Membrane Dynamics and Calcium Signaling

409 Pages·2017·11.363 MB·English

by  Joachim Krebs

Advances in Experimental Medicine and Biology 981
Joachim Krebs E ditor
Membrane
Dynamics
and Calcium
Signaling
Advances in Experimental Medicine and Biology
Volume 981
EditorialBoard
IrunR.Cohen,TheWeizmannInstituteofScience,Rehovot,Israel
AbelLajtha,N.S.KlineInstituteforPsychiatricResearch,Orangeburg,NY,USA
JohnD.Lambris,UniversityofPennsylvania,Philadelphia,PA,USA
RodolfoPaoletti,UniversityofMilan,Milan,Italy
NimaRezaei,TehranUniversityofMedicalSciences,Tehran,Iran
Moreinformationaboutthisseriesathttp://www.springer.com/series/5584
Joachim Krebs
Editor
Membrane Dynamics
and Calcium Signaling
Editor
JoachimKrebs
MPIforBiophysicalChemistry
Göttingen,Germany
ISSN0065-2598 ISSN2214-8019 (electronic)
AdvancesinExperimentalMedicineandBiology
ISBN978-3-319-55857-8 ISBN978-3-319-55858-5 (eBook)
https://doi.org/10.1007/978-3-319-55858-5
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Preface
Calcium as a versatile carrier of many signals can lead to cell-specific Ca2+
signalosomes delivering Ca2+ signals with spatial and temporal characteristics.
Theseareespeciallytrueformembranecontactsites(MCSs)creatingmicrodomains
where two membranes of different organelles are closely apposed to facilitate
molecular communication to promote Ca2+ signaling. The formation of MCSs is a
highlydynamicprocesswhichisimportanttoregulateCa2+homeostasiscontrolled
by a plethora of Ca2+ channels, pumps, and exchangers. MCSs probably emerged
earlyduringeukaryoticevolution(JainA,HolthuisJCM(2017)BBAMolCellRes
1864:1450–1458). They could be visualized early on by electron microscopy (see
Fig.1;Palade1953),buttheirfunctionalimportancebecameevidentmuchlater.
Calciumcontrolsalargenumberofcellularfunctionsreflectedbythenumerous
proteinsregulatingCa2+homeostasis.Therecentsignificantimprovementofdiffer-
ent techniques to solve structures of large and complex proteins at high resolution
andtheirinvolvementinthefunctionofdifferentMCSsincreasedourunderstanding
of Ca2+ signaling to regulate cellular functions. This is due to highly specific
interactionofCa2+withproteinsresultinginspecificmodulationsofprotein–protein
interactions which are followed by conformational changes of the participants. In
recentyears,itbecameevidentthatcalciumoftenfulfillsitssignalingfunctionwithin
microdomains due to MCSs between different intracellular organelles such as the
endo/sarcoplasmic reticulum and mitochondria or between intracellular organelles
andtheplasmamembrane.Knowledgeaboutthedetailsofthesedynamicprocesses
rapidlyincreasedinrecent years.Inthisbook,we review themostrecentdevelop-
mentsbyleadingexpertsinthefield.Itisastate-of-the-artsummaryofourpresent
knowledge in this quickly growing field of calcium signaling in connection with
dynamic membrane processes. The book provides insight into the impressive pro-
gress made in many areas of calcium signaling but also reminds us of how much
remainstobelearned.
Iamgratefultoallparticipantsofthisbookfortheirsupportandtheirexcellent
contributions.IamindebtedtoSpringerInternationalforgivingmetheopportunity
to edit this book. I hope it provides a stimulating guide to workers in this research
v
vi Preface
Fig.1 Thefigureshowstheelectronmicrographofasmallsectionofthecytoplasmofaratliver
cellastakenfromPaladeGE(1953)JHistochemCytochem1:188–211,withthepermissionofthe
publisher. M mitochondria, ER endoplasmic reticulum. The arrows point to possible membrane
contactsitesbetweentheERandamitochondrion
areaandtoabroaderscientificcommunitywithageneralinterestinthefascinating
fieldofcalciumsignaling.MysincerethanksalsogotoAmreiStrehl,Claus-Dieter
Bachem,andRakeshJotheeswaranfromSpringerwhokindlyhelpedinallaspects
of editing this book. I am very grateful to Christian Griesinger, Head of the
Department of NMR-Based Structural Biology at the Max Planck Institute for
BiophysicalChemistry,forhis long-standingsupport.Last butnotleast,Iamvery
thankfultomywife,EvaKrebs-Roubicek,forherpatienceandunderstandingduring
theprocessofeditingthisbook.
Göttingen,Germany JoachimKrebs
August2017
Contents
PartI PlasmaMembrane
1 ThePlasmaMembraneCalciumPump(PMCA):Regulation
ofCytosolicCa2+,GeneticDiversitiesandItsRole
inSub-plasmaMembraneMicrodomains. . . . . . . . . . . . . . . . . . . . 3
JoachimKrebs
2 Structure-FunctionRelationshipoftheVoltage-GatedCalcium
ChannelCa 1.1Complex. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23
v
JianpingWu,NiengYan,andZhenYan
3 Structure-DynamicCouplingThroughCa2+-BindingRegulatory
DomainsofMammalianNCXIsoform/SpliceVariants. . . . . . . . . . 41
DanielKhananshvili
PartII Endoplasmic/SarcoplasmicReticulum
4 TheEndoplasmicReticulumandtheCellularReticularNetwork. . . . 61
LuisB.AgellonandMarekMichalak
5 Structure-FunctionRelationshipoftheSERCAPump
andItsRegulationbyPhospholambanandSarcolipin. . . . . . . . . . 77
PrzemekA.Gorski,DelaineK.Ceholski,andHowardS.Young
6 StructuralInsightsintoIP RFunction. . . . . . . . . . . . . . . . . . . . . . 121
3
IrinaI.Serysheva,MariahR.Baker,andGuizhenFan
7 IP ReceptorPropertiesandFunctionatMembrane
3
ContactSites. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
GemmaRoest,RitaM.LaRovere,GeertBultynck,andJanB.Parys
8 StructuralDetailsoftheRyanodineReceptorCalcium
ReleaseChannelandItsGatingMechanism. . . . . . . . . . . . . . . . . . 179
KatrienWillegemsandRouslanG.Efremov
vii
viii Contents
9 Store-OperatedCalciumEntry:AnHistoricalOverview. . . . . . . . . 205
JamesW.Putney
10 FromStorestoSinks:StructuralMechanismsofCytosolic
CalciumRegulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
MasahiroEnomoto,TadateruNishikawa,NaveedSiddiqui,
SteveChung,MitsuhikoIkura,andPeterB.Stathopulos
11 AssemblyofER-PMJunctions:ACriticalDeterminant
intheRegulationofSOCEandTRPC1. . .. . . . . .. . . . . .. . . . . .. 253
KrishnaP.Subedi,HweiLingOng,andInduS.Ambudkar
PartIII Mitochondria
12 BeyondIntracellularSignaling:TheInsandOutsofSecond
MessengersMicrodomains. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279
RiccardoFiladi,EmyBasso,KonstantinosLefkimmiatis,
andTullioPozzan
13 MitochondrialVDAC,theNa+/Ca2+Exchanger,andtheCa2+
UniporterinCa2+DynamicsandSignaling. . . . . . . . . . . . . . . . . . . 323
VardaShoshan-BarmatzandSoumasreeDe
PartIV Annexins
14 Annexins:Ca2+EffectorsDeterminingMembraneTrafficking
intheLateEndocyticCompartment. . . . . . . . . . . . . . . . . . . . . . . . 351
CarlosEnrich,CarlesRentero,ElsaMeneses-Salas,FrancescTebar,
andThomasGrewal
PartV CytokinesisandCa2+Signaling
15 Ca2+SignallingandMembraneDynamicsDuringCytokinesis
inAnimalCells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 389
SarahE.WebbandAndrewL.Miller
Part I
Plasma Membrane