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About Ingber lecture: From Cellular Mechanotransduction to Biologically Inspired Engineering
Ingber's 2009 Pritzker Award Lecture provides a great overview of the state of cell cytoskeleton comprehension in terms of tensegrity. Ingber divides his talk into eight sections: 1. The living cell as a mechanical structure, 2. A strange idea: tensegrity in cells, 3. Engineering approaches provide new insights into cell structure, 4. Integrins as mechanoreceptors, 5. Structural hierarchies for force transmission in living systems, 6. Solid-state biochemistry and cellular mechanotransduction, 7. Mechanical control of cell function and tissue development and 8. Bioinspired technology fallout. The talk includes a good overview of tensegrity, and details on cell shape stability mechanisms, such as force balances between compressive microtubule struts and tensile actomyosin filaments. He also describes the activity of integrin receptors in the scope of the model. Ingber finds the global nature of tensegrity a good explanation for the behavior of transmembrane surface receptor molecules (e.g., growth factor receptors, integrins, cadherins) and how they induce shape transitions at their cytoplasmic faces, mediating transmembrane signaling. For more details, see http://www.childrenshospital.org/research/ingber/ or http://tensegrity.wikispaces.com/Portal+To+Cellular+Biology
Detailed Information
| Author: | ['Tensegrity Wiki'] |
|---|---|
| Publication Year: | 2010 |
| Pages: | 14 |
| Language: | English |
| Format: | |
| Price: | FREE |
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