Table Of ContentJenny Stanford
Series on
Vol. 7
Biomedical
In the fast-developing field of nanomedicine, a broad variety of materials have been
Nanotechnology
used for the development of advanced delivery systems for drugs, genes, and diagnostic
agents. With the recent breakthroughs in the field, we are witnessing a new age of disease Volume 7
management, which is governed by precise regulation of dosage and delivery.
This book presents the advances in the use of polymeric nanomaterials for medical imaging, M
diagnosis, theranostics, and drug delivery. Beginning with the combinatorial approach a Handbook of
for polymer design, it discusses star-shaped amphiphilic polymers, self-assembling t
polymer–drug conjugates, amphiphilic dendrimers, dendrimer nanohybrids, sustainable e Materials for
green polymeric nanoconstructs, chitosan-based nanogels, and multifunctional hybrid r
i
nanogels. The book provides all available information about these materials and describes a
in detail their advantages and disadvantages and the areas where they could be utilized l Nanomedicine
sH
successfully.
fa
on
Vladimir Torchilin is University Distinguished Professor of pharmaceutical
rd Polymeric Nanomaterials
sciences and the Director of the Center for Pharmaceutical Biotechnology and b
N
Nanomedicine at Northeastern University, USA. His research interests include o
drug delivery and targeting, nanomedicine, multifunctional and stimuli- ao
sensitive pharmaceutical nanocarriers, biomedical polymers, experimental nk
cancer therapy, cancer immunology, and novel imaging agents. He has published more o
o
than 450 original papers, more than 150 reviews and book chapters, and 12 books and mf
holds more than 40 patents. Google Scholar gives more than 66,000 citations of his work
e
with H-index of 114. Prof. Torchilin is editor-in-chief of Drug Delivery and Current Drug
d
Discovery Technologies and is on the editorial boards of several leading journals in the field,
i
including Journal of Controlled Release (review editor), Bioconjugate Chemistry, Advanced c
Drug Delivery Reviews, European Journal of Pharmaceutics and Biopharmaceutics, Journal i
n
of Drug Targeting, Molecular Pharmaceutics, and Journal of Biomedical Nanotechnology. He
e
is also a Full Member of the European Academy of Sciences and Fellow of the American
Institute of Medical and Biological Engineering, American Association of Pharmaceutical
Scientists (AAPS), and the Controlled Release Society. He is a recipient of the 1982 Lenin
Prize in Science and Technology (the highest scientific award in the former USSR), the 2005
Research Achievements in Pharmaceutics and Drug Delivery Award from the AAPS, 2007
Research Achievements Award from the Pharmaceutical Sciences World Congress, 2009
AAPS Journal Award, 2009 International Journal of Nanomedicine Distinguished Scientist T
o
Award, 2010 Controlled Release Society Founders Award, 2012 Life Time Achievements r
c
h
Award from the Journal of Drug Targeting, 2012 Alec Bangham Life Time Award, and 2013
i
l
Blaise Pascal Medal for Biomedicine from the European Academy of Sciences. i
n
edited by
V756
ISBN 978-981-4800-92-1 Vladimir Torchilin
Handbook of
Materials for
Nanomedicine
Polymeric Nanomaterials
Jenny Stanford Series on Biomedical Nanotechnology
Series Editors
Vladimir Torchilin and Mansoor Amiji
Titles in the Series
Published Vol. 5
Handbook of Safety Assessment of
Vol. 1 Nanomaterials: From Toxicological
Handbook of Materials for Testing to Personalized Medicine
Nanomedicine Bengt Fadeel, ed.
Vladimir Torchilin and Mansoor Amiji, 2014
eds. 978-981-4463-36-2 (Hardcover)
2010 978-981-4463-37-9 (eBook)
978-981-4267-55-7 (Hardcover)
978-981-4267-58-8 (eBook) Vol. 6
Handbook of Materials for
Vol. 2 Nanomedicine: Lipid-Based and
Nanoimaging Inorganic Nanomaterials
Beth A. Goins and William T. Phillips, Vladimir Torchilin, ed.
eds. 2020
2011 978-981-4800-91-4 (Hardcover)
978-981-4267-09-0 (Hardcover) 978-1-003-04507-6 (eBook)
978-981-4267-91-5 (eBook)
Vol. 7
Vol. 3 Handbook of Materials for
Biomedical Nanosensors Nanomedicine: Polymeric
Joseph Irudayaraj, ed. Nanomaterials
2013 Vladimir Torchilin, ed.
978-981-4303-03-3 (Hardcover) 2020
978-981-4303-04-0 (eBook) 978-981-4800-92-1 (Hardcover)
Vol. 4 978-1-003-04511-3 (eBook)
Nanotechnology for Delivery of Vol. 8
Therapeutic Nucleic Acids Handbook of Materials for
Dan Peer, ed. Nanomedicine: Metal-Based and Other
2013 Nanomaterials
978-981-4411-04-2 (Hardcover) Vladimir Torchilin, ed.
978-981-4411-05-9 (eBook) 2020
978-981-4800-93-8 (Hardcover)
978-1-003-04515-1 (eBook)
Vol. 9 Vol. 13
Stimuli-Responsive Nanomedicine Microfluidics for Biomedicine
Lin Zhu, ed. Tania Konry, ed.
2020
Vol. 14
978-981-4800-70-9 (Hardcover)
Nanopreparations for Intracellular
978-0-429-29529-4 (eBook)
Targeting
Swati Biswas, ed.
Forthcoming
Vol. 15
Vol. 10
Clinical Nanomedicine: Lessons Learnt
Inorganic Nanomedicine
from Doxil
Bhupinder Singh Sekhon, ed.
Yechezkel Barenholz, ed.
Vol. 11
Vol. 16
Nanotechnology for Personalized
Electrical Interactions in Drug Delivery
Cancer Treatment
Ambika Bajpayee, ed.
Julia Ljubimova, ed.
Vol. 12
Translation Industrial Nanotechnology
Thomas Redelmeier, ed.
Jenny Stanford Series on Biomedical Nanotechnology Volume 7
Handbook of
Materials for
Nanomedicine
Polymeric Nanomaterials
edited by
Vladimir Torchilin
Published by
Jenny Stanford Publishing Pte. Ltd.
Level 34, Centennial Tower
3 Temasek Avenue
Singapore 039190
Email: [email protected]
Web: www.jennystanford.com
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
Handbook of Materials for Nanomedicine:
Polymeric Nanomaterials
All rights reserved. This book, or parts thereof, may not be reproduced in any form
Copyright © 2020 by Jenny Stanford Publishing Pte. Ltd.
or by any means, electronic or mechanical, including photocopying, recording
or any information storage and retrieval system now known or to be invented,
without written permission from the publisher.
For photocopying of material in this volume, please pay a copying fee through
the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923,
USA. In this case permission to photocopy is not required from the publisher.
ISBN 978-981-4800-92-1 (Hardcover)
ISBN 978-1-003-04511-3 (eBook)
Contents
1. Combinatorial Approach to Polymer Design for
Nanomedicines 1
Amit Singh, Meghana Rawal, and Mansoor M. Amiji
1.1 Introduction 1
1.1.1 Advantages of Nanoparticle Drug
Delivery Approach 2
1.1.2 Conventional Approach to Polymeric
Drug Delivery 3
1.1.3 Combinatorial Design 4
1.1.3.1 Parallel synthesis of “building
blocks” 5
1.1.3.2 Controlling property by
“mixing and matching” 5
1.1.3.3 Advantages to Combinatorial
Design 7
1.2 Synthetic Approach 7
1.2.1 Amidation Reactions 8
1.2.2 Michael Addition of Amines to α,β-
Unsaturated Esters 10
1.2.3 Azide-Alkyne 1,3-Dipolar
Cycloadditions 11
1.3 Combinatorially Designed Platforms with
Examples 11
1.3.1 Poly(β-Amino Ester)-Based Platform 12
1.3.2 Hyaluronic Acid-Based Platform 12
1.3.3 Chitosan-Based Platform 14
1.3.4 Dextran-Based Platform 16
1.3.5 Poly(methacryloxysuccinimide)-Based
Platform 17
1.4 Challenges with Combinatorial Approach 19
1.4.1 Synthetic Control and Characterization 20
1.4.2 Material–Property Relationship 21
1.4.3 Identification and Definition of CQAs 22
1.4.4 Scale-Up and Manufacturing 23
viii Contents
1.5 Microfluidic Technologies in Combinatorial
Design 25
1.5.1 Nanoparticle Synthesis 25
1.5.2 In vitro Screening 29
1.5.2.1 2D cell culture screening 29
1.5.2.2 3D cell culture screening 30
1.5.2.3 Organ-on-a-chip screening 31
2. 1St.6ar -ShaCpoendc Alumsipohnisp hilic Polymers as Soluble Carriers 31
for Drug Delivery 37
Karolina A. Kosakowska and Scott M. Grayson
2.1 Introduction—Amphiphiles, Self-Assembly,
and Non-Linear Polymer Architecture 39
2.2 Star-Shaped Amphiphilic Polymers: Synthesis
and Classifications 41
2.2.1 Amphiphilic Homo-Arm Star Polymers
for Drug Delivery 45
2.2.2 Amphiphilic Miktoarm (Hetero-Arm)
Star Polymers for Drug Delivery 51
2.2.3 Amphiphilic Core-Cross-Linked Star
Polymers for Drug Delivery 57
2.2.4 Amphiphilic Star-Dendritic Polymers
for Drug Delivery 61
2.3 Amphiphilic Star-Hyperbranched Polymers 68
2.4 Star-Shaped Amphiphilic Polymers in DDS
Application 76
2.4.1 Biocompatibility and Compliance 77
2.4.2 Size and Morphology 82
2.4.3 Thermodynamic and Kinetic Carrier
Stability 87
2.4.4 Drug Incorporation and Release 91
3. 2Se.5lf -AssSeummblminagr Py oalnymd Oeru–tDloroukg Conjugates 96
Nanomedicine for Drug Delivery 111
Jasbir Singh and Harmeet Kaur
3.1 Introduction 111
3.2 Mechanisms of Drug Release 114
