Male Reproductive Function (Endocrine Updates)

350 Pages·1999·29.84 MB·English

by  Christina Wang

Male Reproductive Function
ENDOCRINE UPDATES
Shlomo Melmed, M. D., Series Editor
1. E.R. Levin and J.L. Nadler (eds.): Endocrinology of
Cardiovascular Function. 1998. ISBN: 0-7923-82 17-X
2. J.A. Fagin (ed.): Thyroid Cancer. 1998.
ISBN: 0-7923-8326-5
3. J.S. Adams and B.P. Lukert (eds.): Osteoporosis: Genetics,
Prevention and Treatment. 1998. ISBN: 0-7923-8366-4.
4. B.-A. Bengtsson (ed.): Growth Hormone. 1999.
ISBN: 0-7923-8478-4
5. C. Wang (ed.): Male Reproductive Function. 1999.
ISBN 0-7923-8520-9
Male Reproductive Function
edited by
CHRISTINA WANG, M.D.
Harbor- UCLA Medical Center
Torrance, California, USA
IUUMrlER ACADEMIC PUBLISHERS
BOSTON/DORDRECHT/LONDON
Distributors for North, Central and South America:
Kluwer Academic Publishers
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4qI
Library of Congress Cataloging-in-PublicationD ata
Male reproductive function / edited by Christina Wang
p. cm. -- (Endocrine updates; 5)
Includes bibliographical references and index.
ISBN 0-7923-8520-9 (alk. paper)
1. Generative organs, Male--Pathophysiology. 2. Generative
organs, Male-Physiology. 3. Testis--Pathophysiology. 4. Testis-
-Physiology. I. Wang, Christina. 11. Series.
[DNLM: 1. Genitalia, Male-physiology. 2. Reproduction-
-physiology. 3. Androgens--physiology. WJ 702 M2455 19991
RC875.M36 1999
6 12.6'1- -dc21
DNLMJDLC
for Library of Congress 99-24999
CIP
Copyright O 1999 by Kluwer Academic Publishers
All rights reserved. No part of this publication may be reproduced, stored in a retrieval
system or transmitted in any form or by any means, mechanical, photo-copying, recording,
or otherwise, without the prior written permission of the publisher, Kluwer Academic
Publishers, 101 Philip Drive, Assinippi Park, Norwell, Massachusetts 02061
Printed on acid-free paper.
Printed in the United States of America
Contents
List of Contributors vii
Preface i x
Endocrine Regulation of Male.Reproduction
Ilpo Huhtaniemi
2. Spermatogenesis and Germ Cell Death 19
Amiya Sinha-Hikim, Y.H: Lue, Christina Wang and Ronald S. Swerdloff
3. Paracrine Control of Testis Function
Bernard Jdgou, Charles Pineau and Alain Dupaix
4. Androgen Metabolism and Action
Terry Brown
5. Male Puberty and its Disorders
Frederick C. W. Wu
6. Male Hypogonadism
Steven J. Winters
7. Male Senescence
J. Lisa Tenover
8. Androgen Replacement Therapy, Risks and Benefits
Christina Wang and Ronald S. Swerdloff
9. The Safety of Androgens: Prostate and Cardiovascular Disease 173
David J, ~andelsman
10. Androgens and Behavior in Men
Gerianne M. Alexander
11. Androgen Abuse in Sport: International and National Anti-Androgen 207
Programs
Don Catlin
12. Male Infertility Causes and Diagnosis
Rebecca Sokol
13. The Genetics of Male Infertility 233
Shalender Bhasin, W.E . Taylor, C. Mallidis, B. Salehian, I. Sinha, M.
Limbo and K. Ma
v i Male Reproductive Function
14. Modern Management of Male Infertility
Gordon W.H. Baker
15. Male Sexual Dysfunction
Manoj Monga and Wayne J. G. Hellstrom
16. Male Contraception in the 2 1" Century
Christina Wang and Ronald S. Swerdloff
17. Environment and Male Reproductive Function 32 1
Niels Jsrgensen, J. Toppari, P. Grandjean and Niels E. SkakkebraG
Index 339
List of Major Contributors
GERIANNE ALEXANDER, Department of Psychology, University of New
Orleans, Lakefront, GP 2001, New Orleans, LA 70148
GORDON W.H. BAKER, Department of Obstetrics & Gynecology, University of
Melbourne, Royal Women's Hospital, Carlton 3053, Victoria, AUSTRALIA
SHALENDER BHASIN, Division of Endocrinology, KingIDrew Medical Center,
1621 E. 120S~tr eet, MP-02, Los Angeles, CA 90059
TERRY BROWN, School of Hygiene & Health, Johns Hopkins University,
Department of ~o~ulatiodynn amics, 615 North Wolfe Street, Room 3606,
Baltimore, MD 21205
DON CATLIN, UCLA Olympic Analytical Laboratory, 2122 Granville Avenue,
Los Angeles, CA 90025
DAVID J. HANDELSMAN, ANZAC Research Institute, University of Sydney,
Sydney, NSW 2006, AUSTRALIA
WAYNE J. G. HELLSTROM, Urology Department, SL42, Tulane University
Medical Center, 1430 Tulane Avenue, New Orleans, LA 701 12
ILPO HUHTANIEMI, Department of Physiology, University of Turku,
Kiinamyllynkatu 10, SF-20520 Turku, FINLAND
BERNARD JEGOU, GERM-INSERM U435, Universite de Rennes, Campus de
Beaulieu Av Gen Leci, 35042 Rennes, Bretagne, FRANCE
NIELS JORGENSEN, Department of Growth & Reproduction, National
University Hospital, 9 Blegdamsvej, DK-2100 Copenhagen, DENMARK
MAN0J MONGA, Department of Urology, University of California, San Diego
CHARLES PINEAU, GERM-INSERM U435, Universite de Rennes, Campus de
Beaulieu Av Gen Leci, 35042 Rennes, Bretagne, FRANCE
AMIYA SINHA-HIKIM, Division of Endocrinology, Box 446, Harbor-UCLA
Medical Center, 1000 West Carson Street, Torrance, CA 90509-2910
NIELS E. SKAKKEBAEK, Department of Growth & Reproduction, National
University Hospital, 9 Blegdamsvej, DK-2100 Copenhagen, DENMARK
...
vlll Male Reproductive Function
REBECCA SOKOL, Women's Hospital Room L-1022, 1240 N Mission Road,
Los Angeles, CA 90033-1078
RONALD S. SWERDLOFF, Division of Endocrinology, Harbor-UCLA Medical
Center, Box 446, 1000 West Carson Street, Torrance, CA 90509-2910
J. LISA TENOVER, Division of Geriatric Medicine, Wesley Woods Hospital,
1821 Clifton Road, NE, Atlanta, GA 20329-5102
CHRISTINA WANG, Genera1 Clinical Research Center, Harbor-UCLA Medical
Center, Box 16, 1000 West Carson Street, Torrance, CA 90509-2910
STEVEN WINTERS, University of Pittsburgh Medical Center, 200 Lothrop
Street, Pittsburgh, PA 15213-2582
FREDERICK C.W. WU, Department of reproductive Medicine, Saint Mary's
Hospital, Whitworth Park, Manchester M 13 OJH, UNITED KINGDOM
Preface
The purpose of this book is to provide the general endocrinologist and internist with up-
to-date information on the recent developments in the understanding of molecular and
cellular events in the testis, and their applications in clinical medicine. Some chapters are
relatively brief, but they provide the current state of the art in the practice of clinical
andrology.
I wish to thank my colleagues throughout the world who responded to my requests with
chapters in each of their respective fields of expertise. The patience and help of my
assistant, Sally Avancena, M.A., is gratefully acknowledged.
Christina Wang, M.D.