Integrative Therapies for Depression: Redefining Models for Assessment, Treatment and Prevention

538 Pages·2015·63.71 MB·English

by  James M. Greenblatt

Psychiatry G INTEGRATIVE THERAPIES
B r
e
Integrative Therapies for Depression: Redefining Models for Assessment, ro e
n
g
b
Treatment, and Prevention summarizes emerging theories and research findings a
l
n a
FOR DEPRESSION
on various nonpharmaceutical therapies to treat mood disorders. t
t
Supported by the review of nearly 3000 scientific studies, the book describes
the concepts of inflammation, genetics, hormonal imbalance, gastrointestinal I
N Redefining Models for Assessment,
conditions, environmental stress, and nutritional deficiencies and their possible
T
link to the pathogenesis of mood disorders.
E Treatment, and Prevention
G
It also examines findings on various nonpharmaceutical therapies used to treat
R
mood disorders including vitamins, botanicals, and other natural products as
Edited by
A
well as exercise, stress reduction, bright light, mind-body practices, and spiritual
T
approaches. I James M. Greenblatt, M.D.
V
E
Also covered are evidence-based approaches to integrative management of Kelly Brogan,
M.D.

mood disorders in pregnant women, adolescents, and the elderly. Separating T
facts from fiction, the book provides practical information that clinicians can H
implement and share with their patients. E
R
The book fills a significant gap in the conventional model of therapeutics for mood A
disorders. It is a valuable resource for psychiatrists, psychologists, therapists P
and family physicians, and all other clinicians who devote their days to caring for I
E
those afflicted with depression.
S

F
O
R

D
E
P
R
E
S
S
I
O
N
K24604
6000 Broken Sound Parkway, NW ISBN: 978-1-4987-0229-4
Suite 300, Boca Raton, FL 33487
90000
711 Third Avenue
New York, NY 10017
an informa business
2 Park Square, Milton Park
www.crcpress.com Abingdon, Oxon OX14 4RN, UK
9 781498 702294
w w w. c r c p r e s s . c o m
K24604 mech rev.indd 1 11/2/15 4:45 PM

Contents
Acknowledgments .............................................................................................................................ix
Foreword ...........................................................................................................................................xi
Editors ..............................................................................................................................................xv
Contributors ...................................................................................................................................xvii
Chapter 1 Shifting the Paradigm: Redefining the Treatment of Mood Disorders ........................1
Emily Deans, MD
Chapter 2 The Role of Inflammation in Depression .....................................................................5
Antolin C. Trinidad, MD, PhD
Chapter 3 The Gut-Brain Axis: The Role of the Gut in Brain Health ........................................15
Court Vreeland, MS, DC, DACNB and Kelly Brogan, MD, ABIHM
Chapter 4 Clostridia Bacteria in the GI Tract Affecting Dopamine and Norepinephrine
Metabolism .................................................................................................................31
William Shaw, PhD
Chapter 5 Stress, Fear, Trauma, and Distress: Underlying Factors in Depression .....................49
Peter Bongiorno, ND, LAc
Chapter 6 Mitochondrial Dysfunction and Physiological Depression ........................................61
Dean Raffelock, DC, Dipl. Ac., DAAIM
Chapter 7 Micronutrient Deficiencies and Mitochondrial Dysfunction .....................................73
Chandler Marrs, MS, MA, PhD
Chapter 8 Vitamin Deficiencies and Depression: Evidence-Based Research.............................97
James M. Greenblatt, MD and Priyank Patel
Chapter 9 Mineral Deficiencies and Depression: Evidence-Based Research ...........................115
James M. Greenblatt, MD and Kayla Grossmann, RN
Chapter 10 Essential Fats and Amino Acids in Depression .......................................................133
Bettina Bernstein, DO
Chapter 11 Sex Steroids and Mood in Women ...........................................................................147
Ann Hathaway, MD
v
vi Contents
Chapter 12 The Hypothalamic-Pituitary-Adrenal Axis in Mood Disorders ..............................171
Sara Gottfried, MD
Chapter 13 Adrenal, Reproductive, and Thyroid Hormone Testing for Depression ...................189
Dean Raffelock, DC, Dipl. Ac., DAAIM and Lara Pizzorno, MAR, MA, LMT
Chapter 14 Exposure to Toxic Chemicals as a Cause of Depression ..........................................209
William Shaw, PhD
Chapter 15 Dietary Peptides and the Spectrum of Food Hypersensitivities ..............................223
Cynthia Gariépy, ND
Chapter 16 Genetic-Based Biomarkers in Psychiatry: An Integrative Approach .......................241
Jay Lombard, DO
Chapter 17 Mood-Related Effects of Medications Prescribed for Non-Psychiatric Indications .....251
Myrto A. Ashe, MD, MPH
Chapter 18 The Rationale for Treating with a Broad Spectrum of Minerals and Vitamins ......263
Julia J. Rucklidge, PhD and Bonnie J. Kaplan, PhD
Chapter 19 Amino Acids and Other Nutrients That Enhance the Synthesis and Regulation
of Neurotransmitters ................................................................................................279
Richard M. Carlton, MD
Chapter 20 Botanicals for Depression: Rhodiola, St. John’s Wort, Curcumin, and Saffron ......293
Judith E. Pentz, MD
Chapter 21 Exercise as an Adjunct to Treating Depression ........................................................307
Ralph E. Carson, LD, RD, PhD
Chapter 22 The Role of Sleep and Light Therapy in Depression ...............................................333
Robin May-Davis, MD
Chapter 23 The Role of Spirituality and Religion in Depression and Treatment .......................357
Natalie L. Hill, M.Div., LICSW
Chapter 24 Depression-Specific Yoga and Mindfulness-Based Cognitive Therapy Model:
Description, Data on Efficacy, and Differences from Contemporary Models .........369
Basant Pradhan, MD
Contents vii
Chapter 25 Meditation and Mindfulness ....................................................................................379
Healy Smith, MD, ABIHM and Gregory Thorkelson, MD
Chapter 26 Narrative Therapy ....................................................................................................395
Antolin C. Trinidad, MD, PhD
Chapter 27 Integrative Psychotherapy: Healing the MindBodyMatrix ......................................403
Martha Stark, MD
Chapter 28 Integrative Approaches to Perinatal Depression ......................................................421
Vesna Pirec, MD, PhD and Kelly Brogan, MD, ABIHM
Chapter 29 Integrative Approaches to Adolescent Depression ...................................................441
Amelia Villagomez, MD and Noshene Ranjbar, MD
Chapter 30 Integrative Approaches for Geriatric Depression .....................................................457
Lewis Mehl-Madrona, MD, PhD, Barbara Mainguy, MA, and Asha Shah, MD
Chapter 31 Clinical Case Studies: Putting It All Together .........................................................479
Kat Toups, MD, DFAPA