Mechanisms in the Pathogenesis of Enteric Diseases 2

330 Pages·1999·7.868 MB·English

by  Fergus Shanahan (auth.), Prem S. Paul, David H. Francis (eds.)

MECHANISMS IN THE
PATHOGENESIS OF
ENTERIC DISEASES 2
Edited by
Prem S. Paul
Iowa State University
Ames, Iowa
and
David H. Francis
South Dakota State University
Brookings, South Dakota
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data
Mechanisms in the pathogenesis of enteric diseases 2/edited by Prem S. Paul and David
H. Francis.
p. ; cm. - (Advances in experimental medicine and biology; v. 473)
Inc\udes bibliographic references and index.
ISBN 978-1-4613-6858-8 ISBN 978-1-4615-4143-1 (eBook)
DOI 10.1007/978-1-4615-4143-1
1. Intestines-Infections-Pathophysiology-Congresses. 1. Paul, Prem S. II. Francis,
David H. III. International Rushmore Conference on Mechanisms in the Pathogenesis of
Enteric Diseases (2nd: 1998: Rapid City, S.D.) IV. Series.
[DNLM: 1. Gastrointestinal Diseases-microbiology-Congresses. 2. Gastrointestinal
Diseases-pathophysiology-Congresses. WI 140 M486 1999]
RC862.E47 M43 1999
616.3' 407-dc21
99-048628
ISSN 0065-2598
Proceedings of the Second International Rushmore Conference on Mechanisms in the Pathogenesis of Enteric
Diseases, held September 30-0ctober 3, 1998, in Rapid City, South Dakota
ISBN 978-1-4613-6858-8
©1999 Springer Science+Business Media New York
Originally published by Kluwer Academic 1 Plenum Publishers in 1999
Softcover reprint ofthe hardcover Ist edition 1999
AII rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means,
electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the
Publisher
MECHANISMS IN THE
PATHOGENESIS OF
ENTERIC DISEASES 2
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
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MECHANISMS IN THE PATHOGENESIS OF ENTERIC DISEASES 2
Edited by Prem S. Paul and David H. Francis
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A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume
immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact
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PREFACE
This book, Mechanisms in the Pathogenesis of Enteric Diseases 2, is an out
come of the Second International Rushmore Conference on Mechanisms in the
Pathogenesis of Enteric Diseases, held September 3D-October 3, 1998 in Rapid City,
South Dakota, USA. Its chapters represent many of the reviews and papers presented at
the conference. The meeting was organized by members of the North-Central Regional
Research Committee "NC-62", a consortium of researchers of bovine and swine enteric
diseases from land-grant institutions supported by the United States Department of
Agriculture. The Rushmore Conferences were conceived as a forum for an interdiscipli
nary discussion of mechanisms of infectious enteric diseases. It was intended that such a
discussion would stimulate cross-pollination of ideas, and nurture synergistic collabora
tions among scientists who might otherwise not interact. Enteric diseases are caused by
widely divergent pathogens and parasites in broadly different settings, and affect multi
ple organ systems. Some enteric diseases affect a single species, while others may affect
multiple species, perhaps including human beings. Some enteric diseases were present in
antiquity, while others have recently emerged. Knowledge regarding a particular disease
or pathogen has frequently proven useful in understanding another disease or pathogen,
because common themes in pathogenesis exist. As this knowledge base grows,strategies
in the prevention and control of various enteric diseases often converge. Cross-discipli
nary discussions and collaborations facilitate growth of this knowledge base, as well as
development of tools for disease interdiction. It is hoped that the Second International
Rushmore conference has had such a facilitating effect.
Participants in the conference came from 13 countries in the continents of North
and South America, Europe, and Asia. They represented institutions of higher learn
ing, government agencies, and private industry. Participants brought expertise from
many disciplines in both human and veterinary medicine. These multiple perspectives,
and an informal atmosphere, provided an environment for lively and thought
provoking discussions. Conference topics included: Pathobiology of Gastroenteric Dis
eases; Mechanisms of Identity and Interaction between Host and Pathogen; Effector
Mechanisms in, and Regulation of, Pathogenic Activity; Epidemiology; and Novel
Approaches to Prevention and Therapy. These topics were addressed by ten keynote,
and six additional invited speakers. Oral and poster presentations were presented by
other conference participants. Keynote speakers included Drs. Richard Guerrant, Uni
versity of Virginia School of Medicine; Fergus Shanahan, National University of
Ireland; Rodney Berg, Louisiana State University; Marian Horzinek, Utrecht Univer-
v
vi Preface
sity; Mary Estes, Baylor College of Medicine (Houston); Virginia Miller, Washington
University (St. Louis); James Slauch, University of Illinois; Roger Glass, Centers for
Disease Control (Atlanta); Lucia Cardenas-Freytag, Tulane University School of Med
icine (New Orleans); and Luis Enjuanes, Antonomous University (Madrid). Invited
presentations were given by Drs. Linda Saif, Ohio State University; Rodney Moxley,
University of Nebraska; David Francis, South Dakota State University; Michael
Konkel, Washington State University; Andreas Baumler, Texas A & M University; and
Richard Isaacson, University of Illinois.
Members of the conference organizing committee were Drs. David Francis and
David Benfield, South Dakota State University; Richard Isaacson, University of Illi
nois; Lynn Joens, University of Arizona; Rodney Moxley, University of Nebraska; Prem
Paul and Mike Wannemuehlar, Iowa State University; and Linda Saif, Ohio State Uni
versity. Drs. Francis and Benfield were the conference hosts. The conference organiz
ing committee expresses sincere thanks to all who presented speeches or papers at the
Second International Rushmore Conference, joined in discussions, and provided an
enthusiastic environment for presentations and discussions, as well as vendors whose
services made conference attendance enjoyable. The committee expresses special grat
itude to organizations whose financial support made the conference possible. Financial
contributors included: South Dakota/NSF EPSCoR (conference support grant EPS-
9720642); USDA-NRICGP (conference support grant No. 9802205); Bayer
Agriculture Division, Shawnee Mission, Kansas; Pfizer-Central Research Division,
Lincoln, Nebraska; Boehringer Ingelheim Animal Health, Saint Joseph, Missouri;
Grand Laboratories, Inc., Freeman, South Dakota; Eli Lilly and Company Foundation,
Indianapolis, Indiana; and Wyeth-Lederle Vaccines and Pediatrics (Wyeth-Ayerst
Laboratories), Pearl River, NY.
Prem S. Paul
David H. Francis
CONTENTS
Preface ............................................................. v
1. Intestinal Lymphoepithelial Communication 1
Fergus Shanahan
2. Bacterial Translocation from the Gastrointestinal Tract 11
Rodney D. Berg
3. Interference with Virus and Bacteria Replication by the Tissue Specific
Expression of Antibodies and Interfering Molecules . . . . . . . . . . . . . 31
L. Enjuanes, I. Sola, A. Izeta, 1. M. Sanchez-Morgado, 1. M. Gonzalez,
S. Alonso, D. Escors, and C. M. Sanchez
4. Comparative Pathogenesis of Enteric Viral Infections of Swine 47
Linda 1. Saif
5. Molecular Evolution of Corona- and Toroviruses 61
Marian C. Horzinek
6. A Viral Enterotoxin: A New Mechanism of Virus-Induced
Pathogenesis ................................................ 73
Mary K. Estes and Andrew P. Morris
7. Comparative Pathology of Bacterial Enteric Diseases of Swine 83
Rodney A. Moxley and Gerald E. Duhamel
8. Mechanisms and Impact of Enteric Infections ........................ 103
Richard L. Guerrant, Aldo A. M. Lima, Manuel Barboza,
Sharon Young, Terezinha Silva, Leah Barrett, Yongde Bao,
Jay Fox, and Sean Moore
9. Insulin Modulates Intestinal Response of Suckling Mice to the Escherichia
coli Heat-Stable Enterotoxin .................................. 113
Ahmad M. AI-Majali, Elikplimi K. Asem, Carlton Lamar,
1. Paul Robinson, James Freeman, and A. Mahdi Saeed
vii
viii Contents
10. Reproduction of Lesions and Clinical Signs with a CNF2-Producing
Escherichia coli in Neonatal Calves ............................ 125
Sigrid Van Bost and Jacques Mainil
11. The Locus for Enterocyte Effacement (LEE) of Enteropathogenic
Escherichia coli (EPEC) from Dogs and Cats . . . . . . . . . . . . . . . . . . . 129
Frederic Goffaux, Bernard China, Laurence Janssen, Vinciane Pirson,
and Jacques Mainil
12. Age-Dependent Variation in the Density and Affinity of Escherichia coli
Heat-Stable Enterotoxin Receptors in Mice ..................... 137
Ahmad M. AI-Majali, 1. Paul Robinson, Elikplimi K. Asem,
Carlton Lamar, M. James Freeman, and A. Mahdi Saeed
13. K88 Adhesins of Enterotoxigenic Escherichia coli and Their Porcine
Enterocyte Receptors ........................................ 147
David H. Francis, Alan K. Erickson, and Philippe A. Grange
14. Edema Disease as a Model for Systemic Disease Induced by
Shiga Toxin-Producing E. coli .................................. 155
Nancy A. Cornick, Ilze Matise, James E. Samuel, Brad T. Bosworth,
and Harley W. Moon
15. Ultrastructure and DNA Fragmentation Analysis of Arterioles in
Swine Infected with Shiga Toxin-Producing Escherichia coli 163
Ilze Matise, Theerapol Sirinarumitr, Brad T. Bosworth,
and Harley W. Moon
16. Pathogenesis of Escherichia coli 0157:H7 in Weaned Calves ............ 173
Evelyn A. Dean-Nystrom, Brad T. Bosworth, and Harley W. Moon
17. Distribution of a Novel Locus Called paa (£orcine Attaching and
Effacing Associated) among Enteric Escherichia coli . . . . . . . . . . . . . . 179
Hongyan An, John M. Fairbrother, Clarisse Desautels,
and Josee Harel
18. Potentiation of the Effectiveness of Lactobacillus Casei in the
Prevention of E. coli Induced Diarrhea in Conventional and
Gnotobiotic Pigs ............................................. 185
Alojz Bomba, Radomira Nemcova, Sofia Gancarcikova,
Robert Herich, and Rudolf Kastel
19. Recovery from Colonic Infection Elicits Serum IgG Antibodies to
Specific Serpulina pilosicoli Outer Membrane Antigens
(SPOMA) ................................................... 191
Peng Zhang, Nancy A. Witters, and Gerald E. Duhamel
20. Motility-Regulated Mucin Association of Serpulina pilosicoli,
The Agent of Colonic Spirochetosis of Humans and Animals . . . . . . . 199
Nancy A. Witters and Gerald E. Duhamel
Contents ix
21. Coiling Phagocytosis Is the Predominant Mechanism for Uptake of the
Colonic Spirochetosis Bacterium Serpulina pilosieoli by Human
Monocytes .................................................. 207
Xiaoxing Cheng, Jeffrey D. Cirillo, and Gerald E. Duhamel
22. Identification of Proteins Required for the Internalization of
Campylobaeter jejuni into Cultured Mammalian Cells 215
Michael E. Konkel, Bong J. Kim, Vanessa Rivera-Amill,
and Steven G. Garvis
23. Secretion of Campylobaeter jejuni Cia Proteins Is Contact
Dependent .................................................. 225
Vanessa Rivera-Amill and Michael E. Konkel
24. Codon Usage in the AfT-Rich Bacterium Campylobaeter jejuni . . . . . . . . . . 231
Sean A. Gray and Michael E. Konkel
25. Prevalence of Campylobaeter, Salmonella, and Areobaeter Species at
Slaughter in Market Age Pigs ................................. 237
Roger B. Harvey, Robin C. Anderson, Colin R. Young,
Michael E. Hume, Kenneth J. Genovese, Richard L. Ziprin,
Leigh A. Farrington, Larry H. Stanker, and David J. Nisbet
26. Cryptosporidium parvum Gene Discovery 241
Mitchell S. Abrahamsen
27. Norepinephrine Stimulates in vitro Growth but Does Not Increase
Pathogenicity of Salmonella eholeraesuis in an in vivo Model 249
Jerome C. Niefeld, Teresa J. Yeary, Randall J. Basaraba,
and Konrad Schauenstein
28. Of Mice, Calves, and Men: Comparison of the Mouse Typhoid Model
with Other Salmonella Infections .............................. 261
Renee M. Tsolis, Robert A. Kingsley, Stacy M. Townsend,
Thomas A. Picht, L. Garry Adams, and Andreas J. Baumler
29. Sips, Sops, and SPIs but Not stn Influence Salmonella
Enteropathogenesis ........................................ 275
T.S. Wallis, M. Wood, P. Watson, S. Paulin, M. Jones, and E. Galyov
30. Phase Variable Switching of in vivo and Environmental Phenotypes of
Salmonella typhimurium ...................................... 281
R.E. Isaacson, C. Argyilan, L. Kwan, S. Patterson, and K. Yoshinaga
31. A Preliminary Survey of Antibiotic Resistance of Salmonella in
Market-Age Swine ........................................... 291
Leigh A. Farrington, Roger B. Harvey, Sandra A. Buckley,
Larry H. Stanker, and Peter D. Inskip
x Contents
32. Prophylactic Administration of Immune Lymphokine Derived from
T Cells of Salmonella enteritidis-Immune Pigs: Protection against
Salmonella choleraesuis Organ Invasion and Cecal Colonization in
Weaned Pigs ................................................ 299
Kenneth 1. Genovese, Robin C. Anderson, David E. Nisbet,
Roger B. Harvey, Virginia K. Lowry, Sandra Buckley,
Larry H. Stanker, and Michael H. Kogut
33. Sialic Acid Dependence and Independence of Group A
Rotaviruses ................................................. 309
Theresa B. Kuhlenschmidt, William P. Hanafin, Howard B. Gelberg,
and Mark S. Kuhlenschmidt
34. New Approaches to Mucosal Immunization .......................... 319
Lucia Cardenas-Freytag, Elly Cheng, and Aysha Mirza
Index ............................................................... 339