Table Of ContentGlaucoma
Update III
Editor
G. K. Krieglstein
With 123 Figures and 70 Tables
Springer-Verlag
Berlin Heidelberg N ew York
London Paris Tokyo
Glaucoma Society of the International
Congress of Ophthalmology
Amsterdam, September 1986
Editor
Professor Dr. G. K. Krieglstein
Direktor der Universitats-Augenklinik Koln
loseph-Stelzmann-StraBe 9
D-5000 Koln 41
ISBN-13: 978-3-540-17399-1 e-ISBN-13: 978-3-642-71785-7
DOl: 10.1007/978-3-642-71785-7
Library of Congress Cataloging-in-Publication Data. Glaucoma update III. "Glaucoma Society of the
International Congress of Ophthalmology, Amsterdam, September 1986" - T.p. verso. Includes
index. 1. Glaucoma - Congresses. I. Kriegistein, G. K. II. International Congress of Ophthalmology.
Glaucoma Society. III. Title: Glaucoma update 3. [DNLM: 1. Glaucoma - congresses. WW 290
G55081986] RE871.G575 1984 617.7'41 87-4897
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List of Contributors
AffiAKSINEN, P.J., Department of Ophthalmology, University of Oulu, Oulu,
Finland
ALANKO, H.I., Department of Ophthalmology, University of Oulu, Oulu, Fin-
land
ANDERSON, D. R., Bascom Palmer Eye Institute, University of Miami School of
Medicine, P.O. Box 016880, Miami, Florida 33101, U.S.A.
AzuMA, I., Department of Ophthalmology, Osaka Medical College, 569
Daigaku-cho 2-7, Takatsuki, Osaka, Japan
BENGTSSON, B., Vardcentralen, S-24010 Dalby, Sweden
BETINJANE, A.J., Division of Ophthalmology, School of Medicine, University
of Sao Paulo, Sao Paulo-01454, Brasil
BILL, A., Department of Physiology and Medical Biophysics, Biomedical
Center, Box 572, S-75123 Uppsala, Sweden
BLOOM, J., Glaucoma Unit and Department of Pharmacy, Moorfields Eye Hos-
pital, High Holborn, London WCl, Great Britain
CALDEIRA, J.A.F., Division of Ophthalmology, School of Medicine, University
of Sao Paulo, Sao Paulo-01454, Brasil
CALIXTO, N., Hospital Sao Geraldo, Faculdade de Medicina, Universidade de
Minas Gerais, Belo-Horizonte, 30000, Brasil
CAMRAS, C.B., Department of Ophthalmology, Mount Sinai School of Medi-
cine, One Gustave L. Levy Place, New York , N.Y., 10029, U.S.A.
CAPRIOLI, J., Glaucoma Unit, Department of Ophthalmology and Visual Science,
Yale University School of Medicine, 330 Cedar Street, New Haven, CT
06510-8061, U.S.A.
CARVALHO, C. A. DE, Division of Ophthalmology, School of Medicine, Univer-
sity of Sao Paulo, Sao Paulo-01454, Brasil
CHVAPIL, M., Oregon Lions Sight and Hearing Institute, 1040 N.W. Twenty-
Second Avenue, Portland, Oregon 97210, U.S.A.
CRONEMBERGER, S., Hospital Sao Geraldo, Faculdade de Medicina, Univer-
sidade de Minas Gerais, Belo-Horizonte, 30000, Brasil
v
D'ANNA, S., Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland 21205, U.S.A.
DIMITRAKos, S.A., Universitats-Augenklinik:, Ramistrasse 100, CH-8091 ZUrich,
Switzerland
DOUGLAS, G.R., Eye Care Centre, Vancouver General Hospital, University of
British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada
DRANCE, S.M., Eye Care Centre, Vancouver General Hospital, University of
British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada
Eps1EIN, D.L., Howe Laboratory of Ophthalmology, Massachusetts Eye and
Ear Infirmary, Harvard Medical School, Boston, MA 02114, U.S.A.
GEIJSSEN, H. c., Eye Clinic of the University of Amsterdam, Academic Medi-
cal Center, Meibergdreef 9, NL-1105 AZ Amsterdam, The Netherlands
GLOOR, B.P., Universitats-Augenklinik, Ramistrasse 100, CH-8091 Zurich,
Switzerland
GREEN, W. R., Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland 21205, U.S.A.
GREVE, E.L., Sint Lucas Hospital, Department of Ophthalmology, Jan Toorop-
straat 164, NL-1061 AE Amsterdam, The Netherlands
HAYREH, S.S., Department of Ophthalmology, University of Iowa, Iowa City,
Iowa 52242, U.S.A.
HEIJL, A., Department of Ophthalmology in Malmo, University of Lund,
S-21401 Malmo, Sweden
HERSCHLER, J., Oregon Lions Sight and Hearing Institute, 1040 N. W. Twenty-
Second Avenue, Portland, Oregon 97210, U.S.A.
HITCHINGS, R.A., Glaucoma Unit and Department of Pharmacy, Moorfields
Eye Hospital, High Holborn, London WCl, Great Britain
HOFMANN, S., Universitats-Augenklinik:, Josef-Schneider-Str.11, D-87oo W\irz-
burg, FRG
HOLMIN, C., Department of Ophthalmology, University of Lund, S-21401
Malmo, Sweden
IWATA, K., Department of Ophthalmology, Niigata University, School of Medi-
cine, 951 Niigata, Asahimachi 1, Japan
JAMPEL, H.D., Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland 21205, U.S.A.
JUVALA, P. A., Department of Ophthalmology, University of Oulu, Oulu, Fin-
land
VI
KAISER-KupFER, M.I., National Eye Institute, Building 31A, Room 6A03, 9000
Rockville Pike, Bethesda, Maryland 20205, U.S.A.
KAy, J.S., Oregon Lions Sight and Hearing Institute, 1040 N.W. Twenty-
Second Avenue, Portland, Oregon 97210, U.S.A.
KrrAzAWA, Y., Department of Ophthalmology, Gifu University School of Medi-
cine, 40 Tsukasa-machi, Gifu-shi 500, Japan
KRAKAu, C. E. T., Department of Ophthalmology, University of Lund, S-21401
Malmo, Sweden
KRrEGLSTEIN, G.K., UniversiUits-Augenklinik Koln, Joseph-Stelzmann-Str.9,
D-5000 KOln 41, FRG
KUPFER, C., National Eye Institute, Building 31A, Room 6A03, 9000 Rock-
ville Pike, Bethesda, Maryland 20205, U.S.A.
KURosAwA, H., Department of Ophthalmology, Niigata University, School of
Medicine, 951 Niigata, Asahimachi 1, Japan
LANGHAM, M.E., The Ocular Pharmacology and Therapeutics Unit, The Johns
Hopkins University School of Medicine, Baltimore, Maryland 21205,
U.S.A.
LATIES, A.M., Department of Ophthalmology, University of Pennsylvania
School of Medicine, Scheie Eye Institute, Philadelphia, PA 19104-6075,
U.S.A. .
LEE, P.-Y., Department of Ophthalmology, Mount Sinai School of Medicine,
One Gustave L. Levy Place, New York, N.Y. 10029, U.S.A.
LINNER, A., Department of Ophthalmology, University of Goteborg, Sahl-
gren's Hospital, S-41345 Goteborg, Sweden
LINNER, E., Department of Ophthalmology, University of Goteborg, Sahl-
gren's Hospital, S-41345 Goteborg, Sweden
LITIN, B.S., Oregon Lions Sight and Hearing Institute, 1040 N.W. Twenty-
Second Avenue, Portland, Oregon 97210, U.S.A.
LOTJEN-DRECOLL, E., Anatomisches Institut der Universitat Erlangen-Niirnberg,
Krankenhausstr. 9, D-8520 Erlangen, FRG
MELAMED, S., Glaucoma Service, Massachusetts Eye and Ear Infirmary, Har-
vard Medical School, 243 Charles St., Boston, MA 02114, U.S.A.
MIKELBERG, F.S., Eye Care Centre, Vancouver General Hospital, University
of British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9,
Canada
MINCKLER, D.S., Department of Ophthalmology, USC School of Medicine,
1355 San Pablo Street, Los Angeles, CA 90033, U.S.A.
NAGASUBRAMANIAN, S., Glaucoma Unit and Department of Pharmacy, Moor-
fields Eye Hospital, High Holbom, London WCl, Great Britain
VII
NAGIN, P., Department of Ophthalmology, New England Medical Center, 171
Harrison Avenue, Boston, MA 02111, U.S.A.
NAKANo, Y., Department of Ophthalmology, University of Tokyo School of
Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
OGDEN, T., Department of Ophthalmology, USC School of Medicine, 1355 San
Pablo Street, Los Angeles, CA 90033, U.S.A.
PODOS, S. M., Department of Ophthalmology, Mount Sinai School of Medicine,
One Gustave L. Levy Place, New York , N.Y. 10029, U.S.A.
POINOOSAWMY, D., Glaucoma Unit and Department of Pharmacy, Moorfields
Eye Hospital, High Holborn, London WC1, Great Britain
POLLACK, I. P., Department of Ophthalmology, Sinai Hospital, Belvedere at
Greenspring Avenue, Baltimore, Maryland 21215, U.S.A.
PRIORE, L. DEL, Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland 21205, U.S.A.
QUIGLEY, H.A., Glaucoma Services, The Wilmer Ophthalmological Institute,
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205,
U.S.A.
RABINEAU, P. A., Universitiits-Augenklinik, Riimistrasse 100, CH-8091 ZUrich,
Switzerland
ROBIN, A. L., Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland 21205, U.S.A.
ROSANDER, B., Department of Ophthalmology, University of Goteborg, Sahl-
gren's Hospital, S-41345 Goteborg, Sweden
SAMPAOLESI, R., Parana 1239 lOA, 1018 Buenos Aires, Argentinia
SAWAGUCHI, S., Department of Ophthalmology, Niigata University, School of
Medicine, 951 Niigata, Asahimachi 1, Japan
SCHULZER, M., Departments of Statistics and Medicine, University of British
Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada
SCHWARTZ, B., Department of Ophthalmology, New England Medical Center,
171 Harrison Avenue, Boston, MA 02111, U.S.A.
SCHWARTZ, D., Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland 21205, U.S.A.
SEARS, M. L., Glaucoma Service, Department of Ophthalmology and Visual
Science, Yale University School of Medicine, 330 Cedar Street, New Haven,
CT 06510, U.S.A.
VIII
SERLE, J. B., Department of Ophthalmology, Mount Sinai School of Medicine,
One Gustave L. Levy Place, New York, N.Y. 10029, U.S.A
SHIRATO, S., Department of Ophthalmology, University of Tokyo School of
Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan
SPERBER, G. 0., Department of Physiology and Medical Biophysics, Biomedi-
cal Center, Box 572, S-75123 Uppsala, Sweden
STONE, RA, 418 Johnson Pavilion, University of Pennsylvania School of Medi-
cine, Philadelphia, PA 19104-6075, U.S.A
STREISFELD, D.L., Department of Ophthalmology, The Wilmer Ophthalmological
Institute, The Johns Hopkins Hospital and Sinai Hospital, Baltimore,
Maryland, 21205, U.S.A.
TAKAMOTO, T., Department of Ophthalmology, New England Medical Center,
171 Harrison Avenue, Boston, MA 02111, U.S.A
TAMM, E., Anatomisches Institut der Universitat Erlangen-Niirnberg, Kran-
kenhausstrasse 9, D-8520 Erlangen, FRG
TANIGUCHI, T., Department of Ophthalmology, Gifu University School of Medi-
cine, 40 Tsukasa-machi, Gifu-shi 500, Japan
TARKKANEN, A., Department of Ophthalmology, Helsinki University Central
Hospital, 00290 Helsinki, Finland
TuoHINo, A, Department of Ophthalmology, University of Oulu, Oulu, Fin-
land
TUULONEN, A., Department of Ophthalmology, University of Oulu, Oulu, Fin-
land
UUSITALO, R. J., Department of Ophthalmology, Helsinki University Central
Hospital, 00290 Helsinki, Finland
VALKONEN, R., Department of Ophthalmology, University of Oulu, Oulu, Fin-
land
VANBUSKIRK, E.M., Department of Ophthalmology, Oregon Health Sciences
University, Portland, Oregon 97210, U.S.A
WUSMAN, K., Eye Care Centre, Vancouver General Hospital, University of
British Columbia, 2550 Willow Street, Vancouver, B.C. V5Z 3N9, Canada
WISHART, P., Glaucoma Unit and Department of Pharmacy, Moorfields Eye
Hospital, High Holborn, London WCl, Great Britain
Wu, D.-C., Department of Ophthalmology, New England Medical Center, 171
Harrison Avenue, Boston, MA 02111, U.S.A.
Xu, S., Department of Ophthalmology, USC School of Medicine, 1355 San
Pablo Street, Los Angeles, CA 90033, U.S.A.
ZYPEN, E. VAN DER, Abteilung fUr Topographische Anatomie, Anatomisches
Institut, Universitat Bern, Buehlstrasse 26, CH-3OO0 Bern 9, Switzerland
IX
Preface
The third Committee Meeting of the Glaucoma Society of the Inter-
national Congress of Ophthalmology was held in Bussum, Nether-
lands, September 11-14, 1986. Traditionally this is a closed meet-
ing, held under the auspices of the International Council of Oph-
thalmology. About 80 experts on glaucoma - active members of
the Committee and invited guests - discussed the latest progress in
glaucoma research. The quite informal scientific lectures, presented
in this book, provided the nucleus for a stimulating and fruitful dis-
cussion.
The scientific program was prepared by Stephan M. Drance
(Vancouver) and Jack Hetherington, Jr. (San Francisco), and the
local organization was in the hands of Erik L. Greve (Amsterdam)
and his group.
The Society is indebted to Chibret International for its generous
support of the meeting and to Pharm Allergan (Germany) for its
generous assistance in covering a large portion of the printing ex-
penses. Finally the editor wishes to thank Springer-Verlag for mak-
ing it possible for this book to be published within such short time-
span.
Koln GONTER K. KRIEGLSTEIN
XI
Contents
Neuroanatomy and Neuroendocrinology of the Chamber Angle
R. A. STONE and A. M. LATIEs. With 8 Figures . . . . . . . 1
Differences in the Amount of "Plaque Material"
in the Outflow System of Eyes with Chronic Simple
and Exfoliation Glaucoma
E. UiTJEN-DRECOLL and E. TAMM. With 4 Figures . . 17
Are Some Retinal Ganglion Cells Killed by Glaucoma Before Others?
H.A. QUIGLEY ••••••••••••••••••••••••••••• 23
Distribution of Axonal Transport Injury in the Lamina
in Experimental Glaucoma in the Monkey
D.S.MINCKLER, S.Xu, and T. OGDEN. With 7 Figures and 1 Table 27
Changes in the Lamina Cribrosa
in Experimental Glaucoma in Monkeys
K. IWATA, S. SAWAGUCm, and H. KUROSAWA. With 2 Figures 36
Factors Determining the Glaucomatous Optic Nerve Head Damage
S. S. HAYREH. With 1 Figure ..................... 40
Optic Nerve Head Blood Flow is Normal
in Chronic Experimental Glaucoma
H. A. QUIGLEY ••••.••••••••• 47
Blood Flow and Glucose Consumption in the Optic Nerve;
Effects of High Intraocular Pressure
A. BILL and G. O. SPERBER. With 5 Figures . . . . . . . . . 51
Ocular Blood Flow and Visual Loss in Glaucomatous Eyes
M. E. LANGHAM. With 5 Figures and 2 Tables ...... . 58
Some Risk Factors in Ocular Hypertension
E. LlNNER, A. LlNNER, and B. ROSANDER. With 4 Figures and 2 Tables 67
How to Find the Risk Factors in Early Glaucoma
I. AZUMA. With 2 Figures and 3 Tables . . . . . . 72
Vascular Risk Factors in Progressive Low Tension Glaucoma
H. C. GEUSSEN and E. L. GREVE. With 10 Tables 77
Changes of Optic Disc Cupping and Pallor Over Time
B.SCHWARTZ, T. TAKAMOTO, and D.-C. Wu. With 6 Figures and 2 Tables 84
XIII
