Lymphangiogenesis in Cancer Metastasis

255 Pages·2009·10.293 MB·English

by  Dr. Steven A. Stacker, Dr. Marc G. Achen (auth.)

LymphangiogenesisinCancerMetastasis
Cancer Metastasis – Biology and Treatment
VOLUME13
SeriesEditors
RichardJ.Ablin,Ph.D.,UniversityofArizona,CollegeofMedicineandTheArizonaCancer
Center,AZ,U.S.A.
WenG.Jiang,M.D.,WalesCollegeofMedicine,CardiffUniversity,Cardiff,U.K.
AdvisoryEditorialBoard
HaroldF.Dvorak,M.D.
PhilGold,M.D.,Ph.D.
DannyWelch,Ph.D.
HiroshiKobayashi,M.D.,Ph.D.
RobertE.Mansel,M.S.,FRCS.
KlausPantel,Ph.D.
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Volume13:LymphangiogenesisinCancerMetastasis
Editors:StevenA.StackerandMarcG.Achen
ISBN978-90-481-2246-2
Lymphangiogenesis
in Cancer Metastasis
Editedby
Steven A. Stacker
LudwigInstituteforCancerResearch,RoyalMelbourneHospital,Parkville,Victoria,Australia
and
Marc G. Achen
LudwigInstituteforCancerResearch,RoyalMelbourneHospital,Parkville,Victoria,Australia
123
Editors
Dr.StevenA.Stacker Dr.MarcG.Achen
LudwigInstituteforCancerResearch LudwigInstituteforCancerResearch
RoyalMelbourneHospital RoyalMelbourneHospital
Parkville,Victoria3050 Parkville,Victoria3050
Australia Australia
[email protected] [email protected]
ISBN:978-90-481-2246-2 e-ISBN:978-90-481-2247-9
DOI10.1007/978-90-481-2247-9
LibraryofCongressControlNumber:2009921270
(cid:2)c SpringerScience+BusinessMediaB.V.2009
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inanyformorbyanymeans,electronic,mechanical,photocopying,microfilming,recording
orotherwise,withoutwrittenpermissionfromthePublisher,withtheexception
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andexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.
Printedonacid-freepaper
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Contents
1 LYMPHANGIOGENESIS IN HEALTH AND DISEASE – AN
OVERVIEW ................................................... 1
StevenA.Stacker,MarcG.Achen,PaulaHaikoandKariAlitalo
2 INSIGHTINTOLYMPHATICVASCULATUREDEVELOPMENT . 11
NicoleC.JohnsonandGuillermoOliver
3 NEWANIMALMODELSOFLYMPHANGIOGENESIS .......... 27
BenjaminM.HoganandStefanSchulte-Merker
4 MOLECULARMECHANISMSOFLYMPHNODEMETASTASIS . 55
MatthiasRinderknechtandMichaelDetmar
5 THE CLINICAL SIGNIFICANCE OF LYMPH-NODE
METASTASIS ................................................. 83
MarkB.FariesandDonaldL.Morton
6 CLINICOPATHOLOGICAL ANALYSIS OF LYMPHATIC
VESSELS AND OF LYMPHANGIOGENESIS
INHUMANCANCER ..........................................119
IlseVanderAuwera,PeterB.VermeulenandLucY. Dirix
7 LYMPHANGIOGENESIS AND IMAGING OF THE
LYMPHATICSINCANCER ....................................159
Baris Turkbey, Gregory Ravizzini, Peter L. Choyke
andHisatakaKobayashi
8 LYMPHANGIOLEIOMYOMATOSIS ............................185
KuniakiSeyama,ToshioKumasaka,TeruhikoSatoandKeikoMitani
9 KAPOSI’SSARCOMAANDTHELYMPHATICS ................211
VictoriaEmussandChrisBoshoff
v
vi Contents
10 LYMPHATICPHYSIOLOGYANDFUNCTIONINHEALTHY
TISSUEANDCANCER.........................................231
JacquelineD.ShieldsandMelodyA.Swartz
Index .............................................................247
Contributors
MarcG.Achen
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville,
Victoria3050,Australia,[email protected]
KariAlitalo
Molecular/CancerBiologyLaboratory,BiomedicumHelsinki,FI-00014Helsinki,
Finland,kari.alitalo@helsinki.fi
ChrisBoshoff
CR-UKViralOncologyGroup,UCLCancerInstitute,UCL,WC1E6BT,London,
UK,[email protected]
PeterL.Choyke
Molecular Imaging Program, National Cancer Institute (NCI), Bethesda, MD
20892-1088,USA,[email protected]
MichaelDetmar
InstituteofPharmaceuticalSciences,SwissFederalInstituteofTechnology,ETH
Zurich,HCIH303,CH-8093Zurich,Switzerland,[email protected]
LucY.Dirix
Translational Cancer Research Group, Laboratory of Pathology, University
of Antwerp/University Hospital Antwerp; Oncology Centre, General Hospital
Sint-Augustinus,2610Wilrijk,Belgium,[email protected]
VictoriaEmuss
CR-UKViralOncologyGroup,UCLCancerInstitute,UCL,WC1E6BT,London,
UK,[email protected]
MarkB.Faries
Division of Surgical Oncology, The Roy E. Coats Research Laboratories, John
WayneCancer Institute,SaintJohn’sHealthCenter,2200 SantaMonicaBlvd.,
SantaMonica,CA90404,USA,[email protected]
PaulaHaiko
Molecular/CancerBiologyLaboratory,BiomedicumHelsinki,FI-00014Helsinki,
Finland,[email protected].fi
vii
viii Contributors
BenjaminM.Hogan
HubrechtInstitute(KNAW),UniversityMedicalCenterUtrecht,Uppsalalaan8,
Utrecht3584CT,TheNetherlands,[email protected]
NicoleC.Johnson
Department of Genetics and Tumor Cell Biology, St Jude Children’s
Research Hospital, 332 N. Lauderdale, Memphis, TN 38105-2794, USA,
[email protected]
HisatakaKobayashi
Molecular Imaging Program, National Cancer Institute (NCI), Bethesda, MD
20892-1088,USA,[email protected]
ToshioKumasaka
Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo,
Bunkyo-Ku,Tokyo113-8421,Japan,kumasaka [email protected]
KeikoMitani
Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo,
Bunkyo-Ku,Tokyo113-8421,Japan,[email protected]
DonaldL.Morton
Division of Surgical Oncology, The Roy E. Coats Research Laboratories, John
WayneCancer Institute,SaintJohn’sHealthCenter,2200 SantaMonicaBlvd.,
SantaMonica,CA90404,USA,[email protected]
GuillermoOliver
Dept.ofGeneticsandTumorCellBiology,St.JudeChildren’sResearchHospital,
262DannyThomasPlace,Memphis,TN38105-3678,[email protected]
GregoryRavizzini
Molecular Imaging Program, National Cancer Institute (NCI), Bethesda, MD
20892-1088,USA,[email protected]
MatthiasRinderknecht
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Tech-
nology, ETH Zurich, HCI H303, CH-8093 Zurich, Switzerland,
[email protected]
TeruhikoSato
DepartmentsofRespiratoryMedicine,JuntendoUniversitySchoolofMedicine,
2-1-1Hongo,Bunkyo-Ku,Tokyo113-8421,Japan,[email protected]
StefanSchulte-Merker
HubrechtInstitute(KNAW),UniversityMedicalCenterUtrecht,Uppsalalaan8,
Utrecht3584CT,TheNetherlands,[email protected]
KuniakiSeyama
DepartmentofRespiratoryMedicine,JuntendoUniversity,SchoolofMedicine,
2-1-1Hongo,Bunkyo-Ku,Tokyo113-8421,Japan,[email protected]
Contributors ix
JacquelineD.Shields
InstituteofBioengineering,E´colePolytechniqueFe´de´raledeLausanne(EPFL),
CH-1015Lausanne,Switzerland,mailto:jacqueline.shields@epfl.ch
StevenA.Stacker
Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Parkville,
Victoria3050,Australia,[email protected]
MelodyA.Swartz
InstituteofBioengineering,E´colePolytechniqueFe´de´raledeLausanne(EPFL),
CH-1015Lausanne,Switzerland,melody.swartz@epfl.ch
BarisTurkbey
Molecular Imaging Program, National Cancer Institute (NCI), Bethesda, MD
20892-1088,USA,[email protected]
IlseVanderAuwera
Translational Cancer Research Group, Laboratory of Pathology, University
of Antwerp/University Hospital Antwerp; Oncology Centre, General
Hospital Sint-Augustinus, Oosterveldlaan 24, 2610 Wilrijk, Belgium,
[email protected]
PeterB.Vermeulen
Translational Cancer Research Group, Laboratory of Pathology, University
of Antwerp/University Hospital Antwerp; Oncology Centre, General Hospital
Sint-Augustinus,2610Wilrijk,Belgium,peter [email protected]