Table Of ContentMammary Tumor Cell Cycle,
Differentiation, and Metastasis
Cancer Treatment and Research
Emil J Freireieh, M.D., D.Se.(Hon.), Series Editor
Lippman ME, Dickson R (eds): Breast Cancer: Cellular and Molecular Biology. 1988. ISBN 0-89838-368-4
Kamps WA, Humphrey GB, Poppema S (eds): Hodgkin's Disease in Children: Controversies and Current
Practice. 1988. ISBN 0-89838-372-2
Muggia FM (ed): Cancer Chemotherapy: Concepts, Clinical Investigations and Therapeutic Advances. 1988.
ISBN 0-89838-381-1
Nathanson L (ed): Malignant Melanoma: Biology, Diagnosis, and Therapy. 1988. ISBN 0-89838-384-6
Pinedo HM, Verweij J (eds): Treatment of Soft Tissue Sarcomas. 1989. ISBN 0-89838-391-9
Hansen HH (ed): Basic and Clinical Concepts of Lung Cancer. 1989. ISBN 0-7923-0153-6
Lepor H, Ratliff TL (eds): Urologic Oncology. 1989. ISBN 0-7923-0161-7
Benz C, Liu E (eds): Oncogenes. 1989. ISBN 0-7923-0237-0
Ozols RF (ed): Drug Resistance in Cancer Therapy. 1989. ISBN 0-7923-0244-3
Surwit EA, Alberts DS (eds): Endometrial Cancer. 1989. ISBN 0-7923-0286-9
Champlin R (ed): Bone Marrow Transplantation. 1990. ISBN 0-7923-0612-0
Goldenberg D (ed): Cancer Imaging with Radiolabeled Antibodies. 1990. ISBN 0-7923-0631-7
Jacobs C (ed): Carcinomas of the Head and Neck. 1990. ISBN 0-7923-0668-6
Lippman ME, Dickson R (eds): Regulatory Mechanisms in Breast Cancer: Advances in Cellular and
Molecular Biology of Breast Cancer. 1990. ISBN 0-7923-0868-9
Nathanson L (ed): Malignant Melanoma: Genetics, Growth Factors, Metastases, and Antigens. 1991.
ISBN 0-7923-0895-6
Sugarbaker PH (ed): Management of Gastric Cancer. 1991. ISBN 0-7923-1102-7
Pinedo HM, Verweij J, Suit HD (eds): Soft Tissue Sarcomas: New Developments in the Multidisciplinary
Approach to Treatment. 1991. ISBN 0-7923-1139-6
Ozols RF (ed): Molecular and Clinical Advances in Anticancer Drug Resistance. 1991. ISBN 0-7923-1212-0
Muggia FM (ed): New Drugs, Concepts and Results in Cancer Chemotherapy 1991. ISBN 0-7923-1253-8
Dickson RB, Lippman ME (eds): Genes, Oncogenes and Hormones: Advances in Cellular and Molecular
Biology of Breast Cancer. 1992. ISBN 0-7923-1748-3
Humphrey G, Bennett, Schraffordt Koops H, MolenaaT WM, Postma A (eds): Osteosarcoma in Adolescents
and Young Adults: New Developments and Controversies. 1993. rSBN 0-7923-1905-2
Benz CC, Liu ET (eds): Oncogenes and Tumor Suppressor Genes in Human Malignancies. 1993.
ISBN 0-7923-1960-5
Freireich EJ, Kantarjian H (eds): Leukemia: Advances in Research and Treatment. 1993.
ISBN 0-7923-1967-2
Dana BW (ed): Malignant Lymphomas, Including Hodgkin's Disease: Diagnosis, Management, and Special
Problems. 1993. ISBN 0-7923-2171-5
Nathanson L (ed): Current Research and Clinical Managementoi Melanoma. 1993. ISBN 0-7923-2152-9
Verweij J, Pinedo HM, Suit HD (eds): Multidisciplinary Treatment of Soft Tissue Sarcomas. 1993.
ISBN 0-7923-2183-9
Rosen ST, Kuzel TM (eds): Immunoconjugate Therapy of Hematologic Malignancies. 1993.
ISBN 0-7923-2270-3
Sugarbaker PH (ed): Hepatobiliary Cancer. 1994. ISBN 0-7923-2501-X
Rothenberg ML (ed): Gynecologic Oncology: Controversies and New DevelopmeG,!s. 1994.
ISBN 0-7923-2634-2
Dickson RB, Lippman ME (eds): Mammary Tumorigenesis and Malignant Progression. 1994.
ISBN 0-7923-2647-4
Hansen HH (ed): Lung Cancer. Advances in Basic and Clinical Research. 1994. ISBN 0-7923-2835-3
Goldstein LJ, Ozols RF (eds): Anticancer Drug Resistance. Advances in Molecular and Clinical Research.
1994. ISBN 0-7923-2836-1
Hong WK, Weber RS (eds): Head and Neck Cancer. Basic and Clinical Aspects. 1994. ISBN 0-7923·3015·3
Thall PF (ed): Recent Advances in Clinical Trial Design and Analysis. 1995. ISBN 0-7923·3235·0
Buckner CD (ed): Technical and Biological Components of Marrow Transplantation. 1995.
ISBN 0·7923-3394-2
Muggia FM (ed): Concepts, Mechanisms, and New Targets for Chemotherapy. 1995. ISBN 0-7923-3525-2
Klastersky J (ed): Infectious Complications of Cancer. 1995. ISBN 0-7923-3598-8
Kurzrock R, Talpaz M (eds): Cytokines: Interleukins and Their Receptors. 1995. ISBN 0-7923-3636-4
Sugarbaker P (ed): Peritoneal Carcinomatosis: Drugs and Diseases. 1995. ISBN 0-7923-3726-3
Sugarbaker P (ed): Peritoneal Carcinomatosis: Principles of Management. 1995. ISBN 0-7923-3727-1
Mammary Tumor Cell
Cycle, Differentiation,
and Metastasis
Advances in Cellular
and Molecular Biology of
Breast Cancer
edited by
Robert B. Dickson
Marc E. Lippman
Lombardi Cancer Research Center
Washington, D.C.
KLUWER ACADEMIC PUBLISHERS
1996 BOSTON / DORDRECHT / LONDON
Distributors for North America:
Kluwer Academic Publishers
101 Philip Drive
Assinippi Park
Norwell, Massachusetts 02061 USA
Distributors for all other countries:
Kluwer Academic Publishers Group
Distribution Centre
Post Office Box 322
3300 AH Dordrecht, THE NETHERLANDS
Library of Congress Cataloging-in-Publication Data
Mammary tumor cell cycle, differentiation, and metastasis: advances
in cellular and molecular biology of breast cancer / edited by
Robert B. Dickson, Marc E. Lippman.
p. cm. -- (Cancer treatment and research; v. 83)
Includes bibliographical references and index.
ISBN-13:978-1-4612-8536-6 e-ISBN-13:978-1-4613-1259-8
DOl: 10.1007/978-1-4613-1259-8
1. Breast--Cancer--Molecular aspects. 2. Cancer cells. 3. Cell
differentiation. 4. Metastasis. 5. Cell transformation.
I. Dickson, Robert B. (Robert Brent), 1952- . II. Lippman, Marc
E., 1945- . III. Series.
[DNLM: 1. Breast Neoplasms. 2. Cell Differentiation. 3. Neoplasm
Metastasis. WI CA693 v.83 1995/ WP 870 M262 1995]
RC280.B8M2651995
616.99' 449071--dc20
DNLM/DLC
for Library of Congress 96-4654
CIP
Copyright © 1996 by Kluwer Academic Publishers
Softcover reprint of the hardcover 1s t edition 1996
All rights reserved. No part of this publication may be reproduced, stored in a
retrieval system or transmitted in any form or by any means, mechanical,
photo-copying, recording, or otherwise, without the prior written permission
of the publisher, Kluwer Academic Publishers, 101 Philip Drive, Assinippi
Park, Norwell, Massachusetts 02061
Printed on acid-free paper.
Contents
Contributing authors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . IX
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. xiii
A. Mouse models of mammary development and tumorigenesis . . . . . . 1
1. Programmed cell death and mammary neoplasia . . . . . . . . . . . . . 3
PEPPER J. SCHEDIN, LARISSA B. THACKRAY ,
PATRICIA MALONE, SUSAN C. FONTAINE,
ROBERT R. FRIIS, and ROBERT STRANGE
2. Tissue reconstitution or transgenic mammary gland technique
for modeling breast cancer development . . . . . . . . . . . . . . . . . . . . 23
PAUL A.W. EDWARDS
3. Pre neoplasia in mammary tumorigenesis. . . . . . . . . . . . . . . . . . . . 37
DANIEL MEDINA
4. Transgenic models of breast cancer metastasis . . . . . . . . . . . . . . . 71
DAVID L. DANKORT and WILLIAM J. MULLER
B. Human breast cancer: Receptors, signaling, and the cell cycle ..... 89
5. Protein kinase C and breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . .. 91
NANCY E. DAVIDSON and M. JOHN KENNEDY
6. Protein tyrosine phosphatases: Cellular regulators of human
breast cancer? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 107
YI-FAN ZHAI, JULIE J. WIRTH, CLIFFORD W. WELSCH,
and WALTER J. ESSELMAN
7. Role of the nuclear matrix in breast cancer. . . . . . . . . . . . . . . . .. 127
TRACY S. REPLOGLE and KENNETH J. PIENTI
8. Cyclins and breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 141
KIMBERLY J.E. SWEENEY, ELIZABETH A. MUSGROVE,
COLIN KW. WATTS, and ROBERT L. SUTHERLAND
9. Nuclear oncogenes in breast cancer ........................ 171
DON DUBIK, PETER H. WATSON,
MARCELLO VENDITTI, and ROBERT P.e. SHIU
10. Antiprogestin-progestin interactions ....................... 191
H. MICHNA, KH. FRITZEMEIER, K PARCZYK,
Y. NISHINO, and M.R. SCHNEIDER
11. Antiestrogen-estrogen receptor interactions. . . . . . . . . . . . . . . .. 213
MALCOLM G. PARKER
e. Human breast cancer: Invastion, Metastasis, Angiogenesis,
and Immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 225
12. Differentiation antigens in stromal and epithelial cells
of the breast. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 227
TEHEREH KAMALATI, BIRUNTHI NIRANJAN,
AMANDA ATHERTON, RAMASAW AMY ANBAZHAGAN,
and BARRY GUSTERSON
13. Models of progression spanning preneoplasia and metastasis:
The human MCF-10A neo T.TGN series and a panel of mouse
mammary tumor subpopulations . . . . . . . . . . . . . . . . . . . . . . . . . .. 243
FRED R. MILLER
14. Angiogenesis in breast cancer ............................. 265
NOEL WEIDNER
15. Cell motility in breast cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 303
JASON D. KANTOR and BRUCE R. ZETTER
16. Cathepsins D and B in breast cancer. . . . . . . . . . . . . . . . . . . . . .. 325
WEI-PING REN and BONNIE F. SLOANE
17. Stromelysin-3 and other stromelysins in breast cancer:
Importance of epithelial-stromal interactions during
tumor progression ....................................... 353
PAUL BASSETT, JEAN-PIERRE BELLOCQ, PATRICK
ANGLARD, MARIE-PIERRE CHENARD, OLIVIER
LEFEBVRE, AGNES NOEL, AKIKO OKADA, NICOLAS
vi
ROUYER, MARIA SANTAV ICCA, ISABELLE STOLL,
CATHERINE WOLF, and MARIE-CHRISTINE RIO
18. Endothelins in breast cancer .............................. 369
KIVTI V. PATEL and MICHAEL P. SCHREY
19. Breast cancer immunology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 395
WEI-ZEN WEI and GLORIA H. HEPPNER
Index... . . . . . .. . . . . ... . . . . .. . . . . .. . . . .. ... . . .. . . .. ... . . . . .. . .. 411
vii
Contributing Authors
RAMASAW AN ANBAZHAGA, Section of Cell Biology and Experimental
Pathology, Institute of Cancer Research, London, SMZ 5 NG, UK
PATRICK ANGLARD, PHD, Institut de Genetigue et de Biologie
Moleculaire at Cellulaire (IGBMC), CNRS/INSERMIULP, P.P. 163,
67404 Illkirch Cedex, CN. de Strasbourg, France
AMANDA ATHERTON, PHD, Johns Hopkins University, Baltimore, MD
21205, USA
PAUL BASSETT, PHD, Institut de Genetique et de Biologie Moleculaire et
Cellulaire (IGBMC), CNRS/INSERM/ULP, P.P. 163, 67404 Ilkirch
Cedex, CN. de Strasbourg, Cedex, France
JEAN PIERRE BELLOCQ, MD, Service d'Anatomic Pathologique
Generale, Centre Hospitalier Universitaire, Hopital de Hautepierre, 1
A venue Moliere, 67098 Strasbourg, Cedex, France
MARIE-PIERRE CHENARD, MD, Service d'Anatomic Pathologique
Generale, Centre Hospitalier Universitaire, Hopital de Hautepierre, 1
Avenue Molier, 67098 Strasbourg, Cedex, France
DAVID L. DANKORT, PHD, Institute for Molecular Biology and Biotech
nology, Department of Biology, McMaster University, 1280 Main Street
W., Hamilton, Ontario, L85 4K1 Canada
NANCY E. DAVIDSON, MD, The Johns Hopkins Oncology Center, 422
North Bond St., Baltimore, MD 21231-1001, USA
ROBERT B. DICKSON, PHD, Departments of Cell Biology and Pharmacol
ogy, Lombardi Cancer Center, The Research Building, 3970 Reservoir
Road, Washington, DC 20007, USA
DON DUBIK, PHD, Department of Physiology, University of Manitoba,
Winnipeg, MB, R3E OW3, Canada
PAUL A. EDWARDS, PHD, Division of Cellular Pathology, Department of
Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2
1QP, UK
WALTER J. ESSELMAN, PHD, Department of Microbiology, Michigan
State University, East Lansing, MI 48824, USA
S.c. FONTAINE, PHD, AMC Cancer Research Center, Lakewood, CO
80214, USA
RR FRIIS, PHD, Laboratory of Clinical and Experimental Research, Uni
versity of Berne, Berne, Switzerland CH-3004
K.H. FRITZEMEIER, PHD, Experimental Oncology, Research Laborato
ries of Schering AG, Berlin, FRG
BARRY GUSTERSON, PHD, MRCPATH, Section of Cell Biology and
Experimental Pathology, Institute of Cancer Research, London, SMZ
5NG, UK
GLORIA H. HEPPNER, PHD, Breast Cancer Program, Karmanos Cancer
Institute, 110 East Warren, Detroit, MI 48201, USA
TAHEREH KAMALATI, PHD, Section of Cell Biology and Experimental
Pathology, Institute of Cancer Research, London, SMZ 5NG, UK
JASON D. KANTOR, PHD, Department of Surgery, Children's Hospital,
and Program in Biological and Biomedical Sciences, Harvard Medical
School, Boston, MA 02115, USA
M. JOHN KENNEDY, MB, FRCPI, The Johns Hopkins Oncology Center,
422 North Bond St., Baltimore, MD 21231-1001, USA
OLIVIER LEFEBVRE, PHD, Institut de Genetique et de Biologie
Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163,
67404 Illkirch Cedex, C.N. de Strasbourg, France
MARC E. LIPPMAN, MD, Departments of Medicine and Pharmacology,
Lombardi Cancer Center, The Research Building, 3970 Reservoir Road,
Washington, CD 20007, USA
P. MALONE, PHD, AMC Cancer Research Center, Lakewood, CO 80214,
USA
DANIEL MEDINA, PHD, Department of Cell Biology, Baylor College of
Medicine, One Baylor Plaza, Houston, TX 77030, USA
HORST MICHNA, PHD, Experimental Oncology, Research Laboratories of
Schering AG, Berlin, FRG
FRED R MILLER, PHD, Breast Cancer Program, Michigan Cancer Founda
tion, 110E. Warren Ave., Detroit, MI 48201, USA
WILLIAM J. MULLER, PHD, Institute for Molecular Biology and Biotech
nology, Departments of Biology and Pathology, McMaster University,
1280 Main St. W., Hamilton, Ontario, L85 4K1, Canada
ELIZABETH A. MUSGROVE, PHD, Cancer Biology Division, Garvin In
stitute of Medical Research, St. Vincents Hospital, Sydney, N.S.W. 2010
Australia
BIRUNTHI NIRANJAN, PHD, Section of Cell Biology and Experimental
Pathology, Institute of Cancer Research, London, SM2 5NG, UK
Y. NISHINO, PHD, Experimental Oncology, Research Laboratories of
Schering AG, Berlin, FRG
x
AGNES NOEL, PHD, Institut de Genetique et de Biologie Moleculaire et
Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch
Cedex, e.N. de Strasbourg, France
AKIKO OKADA, PHD, Institut de Genetique et de Biologie Moleculaireet
Cellulaire (IBBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch
Cedex, e.N. de Strasbourg, France
MALCOLM G. PARKER, PHD, Laboratory of Molecular Endocrinology,
Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A
3PX, UK
KIRTI V. PATEL, PHD, Institute of Cancer Research, The Haddow
Laboratories, Cell Biology and Experimental Pathology, Belmont, Sutton,
UK
KENNETH l. PIENTA, PHD, The University of Michigan Comprehensive
Cancer Center and Division of Hematology/Oncology, Department of
Internal Medicine, 5510 MS RB I, 1150 W. Medical Center Drive, Ann
Arbor, MI 48109-0680, USA
K. PARCYZYK, PHD, Experimental Oncology, Research Laboratories of
Schering AG, Berlin, FRG
WEI-PING REN, PHD, Department of Pharmacology, Wayne State Univer
sity, 540 E. Canfield, Detroit, MI 48201, USA
TRACY S. REPLOGLE, PHD, The University of Michigan Comprehensive
Cancer Center and Division of Hematology/Oncology, Department of
Internal Medicine, 5510 MS RB I, 1150 W. Medical Center Drive, Anlll
Arbor, MI 48109-0680, USA
MARIE-CHRISTINE RIO, Institut de Genetique et de Biologie Moleculaire
et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163, 67404 Illkirch
Cedex, e.N. de Strasbourg, France
NICOLAS ROUYER, MD, Institut de Genetique et de Biologie Moleculaire
et Cellulaire (IGBMC), CNRS/INSERMIULP, p.p. 163, 67404 Illkirch
Cedex, e.N. de Strasbourg, France
MARIA SANTAV ICC, PHD, Institut de Genetique et de Biologie
Moleculaire et Cellulaire (IGBMC), CNRS/INSERM/ULP, p.p. 163,
67404 Illkirch Cedex, e.N. de Strasbourg, France
P.l. SCHEDIN, PHD, AMC Cancer Research Center, Lakewood, CO 80214,
USA
MARTIN R. SCHNEIDER, PHD, Experimental Oncology, Research Labo
ratories of Schering AG, Berlin, FRG
ROBERT P.e. SHIU, PHD, Department of Physiology, University of
Manitoba, Winnipeg, MB, R3E OW3, Canada
MICHAEL P. SCHREY, PHD, Unit of Metabolic Medicine, St. Mary's Hos
pital Medical School, Praed St., Paddington, London W2 lPG, UK
BONNIE F. SLOANE, PHD, Department of Pharmacology, Wayne State
University, 540 E. Canfield, Detroit, MI 48201, USA
Xl
