Table Of Contentmore information – www.cambridge.org/9781107016774
Materiomics
This complete, yet concise, guide introduces you to the rapidly developing field of
high-throughput screening of biomaterials: materiomics. Bringing together the key
conceptsandmethodologiesusedtodeterminebiomaterialproperties,itwillallowyou
to understand the adaptation and application of materiomics in areas such as rapid
prototyping, lithography and combinatorial chemistry. Each chapter is written by
internationally renowned experts, and includes tutorial paragraphs on topics such as
biomaterial-banking, imaging, assay development, translational aspects and infor-
matics. Case studies of state-of-the-art experiments provide illustrative examples,
while lists of key publications allow you to read up easily on the most relevant
background material. Whether you are a professional scientist in industry, a student
oraresearcher,thisbookisnottobemissedifyouareinterestedinthelatestdevelop-
mentsinbiomaterialsresearch.
Jan de Boer is a Professor of Applied Cell Biology at the University of Twente, the
Netherlands,attheMIRAInstituteforBiomedicalTechnologyandTechnicalMedicine,
where his team performs innovative research on molecular and cellular engineering of
bone tissue. He is chair of the Netherlands Society of Biomaterials and Tissue
Engineering,andco-founderofthebiotechcompanyMateriomicsB.V.
Clemens A. van Blitterswijk is Professor of Tissue Regeneration at the University of
Twente, and chair of the Department of Tissue Regeneration at MIRA. Clemens has
publishedover300papersandisco-inventoronover100patents.Heisoneofonlytwo
individualstohavereceivedboththeJeanLerayAwardandtheGeorgeWinterAward,the
twoprestigiousprizesoftheEuropeanSocietyforBiomaterials.Hewasrecentlyappointed
as a fellow of the Royal Netherlands Academy of Sciences and is a fellow of the
NetherlandsAcademyofTechnologyandInnovation.
Materiomics
High-Throughput Screening of Biomaterial
Properties
JAN DE BOER
UniversityofTwente
CLEMENS A. VAN BLITTERSWIJK
UniversityofTwente
cambridge university press
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Firstpublished2013
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Materiomics:high-throughputscreeningofbiomaterialproperties/[editedby]JandeBoer,
ClemensvanBlitterswijk.
p. ; cm.
Includesbibliographicalreferences.
ISBN978-1-107-01677-4(hardback)
I. Boer,Jande,1970– II. Blitterswijk,ClemensA.van.
[DNLM:1. BiocompatibleMaterials–chemistry. 2. BiocompatibleMaterials–analysis. 3. Materials
Testing. 4. RegenerativeMedicine–methods. 5. TissueEngineering–methods. QT37]
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Contents
Listofcontributors pageviii
Preface xiii
Chapter1 Introducingmateriomics 1
NathalieGroen,StevenW.Cranford,JandeBoer,MarkusJ.Buehler
andClemensA.VanBlitterswijk
1.1 Introductiontomateriomics 1
1.2 Thechallengeof‘living’materialsscience 2
1.3 Dealingwithcomplexity 3
1.4 Emergenceofmateriomics 7
1.5 Conclusionandbookoutline 9
Chapter2 Physico-chemicalmaterialpropertiesandanalysistechniques
relevantinhigh-throughputbiomaterialsresearch 13
ErwinZant,MirjamJ.BosmanandDirkW.Grijpma
2.1 Basicprinciples:physicalandchemicalpropertiesof
polymericbiomaterials 13
2.2 Relationtomateriomics:techniquesthatallow
high-throughputmaterialcharacterization 20
2.3 Futureperspectives 24
2.4 Snapshotsummary 26
Chapter3 Materiomicsusingsyntheticmaterials:metals,cements,covalent
polymersandsupramolecularsystems 31
BjörneB.Mollet,A.C.H.(Bram)Pape,RosaP.FélixLanao,SanderC.G.Leeuwenburgh
andPatriciaY.W.Dankers
3.1 Introduction 31
3.2 Basicprinciplesofdifferentsyntheticmaterials 32
3.3 Materiomicsusingsyntheticmaterials 35
3.4 Futureperspectives 44
3.5 Snapshotsummary 45
vi Contents
Chapter4 Microfabricationtechniquesinmateriomics 51
HemantUnadkat,RobertGauvin,ClemensA.vanBlitterswijk,AliKhademhosseini,
JandeBoerandRomanTruckenmüller
4.1 Basicprinciplesofmicrofabrication 51
4.2 Theapplicationofmicrofabricationinmateriomics 59
4.3 Futureperspectives 61
4.4 Snapshotsummary 62
Chapter5 Bioassaydevelopment 67
HugoFernandes,RoderickBeijersbergen,LinoFerreira,KoenDechering,
PrabhasMogheandKatharinaManiura-Weber
5.1 Basicprinciplesofassaydevelopment 67
5.2 Relationtomateriomics 72
5.3 Futureperspectives 79
5.4 Snapshotsummary 80
Chapter6 High-contentimaging 85
FritsHulshof,ErLiu,AndreaNegro,SamyGobaa,MatthiasLutolf,
PrabhasV.MogheandHugoFernandes
6.1 Originsofhigh-contentimaging 85
6.2 High-contentimagingtechniques 86
6.3 Theimageanalysispipeline 90
6.4 Software 92
6.5 High-contentimaginginmateriomics 94
6.6 Futureperspectives 96
6.7 Snapshotsummary 97
Chapter7 Computationalanalysisofhigh-throughputmaterialscreens 101
MarcHulsman,LiesbetGerisandMarcelJ.T.Reinders
7.1 Basicprinciplesofdataanalysis 101
7.2 Computationalanalysisinmateriomicsresearch 116
7.3 Futureperspectives 125
7.4 Snapshotsummary 126
Chapter8 Upscalingofhigh-throughputmaterialplatforms
intwoandthreedimensions 133
GustavoA.Higuera,RomanK.Truckenmüller,RongZhang,SalvatorePernagallo,
FabienGuillemotandLorenzoMoroni
8.1 Basicupscalingprinciples 133
8.2 Upscalingandmateriomics 140
8.3 Futureperspectives 146
8.4 Snapshotsummary 149
Contents vii
Chapter9 Developmentofmaterialsforregenerativemedicine:fromclinical
needtoclinicalapplication 155
CharlèneDanoux,RahulTare,JamesSmith,MarkBradley,JohnA.Hunt,
RichardO.C.OreffoandPamelaHabibovic
9.1 Basicprinciples:developmentofmaterialsforregenerativemedicine 155
9.2 Relationtomateriomics:fromhigh-throughputscreeningtolarge
animalstudiesandbeyond 164
9.3 Futureperspectives 171
9.4 Snapshotsummary 172
Chapter10 Non-biomedicalapplicationsofmateriomics 177
CarsonMeredith,SangilHan,IsmaelGomez,JohannesLeisenandHaskellBeckham
10.1 Tutorialonbasicprinciples 177
10.2 Relationtomateriomics 183
10.3 Futureperspectives 193
10.4 Snapshotsummary 194
Chapter11 Beyondbedandbench 199
TahirA.MahmoodandJandeBoer
Index 203
Contributors
Beckham,Haskell
GeorgiaInstituteofTechnology,SchoolofMaterialsScienceand
Engineering,Atlanta,USA
Beijersbergen,Roderick
TheNetherlandsCancerInstitute,DivisionMolecularCarcinogenesis,
Amsterdam,TheNetherlands
vanBlitterswijk,ClemensA.
DepartmentofTissueRegeneration,MIRAInstituteforBiomedical
TechnologyandTechnicalMedicine,UniversityofTwente,
Enschede,TheNetherlands
deBoer,Jan
DepartmentofTissueRegeneration,MIRAInstituteforBiomedical
TechnologyandTechnicalMedicine,UniversityofTwente,
Enschede,TheNetherlands
Bosman,Mirjam
DepartmentofBiomaterialsScienceandTechnology,UniversityofTwente,
Enschede,TheNetherlands
Bradley,Mark
SchoolofChemistry,UniversityofEdinburgh,Edinburgh,UK
Buehler,Markus
DepartmentofCivilandEnvironmentalEngineering,MIT,Cambridge,USA
Cranford,Steven
DepartmentofCivilandEnvironmentalEngineering,MIT,Cambridge,USA
Dankers,Patricia
InstituteforComplexMolecularSystemsandLaboratoryofChemicalBiology,
EindhovenUniversityofTechnology,Eindhoven,TheNetherlands
