lacking in the first edition, could now be addressed. So a second edition was
in order.
Most of the authors had already contributed to the first edition. They have done a
fine job once more, not only refining their earlier contributions, but also thoroughly
updating them to make this book a most valuable store of information and insight. Some
of the original authors were unable to contribute again for various reasons, but new
authors bring fresh ideas and new viewpoints. I warmly thank all the contributors.
Despite all possible efforts, some topics (AIDS, transplantation, etc.) remain unad-
dressed in this edition. I may be able to correct this in a third edition. Who knows?
Lastly, I am most grateful for the secretarial assistance of Solange Ngon in the prep-
aration of the book. Her perseverance in handling hundreds of e-mails, opening obstinate
attachments, and dealing with the different versions of the manuscripts was decisive for
a successful outcome.
Luc A. Cynober
Paris
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About the Editor
Luc A. Cynober, Ph.D., is head of the Department of Clinical Biochemistry, Hotel-Dieu
Hospital, Paris, and is professor of nutrition and head of the Biological Nutrition Labo-
ratory at the School of Pharmacy, University of Paris, France.
Dr. Cynober obtained his Pharm.D. degree in 1979 from the School of Pharmacy, Paris
XI University. In 1985, he received his Ph.D. degree in biological and pharmaceutical
sciences from the same university.
Dr. Cynober is a member of the European Society of Parenteral and Enteral Nutrition,
the American Society of Parenteral and Enteral Nutrition, the French-Speaking Society of
Clinical Biology, and the French Society of Biochemistry and Molecular Biology, among
others.
He served from 1992 to 2000 as officer in the executive committee of the European
Society of Parenteral and Enteral Nutrition, and since 2001 as chairman of the French-
Speaking Society of Enteral and Parenteral Nutrition. He served (1987–1992) as editor-in-
chief of Nutrition Clinique & Métabolisme. He is presently (since 1998) editor-in-chief of
Current Opinion in Clinical Nutrition and Metabolic Care.
Among other awards, he has received the Pharmacy Academy Award for his Ph.D.
thesis and the International Research Award of the French Society of Clinical Biology.
Dr. Cynober has presented over 70 invited lectures at international and national
meetings and over 150 guest lectures at universities and institutes. He has published more
than 200 research papers. His current major research interests relate to amino acid metab-
olism and therapy in critical illness and aging.
Description:The first edition of this innovative book brought a new perspective to the metabolic and therapeutic aspects of amino acids in clinical nutrition. Since its publication, a number of very important advances have been made in the field and interesting new findings have emerged. Until now, no reference
