Table Of ContentRamon Andrade de Mello
Álvaro Tavares
Editors
Giannis Mountzios
International
Manual
of Oncology
Practice
(iMOP) - Principles of Medical Oncology
International Manual of Oncology Practice
Ramon Andrade de Mello
Álvaro Tavares • Giannis Mountzios
Editors
International Manual
of Oncology Practice
(iMOP) - Principles of Medical Oncology
Editors
Ramon Andrade de Mello Álvaro Tavares
Medical Oncology Biomedical Sciences and Medicine
University of Algarve University of Algarve
Faro , Portugal Faro, Portugal
Giannis Mountzios
Medical Oncology
University of Athens
Athens , Greece
ISBN 978-3-319-21682-9 ISBN 978-3-319-21683-6 (eBook)
DOI 10.1007/978-3-319-21683-6
Library of Congress Control Number: 2015957124
Springer Cham Heidelberg New York Dordrecht London
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Pref ace
Dear Colleague,
N owadays, cancer is a serious disease which presents normally with a high mortal-
ity and important treatment sequels. The clinical approach of the cancer patients is
really a challenge for the physicians, nurses, phycologists, and all subjects involved,
namely, the patients and their family. Fortunately, the cancer sciences currently had
been developing several strategies to overcome this issue: personalizing medicine,
predictive and prognostic biomarkers, novel target therapies, and also innovative
supportive therapies. Thus, the oncological treatment is a multimodal process which
involves a comprehensive approach. More recently, the most important medical
oncology societies are important key institutions to disseminate knowledge and
establish clinical practice guidelines for the patient’s care. Also, they focus on an
intensive task force to create a good and solid network education platform for young
and senior medical oncologists’ updating. Nevertheless, medical oncology training
directors and the national board examination council worldwide concurrently work
to try to adapt the novel evidence to their reality and clinical practice. Taking into
account all these paramount features, the I nternational Manual of Oncology
Practice working group had developed a very comprehensive and evidence- based
book to help the clinicians worldwide integrate the knowledge to fi t to their clinical
practice. Experts from Europe, North America, Latin America, Asia, Middle East,
and Oceania had stablished a solid and well-developed network platform to share
experiences and write a consistent evidence-based book for the global oncology
community, according to their local economical and sociocultural concerns. We
hope you enjoy our work.
Faro, Portugal Sincerely yours,
Ramon Andrade de Mello,
On behalf of all authors and editors
v
Biography
Ramon Andrade de Mello , M.D., Ph.D. is board cer-
tifi ed medical oncologist by the Portuguese Medical
Association (Ordem dos Médicos Portuguesa), Lisbon,
Portugal, with clinical and scientifi c interest in lung,
GI and GU Tumors. He received the MD degree at the
Faculty of Medicine, Federal University of Ceará,
Fortaleza, Ceará, Brazil, with MD recognition from
University of Lisbon, Portugal, and holds the Certifi cate
in Medical Oncology by has passed in the European
examination of ESMO (European Society for Medical
Oncology), Switzerland, and in the National Board
Examination (ACSS), Lisbon, Portugal. He completed
specialization in medicine and molecular oncology and his PhD in Oncology (lung
cancer) at the Faculty of Medicine, University of Porto, Portugal (recognized by the
Federal University of Ceará, Fortaleza, and by the Ministry of Education and
Science (MEC), Brasilia, Brazil). He also completed the medical oncology training
in Portugal supported by ACSS (Ministry of Health, Portugal) and a postdoctoral
clinical research fellowship in lung cancer clinical trials at the Lung Unit, Royal
Marsden NHS Foundation Trust, Chelsea, London, United Kingdom, supported by
the ESMO. Currently, he teaches at the Department of Medicine of the University
of Porto and School of Medicine, University of Algarve, Faro, Portugal. Ramon De
Mello performs both basic and clinical research on angiogenesis, palliative medi-
cine, internal medicine, gastro-intestinal tumors and lung cancer; further, he has an
active offi ce working. He is editor of 3 books (International Manual of Oncology
Practice, Springer 2015; Tamoxifen Concepts and Cancer: New Paradigms and
Vimentin Concepts and Molecular Mechanisms, Nova Science, NY, USA, 2013),
author of many scientifi c articles, chapters and comments on basic and clinical
research. He presented more than 50 papers in congresses and conferences in sev-
eral countries, such as United States, Sweden, Brazil, Portugal and Spain.
Furthermore, he serves as editorial board of several reputed scientifi c journals, such
vii
viii Biography
as PLoS ONE, Rare tumors, Oncology Reviews and scientifi c reviewer of the The
Lancet, The British Journal of Cancer, Journal of Thoracic Oncology and Annals of
Internal Medicine. He is expert reviewer for research grant applications at University
of Coimbra, Portugal, National Science Centre, Kraków, Poland and British Lung
Foundation London, England; Ramon is ad hoc consultant for the national program
to support cancer care (PRONON) at Department of Science and Technology,
Ministry of Health, Brasília, Brazil. He was selected to be an active member of the
ESMO Young Oncologist Committee since January 2015.
Álvaro Tavares born in 1964, obtained his degree in
Biochemistry from the University of Lisbon, Portugal.
He later obtained a M.Sc. in Molecular Biology from
the New University of Lisbon and a Ph.D. in Biomedical
Sciences from the University of Porto, Portugal. He
then moved to Scotland, where for 5 years he was a
postdoc at the Department of Anatomy and Physiology
of the University of Dundee. In 1999, having been
appointed professor at the Instituto Superior Técnico,
Lisbon, he started his own research group at the
Gulbenkian Science Institute. In 2009 he moved to the
University of Algarve, to the newly formed Department
of Biomedical Sciences and Medicine, where he cur-
rently directs the Cell Division and Cancer Biology Research Group.
In the course of his research career, Álvaro Tavares has studied proteolytic sys-
tems in rat liver mitochondria, proteolysis regulation in differentiation in the plant
Lupinus albus , genetic regulation and expression in yeast S . cereviseae , and molec-
ular and genetic characterization of genes required for cell proliferation in
Drosophila melanogaster. The underlying theme behind the current work of his
laboratory is the basic biology of mitotic cell division, in particular the aspects regu-
lating the formation of a bipolar mitotic spindle and the connection between centro-
somes and cytokinesis. The ultimate goal is to understand how modifi cations of
these processes contribute to the transformation of normal cells into cancer cells.
These problems are approached through a combination of biochemical, genetic, and
cytological techniques, taking advantage of D rosophila melanogaster genetics and
human tissue-cultured cells.
Biography ix
Dr. Giannis Mountzios , M.D., M.Sc., Ph.D.
w as born in Larissa, Greece, in 1974. He obtained his
medical degree (MD) from the Aristotle University of
Thessaloniki in 1998 with a scholarship from the
Greek Ministry of Education and graduated from the
Hellenic Military Medical Academy the same year. He
completed his residency in Internal Medicine at the
Airforce General Hospital of Athens and in Medical Oncology at the University of
Athens School of Medicine, “Alexandra” University Hospital (Pr. M.A. Dimopoulos).
He then obtained a master (MSc) in translational and clinical research in Oncology
from the Institut Gustave-Roussy and the University Paris XI (Paris-Sud), France,
in 2007 (Pr. Jean-Charles Soria) and became board-specifi ed in Medical Oncology
in 2009. In 2010 he obtained his PhD in Medical Oncology from the University of
Athens School of Medicine. He is currently working as a consultant Medical
Oncologist at the University of Athens School of Medicine. Dr Mountzios has
received fellowships from the American Society of Clinical Oncology (Young
Investigator award), the European Society for Medical Oncology (Annual
Fellowship for Translational Research in 2005, Annual Fellowship for Clinical
Research in 2009) and the Hellenic Society for Medical Oncology (HESMO). He is
currently member of the board of directors of HESMO, chair of the HESMO young
medical oncologists committee and member of the steering committee of the young
medical oncologists of ESMO.
