Table Of ContentSetsuro Fujii · Hiroshi Moriya
Editors
Tomoji Suzuki
Kinins IIA : Biochemistry
Pathophysiology and
Clinical Aspects
KININS-11
Biochemistry, Pathophysiology,
and Clinical Aspects
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
Nathan Back State Univer!ity of New York at Bu/falo
N. R. Di Luzio Tulane Univer!ity School of Medicine
Ephraim Katchalski The W ei:mann Institute of Science
David Kritchevsky Wistar Institute
Abel Lajtha New York State Re!earch lmtitute for Neurochemistry and Drus Addiction
Rodolfo Paolelli University of Milan
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KIN INS-II
Biochemistry, Pathophysiology,
and Clinical Aspects
Edited by
Setsuro Fujii
Institute for Protein Research
Osaka University
Osaka, Japan
Hiroshi Moriya
Science University of Tokyo
Tokyo, Japan
and
Tomoji Suzuki
Meiji College of Pharmacy
Tokyo, Japan
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging in Publication Data
International Symposium on Kinins, Tokyo, 1978.
Kinins II.
(Advances in experimental medicine and biology; v. 120)
Includes index.
1. Kinins-Congresses. 2. Kallikrein-Congresses. I. Fujii, Setsuro, 1925-.
II. Moriya, Hiroshi. III. Suzuki, Tomoji.IV. Title. V. Series.
QP552.K5155 1978 615.7 79-9079
ISBN 978-1-4757-0928-5 ISBN 978-1-4757-0926-1 (eBook)
DOI 10.1007/978-1-4757-0926-1
Proceedings of the International Symposium on Kinins,
held in Tokyo, Japan, November 6-9, 1978.
© 1979 Springer Science+Business Media New York
Originally published by Plenum Press, New York 1979
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
Preface
In this brief historical retrospect of kinin studies, we
recall the discovery of bradykinin by Professor M. Rocha e Silva
and the pioneer investigations on tissue kallikrein initiated by
Dr. E.K. Frey followed by the work of Professor H. Kraut and
Professor E. Werle who opened the way for the-present flourishing
investigations of kinins. The elucidation of the structure of
bradykinin by Dr. F. Elliott in 1960 stimulated further research
of the vasoactive peptides. During the following years, the
physiological and pathological significance of kinins was explored
extensively, resulting in the rapid accumulation of information
regarding their potential importance. Tremendous progress in
our understanding of the involvement of the kallikrein-kinin system
in many physiological phenomena has been facilitated by the
friendly atmosphere among "kininologists" engendered at previous
international kinin symposia. During that time studies were
reported as to the role of kinins in functional vasodilation,
alteration of blood pressure and vascular permeability, shock,
inflammation, and pain production. Thus, through knowledge from
these basic studies, the action of kinins in morhidity is better
understood as are the counter measures for many diseases associated
with kinin formation.
Recent discoveries have focused on abnormally delayPd blood
coagulation in the hereditary deficiency of high molecular weight
kininogen together with prekallikrein deficiency. Thus great strides
have been made in elucidating the interrelationships amongst the
blood coagulation, fibrinolysis, and vasopeptide kinin systems.
Moreover, apart from the aforementioned role of bradykinin as a
pharmacologically active substance, other important findings
involving the coordinated actions of prostaglandin and catecholamine
biosynthesis, particularly in the inflammatory process, have en
hanced our appreciation of the complexity of the vasopeptide kinin
system.
The participation of more than 330 scientists from 16 countries
of the world in this International Symposium on Kinins-Kinin '78
Tokyo reflects accurately the interest and research activity in the
v
PREFACE
diverse and broad implications of the physiological and pathological
functions of the kallikrein-kinin system. A total of 128 papers,
including posters, were presented, attesting to the unquestioned
success of the KININ '78 TOKYO Symposium. This volume in two
sections contains the collective studies presented, studies of
high scientific standard that provoked lively discussions. Also
included in this volume are the two plenary lectures presented
by Dr. K. Austen (USA) and Dr. Hamao Umezawa (JAPAN).
In the future, further closer exchange of information among
investigators from varied bio-medical disciplines will contribute
significantly to our understanding of the important roles played
by the kallikrein-kinin and interrelated systems. Thus will the
scope of the kinin studies be broadened thereby enhancing our
appreciation of cell physiology as well as the possible clinical
impact of the system.
On behalf of the Organizing Committee, the editors of this
volume express their sincere gratitude for the support of the
Ministry of Education, The Scientific Council of Japan, and the
following academic societies in the various branches of medical
science: The Japanese Biochemical Society, The Japanese
Pharmacological Society, The Pharmaceutical Society of Japan, The
Japan Hematological Society, Japanese College of Angiology, The
Japanese Rheumatism Association, and the Japanese Society of
Allergology. The editors also express their gratitude for the
generous financial help provided by the Japan World Exposition
Commemorative Fund and other Foundations and Corporations.
The editors deeply appreciate the dedicated assistance of
Professor N. Back (USA) for helping facilitate the publication of
this volume. Appreciation also is extended to Ms. Patricia
Poczkalski of the State University of New York for her skillful
transcription of the manuscripts to uniform type seen in this
volume, and to Mr. Derrick Mancini, Editor at Plenum Press, and his
associates for their cooperation in publishing attractively and
speedily this volume. The editors express their indebtedness to
Aaron I. Back for his meticulous proofreading of the manuscripts.
Setsuro Fujii
Hiroshi Moriya
Tomoji Suzuki
Contents
Special Lecture: Presentation of a Film on the "Central
Effects of Bradykinin" . • . • • • • . . . • • . . . . . . . • • • . . . . . . • . • . . 1
M. Rocha e Silva
CHEMISTRY OF KININS AND RELATED PEPTIDES
The New Vasoactive Peptides in Amphibian Skin .•...•..•.•.... 7
V. Erspamer, T. Yasuhara, T. Nakajima
Specific Isolation of Biologically-Active Peptides by
Means of Immobilized Anhydrotrypsin and
Anhydrochymotrypsin . . . . . . . . . • . . . . . . . . . . . . . . . . . • . . . . . • . 15
S. Ishii, H. Yokosawa, S. Shiba, K. Kasai
Comparative Study on Distribution of Bombesin-, Neurotensin
and a-Endorphin-Like Immunoreactivities in
Canine Tissues . . . . . . . . . . . . . . . • • . . . . . . . . . . . . . . . . . . . . . . . 29
N. Yanaihara, H. Sato, A. Inoue,
N. Sakura, M. Sakagami, T. Mochizuki,
H. Nakamura, C. Yanaihara
Preparation of Intrinsically-Labelled Kinins 39
A. Chung, J.W. Ryan, P. Berryer,
R. Block
Kininogenase Activity and Kinin-Like Substance in the
Venomous Spicules and Spines of Lepidopteran
Larvae . . . . . . . . . . . . . . . . . . . . . . . . . . . . • . . . • . . . . . . . . . . . . . . . 51
F. Kawamoto, N. Kumada
ASSAYS OF COMPONENTS OF THE KALLIKREIN-KININ SYSTEM
An Approach to the Chemical Quantitation of Kinins
for the Assay of Kininogenases •...........• ..•........ 59
B.T. Khouw
vii
viii CONTENTS
Determination of Prekallikrein in Plasma by Means
of a Chromogenic Tripeptide Substrate for
Plasma Kallikrein . . . . . . . . . . . . . • . . • . . . . . . • . • . • • . • • • . • • . 67
P. Friberger, E. Eriksson, S. Gustavsson,
G. Claeson
Methods for the Determination of Glandular Kallikrein
by Means of a Chromogenic Tripeptide
Substrate................ .............................. 83
E. Amundsen, J. Putter, P. Friberger,
M. Knos, M. Larsbraten, G. Claeson
A Direct Radioimmunoassay for Human Urinary Kallikrein 97
N.B. Oza, J.W. Ryan
Estimation of Urinary Kininogenase Activity Using
Bovine Serum Low Molecular Weight Kininogen 105
K. Abe, H. Kato, Y. Sakurai, T. Itoh,
K. Saito, T. Haruyama, Y. Otsuka,
K. Yoshinaga
A Simple Radioassay for Human Urinary Kallikrein 115
A. Chung, J.W. Ryan, G. Pena, N.B. Oza
Glandular Kallikrein in Plasma and Urine: Evaluation
of a Direct RIA for Its Determination •••.••.•.•....•.• 127
S.F. Rabito, V. Amin, A.G. Scicli,
O.A. Carretero
Method for Measurement of Human Urinary Kininase
Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143
G. Porcelli , M. Di Jorio, M. Ranieri,
L. Ranalli, L. D'Acquarica
Fluorogenic Peptide Substrates for Proteases in Blood
Coagulation, Kallikrein-Kinin and Fibrinolysis
Systems . . • . . • . . • . . . • . . • • • . . . . • • • • • • • • • . • . • . . • . . • . . • • • . 147
S. Iwanaga, T. Morita, H. Kato, T. Harada,
N. Adachi, T. Sugo, I. Maruyama, K. Takada,
T. Kimura, S. Sakakibara
Determination of Hageman Factor (HG, Factor XII) and
Plasma Prekallikrein (Fletcher Factor) by
Radioimmunoassays . . • . . . • . . . . . . . . . . . • . . . . . . • . . • . . . . . . . . 165
H. Saito
CONTENTS ix
Assay Methods for Prekallikrein and Kininogens
and Their Applications . . . . . . . . . . . . . • . . . . . . . . . . . . . . . . . . 173
Y. Uchida, S. Oh-Ishi, K. Tanaka, Y. Harada,
A. Ueno, M. Katori, S. Funahashi, T. Hashimoto
T. Ueno, J. Kodama
Synthetic Bradykinin-Like Peptides • . . . . . . • . . . . . . . . . . . . . . . . . 185
C. Yanaihara, M. Sakagami, M. Kubota,
H. Sato, T. Mochizuki, A. Inoue,
N. Yanaihara, T. Yasuhara, T. Kanajima,
T. Hashimoto
Enzyme Immunoassay of Bradykinin ....•.....•...••••.......•• 195
A. Ueno, S. Oh-Ishi, T. Kitagawa,
M. Katori
Assay of Angiotensin I by Fluorescence Polarization
Method • . . . • . . . • . . . . . . • • . . . . • . . . . . • • . . . • . . . . . . . . . . . • . . . 203
H. Maeda, M. Nakayama, D. Iwaoka,
T. Sa to
A System for the Study of Kallikreins 213
J.M. Stewart, D.H. Morris
BIOCHEMICAL CHARACTERIZATION OF COMPONENTS OF THE PLASMA
AND TISSUE KALLIKREIN-KININ SYSTEM
Chemical Relations Between Renal and Urinary Kallikrein
of Rat . • . • . . . • • . • . . • • • . . . . . . . . • . . . . . • . . . . • . • • . . . • . • • . . 221
G. Porcelli, G.B. Marini-Bettolo,
H.R. Croxatto, M. Di Jorio
Radioimmunoassay of Rat Submandibular Gland Kallikrein
and the Detection of Immunoreactive Antigen
in Blood . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225
K. Nustad, K. Gautvik, T. 0rstavik
Human Urinary Kallikrein - Biochemical and Physiological
Aspects . . • . . . . . . . . . . • . . . . . . . . . . . . . . . . . • . . . . . . . . . . . . . . . 235
R. ·Geiger, U. Stuckstedte, B. Forg-Brey,
E. Fink
The Primary Structure of Porcine Glandular Kallikreins 245
H. Tschesche, G. Mair, G. Godec,
F. Fiedler, W. Ehret, C. Hirschauer,
M. Lemon, H. Fritz, G. Schmidt-Kastner,
C. Kutzbach
