Immunodiagnostic Technologies from Laboratory to Point-Of-Care Testing

247 Pages·2020·7.019 MB·English

by  Pankaj Suman, Pranjal Chandra

Pankaj Suman
Pranjal Chandra  Editors
Immunodiagnostic
Technologies
from Laboratory
to Point-Of-Care
Testing
Immunodiagnostic Technologies
from Laboratory to Point-Of-Care Testing
(cid:129)
Pankaj Suman Pranjal Chandra
Editors
Immunodiagnostic
Technologies
from Laboratory
to Point-Of-Care Testing
Editors
PankajSuman PranjalChandra
AnimalBiotechnologyLaboratory SchoolofBiochemicalEngineering,Indian
NationalInstituteofAnimal InstituteofTechnology
Biotechnology(NIAB)Hyderabad LaboratoryofBio-PhysioSensors
Hyderabad,Telangana,India andNano-bioengineering
Varanasi,UttarPradesh,India
ISBN978-981-15-5822-1 ISBN978-981-15-5823-8 (eBook)
https://doi.org/10.1007/978-981-15-5823-8
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Contents
BiosensorsforClinicalSamples:ConsiderationandApproaches. . . . . . 1
MihaelaTertis,OanaHosu,AncaFlorea,andCeciliaCristea
ImmunodiagnosisbyElectrochemicalMultiplexing
inClinicalSamples. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 33
S.Campuzano,P.Yáñez-Sedeño,andJoséM.Pingarrón
PrincipleandApplicationsofImmunodiagnosticsUsingRadioisotope
asTracers. .. . . . . . . .. . . . . . . . .. . . . . . . . .. . . . . . . .. . . . . . . . .. . . 61
ShishuKantSuman,RohitSharma,andChandanKumar
RedoxCyclingTechnologiesforPoint-of-CareImmunodiagnostics
inVariousMatrices. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
GorachandDutta,DespinaMoschou,andRiddhipratimMandal
Next-GenerationImmunosensingTechnologiesBased
onNano-Bio-EngineeredPaperMatrices. . . . . . . . . . . . . . . . . . . . . . . . 93
KuldeepMahato,BudhhadevPurohit,AshutoshKumar,
AnanyaSrivastava,andPranjalChandra
AlternativeAnalyte-BindingCompoundsforImmunosensor-Like
Point-of-CareApplication. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
AnkitaKushwaha,YuzuruTakamura,andManishBiyani
Bead-BasedSELEXforAptamersSelectionandTheirApplication
inDetectionofDiverseAntigens. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125
DevikaN.Nagar,T.Yathirajarao,PankajKumar,PoojaKushwaha,
andPankajSuman
ChangingTrendsinImmunosensingTechnologiesandTheir
CommercialAspectsinAnimalHealthandWelfare. . . . . . . . . . . . . . . . 141
SherinKaul,RajniSingh,SharanyaKamaraju,andPankajSuman
MethodsforEnhancingAptamerAffinityforAntigenDetection
andItsCharacterization. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 163
KomalBirader,L.SaiKeerthana,T.Yathirajarao,JeannieAliceBarla,
andPankajSuman
vv
vi Contents
ApplicationofBiosensorstoEnhanceReproductiveEfficiency
andProductionofLivestockandPoultrybyDiverseAntigenAnalysis. . . 185
PankajKumar,ShaliniChakraborty,DevikaNagar,KomalBirader,
andPankajSuman
ClinicalImplicationsofCortisolandBioanalyticalMethods
forTheirDeterminationinVariousBiologicalMatrices. . . . . . . . . . . . . 195
AjayKumarSahi,NeelimaVarshney,RakeshKumarSidu,
SuruchiPoddar,Pallawi,KameshwarnathSingh,
andSanjeevKumarMahto
ReceptorsinImmunodiagnostics:Antibodies,AntibodyFragments,
SingleDomainAntibodiesandAptamers. . . . . . . . . . . . . . . . . . . . . . . . 223
NachiketShembekar
About the Authors
PankajSuman isaScientistandPrincipalInvestigatorattheNationalInstituteof
Animal Biotechnology, Hyderabad, India. He did his Bachelors in Veterinary
Medicine from Maharashtra Animal & Fishery Sciences University, Nagpur, India
and obtained his MS degree from the Indian Institute of Technology Roorkee,
Roorkee, India. He did his Ph.D. at the National Institute of Immunology, New
Delhi. He also worked as visiting scholar at Friedrich-Schiller University, Jena,
Germany(2007–2010).Hisresearchexperiencespansthroughvaryingdisciplineof
science pertaining to immunology, reproductive biology, veterinary, and clinical
medicine. In the past, he has made a significant contribution in understanding the
molecular mechanisms behind the immunological basis of pregnancy, vaccine
delivery, and diagnostics. His current research is focused on the development of
biosensing devices for the detection of small molecules (toxins, metabolites, etc.)
throughdesigningsmallantibodiesandaptamersasatoolfordetection.Tillnow,he
haspublishedover25researcharticlesinvariousreputedjournals.Heisarecipient
ofseveralprestigiousfellowships andawardsfromagencieslikeCouncilofScien-
tific&IndustrialResearch,India,DepartmentofScienceandTechnology,India,and
United States Department of Agriculture, USA. He is also a recipient of the
prestigious G. P. Talwar Young Scientist award for outstanding contribution in
reproductivehealth.Hehasattendedseveralnationalandinternationalconferences
anddeliveredinvitedtalks.
PranjalChandra iscurrentlyemployedasanAssistantProfessorattheSchoolof
Biochemical Engineering, Indian Institute of Technology (BHU), Varanasi, India.
He earned his Ph.D. from Pusan National University, South Korea and did his
postdoctoraltrainingatTechnion-IsraelInstituteofTechnology,Israel.Hisresearch
focus is highly interdisciplinary, spanning a wide range in biotechnology,
nanobiosensors, material engineering, nanomedicine, etc. He has designed several
commercially viable biosensing prototypes that can be operated for onsite analysis
forbiomedicaldiagnostics,environmentalmonitoring,andotherpoint-of-caretest-
ing applications. He has published six books on various aspects of biosensors/
medical diagnostics from IET London, Springer Nature, and CRC Press, USA. He
has also published over 85 journal articles in topmost journals in his research area
including Biosensors and Bioelectronics, Analytical Chemistry, Biomaterials,
vviiii
viii AbouttheAuthors
Chemical Communications, Electroanalysis, etc. His work has been greatly
highlighted in over 300 topmost news agencies globally including Rajya Sabha
TV; DD Science; Science Trends, USA; Nature India; Vigyan Prasar; Global
Medical Discovery, Canada; APBN Singapore; Business Wire, Dublin; etc. He is
a recipient of many prestigious awards and fellowships such as DST Ramanujan
Fellowship (Government of India); Early Career Research Award (DST, Govern-
ment of India); Brain Korea-21 and National Research Foundation Fellowship,
South Korea; Technion Postdoctoral Fellowship, Israel; NMS Young Scientist
Award, Biotech Research Society India Young Scientist Award, Young Engineers
Award2018,RSCHighlyCitedCorrespondingAuthorAward(generalchemistry);
ACS/ElsevierOutstandingReviewerAwards,etc.Heisareviewerofover50inter-
national journals and expert project reviewer of various national/international
funding agencies. He is Associate Editor of Sensors International and an editorial
boardmemberofMaterialsScienceforEnergyTechnologiesbyKeAiandElsevier;
WorldJournalofMethodology,USA;FrontiersinBiosciences,USA;andReportsin
PhysicalSciences,Singapore.
Biosensors for Clinical Samples:
Consideration and Approaches
Mihaela Tertis, Oana Hosu, Anca Florea, and Cecilia Cristea
Abbreviations
Ab Antibody
AD Autoimmunediseases
Ag Antigen
AGA Antigliadinantibodies
anti-CPP Anti-citrullinepeptide
anti-tTG Anti-transglutaminaseantibodies
AFP Alphafetoprotein
AChE Acetylcholinesterase
AP Alkalinephosphatase
APTES 3-aminopropyltrietoxysilane
Apt Aptamer
ASV Anodicstrippingvoltammetry
AuNPs Goldnanoparticles
BSA Bovineserumalbumin
c-Myc Myelocytomatosisoncogene
cTnT Troponin-T
cTnI CardiacTroponin-I
CA125(MUC16) Cancerantigen125
CA19-9 Carbohydrateantigen19-9
CEA Carcinoembryonicantigen
CA125 Carcinomaantigen125
CK-MB CreatinekinaseMB
M.Tertis·O.Hosu·A.Florea·C.Cristea(*)
AnalyticalChemistryDepartment,FacultyofPharmacy,“IuliuHaţieganu”UniversityofMedicine
andPharmacy,Cluj-Napoca,Romania
e-mail:[email protected]
#SpringerNatureSingaporePteLtd.2021 1
P.Suman,P.Chandra(eds.),ImmunodiagnosticTechnologiesfromLaboratoryto
Point-Of-CareTesting,https://doi.org/10.1007/978-981-15-5823-8_1
2 M.Tertisetal.
CK-MM CreatinekinaseMM
CNT Carbonnanotubes
CSF Cerebrospinalfluid
CRP C-reactiveprotein
CV Cyclicvoltammetry
CVD Cardiovasculardiseases
ECL Electrochemiluminescence
ELISA Enzyme-linkedimmunosorbentassay
DDAB Didodecyldimethylammoniumbromide
Den Dendrimer
DPV Differentialpulsevoltammetry
EGFR(ErbB-1;HER1) Epidermalgrowthfactorreceptor
EIS Electrochemicalimpedancespectroscopy
GADA Glutamatedecarboxylaseantibody
GCE Glassycarbonelectrode
GO Grapheneoxide
hCG Humanchorionicgonadotropin
HER-3 Humanepidermalgrowthfactorreceptor3
HE4 Humanepididymis-specificprotein4
HIgG HumanimmunoglobulinG
HRP Horseradishperoxidase
IgA ImmunoglobulinA
IgB ImmunoglobulinB
IgG ImmunoglobulinG
IL-8(CXCL-8) Interleukin8
IL-17 Interleukin17
ITO Indiumtinoxide
LF Lateral-flow
LFTSs Lateral-flowteststrips
LSW Linearsweepvoltammetry
MBP Myelinbasicprotein
MBs Magneticbeads
MBP Myelinbasicproteins
MDM2 Murinedoubleminute2
MH Mercaptohexanoicacid
MIF Macrophagemigrationinhibitoryfactor
MPR Myeloperoxidase
MS Multiplesclerosis
MUC4 Mucin4
Myo Myoglobin
MWCNT Multi-walledcarbonnanotubes
ND Neurologicaldisorders
NSE Neuron-specificenolase
NT Neurotransmitters
PB Prussianblue