Table Of ContentK. Livingston E ditor
Limbic
Mechanisms:The
Continuing Evolution
of the Limbic System
Concept
LIMBIC
MECHANISMS
The Continuing Evolution of
thelin1bic System Concept
'
. i
~j
---
' \
JAMES WENCESLAS PAPEZ
August 19, 1883-Aprill3, 1958
LIMBIC
MECHANISMS
The Continuing Evolution of
the Limbic Systen1 Concept
Edited by
Kenneth E. Livingston
University of Toronto
and
Oleh Hornykiewicz
University of Vienna
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging in Publication Data
Limbic System Symposium, University ofToronto, 1976.
Limbic mechanisms.
Includes index.
l. Limbic system-Congresses. I. Livingston, Kenneth E. II. Homykiewicz, Oleh. III.
Society for Neuroscience. IV. Title [DNLM: 1. Limbic system-Physiology-Con
gresses. 2. Limbic system-Physiopathology-Congresses. WL314 L733L 1976]
OP383.2.L53 1976 599'.01'88 78-1542
ISBN 978-1-4757-0718-2 ISBN 978-1-4757-0716-8 (eBook)
DOI 10.1007/978-1-4757-0716-8
Proceedings of the Lirnbic System Symposiumheld
at the University ofToronto, Ontario, Canada, November 5-6, 1976,
as a satellite to the Sixth Annual Meeting of the Society of Neuroscience
© 197 8 Springer Science+ Business Media New York
Originally published by Plenum Press, New York in 1978
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying; microftlrning,
recording, or otherwise, without written permission from the Publisher
Acknowledgments
In setting up plans for this Symposium which was held as a
satellite event of the 1976 meeting of the Society for Neuroscience,
we are particularly indebted to Dr. Ted Bullock and Dr. Ed Evarts,
senior officers of the Society and to its executive secretary,
Marjorie Wilson.
Technical preparations for the Symposium were carried out in
collaboration with the University of Toronto, Division of Post
graduate Medical Education with the special assistance of Doris
McBride.
Additional financial assistance for which we are most grateful
was provided through the offices of Dean Brian Holmes and Dean Jan
Steiner of the University of Toronto, Faculty of Medicine.
In preparation of the manuscripts for this volume the major
burden has fallen on the shoulders of the individual participants
coordinated by our able associate, Dr. Richard Perrin, and supported
by two outstanding secretaries, Nancy Stead and Suzanne McNeill.
Finally we are most indebted to the W.P. Scott family without
whose active interest, support, and participation this Symposium
would not have been possible.
Kenneth E. Livingston
Oleh Hornykiewicz
v
Preface
This volume records the proceedings of a Limbic System Sympos
ium held at the University of Toronto, November 5-6th, 1976 as a
satellite event to the Sixth Annual Meeting of the Society of
Neuroscience.
The Symposium was designed in part as a tribute to James Papez
on the 40th anniversary of the publication of his epochal paper
"A Proposed Mechanism of Emotion".
Papers by MacLean, Yakovlev, and Angevine provide personal
recollections of Papez and an assessment of the significant contri
bution he made to breaking down the still formidable barriers that
separate our concepts of brain, mind, emotion, and behavior.
Against this background subsequent speakers presented new
information that further illuminates the anatomical, physiological
and biochemical mechanisms underlying limbic system function.
Viewed in juxtaposition this new information from "disparate" fields
of neuroscience provides an increasingly coherent picture of the
neuronal organization subserving a dynamic limbic system that we
can now begin to visualize in operational and transactional terms.
The final section of the symposium focusses on the recently
identified "kindling" phenomenon which is viewed as a general model
of neural plasticity and more particularly as a model of experi
mentally induced limbic system dysfunction. Using this model it is
possible to display, analyse, and experimentally manipulate long
lasting changes in limbic system activity, which develop over ex
tended periods of time and are expressed in a variety of behavioral
end points involving learning and memory, seizure activity, and
changes in emotionality and behavior.
Within this dynamic framework, anatomical, physiological and
biochemical information takes on new meaning and has new relevance
not only to a variety of disease states in man, but also to a broad
spectrum of human physical, emotional and psychosocial dysfunction.
vii
viii PREFACE
This symbiosis between our still evolving concepts of limbic
system function and recently acquired insight into the phenomena of
kindling provides a substantive bridge between brain and behavior
that will contribute significantly to our better understanding of
man.
Kenneth E. Livingston
Oleh Hornykiewwicz
University of Toronto
December 1st, 1977
Contents
. . . . . . . . . . . . . . . . . . . . . . .
Introduction xiii
A: THE LIMBIC SYSTEM CONCEPT
1. Challenges of the Papez Heritage 1
Paul D. MacLean
2. A Casual Glimpse of Evolution and Development
Relating to the Limbic System • • • • • • • 17
Robert B. Livingston
3. Embryogenesis and Phylogenesis in the
Limbic System • • • • • • • • • 23
Jay B. Angevine. Jr.
4. Synapse Formation and Plasticity in the
Developing Dentate Gyrus • • • • • • • • 47
Carl W. Cotman
5. Re-establishment of Terminal Patterns in the Adult
Hippocampus by Grafted Monoaminergic Neurons 67
Anders Bj8rklund and Ulf Steveni
6. Crossroads of Limbic and Striatal Circuitry:
llypothalarno-Nigral Connections • . • • • • • 75
Walle J.H. Nauta and Valerie B. Domesick
7. The Olfactory Cortex and the Ventral Striatum 95
Lennart Heimer
8. Inputs and Outputs of the Amygdala:
What the Amygdala is Trying to Tell the Rest
of the Brain . . . . . . . . . . . . . . . . . . . . . . . 189
Peter Gloor
ix
X CONTENTS
9. The Role of the Limbic System in
Neuroendocrine Regulation • • • • • • • • • • • •• 211
J.O. Willoughby and Joseph B. Martin
10. The Biochemical Pharmacology of the Limbic
System: Neuroleptic Drugs • • . • • • • • • • • • • • 263
Kenneth G. Lloyd
11. The Meso-telencephalic Dopamine Neuron System:
A Review of Its Anatomy • . • • • • • • • • • • • • • 307
Anders Bjorklund and Olle Lindvall
12. Monoaminergic Systems in the Human Limbic System • • ••• 333
I.J. Farley, K.S. Price, and Oleh Hornykiewicz
13. Recollections of James Papez and Comments on the
Evolution of the Limbic System Concept . • • • • • • • • • 351
Paul I. Yakovlev
B: TilE KINDLING PHENOMENON: A DYNAMIC MODEL OF
NEURAL PLASTICITY AND INDUCED LIMBIC SYSTEM DYSFUNCTION
14. Synaptic Change in the Limbic System:
Evidence from Studies Using Electrical
Stimulation with and without Seizure Activity ••••.. 355
Graham V. Goddard, B. L. McNaughton,
R.M. Douglas, and C.A. Barnes
15. The Clinical Relevance of Kindling:
Species, Brain Sites, and Seizure Susceptibility • • • • • 369
Juhn A. Wada
16. The Endogenous Psychoses: A Reflection of
Lateralized Dysfunction of the Anterior
Limbic System • • • • • . • • • • • • • • • • • • • 389
Pierre Flor-Henry
17. Normal and Abnormal Limbic System Mechanisms
of Emotive Biasing ••••••••••••••••.••• 405
Robert E. Adamec
18. A Further Investigation into the Hechanisms
Underlying the Kindling Phenomenon •••••• , ••••• 457
Ronald Racine and J. Zaide
19. Kindling and Memory: .T h.e .A .d r.e n.al .S .ys t.e m. a.n d.
the Bisected Brain • • • • • • • 495
Dan C. Mcintyre
