Download Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation PDF Free - Full Version
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About Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
Detailed Information
| Author: | Colm Duffy (auth.) |
|---|---|
| Publication Year: | 2012 |
| ISBN: | 9783642246319 |
| Pages: | 150 |
| Language: | English |
| File Size: | 5.07 |
| Format: | |
| Price: | FREE |
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