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About Global Strategies for Disease Detection and Treatment (Disease Markers)
The field of proteomics holds great promise for identifying non-targeted, global molecular profiles "signatures" of normal and diseased cells. While genomics offers an array of tools for identifying mutated or dysregulated genes, proteonomics offers the ability to measure post-translational modifications, protein stability, phosphorylation state, protein-protein interactions, and protein DNA-binding affinities. This work shows that strategies based on the separate analysis of subcellular compartments provide the means to determine protein location in a cell. Selective enrichment for a subset of proteins of interest can be achieved using a variety of techniques from centrifugation procedures to affinity capture.
Detailed Information
| Author: | S. Hanash |
|---|---|
| Publication Year: | 2002 |
| ISBN: | 9780585458816 |
| Pages: | 115 |
| Language: | English |
| File Size: | 15.137 |
| Format: | |
| Price: | FREE |
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