Table Of ContentLatest Advances in
Diagnosis and Treatment
of Women-Associated
Cancers
There has been tremendous progress in cancer diagnosis and treatment
methodologies, and this book focuses on major cancers of the cervix, breast,
endometrium and the associated female reproductive system. It focuses on
specific diagnostic techniques and treatment strategies including computational
tools, nanomedicine, and the use of machine learning, artificial intelligence,
big data and other latest techniques, including the evolution of these treatments
over the years. Oncologists, cancer scientists and professionals will find using
the content on cutting-edge interventions by experts in their field, significantly
improving earlier diagnosis and treatment options.
Key Features:
• Helps to improve quality of life after treatment, as the focus of
healthcare is shifting from curative methods to primary prevention
of diseases, screening methods, and early detection and treatment.
• Appeals to clinicians and residents interested in exploring cutting-
edge technology for early diagnoses and treatment of women-
associated cancers.
• Features a chapter on the clinician’s perspective on advanced diag-
nostic and treatment methods.
Latest Advances in
Diagnosis and Treatment
of Women-Associated
Cancers
Edited by
Dr. Shazia Rashid, PhD
Centre for Medical Biotechnology, Amity Institute of
Biotechnology (AIB), Amity University Uttar Pradesh, India
Dr. Ankur Saxena, PhD
Amity Institute of Biotechnology (AIB),
Amity University Uttar Pradesh, India
Dr. Sabia Rashid, MRCP, FRCPath
Queen Elizabeth Hospital and
Kings College Hospital London, UK
First edition published 2023
by CRC Press
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CRC Press is an imprint of Taylor & Francis Group, LLC
© 2023 selection and editorial matter, Shazia Rashid, Ankur Saxena and Sabia Rashid, individual
chapters, the contributors
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ISBN: 978-1-032-19636-7 (hbk)
ISBN: 978-1-032-19638-1 (pbk)
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DOI: 10.1201/9781003260172
Typeset in Times
by Apex CoVantage, LLC
For my family, who always stand by me, and the students who keep me
inspired!
—Sh.R
For my family, who always comforts, consoles, and never complains; for
their unwavering support!
—A.S
For my patients, who teach me humility and belief in humanity and
keep me grounded!
—Sa.R
Contents
Preface ix
Acknowledgements xi
About the Editors xiii
List of Contributors xv
List of Abbreviations xix
Glossary xxvii
1 Overview of Traditional Methods of Diagnosis
and Treatment for Women-Associated Cancers 1
Malika Ranjan, Namyaa Kumar, Safiya Arfi
and Shazia Rashid
2 Cancer Drugs and Treatment Formulations for
Women-Associated Cancers 15
Reetika Arora and Pawan K. Maurya
3 Imaging as an Important Tool for Diagnosis
of Breast Cancer 25
Priyanka Mudaliar, Shafina Siddiqui, Sangeeta Ballav,
Narrayan Raam Shankar, Soumya Basu and Jyotirmoi Aich
4 Use of Immunotherapy in Gynaecological and
Breast Cancer 37
Showket Hussain, Sandeep Sisodiya, Vishakha Kasherwal,
Sonam Tulsyan and Asiya Khan
5 Computational Drug Discovery and Development
Along With Their Applications in the Treatment
of Women-Associated Cancers 51
Rahul Kumar, Rakesh Kumar, Harsh Goel, Somorjit Singh
Ningombam and Pranay Tanwar
vii
viii Contents
6 Advances in Nanotechnology for Treatment
of Women-Specific Cancers 65
Smriti Arora, Ananya Bishnoi, Gunjan Vasant Bonde
and Ashish Mathur
7 Identifying Breast Cancer Treatment Biomarkers
Using Transcriptomics 75
Ashfaq Ali Mir
8 Integrating CADD and Herbal Informatics Approach
to Explore Potential Drug Candidates Against HPV E6
Associated With Cervical Cancer 85
Arushi Verma, Jyoti Bala, Navkiran Kaur
and Anupama Avasthi
9 Advances in Big Data and Machine Learning
in Cancer Detection in Women-Associated Cancers 103
Dhaval Kumar Srivastava, Aditya Vikram Singh
and Ankur Saxena
10 Clinicians’ Perspective in the Use and Adaptability
of the Latest Methods of Diagnosis and Treatment
for Cancers in Women 113
Umme Abiha and Charu Sharma
Index 127
Preface
Women-associated cancers such as breast and cervical cancers are the top
cancers affecting women worldwide. World Health Organization (WHO) in
2020 gave the mandate for elimination of cervical cancer as a public health
problem and supporting governments in formulating comprehensive responses
to the growing cancer burden. In order to address this global burden, early
diagnosis is the best alternative for prevention. Currently, in most low- and
middle-income countries (LMIC), cancer is diagnosed at an advanced stage,
when treatment is generally less effective, more expensive and more disabling.
The main triggers for women contacting health services are severity and per-
sistence, which are also related to social sanctioning by people in women’s
networks.
Early diagnosis for symptomatic disease and screening of asymptomatic
individuals can be important in managing gynaecological and breast cancers.
Programs for early diagnosis consist of raising awareness about cancer symp-
toms, ensuring the capacity for rapid clinical and pathological diagnosis and
timely referral to a site where effective treatment can be given.
Cancer management is generally more complex and conventional treat-
ment can involve surgery, chemotherapy and radiotherapy. These treatments
have their side effects and may not always be specific and targeted.
The past half century has seen tremendous progress in cancer diagnosis
and treatment methodologies, mainly through advances in systemic therapy,
and more recently using computational tools, nanotechnology, artificial intel-
ligence (AI), machine learning (ML) and big data and other latest techniques.
This book is about cancers affecting women worldwide. It focuses on
major cancers affecting women with special emphasis on breast and gynae-
cological cancers. It covers the advances in diagnosis and latest treatment and
management strategies available for these cancers.
The book has been divided into chapters which focus on specific diag-
nostic and treatment strategies including new imaging techniques, computa-
tional tools, nanomedicine, use of ML, AI, big data and the evolution of these
modalities over the years.
The target audiences for this book are oncologists, cancer scientists, acade-
micians, public health researchers, physicians, PhD students and postgraduate
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